CO5670350A2 - Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico - Google Patents

Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico

Info

Publication number
CO5670350A2
CO5670350A2 CO05004558A CO05004558A CO5670350A2 CO 5670350 A2 CO5670350 A2 CO 5670350A2 CO 05004558 A CO05004558 A CO 05004558A CO 05004558 A CO05004558 A CO 05004558A CO 5670350 A2 CO5670350 A2 CO 5670350A2
Authority
CO
Colombia
Prior art keywords
sub
oxazol
benzoic
acid derivatives
prepare acid
Prior art date
Application number
CO05004558A
Other languages
English (en)
Inventor
Michael R Reeder
Rick J Imbordino
Original Assignee
Pharmacia And Upjohn Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia And Upjohn Company Llc filed Critical Pharmacia And Upjohn Company Llc
Publication of CO5670350A2 publication Critical patent/CO5670350A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)

Abstract

1.- Un proceso para preparar un compuesto de la fórmula En donde:R1 es alcoxi C1-C6 o OH;R2 y R3 son independientemente H, fenilo, o alquilo C1-C4; oR2 y R3 y los átomos a los cuales ellos están adheridos forman un anillo benzo, que está opcionalmente sustituido con alquilo C1-C4, alcoxi C1-C4, o dialquilamino; yR6 es alcoxi C1-C6, o NR4R5; en dondeR4 y R5 son independientemente alquilo C1-C6;Que comprende:Formar una mezcla de reacción que comprende un compuesto de fórmula I: X es Br, I, Otf, o Oms;Un compuesto de la fórmula II: Un catalizador, un aditivo opcional, y al menos un solvente.2.- Un proceso de acuerdo con la reivindicación 1, en donde el catalizador es un catalizador de metal de transición.3.- Un proceso de acuerdo con la reivindicación 2 en donde el catalizador de metal de transición es Pd(PPh3)4, PdCI2(PPh3)2, PdCI2, PdCI2 y PPh3, o Pd(OCOCh3)2.4.- Un proceso de acuerdo con la reivindicación 3 en donde el catalizador es Pd(PPh3)4.
CO05004558A 2002-06-20 2005-01-20 Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico CO5670350A2 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39028502P 2002-06-20 2002-06-20
US45047803P 2003-02-27 2003-02-27

Publications (1)

Publication Number Publication Date
CO5670350A2 true CO5670350A2 (es) 2006-08-31

Family

ID=30003150

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05004558A CO5670350A2 (es) 2002-06-20 2005-01-20 Proceso para preparar derivados de acido 5-(1,3-oxazol- 2-il) benzoico

Country Status (18)

Country Link
US (2) US7115747B2 (es)
EP (1) EP1532123B1 (es)
JP (1) JP2005533811A (es)
CN (1) CN1324017C (es)
AT (1) ATE370131T1 (es)
AU (1) AU2003249344A1 (es)
BR (1) BR0312439A (es)
CA (1) CA2489988A1 (es)
CO (1) CO5670350A2 (es)
DE (1) DE60315664D1 (es)
EA (1) EA008389B1 (es)
HK (1) HK1081543A1 (es)
IL (1) IL165763A0 (es)
MX (1) MXPA04012630A (es)
NO (1) NO20045497L (es)
NZ (1) NZ537390A (es)
PL (1) PL374999A1 (es)
WO (1) WO2004000821A1 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7351738B2 (en) * 2002-11-27 2008-04-01 Elan Pharmaceuticals, Inc. Substituted ureas and carbamates
TW200738701A (en) 2005-07-26 2007-10-16 Du Pont Fungicidal carboxamides
US7745484B2 (en) 2005-11-21 2010-06-29 Amgen Inc. Beta-secretase modulators and methods of use
US7872009B2 (en) * 2005-11-21 2011-01-18 Amgen Inc. Beta-Secretase modulators and methods of use
US7838676B2 (en) * 2005-11-21 2010-11-23 Amgen Inc. Beta-secretase modulators and methods of use
EP1971598A1 (en) 2005-11-21 2008-09-24 Amgen Inc. Beta-secretase modulators and methods of use
US20080277393A1 (en) * 2007-05-07 2008-11-13 True Charles W Collapsible, stackable, semi-rigid universal cotainer for hazardous and non-hazardous goods
WO2008147544A1 (en) 2007-05-25 2008-12-04 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US8163909B2 (en) 2007-05-25 2012-04-24 Amgen Inc. Substituted hydroxyethyl amine compounds as beta-secretase modulators and methods of use
US7803809B2 (en) 2008-11-12 2010-09-28 Amgen Inc. Substituted pyrano [2,3-b] pyridinamine compounds as beta-secretase modulators and methods of use
EA201100461A1 (ru) 2008-09-11 2011-10-31 Амген Инк. Спиро-трициклические соединения как модуляторы бета-секретазы и способы их использования
WO2011063233A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
WO2011063272A1 (en) 2009-11-23 2011-05-26 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
CA2788363A1 (en) 2010-01-19 2011-07-28 Amgen Inc. Amino heteroaryl compounds as beta-secretase modulators and methods of use
AU2011227511B2 (en) 2010-03-15 2014-02-20 Amgen Inc. Spiro-tetracyclic ring compounds as Beta - secretase modulators
EP2547686B1 (en) 2010-03-15 2014-01-22 Amgen Inc. Amino-dihydrooxazine and amino-dihydrothiazine spiro compounds as beta-secretase modulators and their medical use
WO2012109165A1 (en) 2011-02-07 2012-08-16 Amgen Inc. 5-amino-oxazepine and 5-amino-thiazepane compounds as beta-secretase antagonists and methods of use
WO2013044092A1 (en) 2011-09-21 2013-03-28 Amgen Inc. Amino-oxazines and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
WO2014078314A1 (en) 2012-11-15 2014-05-22 Amgen Inc. Amino-oxazine and amino-dihydrothiazine compounds as beta-secretase modulators and methods of use
US11272751B2 (en) 2016-03-01 2022-03-15 Nicholas Popejoy Protective headgear, impact diffusing systems and methods
US9462841B1 (en) 2016-03-01 2016-10-11 William Popejoy Protective headgear and shoulder pad apparatus and methods

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020276A1 (es) * 2000-06-30 2002-04-06 Elan Pharm Inc COMPUESTOS DE AMINA SUSTITUIDA COMO INHIBIDORES DE ß-SECRETASA PARA EL TRATAMIENTO DE ALZHEIMER
MXPA04003245A (es) * 2001-10-04 2004-08-11 Elan Pharm Inc Hidroxipropilaminas.
US7176242B2 (en) * 2001-11-08 2007-02-13 Elan Pharmaceuticals, Inc. N,N′-substituted-1,3-diamino-2-hydroxypropane derivatives
GB0325830D0 (en) * 2003-11-05 2003-12-10 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
IL165763A0 (en) 2006-01-15
US7115747B2 (en) 2006-10-03
US20070105921A1 (en) 2007-05-10
NZ537390A (en) 2006-07-28
DE60315664D1 (de) 2007-09-27
US20040063965A1 (en) 2004-04-01
NO20045497L (no) 2005-03-07
NO20045497D0 (no) 2004-12-16
ATE370131T1 (de) 2007-09-15
JP2005533811A (ja) 2005-11-10
EP1532123A1 (en) 2005-05-25
MXPA04012630A (es) 2005-09-30
BR0312439A (pt) 2005-05-10
EP1532123B1 (en) 2007-08-15
EA200401510A1 (ru) 2005-06-30
CN1324017C (zh) 2007-07-04
WO2004000821A1 (en) 2003-12-31
HK1081543A1 (en) 2006-05-19
EA008389B1 (ru) 2007-04-27
CN1662510A (zh) 2005-08-31
CA2489988A1 (en) 2003-12-31
AU2003249344A1 (en) 2004-01-06
PL374999A1 (en) 2005-11-14

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