DOP2022000281A - Antagonistas del receptor de melanocortina 4 y usos de estos - Google Patents

Antagonistas del receptor de melanocortina 4 y usos de estos

Info

Publication number
DOP2022000281A
DOP2022000281A DO2022000281A DO2022000281A DOP2022000281A DO P2022000281 A DOP2022000281 A DO P2022000281A DO 2022000281 A DO2022000281 A DO 2022000281A DO 2022000281 A DO2022000281 A DO 2022000281A DO P2022000281 A DOP2022000281 A DO P2022000281A
Authority
DO
Dominican Republic
Prior art keywords
compounds
salts
melanocortin
receptor antagonists
anorexia
Prior art date
Application number
DO2022000281A
Other languages
English (en)
Inventor
Christopher Smith Aaron
Forrest Sammons Matthew
Renee Garnsey Michelle
Ryan Butler Christopher
Yang Qingyi
Alexander Ogilvie Kevin
Polivkova Jana
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DOP2022000281A publication Critical patent/DOP2022000281A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En la presente se describen compuestos de la Fórmula I: I y sus sales aceptables desde el punto de vista farmacéutico, en donde R1, R2, R3, X1, Y1, Y2, Y3, Y4 e Y5 se definen en la presente; su uso como antagonistas de MC4R; composiciones farmacéuticas que contienen tales compuestos y sales; el uso de tales compuestos y sales para tratar, por ejemplo, caquexia, anorexia o anorexia nerviosa; e intermediarios y procesos para preparar tales compuestos y sales.
DO2022000281A 2020-06-09 2022-12-08 Antagonistas del receptor de melanocortina 4 y usos de estos DOP2022000281A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063036798P 2020-06-09 2020-06-09
US202163167271P 2021-03-29 2021-03-29
PCT/IB2021/054970 WO2021250541A1 (en) 2020-06-09 2021-06-07 Spiro compounds as melanocortin 4 receptor antagonists and uses thereof

Publications (1)

Publication Number Publication Date
DOP2022000281A true DOP2022000281A (es) 2023-01-15

Family

ID=76422026

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2022000281A DOP2022000281A (es) 2020-06-09 2022-12-08 Antagonistas del receptor de melanocortina 4 y usos de estos

Country Status (21)

Country Link
US (2) US11643412B2 (es)
EP (1) EP4161927B1 (es)
JP (1) JP7288554B1 (es)
KR (1) KR20230011968A (es)
CN (1) CN116113635A (es)
AU (1) AU2021289169B2 (es)
BR (1) BR112022024527A2 (es)
CA (1) CA3186348A1 (es)
CL (1) CL2022003503A1 (es)
CO (1) CO2022017790A2 (es)
CR (1) CR20220632A (es)
DK (1) DK4161927T3 (es)
DO (1) DOP2022000281A (es)
EC (1) ECSP22093794A (es)
IL (1) IL298891A (es)
MX (1) MX2022015706A (es)
PE (1) PE20231215A1 (es)
TW (1) TWI843949B (es)
UY (1) UY39260A (es)
WO (1) WO2021250541A1 (es)
ZA (1) ZA202213427B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024173905A1 (en) * 2023-02-17 2024-08-22 Endevica Bio, Inc. Methods of preventing and/or treating side effects associated with anti-cancer agents using non-naturally occurring melanocortin analogs with anti-gdf-15 antibodies

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Also Published As

Publication number Publication date
AU2021289169B2 (en) 2024-01-04
MX2022015706A (es) 2023-01-24
KR20230011968A (ko) 2023-01-25
US20230174532A1 (en) 2023-06-08
EP4161927A1 (en) 2023-04-12
PE20231215A1 (es) 2023-08-17
IL298891A (en) 2023-02-01
JP7288554B1 (ja) 2023-06-07
US20230019853A1 (en) 2023-01-19
AU2021289169A1 (en) 2023-01-19
CR20220632A (es) 2023-01-23
TW202204357A (zh) 2022-02-01
BR112022024527A2 (pt) 2022-12-27
EP4161927B1 (en) 2024-08-07
TWI843949B (zh) 2024-06-01
ECSP22093794A (es) 2023-01-31
JP2023525394A (ja) 2023-06-15
CA3186348A1 (en) 2021-12-16
CL2022003503A1 (es) 2023-09-01
DK4161927T3 (da) 2024-08-26
ZA202213427B (en) 2023-07-26
CN116113635A (zh) 2023-05-12
US11643412B2 (en) 2023-05-09
CO2022017790A2 (es) 2022-12-20
WO2021250541A1 (en) 2021-12-16
UY39260A (es) 2022-01-31

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