CR20220632A - Antagonistas del receptor de melanocortina 4 y usos de estos - Google Patents

Antagonistas del receptor de melanocortina 4 y usos de estos

Info

Publication number
CR20220632A
CR20220632A CR20220632A CR20220632A CR20220632A CR 20220632 A CR20220632 A CR 20220632A CR 20220632 A CR20220632 A CR 20220632A CR 20220632 A CR20220632 A CR 20220632A CR 20220632 A CR20220632 A CR 20220632A
Authority
CR
Costa Rica
Prior art keywords
melanocortin
receptor antagonists
spiro compounds
compounds
salts
Prior art date
Application number
CR20220632A
Other languages
English (en)
Inventor
Kevin Alexander Ogilvie
Aaron Christopher Smith
Jana Polivkova
Michelle Renee Garnsey
Matthew Forrest Sammons
Christopher Ryan Butler
Qingyi Yang
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CR20220632A publication Critical patent/CR20220632A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/20—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Otolaryngology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

En la presente se describen compuestos de la Fórmula I: <img alt="" src="data:image/png;base64,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 (***)
CR20220632A 2020-06-09 2021-06-07 Antagonistas del receptor de melanocortina 4 y usos de estos CR20220632A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063036798P 2020-06-09 2020-06-09
US202163167271P 2021-03-29 2021-03-29
PCT/IB2021/054970 WO2021250541A1 (en) 2020-06-09 2021-06-07 Spiro compounds as melanocortin 4 receptor antagonists and uses thereof

Publications (1)

Publication Number Publication Date
CR20220632A true CR20220632A (es) 2023-01-23

Family

ID=76422026

Family Applications (1)

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CR20220632A CR20220632A (es) 2020-06-09 2021-06-07 Antagonistas del receptor de melanocortina 4 y usos de estos

Country Status (23)

Country Link
US (2) US11643412B2 (es)
EP (1) EP4161927B1 (es)
JP (1) JP7288554B1 (es)
KR (1) KR20230011968A (es)
CN (1) CN116113635A (es)
AU (1) AU2021289169B2 (es)
BR (1) BR112022024527A2 (es)
CA (1) CA3186348A1 (es)
CL (1) CL2022003503A1 (es)
CO (1) CO2022017790A2 (es)
CR (1) CR20220632A (es)
DK (1) DK4161927T3 (es)
DO (1) DOP2022000281A (es)
EC (1) ECSP22093794A (es)
FI (1) FI4161927T3 (es)
IL (1) IL298891A (es)
LT (1) LT4161927T (es)
MX (1) MX2022015706A (es)
PE (1) PE20231215A1 (es)
TW (1) TWI843949B (es)
UY (1) UY39260A (es)
WO (1) WO2021250541A1 (es)
ZA (1) ZA202213427B (es)

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BR112022024527A2 (pt) 2022-12-27
CN116113635A (zh) 2023-05-12
CL2022003503A1 (es) 2023-09-01
KR20230011968A (ko) 2023-01-25
AU2021289169A1 (en) 2023-01-19
EP4161927B1 (en) 2024-08-07
FI4161927T3 (fi) 2024-10-03
CO2022017790A2 (es) 2022-12-20
WO2021250541A1 (en) 2021-12-16
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JP2023525394A (ja) 2023-06-15
ZA202213427B (en) 2023-07-26
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IL298891A (en) 2023-02-01
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US20230174532A1 (en) 2023-06-08
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US20230019853A1 (en) 2023-01-19
DOP2022000281A (es) 2023-01-15
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