DOP2022000034A - Derivados de 1,3fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades - Google Patents
Derivados de 1,3fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedadesInfo
- Publication number
- DOP2022000034A DOP2022000034A DO2022000034A DO2022000034A DOP2022000034A DO P2022000034 A DOP2022000034 A DO P2022000034A DO 2022000034 A DO2022000034 A DO 2022000034A DO 2022000034 A DO2022000034 A DO 2022000034A DO P2022000034 A DOP2022000034 A DO P2022000034A
- Authority
- DO
- Dominican Republic
- Prior art keywords
- diseases
- treatment
- derivatives
- substituted phenyl
- heteroaryl substituted
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 201000010099 disease Diseases 0.000 title abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 208000025678 Ciliary Motility disease Diseases 0.000 abstract 2
- 201000003883 Cystic fibrosis Diseases 0.000 abstract 2
- 201000009266 primary ciliary dyskinesia Diseases 0.000 abstract 2
- 206010006458 Bronchitis chronic Diseases 0.000 abstract 1
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 abstract 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 abstract 1
- 206010057190 Respiratory tract infections Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 208000006673 asthma Diseases 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 201000009267 bronchiectasis Diseases 0.000 abstract 1
- 206010006451 bronchitis Diseases 0.000 abstract 1
- 208000007451 chronic bronchitis Diseases 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 201000005296 lung carcinoma Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 208000020029 respiratory tract infectious disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La invención se refiere a compuestos heterocíclicos de la fórmula formula (I) en donde todas las variables son como se definen en la memoria descriptiva, capaces de modular la actividad de TMEM16a. La invención proporciona además un método para fabricar compuestos de la invención, y sus usos terapéuticos. La invención proporciona además métodos para su preparación, para su uso médico, en particular, para su uso en el tratamiento y abordaje de enfermedades o trastornos que incluyen EPOC, bronquiectasia, asma, fibrosis quística, disquinesia ciliar primaria, bronquitis crónica, fibrosis quística, disquinesia ciliar primaria, infecciones del tracto respiratorio (aguda y crónica; viral y bacteriana), carcinoma de pulmón.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962892664P | 2019-08-28 | 2019-08-28 | |
PCT/IB2020/057905 WO2021038426A1 (en) | 2019-08-28 | 2020-08-24 | Substituted 1,3-phenyl heteroaryl derivatives and their use in the treatment of disease |
Publications (1)
Publication Number | Publication Date |
---|---|
DOP2022000034A true DOP2022000034A (es) | 2022-03-15 |
Family
ID=72292591
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DO2022000034A DOP2022000034A (es) | 2019-08-28 | 2022-02-10 | Derivados de 1,3fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades |
Country Status (20)
Country | Link |
---|---|
US (1) | US20220306617A1 (es) |
EP (1) | EP4021572A1 (es) |
JP (1) | JP2022547427A (es) |
KR (1) | KR20220052934A (es) |
CN (1) | CN114341132A (es) |
AR (1) | AR119819A1 (es) |
AU (1) | AU2020338971B2 (es) |
BR (1) | BR112022002569A2 (es) |
CA (1) | CA3146109A1 (es) |
CO (1) | CO2022001387A2 (es) |
CR (1) | CR20220060A (es) |
DO (1) | DOP2022000034A (es) |
EC (1) | ECSP22011156A (es) |
IL (1) | IL289616A (es) |
JO (1) | JOP20220044A1 (es) |
MX (1) | MX2022002374A (es) |
PE (1) | PE20220346A1 (es) |
TW (1) | TWI753550B (es) |
UY (1) | UY38860A (es) |
WO (1) | WO2021038426A1 (es) |
Family Cites Families (104)
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GB0225287D0 (en) | 2002-10-30 | 2002-12-11 | Glaxo Group Ltd | Novel compounds |
GB0225540D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
GB0225535D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Medicinal compounds |
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PE20040950A1 (es) | 2003-02-14 | 2005-01-01 | Theravance Inc | DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS |
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EP1460064A1 (en) | 2003-03-14 | 2004-09-22 | Pfizer Limited | Indole-2-carboxamide derivatives useful as beta-2 agonists |
GB0312832D0 (en) | 2003-06-04 | 2003-07-09 | Pfizer Ltd | 2-amino-pyridine derivatives useful for the treatment of diseases |
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US9790218B2 (en) * | 2011-08-05 | 2017-10-17 | The Regents Of The University Of California | Small molecule activators of calcium-activated chloride channels and methods of use |
CA2952862A1 (en) * | 2014-06-19 | 2015-12-23 | Proteostasis Therapeutics, Inc. | Compounds, compositions and methods of increasing cftr activity |
-
2020
- 2020-08-24 EP EP20764788.4A patent/EP4021572A1/en active Pending
- 2020-08-24 PE PE2022000246A patent/PE20220346A1/es unknown
- 2020-08-24 JP JP2022513293A patent/JP2022547427A/ja active Pending
- 2020-08-24 CN CN202080059610.2A patent/CN114341132A/zh active Pending
- 2020-08-24 AU AU2020338971A patent/AU2020338971B2/en not_active Expired - Fee Related
- 2020-08-24 AR ARP200102380A patent/AR119819A1/es unknown
- 2020-08-24 BR BR112022002569A patent/BR112022002569A2/pt unknown
- 2020-08-24 KR KR1020227006043A patent/KR20220052934A/ko unknown
- 2020-08-24 MX MX2022002374A patent/MX2022002374A/es unknown
- 2020-08-24 US US17/638,106 patent/US20220306617A1/en active Pending
- 2020-08-24 JO JOP/2022/0044A patent/JOP20220044A1/ar unknown
- 2020-08-24 CA CA3146109A patent/CA3146109A1/en active Pending
- 2020-08-24 CR CR20220060A patent/CR20220060A/es unknown
- 2020-08-24 UY UY0001038860A patent/UY38860A/es unknown
- 2020-08-24 WO PCT/IB2020/057905 patent/WO2021038426A1/en active Application Filing
- 2020-08-26 TW TW109129135A patent/TWI753550B/zh active
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2022
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JP2022547427A (ja) | 2022-11-14 |
PE20220346A1 (es) | 2022-03-14 |
IL289616A (en) | 2022-03-01 |
JOP20220044A1 (ar) | 2023-01-30 |
AR119819A1 (es) | 2022-01-12 |
TWI753550B (zh) | 2022-01-21 |
US20220306617A1 (en) | 2022-09-29 |
CO2022001387A2 (es) | 2022-03-18 |
CA3146109A1 (en) | 2021-03-04 |
TW202122386A (zh) | 2021-06-16 |
BR112022002569A2 (pt) | 2022-07-19 |
CN114341132A (zh) | 2022-04-12 |
AU2020338971B2 (en) | 2023-11-23 |
ECSP22011156A (es) | 2022-03-31 |
UY38860A (es) | 2021-02-26 |
MX2022002374A (es) | 2022-03-29 |
CR20220060A (es) | 2022-03-01 |
WO2021038426A1 (en) | 2021-03-04 |
EP4021572A1 (en) | 2022-07-06 |
AU2020338971A1 (en) | 2022-01-27 |
KR20220052934A (ko) | 2022-04-28 |
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