DOP2011000393A - Derivados de pirazinooxazepina - Google Patents

Derivados de pirazinooxazepina

Info

Publication number
DOP2011000393A
DOP2011000393A DO2011000393A DO2011000393A DOP2011000393A DO P2011000393 A DOP2011000393 A DO P2011000393A DO 2011000393 A DO2011000393 A DO 2011000393A DO 2011000393 A DO2011000393 A DO 2011000393A DO P2011000393 A DOP2011000393 A DO P2011000393A
Authority
DO
Dominican Republic
Prior art keywords
pirazinooxazepina
derivatives
compound
serotonin
symbol
Prior art date
Application number
DO2011000393A
Other languages
English (en)
Inventor
Shigekazu Sasaki
Tomokazu Kusumoto
Izumi Nomura
Hironobu Maezaki
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of DOP2011000393A publication Critical patent/DOP2011000393A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporciona un compuesto que tiene una acción activadora del receptor de 5-HT2c de serotonina. Un compuesto representado por la fórmula (I) en donde cada símbolo es como se definió en la memoria descriptiva o una de sus sales.
DO2011000393A 2009-06-15 2011-12-14 Derivados de pirazinooxazepina DOP2011000393A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009142673 2009-06-15

Publications (1)

Publication Number Publication Date
DOP2011000393A true DOP2011000393A (es) 2012-02-15

Family

ID=42561089

Family Applications (1)

Application Number Title Priority Date Filing Date
DO2011000393A DOP2011000393A (es) 2009-06-15 2011-12-14 Derivados de pirazinooxazepina

Country Status (41)

Country Link
US (4) US8318722B2 (es)
EP (1) EP2442870B1 (es)
JP (2) JP5579262B2 (es)
KR (1) KR101768234B1 (es)
CN (1) CN102458579B (es)
AR (1) AR077094A1 (es)
AU (1) AU2010260847B2 (es)
BR (1) BRPI1011502A2 (es)
CA (1) CA2765239C (es)
CL (1) CL2011003154A1 (es)
CO (1) CO6491037A2 (es)
CR (1) CR20120021A (es)
CY (1) CY1115483T1 (es)
DK (1) DK2442870T3 (es)
DO (1) DOP2011000393A (es)
EA (1) EA021079B1 (es)
EC (1) ECSP12011603A (es)
ES (1) ES2480275T3 (es)
GE (1) GEP20146168B (es)
HK (1) HK1169623A1 (es)
HR (1) HRP20140589T1 (es)
IL (1) IL216761A (es)
JO (1) JO3087B1 (es)
MA (1) MA33430B1 (es)
ME (1) ME01835B (es)
MX (1) MX2011013081A (es)
MY (1) MY157497A (es)
NZ (1) NZ597507A (es)
PE (1) PE20121049A1 (es)
PL (1) PL2442870T3 (es)
PT (1) PT2442870E (es)
RS (1) RS53414B (es)
SG (1) SG176696A1 (es)
SI (1) SI2442870T1 (es)
SM (1) SMT201400080B (es)
TN (1) TN2011000630A1 (es)
TW (2) TW201529584A (es)
UA (1) UA108357C2 (es)
UY (1) UY32707A (es)
WO (1) WO2010147226A1 (es)
ZA (1) ZA201109370B (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007132841A1 (ja) * 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
CN102458579B (zh) * 2009-06-15 2014-11-05 武田药品工业株式会社 吡嗪并氧氮杂*衍生物
WO2012030953A1 (en) 2010-09-01 2012-03-08 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists in the treatment of disorders ameliorated by reduction of norepinephrine level
JP2014201578A (ja) * 2013-04-09 2014-10-27 武田薬品工業株式会社 線維筋痛症治療剤
JP2014214132A (ja) * 2013-04-26 2014-11-17 武田薬品工業株式会社 ニコチン依存症の予防・治療剤
WO2015066344A1 (en) 2013-11-01 2015-05-07 Arena Pharmaceuticals, Inc. 5-ht2c receptor agonists and compositions and methods of use
WO2017026538A1 (en) 2015-08-07 2017-02-16 Takeda Pharmaceutical Company Limited Production method of pyrazine
TW201729814A (zh) 2015-12-24 2017-09-01 武田藥品工業股份有限公司 固形製劑
US9985579B2 (en) 2016-04-12 2018-05-29 Preformed Line Products Co. Mounting assembly for mounting a solar panel
EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2992677B2 (ja) 1995-06-05 1999-12-20 武田薬品工業株式会社 骨形成促進医薬組成物
SE0002754D0 (sv) 2000-07-21 2000-07-21 Pharmacia & Upjohn Ab New pharmaceutical combination formulation and method of treatment with the combination
CA2449899C (en) 2000-11-20 2010-04-06 Biovitrum Ab Piperazinylpyrazines compounds as antagonists of serotonin 5-ht2 receptor
AU2002314744A1 (en) 2001-04-17 2002-10-28 Sepracor, Inc. Thiazole and other heterocyclic ligands and use thereof
SE0201544D0 (sv) 2002-05-17 2002-05-17 Biovitrum Ab Novel compounds and thier use
SI1645558T1 (sl) 2002-06-19 2008-10-31 Biovitrum Ab Publ Piperazinilpirazini kot modulatorji serotonin 5-HT2C receptorja
CA2485537A1 (en) 2002-06-19 2003-12-31 Biovitrum Ab Novel compounds, their use and preparation
EP1591120A4 (en) 2003-01-28 2009-06-10 Takeda Chemical Industries Ltd RECEPTOR AGONISTS
CL2004000826A1 (es) 2003-04-25 2005-03-04 Pfizer Uso de un agonista para el receptor 5-ht2c para preparar un medicamento util en el tratamiento de la incontinencia urinaria provocada por estres, con la condicion de que el agonista no sea 1-[6-cloro-5-(trifluorometil)-2-piridinil]piperazina (org-129
HUE028976T2 (en) * 2003-06-17 2017-02-28 Arena Pharm Inc 8-Chloro-1-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride
EA016558B1 (ru) * 2003-06-17 2012-05-30 Арена Фармасьютикалз, Инк. Производные бензазепина, используемые для лечения заболеваний, ассоциированных с 5-ht-рецептором
JP2006056881A (ja) 2004-07-21 2006-03-02 Takeda Chem Ind Ltd 縮合環化合物
SI1926712T1 (sl) 2005-09-01 2010-01-29 Lilly Co Eli 6-substituirani 2,3.4,5-tetrahidro-1h-benzo(d)azepini kot agonisti 5-ht2c receptorja
FR2895259B1 (fr) 2005-12-22 2008-02-22 Urosphere Sas Methodes de traitement des incontinences urinaires
WO2007132841A1 (ja) * 2006-05-16 2007-11-22 Takeda Pharmaceutical Company Limited 縮合複素環化合物およびその用途
JP5497429B2 (ja) 2007-03-07 2014-05-21 武田薬品工業株式会社 ベンゾオキサゼピン誘導体およびその用途
WO2009032754A2 (en) 2007-08-31 2009-03-12 Kalypsys, Inc. Heterocyclodiazepine cannabinoid receptor modulators for treatment of disease
EP2216023A4 (en) 2007-11-15 2013-03-13 Takeda Pharmaceutical CONDENSED PYRIDINE DERIVATIVE AND USE THEREOF
WO2009063993A1 (ja) * 2007-11-15 2009-05-22 Takeda Pharmaceutical Company Limited 縮合ピリジン誘導体およびその用途
JP5361733B2 (ja) * 2007-11-15 2013-12-04 武田薬品工業株式会社 ピリドオキサゼピン誘導体およびその用途
CN102458579B (zh) * 2009-06-15 2014-11-05 武田药品工业株式会社 吡嗪并氧氮杂*衍生物
US8299103B2 (en) 2009-06-15 2012-10-30 Boehringer Ingelheim International Gmbh Compounds which selectively modulate the CB2 receptor

Also Published As

Publication number Publication date
NZ597507A (en) 2013-09-27
US8314088B2 (en) 2012-11-20
PL2442870T3 (pl) 2014-12-31
US20120135979A1 (en) 2012-05-31
ME01835B (me) 2014-12-20
ZA201109370B (en) 2012-10-31
SI2442870T1 (sl) 2014-07-31
AU2010260847A1 (en) 2012-01-19
CL2011003154A1 (es) 2012-06-15
EP2442870A1 (en) 2012-04-25
IL216761A0 (en) 2012-02-29
US8324201B2 (en) 2012-12-04
MA33430B1 (fr) 2012-07-03
TW201529584A (zh) 2015-08-01
TW201109338A (en) 2011-03-16
UY32707A (es) 2011-01-31
IL216761A (en) 2016-03-31
HK1169623A1 (en) 2013-02-01
US9115139B2 (en) 2015-08-25
PT2442870E (pt) 2014-07-16
ECSP12011603A (es) 2012-03-30
TN2011000630A1 (en) 2013-05-24
AU2010260847B2 (en) 2016-11-24
UA108357C2 (xx) 2015-04-27
US20110288291A1 (en) 2011-11-24
JP5579203B2 (ja) 2014-08-27
SG176696A1 (en) 2012-01-30
JO3087B1 (ar) 2017-03-15
JP2012107032A (ja) 2012-06-07
SMT201400080B (it) 2014-09-08
RS53414B (en) 2014-12-31
BRPI1011502A2 (pt) 2016-03-22
CN102458579B (zh) 2014-11-05
MX2011013081A (es) 2012-01-20
JP5579262B2 (ja) 2014-08-27
KR101768234B1 (ko) 2017-08-14
GEP20146168B (en) 2014-09-25
US20110282054A1 (en) 2011-11-17
EA201270017A1 (ru) 2012-07-30
EA021079B1 (ru) 2015-03-31
TWI542592B (zh) 2016-07-21
CY1115483T1 (el) 2017-01-04
ES2480275T3 (es) 2014-07-25
WO2010147226A1 (en) 2010-12-23
CA2765239A1 (en) 2010-12-23
HRP20140589T1 (hr) 2014-08-01
CN102458579A (zh) 2012-05-16
DK2442870T3 (da) 2014-06-30
CR20120021A (es) 2012-03-06
AR077094A1 (es) 2011-08-03
EP2442870B1 (en) 2014-04-16
US20100317651A1 (en) 2010-12-16
US8318722B2 (en) 2012-11-27
PE20121049A1 (es) 2012-08-22
KR20120034734A (ko) 2012-04-12
CO6491037A2 (es) 2012-07-31
JP2012530051A (ja) 2012-11-29
CA2765239C (en) 2018-08-07
MY157497A (en) 2016-06-15

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