DK576782A - Bicycliske aminosyrer, fremgangsmaader og mellemprodukter til deres fremstilling og deres anvendelse - Google Patents

Bicycliske aminosyrer, fremgangsmaader og mellemprodukter til deres fremstilling og deres anvendelse Download PDF

Info

Publication number
DK576782A
DK576782A DK576782A DK576782A DK576782A DK 576782 A DK576782 A DK 576782A DK 576782 A DK576782 A DK 576782A DK 576782 A DK576782 A DK 576782A DK 576782 A DK576782 A DK 576782A
Authority
DK
Denmark
Prior art keywords
intermediates
procedures
preparation
amino acids
bicyclic amino
Prior art date
Application number
DK576782A
Other languages
English (en)
Other versions
DK170444B1 (da
Inventor
Hansjoerg Urbach
Rainer Henning
Volker Teetz
Rolf Geiger
Reinhard Becker
Holger Gaul
Original Assignee
Hoechst Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25798350&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK576782(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE19813151690 external-priority patent/DE3151690A1/de
Priority claimed from DE19823210701 external-priority patent/DE3210701A1/de
Application filed by Hoechst Ag filed Critical Hoechst Ag
Publication of DK576782A publication Critical patent/DK576782A/da
Application granted granted Critical
Publication of DK170444B1 publication Critical patent/DK170444B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C07K5/0222—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2 with the first amino acid being heterocyclic, e.g. Pro, Trp
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK576782A 1981-12-29 1982-12-28 Analogifremgangsmåde til fremstilling af bicycliske aminosyrederivater og deres fysiologisk uskadelige salte DK170444B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19813151690 DE3151690A1 (de) 1981-12-29 1981-12-29 "neue derivate bicyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung"
DE3151690 1981-12-29
DE19823210701 DE3210701A1 (de) 1982-03-24 1982-03-24 2-azabicycloalkan-3-carbonsaeuren und verfahren zu ihrer herstellung
DE3210701 1982-03-24

Publications (2)

Publication Number Publication Date
DK576782A true DK576782A (da) 1983-06-30
DK170444B1 DK170444B1 (da) 1995-09-04

Family

ID=25798350

Family Applications (2)

Application Number Title Priority Date Filing Date
DK576782A DK170444B1 (da) 1981-12-29 1982-12-28 Analogifremgangsmåde til fremstilling af bicycliske aminosyrederivater og deres fysiologisk uskadelige salte
DK119992A DK171232B1 (da) 1981-12-29 1992-09-28 Azabicycliske forbindelser og fremgangsmåde til deres fremstilling

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK119992A DK171232B1 (da) 1981-12-29 1992-09-28 Azabicycliske forbindelser og fremgangsmåde til deres fremstilling

Country Status (27)

Country Link
US (3) US5008400A (da)
EP (1) EP0084164B1 (da)
JP (3) JPS58118569A (da)
KR (1) KR890003424B1 (da)
AR (1) AR247571A1 (da)
AU (1) AU559140B2 (da)
BG (1) BG60936B2 (da)
CA (1) CA1341296C (da)
CS (1) CS409591A3 (da)
DE (2) DE3280014D1 (da)
DK (2) DK170444B1 (da)
DZ (1) DZ490A1 (da)
ES (2) ES8308850A1 (da)
FI (1) FI80017C (da)
GR (1) GR78413B (da)
HK (1) HK74989A (da)
HU (1) HU194167B (da)
IE (1) IE55867B1 (da)
IL (1) IL67572A (da)
LU (1) LU88263I2 (da)
MA (1) MA19672A1 (da)
NL (1) NL930048I2 (da)
NO (1) NO156786C (da)
NZ (1) NZ202903A (da)
PH (2) PH18918A (da)
PT (1) PT76052B (da)
SG (1) SG1389G (da)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
DK156484A (da) * 1983-03-16 1984-09-17 Usv Pharma Corp Aminosyrederivater
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
DE3410732A1 (de) * 1984-03-23 1985-09-26 Hoechst Ag, 6230 Frankfurt Methode zur behandlung des glaukoms
US5684016A (en) * 1984-04-12 1997-11-04 Hoechst Aktiengesellschaft Method of treating cardiac insufficiency
DE3413710A1 (de) * 1984-04-12 1985-10-24 Hoechst Ag, 6230 Frankfurt Verfahren zur behandlung der herzinsuffizienz
JPS61502818A (ja) * 1984-07-30 1986-12-04 シェリング・コ−ポレ−ション シス、エンド−オクタヒドロシクロペンタ〔ｂ〕ピロ−ル−２−カルボキシレ−トの新規製造方法
GB8422165D0 (en) * 1984-09-01 1984-10-03 Wellcome Found Compounds
US5231084A (en) * 1986-03-27 1993-07-27 Hoechst Aktiengesellschaft Compounds having a cognition adjuvant action, agents containing them, and the use thereof for the treatment and prophylaxis of cognitive dysfuncitons
FR2605630B1 (fr) * 1986-10-22 1989-06-30 Roussel Uclaf Procede de preparation de derives de l'octahydroindole et intermediaires de preparation
DE3641451A1 (de) * 1986-12-04 1988-06-16 Hoechst Ag Derivate bicyclischer aminocarbonsaeuren, verfahren und zwischenprodukte zu deren herstellung sowie deren verwendung
DE3722007A1 (de) * 1987-07-03 1989-01-12 Hoechst Ag Verfahren zur herstellung bicyclischer aminocarbonsaeuren, zwischenprodukte dieses verfahrens und deren verwendung
TW197945B (da) * 1990-11-27 1993-01-11 Hoechst Ag
DE4109134A1 (de) * 1991-03-20 1992-09-24 Knoll Ag Erzeugnisse, enthaltend verapamil und trandolapril
LT3872B (en) 1993-12-06 1996-04-25 Hoechst Ag Novel peptides and pharmaceutical compositions containing them
US5602167A (en) * 1995-05-17 1997-02-11 Ortho Pharmaceutical Corporation 4-arylcyclohepta[c] pyrrole analgesics
PT796855E (pt) 1996-03-20 2002-07-31 Hoechst Ag Inibicao da reabsorcao nos ossos e antagonistas de vitronectina
FR2746394B1 (fr) 1996-03-20 1998-05-29 Roussel Uclaf Nouveaux composes tricycliques, leur procede de preparation, et les intermediaires de ce procede, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant
DE19653647A1 (de) 1996-12-20 1998-06-25 Hoechst Ag Vitronectin - Rezeptorantagonisten, deren Herstellung sowie deren Verwendung
DE19703430A1 (de) * 1997-01-30 1998-08-06 Bayerische Motoren Werke Ag Knieschutzsystem für den Beifahrer in Personenkraftwagen
DE19741235A1 (de) 1997-09-18 1999-03-25 Hoechst Marion Roussel De Gmbh Neue Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19741873A1 (de) * 1997-09-23 1999-03-25 Hoechst Marion Roussel De Gmbh Neue 5-Ring-Heterocyclen, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19751251A1 (de) 1997-11-19 1999-05-20 Hoechst Marion Roussel De Gmbh Substituierte Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmezeutische Präparate
DE19821483A1 (de) 1998-05-14 1999-11-18 Hoechst Marion Roussel De Gmbh Imidazolidinderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE19900205A1 (de) 1999-01-07 2000-07-13 Basf Ag Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür
CA2363658C (en) * 2001-11-21 2005-12-13 Brantford Chemicals Inc. Improved process for the preparation of ramipril
WO2003074048A1 (en) * 2002-03-01 2003-09-12 Warner-Lambert Company Llc Method of treating osteoarthritis
RS20050106A (en) 2002-08-19 2007-11-15 Pfizer Products Inc., Combination therapy for hyperproliferative diseases
US6812355B2 (en) 2002-10-22 2004-11-02 Sekhsaria Chemicals Limited Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
CL2004000366A1 (es) * 2003-02-26 2005-01-07 Pharmacia Corp Sa Organizada B USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA.
US20040220252A1 (en) * 2003-02-27 2004-11-04 Parthasaradhi Reddy Bandi Novel crystalline forms of trandolapril
ES2250846T3 (es) * 2003-02-28 2006-04-16 Les Laboratoires Servier Nuevo procedimiento para la sintesis de perindopril y de sus sales farmaceuticamente aceptables.
DK1338591T3 (da) * 2003-02-28 2006-01-23 Servier Lab Fremgangsmåde til syntese af (2S,3aS,7aS)-perhydroindol-2-carboxylsyre og estere heraf samt anvendelse heraf ved syntese af perindopril
DE60301774T2 (de) * 2003-02-28 2006-07-20 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-1-((S)-Alanyl)-octahydro-1H-indol-2-carbonsäurederivaten und Verwendung in der Synthese von Perindopril
PT1323729E (pt) * 2003-03-12 2005-02-28 Servier Lab Novo processo de sintese do acido (2s,3as, 7as)-per-hidroindole-2-carboxilico e os seus esteres e aplicacao a sintese do perindopril
EP1319668B1 (fr) * 2003-03-12 2004-10-27 Les Laboratoires Servier Nouveau procédé de synthèse de dérivés de l'acide (2S, 3aS, 7aS)-1-[(S)]-alanyl]-octahydro-1H-indole-2-carboxylique et application à la synthèse du perindopril
EP1321471B1 (fr) * 2003-03-12 2005-05-04 Les Laboratoires Servier Nouveau procédé de synthèse du perindopril et de ses sels pharmaceutiquement acceptables
CL2004000544A1 (es) * 2003-03-18 2005-01-28 Pharmacia Corp Sa Organizada B Uso de una combinacion farmaceutica, de un antagonista del receptor de aldosterona y un inhibidor de endopeptidasa neutral, util para el tratamiento y prevencion de una condicion patologica relacionada con hipertension, disfuncion renal, insulinopati
US20050032784A1 (en) * 2003-04-01 2005-02-10 University Of Florida Research Foundation, Inc. Combination drug therapy for treating hypertension
EP1354874B1 (fr) * 2003-04-15 2004-11-24 Les Laboratoires Servier Nouveau procédé de synthèse de l'acide (2s, 3aS, 7aS)-perhydroindole-2-carboxylique et de ses esters, et application a la synthèse du perindopril
WO2004092132A1 (en) * 2003-04-15 2004-10-28 Warner-Lambert Company Llc [b]-fused bicyclic proline derivatives and their use for treating arthritic conditions
ATE283258T1 (de) * 2003-05-19 2004-12-15 Servier Lab Verfahren zur synthese von (2s,3as,7as)- perhydroindol-2-carbonsäure und seiner estern, und verwendung in der synthese von perindopril
DE60300558T2 (de) * 2003-06-13 2006-02-23 Les Laboratoires Servier Verfahren zur Synthese von (2S,3aS,7aS)-Perhydroindol-2-carbonsäure und seiner Estern, und Verwendung in der Synthese von Perindopril
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
US20070225505A1 (en) * 2003-11-25 2007-09-27 Pau Cid Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate
US20070135513A1 (en) * 2003-11-28 2007-06-14 Mirko Pogutter Method for producing {n-[1-(s)-carbalkoxy-3-phenylpropyl]-s-alanyl-2s, 3ar, 7as-octahydroindole-2-carboxylic acid} compounds
GB2413128A (en) * 2004-04-13 2005-10-19 Neopharma Ltd Process for the preparation of perindopril
WO2006014916A2 (en) * 2004-07-26 2006-02-09 Dr. Reddy's Laboratories Ltd. Preparation of trandolapril
US20060079698A1 (en) * 2004-10-07 2006-04-13 Glenmark Pharmaceuticals Limited Process for the preparation of intermediates of trandolapril and use thereof for the preparation of trandolapril
US20080171885A1 (en) * 2005-02-14 2008-07-17 Lupin Limited Process for Preparation of Highly Pure Trandolapril
EP1724260B1 (en) * 2005-05-06 2008-02-20 Sochinaz SA Process for the synthesis of (2S, 3aR, 7aS)octahydroindole-2-carboxylic acid and its conversion to trandolapril
WO2007003947A2 (en) * 2005-07-05 2007-01-11 Cipla Limited Process for the synthesis of the ace inhibitor trandolapril
WO2007026372A2 (en) * 2005-09-01 2007-03-08 Wockhardt Limited Novel crystalline polymorph of trandolapril and a process for preparation thereof
WO2007026371A2 (en) * 2005-09-01 2007-03-08 Wockhardt Limited Process for preparing trandolapril and intermediates thereof
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7943655B2 (en) * 2006-04-05 2011-05-17 Universitat Zurich Polymorphic and pseudopolymorphic forms of trandolaprilat, pharmaceutical compositions and methods for production and use
US8404896B2 (en) 2006-12-01 2013-03-26 Bristol-Myers Squibb Company N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as CETP inhibitors for the treatment of atherosclerosis and cardiovascular diseases
CN101302185B (zh) * 2007-05-08 2010-09-01 上海医药工业研究院 群多普利拉的制备方法
CN101302218B (zh) * 2007-05-08 2011-02-23 上海医药工业研究院 群多普利双酮的制备方法
AU2010273259B2 (en) 2009-07-16 2013-03-07 Abbott Laboratories Processes for the synthesis of (2S, 3aR, 7aS)-octahydro-1H-indole carboxylic acid as an intermediate for trandolapril
CN104045593B (zh) * 2013-03-12 2016-11-02 上海交通大学 一种群多普利中间体的制备方法
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
CN103288710A (zh) * 2013-05-20 2013-09-11 大连海荣科技开发有限公司 群多普利中间体（2S，3aR，7aS）-八氢-1H-吲哚-2-羧酸的制备方法
CN104086623B (zh) * 2014-07-02 2017-05-24 牡丹江友搏药业有限责任公司 一种新的具有降压和细胞保护作用的化合物
WO2016055901A1 (en) 2014-10-08 2016-04-14 Pfizer Inc. Substituted amide compounds
MX2021008533A (es) 2019-01-18 2021-08-19 Astrazeneca Ab Inhibidores de la pcsk9 y metodos de uso de los mismos.

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR31741E (fr) * 1926-03-29 1927-06-10 Essuie-glace
JPS5572169A (en) * 1978-11-27 1980-05-30 Tanabe Seiyaku Co Ltd Isoquinoline derivative and its preparation
IL58849A (en) * 1978-12-11 1983-03-31 Merck & Co Inc Carboxyalkyl dipeptides and derivatives thereof,their preparation and pharmaceutical compositions containing them
US4294832A (en) * 1979-04-28 1981-10-13 Tanabe Seiyaku Co., Ltd. Tetrahydroisoquinoline compounds and a pharmaceutical composition thereof
FR2487829A2 (fr) * 1979-12-07 1982-02-05 Science Union & Cie Nouveaux imino acides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4508729A (en) * 1979-12-07 1985-04-02 Adir Substituted iminodiacids, their preparation and pharmaceutical compositions containing them
FR2503155A2 (fr) * 1980-10-02 1982-10-08 Science Union & Cie Nouveaux imino diacides substitues, leurs procedes de preparation et leur emploi comme inhibiteur d'enzyme
US4616029A (en) * 1979-12-07 1986-10-07 Adir Perhydromdole-2-carboxylic acids as antihypertensives
ZA811493B (en) * 1980-04-02 1982-03-31 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
IE52663B1 (en) * 1980-04-02 1988-01-20 Warner Lambert Co Substituted acyl derivatives of octahydro-1h-indole-2-carboxylic acids
US4350704A (en) * 1980-10-06 1982-09-21 Warner-Lambert Company Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids
US4344449A (en) * 1980-05-16 1982-08-17 The United States Of America As Represented By The United States Department Of Energy Fast-acting valve and uses thereof
DE3177311D1 (de) * 1980-08-30 1994-06-09 Hoechst Ag Aminosäurederivate, Verfahren zu ihrer Herstellung, diese enthaltende Mittel und deren Verwendung.
IL63813A0 (en) * 1980-09-17 1981-12-31 Univ Miami Carboxyalkyl peptides and thioethers and ethers of peptides,antihypertensive compositions and methods for their use
US4344949A (en) * 1980-10-03 1982-08-17 Warner-Lambert Company Substituted acyl derivatives of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
DE3174844D1 (en) * 1980-10-23 1986-07-24 Schering Corp Carboxyalkyl dipeptides, processes for their production and pharmaceutical compositions containing them
ZA817261B (en) * 1980-10-23 1982-09-29 Schering Corp Carboxyalkyl dipeptides,processes for their production and pharmaceutical compositions containing them
GB2086390B (en) * 1980-11-03 1984-06-06 Ciba Geigy Ag 1-carboxy-azaalkanoylindoline-2-carboxylic acids process for their manufacture pharmaceutical preparations containing these compounds and their therapeutic application
US4820729A (en) * 1981-03-30 1989-04-11 Rorer Pharmaceutical Corporation N-substituted-amido-amino acids
DE3226768A1 (de) * 1981-11-05 1983-05-26 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(3.3.0)-octan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
CA1341296C (en) * 1981-12-29 2001-09-25 Hansjorg Urbach 2-azabicycloalkane-3-carboxylic acid derivatives, processes for their preparation, agents containing these compounds and their use
DE3210496A1 (de) * 1982-03-23 1983-10-06 Hoechst Ag Neue derivate bicyclischer aminsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3211397A1 (de) * 1982-03-27 1983-11-10 Hoechst Ag, 6230 Frankfurt Spiro (4.(3+n))-2-aza-3-carbonsaeure-derivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
DE3211676A1 (de) * 1982-03-30 1983-10-06 Hoechst Ag Neue derivate von cycloalka (c) pyrrol-carbonsaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue cycloalka (c) pyrrol-carbonsaeuren als zwischenstufen und verfahren zu deren herstellung
US4490386A (en) * 1982-09-23 1984-12-25 Warner-Lambert Company Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof
DE3242151A1 (de) * 1982-11-13 1984-05-17 Hoechst Ag, 6230 Frankfurt Neue derivate tricyclischer aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung, sowie neue bicyclische aminosaeuren als zwischenstufen und verfahren zu deren herstellung
DE3246503A1 (de) * 1982-12-16 1984-06-20 Hoechst Ag, 6230 Frankfurt Derivate der cis, endo-2-azabicyclo-(5.3.0)-decan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung
US4468396A (en) * 1982-12-20 1984-08-28 Schering Corporation Antihypertensive benzothiadiazines
DE3300316A1 (de) * 1983-01-07 1984-07-12 Hoechst Ag, 6230 Frankfurt Disubstituierte prolinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3300774A1 (de) * 1983-01-12 1984-07-12 Hoechst Ag, 6230 Frankfurt Neue spirocyclische aminosaeuren, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie neue spirocyclische aminosaeuren als zwischenprodukte und verfahren zu deren herstellung
DE3303112A1 (de) * 1983-01-31 1984-08-09 Hoechst Ag, 6230 Frankfurt Verfahren zur racemattrennung optisch aktiver bicyclischer imino-(alpha)-carbonsaeuren
DE3315464A1 (de) * 1983-04-28 1984-10-31 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von n-alkylierten dipeptiden und deren estern
DE3322530A1 (de) * 1983-06-23 1985-01-10 Hoechst Ag, 6230 Frankfurt Verfahren zur herstellung von mono-, bi- und tricyclischen aminosaeuren
DE3324263A1 (de) * 1983-07-06 1985-01-17 Hoechst Ag, 6230 Frankfurt Derivate der 2-azabicyclo(3.1.0)hexan-3-carbonsaeure, verfahren zu ihrer herstellung, diese enthaltende mittel und deren verwendung sowie 2-azabicyclo(3.1.0)hexan-derivate als zwischenprodukte und verfahren zu deren herstellung
US4559340A (en) * 1983-11-25 1985-12-17 Schering Corporation Antihypertensive agents
DE3345355A1 (de) * 1983-12-15 1985-06-27 Hoechst Ag, 6230 Frankfurt Verfahren zur racematspaltung bicyclischer imino-(alpha)-carbonsaeureester

Also Published As

Publication number Publication date
DK170444B1 (da) 1995-09-04
DZ490A1 (fr) 2004-09-13
FI80017B (fi) 1989-12-29
DE3275293D1 (en) 1987-03-05
US5008400A (en) 1991-04-16
JPS58118569A (ja) 1983-07-14
US5101039A (en) 1992-03-31
HK74989A (en) 1989-09-22
AU9193182A (en) 1983-07-07
BG60936B2 (bg) 1996-06-28
PT76052B (de) 1985-11-28
ES518574A0 (es) 1983-10-01
GR78413B (da) 1984-09-27
DK119992A (da) 1992-09-28
NO156786B (no) 1987-08-17
PH19771A (en) 1986-06-27
FI824474L (fi) 1983-06-30
ES8308850A1 (es) 1983-10-01
NO824394L (no) 1983-06-30
KR840002810A (ko) 1984-07-21
JPH0587504B2 (da) 1993-12-16
IE823065L (en) 1983-06-29
NL930048I1 (nl) 1993-09-01
IL67572A (en) 1992-08-18
FI80017C (fi) 1990-04-10
JPH01301659A (ja) 1989-12-05
KR890003424B1 (ko) 1989-09-20
HU194167B (en) 1988-01-28
EP0084164A2 (de) 1983-07-27
LU88263I2 (da) 1994-02-03
JPH01301695A (ja) 1989-12-05
JPH064586B2 (ja) 1994-01-19
CS409591A3 (en) 1992-04-15
NL930048I2 (nl) 1994-01-03
EP0084164A3 (en) 1983-10-12
EP0084164B1 (de) 1987-01-28
ES521740A0 (es) 1984-01-16
DK119992D0 (da) 1992-09-28
PH18918A (en) 1985-11-06
DK171232B1 (da) 1996-08-05
NZ202903A (en) 1988-01-08
CA1341296C (en) 2001-09-25
NO156786C (no) 1987-11-25
FI824474A0 (fi) 1982-12-27
PT76052A (de) 1983-01-01
US4933361A (en) 1990-06-12
IL67572A0 (en) 1983-05-15
MA19672A1 (fr) 1983-07-01
DE3280014D1 (en) 1989-12-14
SG1389G (en) 1989-06-02
AU559140B2 (en) 1987-02-26
AR247571A1 (es) 1995-01-31
ES8402271A1 (es) 1984-01-16
IE55867B1 (en) 1991-02-14

Similar Documents

Publication Publication Date Title
DK576782A (da) Bicycliske aminosyrer, fremgangsmaader og mellemprodukter til deres fremstilling og deres anvendelse
DK345488D0 (da) Azolylmethyl-cyclopropyl-derivater, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
DK446982A (da) Cyanosteroider og fremgangsmaade til deres fremstilling
DK43685A (da) Benzobicycliske lactamsyrer og derivater deraf, fremgangsmaade til deres fremstilling samt deres anvendelse
NO169068C (no) Bis-(2-etylamino-4-dietylamino-s-triazin-6-yl)-tetrasulfid, fremgangsmaate til fremstilling og dets anvendelse
NO875051L (no) Derivater og bicykliske aminokarboksylsyrer, fremgangsmaate og mellomprodukter til deres fremstilling, samt deres anvendelse.
DK440488A (da) 1-phenyl-3-(1-piperazinyl)-1h-indazoler, fremgangsmaade og mellemprodukter til fremstilling heraf, samt deres anvendelse
DK48482A (da) Azopigmentpraeparater,fremgangsmaade til deres fremstilling og deres anvendelse
DK398986A (da) Aminosyrederivater, fremgangsmaade til deres fremstilling og deres anvendelse
NO822796L (no) Aminoorganoaminosilaner, fremgangsmaate til deres fremstilling og deres anvendelse
DK409886A (da) Azolyl-cyclopropyl-ethanol-derivater, fremgangsmaade til deres fremstilling og deres anvendelse
DK354485A (da) 3-substituerede l-aminoalkyl-lh-indol-forbindelser, fremgangsmaader til fremstilling deraf og mellemprodukter til anvendelse derved samt farmaceutiske praeparater
DK401882A (da) Cyclopentadienderivater og fremgangsmaader til deres fremstilling
DK104589D0 (da) Substituerede acrylsyreestere, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
IT1183883B (it) Procedimento per la preparazione di amminoidrossicefamcarbossilati
NO884324D0 (no) Fremgangsmaate til fremstilling av reninhemmende peptider og deres anvendelse.
NO812618L (no) Dekorative overflategjenstander og fremgangsmaate til deres fremstilling
DK247884D0 (da) Substituerede tetrahydrothiopyran-3,5-dion-4-carboxamider,fremgangsmaade til deres fremstilling og deres anvendelse samt mellemprodukter til fremstillingen
DK639888A (da) 3-aminopyrazolin-5-oner, fremgangsmaader og mellemprodukter til deres fremstilling samt deres anvendelse
ES507180A0 (es) Procedimiento de preparacion de amino alcosi furanos o tio- fenos.
DK79389A (da) Thiorhodaminer samt fremgangsmaade og mellemprodukter til deres fremstilling
NO880802D0 (no) Mellomprodukter og fremgangsmaater til fremstilling av antihyperkolesterolemiske tetrazolforbindelser.
DK332782A (da) 2-cyanosteroider og fremgangsmaade til deres fremstilling
DK182186D0 (da) Ethanobenzazepiner, fremgangsmaade og mellemprodukter til deres fremstilling og deres anvendelse som laegemidler
DK165182A (da) L-substitueret-4-phenyl-polyhydro-pyridiner og-pyrrolidiner,fremgangsmaade til deres fremstilling samt deres anvendelse

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1996 00006, 960301

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1996 00006, 960301, EXPIRES: 20070219

PUP Patent expired