DK3843759T3 - Anvendelse af tumorinfiltrerende lymfocytter til behandling af patienter med nsclc, der er refraktære over for anti-pd-1-antistof - Google Patents
Anvendelse af tumorinfiltrerende lymfocytter til behandling af patienter med nsclc, der er refraktære over for anti-pd-1-antistof Download PDFInfo
- Publication number
- DK3843759T3 DK3843759T3 DK19856433.8T DK19856433T DK3843759T3 DK 3843759 T3 DK3843759 T3 DK 3843759T3 DK 19856433 T DK19856433 T DK 19856433T DK 3843759 T3 DK3843759 T3 DK 3843759T3
- Authority
- DK
- Denmark
- Prior art keywords
- lymphocytes
- antibodies
- tumor
- filtering
- treatment
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title 1
- 238000001914 filtration Methods 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 title 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464499—Undefined tumor antigens, e.g. tumor lysate or antigens targeted by cells isolated from tumor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0635—B lymphocytes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/55—Lung
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862725976P | 2018-08-31 | 2018-08-31 | |
US201862726919P | 2018-09-04 | 2018-09-04 | |
PCT/US2019/049384 WO2020096682A2 (en) | 2018-08-31 | 2019-09-03 | Treatment of nsclc patients refractory for anti-pd-1 antibody |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3843759T3 true DK3843759T3 (da) | 2024-05-21 |
Family
ID=69701469
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK19856433.8T DK3843759T3 (da) | 2018-08-31 | 2019-09-03 | Anvendelse af tumorinfiltrerende lymfocytter til behandling af patienter med nsclc, der er refraktære over for anti-pd-1-antistof |
Country Status (16)
Country | Link |
---|---|
US (1) | US20220118012A1 (da) |
EP (2) | EP4378530A2 (da) |
JP (1) | JP2021535128A (da) |
KR (1) | KR20210053922A (da) |
CN (1) | CN112955160A (da) |
AU (1) | AU2019377771A1 (da) |
BR (1) | BR112021003491A2 (da) |
CA (1) | CA3111210A1 (da) |
DK (1) | DK3843759T3 (da) |
FI (1) | FI3843759T3 (da) |
IL (1) | IL281022A (da) |
MX (1) | MX2021002241A (da) |
PL (1) | PL3843759T3 (da) |
SG (1) | SG11202101792TA (da) |
TW (1) | TW202031273A (da) |
WO (1) | WO2020096682A2 (da) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
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GB201522097D0 (en) | 2015-12-15 | 2016-01-27 | Cellular Therapeutics Ltd | Cells |
GB201700621D0 (en) | 2017-01-13 | 2017-03-01 | Guest Ryan Dominic | Method,device and kit for the aseptic isolation,enrichment and stabilsation of cells from mammalian solid tissue |
EP4077641A1 (en) | 2019-12-20 | 2022-10-26 | Instil Bio (Uk) Limited | Devices and methods for isolating tumor infiltrating lymphocytes and uses thereof |
TW202241468A (zh) * | 2020-12-11 | 2022-11-01 | 美商艾歐凡斯生物治療公司 | 用腫瘤浸潤性淋巴球療法與braf抑制劑及/或mek抑制劑組合治療癌症患者 |
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-
2019
- 2019-09-02 TW TW108131519A patent/TW202031273A/zh unknown
- 2019-09-03 CN CN201980070374.1A patent/CN112955160A/zh active Pending
- 2019-09-03 DK DK19856433.8T patent/DK3843759T3/da active
- 2019-09-03 FI FIEP19856433.8T patent/FI3843759T3/fi active
- 2019-09-03 US US17/271,601 patent/US20220118012A1/en active Pending
- 2019-09-03 SG SG11202101792TA patent/SG11202101792TA/en unknown
- 2019-09-03 AU AU2019377771A patent/AU2019377771A1/en active Pending
- 2019-09-03 JP JP2021510198A patent/JP2021535128A/ja active Pending
- 2019-09-03 CA CA3111210A patent/CA3111210A1/en active Pending
- 2019-09-03 MX MX2021002241A patent/MX2021002241A/es unknown
- 2019-09-03 EP EP24156569.6A patent/EP4378530A2/en active Pending
- 2019-09-03 EP EP19856433.8A patent/EP3843759B8/en active Active
- 2019-09-03 KR KR1020217009091A patent/KR20210053922A/ko active Search and Examination
- 2019-09-03 BR BR112021003491-9A patent/BR112021003491A2/pt unknown
- 2019-09-03 PL PL19856433.8T patent/PL3843759T3/pl unknown
- 2019-09-03 WO PCT/US2019/049384 patent/WO2020096682A2/en unknown
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2021
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Also Published As
Publication number | Publication date |
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FI3843759T3 (fi) | 2024-05-16 |
EP4378530A2 (en) | 2024-06-05 |
TW202031273A (zh) | 2020-09-01 |
WO2020096682A3 (en) | 2020-06-25 |
WO2020096682A2 (en) | 2020-05-14 |
CN112955160A (zh) | 2021-06-11 |
AU2019377771A1 (en) | 2021-04-15 |
EP3843759B1 (en) | 2024-02-14 |
IL281022A (en) | 2021-04-29 |
PL3843759T3 (pl) | 2024-06-17 |
KR20210053922A (ko) | 2021-05-12 |
SG11202101792TA (en) | 2021-03-30 |
JP2021535128A (ja) | 2021-12-16 |
US20220118012A1 (en) | 2022-04-21 |
BR112021003491A2 (pt) | 2021-05-18 |
EP3843759B8 (en) | 2024-03-20 |
CA3111210A1 (en) | 2020-05-14 |
EP3843759A2 (en) | 2021-07-07 |
MX2021002241A (es) | 2021-05-27 |
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