DK3717488T3 - Substituerede furanopyrimidinforbindelser som pde1-inhibitorer - Google Patents

Substituerede furanopyrimidinforbindelser som pde1-inhibitorer Download PDF

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Publication number
DK3717488T3
DK3717488T3 DK18819287.6T DK18819287T DK3717488T3 DK 3717488 T3 DK3717488 T3 DK 3717488T3 DK 18819287 T DK18819287 T DK 18819287T DK 3717488 T3 DK3717488 T3 DK 3717488T3
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Prior art keywords
furanopyrimidi
substituted
compounds
pde1 inhibitors
pde1
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DK18819287.6T
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Danish (da)
English (en)
Inventor
Brett Bookser
Iriny Botrous
Aaron Burns
Demichael Chung
Brian Dyck
Andrew Kleinke
Dange Vijay Kumar
Margaret Mccarrick
Nicholas Raffaele
Joe Tran
Michael Weinhouse
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Dart Neuroscience Llc
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Publication of DK3717488T3 publication Critical patent/DK3717488T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK18819287.6T 2017-11-27 2018-11-26 Substituerede furanopyrimidinforbindelser som pde1-inhibitorer DK3717488T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762591105P 2017-11-27 2017-11-27
PCT/US2018/062493 WO2019104285A1 (en) 2017-11-27 2018-11-26 Substituted furanopyrimidine compounds as pde1 inhibitors

Publications (1)

Publication Number Publication Date
DK3717488T3 true DK3717488T3 (da) 2021-12-13

Family

ID=64665119

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18819287.6T DK3717488T3 (da) 2017-11-27 2018-11-26 Substituerede furanopyrimidinforbindelser som pde1-inhibitorer

Country Status (11)

Country Link
US (3) US11434247B1 (enExample)
EP (1) EP3717488B1 (enExample)
JP (1) JP7254078B2 (enExample)
KR (1) KR102794907B1 (enExample)
CN (1) CN111655695B (enExample)
AU (1) AU2018373258B2 (enExample)
CA (1) CA3120971A1 (enExample)
DK (1) DK3717488T3 (enExample)
ES (1) ES2902365T3 (enExample)
MX (2) MX2020005447A (enExample)
WO (1) WO2019104285A1 (enExample)

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MX390582B (es) 2016-12-28 2025-03-20 Dart Neuroscience Llc Star Compuestos de pirazolopirimidinona sustituida como inhibidores de fosfodiesterasas 2 (pde2)
KR102794907B1 (ko) 2017-11-27 2025-04-14 다트 뉴로사이언스, 엘엘씨 Pde1 억제제로서의 치환된 푸라노피리미딘 화합물
JP2022541954A (ja) * 2019-07-17 2022-09-28 小野薬品工業株式会社 Ｋｄｍ５阻害活性を有する化合物およびその医薬用途
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CA3198635A1 (en) * 2020-12-03 2022-06-09 UCB Biopharma SRL Octahydroisoquinolinyl derivatives
WO2023014979A1 (en) * 2021-08-06 2023-02-09 Rayzebio, Inc. Conjugates comprising covalent binders for targeting intracellular kras g12c proteins
US20250049748A1 (en) * 2021-12-16 2025-02-13 Terran Biosciences Inc. Analogs of 4-bromo-2,5-dimethoxyphenethylamine
WO2025036472A1 (en) * 2023-08-16 2025-02-20 Pharmaengine, Inc. Spirocyclic mta-cooperative prmts inhibitor

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Publication number Publication date
AU2018373258B2 (en) 2023-03-02
KR20200108419A (ko) 2020-09-18
US20230295178A1 (en) 2023-09-21
ES2902365T3 (es) 2022-03-28
JP7254078B2 (ja) 2023-04-07
WO2019104285A1 (en) 2019-05-31
US20250145633A1 (en) 2025-05-08
CN111655695B (zh) 2025-05-27
US11434247B1 (en) 2022-09-06
AU2018373258A1 (en) 2020-07-16
JP2021504380A (ja) 2021-02-15
KR102794907B1 (ko) 2025-04-14
US12006325B2 (en) 2024-06-11
CA3120971A1 (en) 2019-05-31
EP3717488A1 (en) 2020-10-07
EP3717488B1 (en) 2021-09-29
MX2020005447A (es) 2020-12-03
CN111655695A (zh) 2020-09-11
MX2023004603A (es) 2023-05-08

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