DK3615516T3 - Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner - Google Patents

Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner Download PDF

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Publication number
DK3615516T3
DK3615516T3 DK18722450.6T DK18722450T DK3615516T3 DK 3615516 T3 DK3615516 T3 DK 3615516T3 DK 18722450 T DK18722450 T DK 18722450T DK 3615516 T3 DK3615516 T3 DK 3615516T3
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Prior art keywords
luciferines
manufacturing
imidazopyrazine derivatives
imidazopyrazine
derivatives
Prior art date
Application number
DK18722450.6T
Other languages
English (en)
Inventor
Yves-Louis Janin
Eloi Paul Coutant
Vincent Hervin
Glwadys Gagnot
Yves Jacob
Sophie Goyard
Thierry Rose
Original Assignee
Pasteur Institut
Centre Nat Rech Scient
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Application filed by Pasteur Institut, Centre Nat Rech Scient filed Critical Pasteur Institut
Application granted granted Critical
Publication of DK3615516T3 publication Critical patent/DK3615516T3/da

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/001Preparation for luminescence or biological staining
    • A61K49/0013Luminescence
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/16Halogen atoms; Nitro radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/20Nitrogen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76Chemiluminescence; Bioluminescence
    • G01N21/763Bioluminescence
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plasma & Fusion (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
DK18722450.6T 2017-04-28 2018-04-30 Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner DK3615516T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP17168838.5A EP3395803A1 (en) 2017-04-28 2017-04-28 Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins
PCT/EP2018/061050 WO2018197727A1 (en) 2017-04-28 2018-04-30 Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins

Publications (1)

Publication Number Publication Date
DK3615516T3 true DK3615516T3 (da) 2022-01-17

Family

ID=58640785

Family Applications (1)

Application Number Title Priority Date Filing Date
DK18722450.6T DK3615516T3 (da) 2017-04-28 2018-04-30 Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner

Country Status (7)

Country Link
US (1) US11938199B2 (da)
EP (3) EP3395803A1 (da)
JP (2) JP7366752B2 (da)
CA (1) CA3061245A1 (da)
DK (1) DK3615516T3 (da)
ES (1) ES2904366T3 (da)
WO (1) WO2018197727A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3841173A1 (en) * 2018-08-23 2021-06-30 Promega Corporation Coelenterazine analogues
CN111116594B (zh) * 2019-12-03 2021-05-28 山东大学 一种C-6位改造NanoLuc类型类似物及其制备方法与应用
EP3904508A1 (en) 2020-04-27 2021-11-03 Institut Pasteur Luciferase linked immunosorbent assay
CN113214232B (zh) * 2021-05-26 2022-07-12 无锡捷化医药科技有限公司 一种腔肠素pbi 3939中间体及其制备方法
WO2023025816A1 (en) 2021-08-24 2023-03-02 Institut Pasteur Luminescent based antigen assay
US20240150363A1 (en) * 2022-10-14 2024-05-09 Promega Corporation Coelenterazine analogues

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2520088A (en) 1948-05-28 1950-08-22 Lilly Co Eli Process of preparing pyrazines
US4046763A (en) 1968-11-08 1977-09-06 Mcneil Laboratories, Incorporated 2,3-Diphenyl-5-ethylpyrazine
US20090075309A1 (en) 2007-09-06 2009-03-19 Gambhir Sanjiv S Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems
GB2479847B (en) * 2009-02-09 2014-02-19 Jnc Corp Coelenterazine analogs and manufacturing method thereof
GB0910003D0 (en) 2009-06-11 2009-07-22 Univ Leuven Kath Novel compounds for the treatment of neurodegenerative diseases
PL2635583T3 (pl) * 2010-11-02 2015-11-30 Promega Corp Pochodne koelenterazyny i metody ich wykorzystania
JP6139415B2 (ja) 2011-03-02 2017-05-31 バイオエナジェニックス Paskの阻害のための複素環化合物
JP6511720B2 (ja) 2013-02-28 2019-05-15 Jnc株式会社 コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法
JP6040846B2 (ja) 2013-04-08 2016-12-07 Jnc株式会社 セレンテラジン類縁体
EP3099691B1 (en) * 2014-01-29 2019-11-20 Promega Corporation Pro-substrates for live cell applications
JP6703484B2 (ja) * 2014-01-29 2020-06-03 プロメガ コーポレイションPromega Corporation 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ
EP3416968B1 (en) * 2016-02-15 2022-07-27 Promega Corporation Coelenterazine analogues
CN105968114B (zh) * 2016-05-27 2018-11-09 山东大学 一种腔肠素类似物及其制备方法与应用

Also Published As

Publication number Publication date
US20200129644A1 (en) 2020-04-30
JP2024009933A (ja) 2024-01-23
EP3615516A1 (en) 2020-03-04
US11938199B2 (en) 2024-03-26
JP7366752B2 (ja) 2023-10-23
EP3964501A1 (en) 2022-03-09
EP3615516B1 (en) 2021-11-17
WO2018197727A1 (en) 2018-11-01
CA3061245A1 (en) 2018-11-01
EP3395803A1 (en) 2018-10-31
JP2020521724A (ja) 2020-07-27
ES2904366T3 (es) 2022-04-04

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