DK3615516T3 - Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner - Google Patents
Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner Download PDFInfo
- Publication number
- DK3615516T3 DK3615516T3 DK18722450.6T DK18722450T DK3615516T3 DK 3615516 T3 DK3615516 T3 DK 3615516T3 DK 18722450 T DK18722450 T DK 18722450T DK 3615516 T3 DK3615516 T3 DK 3615516T3
- Authority
- DK
- Denmark
- Prior art keywords
- luciferines
- manufacturing
- imidazopyrazine derivatives
- imidazopyrazine
- derivatives
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/16—Halogen atoms; Nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
- G01N21/763—Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Plasma & Fusion (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17168838.5A EP3395803A1 (en) | 2017-04-28 | 2017-04-28 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
| PCT/EP2018/061050 WO2018197727A1 (en) | 2017-04-28 | 2018-04-30 | Imidazopyrazine derivatives, process for preparation thereof, and their uses as luciferins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3615516T3 true DK3615516T3 (da) | 2022-01-17 |
Family
ID=58640785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK18722450.6T DK3615516T3 (da) | 2017-04-28 | 2018-04-30 | Imidazopyrazinderivater, fremgangsmåde til fremstilling deraf og deres anvendelser som luciferiner |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11938199B2 (da) |
| EP (3) | EP3395803A1 (da) |
| JP (2) | JP7366752B2 (da) |
| CA (1) | CA3061245A1 (da) |
| DK (1) | DK3615516T3 (da) |
| ES (1) | ES2904366T3 (da) |
| WO (1) | WO2018197727A1 (da) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020041579A1 (en) * | 2018-08-23 | 2020-02-27 | Promega Corporation | Coelenterazine analogues |
| CN111116594B (zh) * | 2019-12-03 | 2021-05-28 | 山东大学 | 一种C-6位改造NanoLuc类型类似物及其制备方法与应用 |
| EP3904508A1 (en) | 2020-04-27 | 2021-11-03 | Institut Pasteur | Luciferase linked immunosorbent assay |
| CN113214232B (zh) * | 2021-05-26 | 2022-07-12 | 无锡捷化医药科技有限公司 | 一种腔肠素pbi 3939中间体及其制备方法 |
| KR20240046876A (ko) | 2021-08-24 | 2024-04-11 | 앵스띠뛰 파스퇴르 | 발광 기반 항원 분석 |
| US20240150363A1 (en) * | 2022-10-14 | 2024-05-09 | Promega Corporation | Coelenterazine analogues |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2520088A (en) | 1948-05-28 | 1950-08-22 | Lilly Co Eli | Process of preparing pyrazines |
| US4046763A (en) | 1968-11-08 | 1977-09-06 | Mcneil Laboratories, Incorporated | 2,3-Diphenyl-5-ethylpyrazine |
| US20090075309A1 (en) | 2007-09-06 | 2009-03-19 | Gambhir Sanjiv S | Bisdeoxycoelenterazine derivatives, methods of use, and BRET2 systems |
| WO2010090319A1 (ja) * | 2009-02-09 | 2010-08-12 | チッソ株式会社 | セレンテラジン類縁体及びその製造方法 |
| GB0910003D0 (en) | 2009-06-11 | 2009-07-22 | Univ Leuven Kath | Novel compounds for the treatment of neurodegenerative diseases |
| US9487520B2 (en) * | 2010-11-02 | 2016-11-08 | Promega Corporation | Coelenterazine derivatives and methods of using same |
| EP2681207B1 (en) | 2011-03-02 | 2016-12-28 | Bioenergenix | Heterocyclic compounds for the inhibition of pask |
| JP6511720B2 (ja) | 2013-02-28 | 2019-05-15 | Jnc株式会社 | コドン最適化変異エビルシフェラーゼ遺伝子およびその使用方法 |
| JP6040846B2 (ja) | 2013-04-08 | 2016-12-07 | Jnc株式会社 | セレンテラジン類縁体 |
| JP6588917B2 (ja) * | 2014-01-29 | 2019-10-09 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 生細胞への適用のためのプロ基質 |
| JP6703484B2 (ja) * | 2014-01-29 | 2020-06-03 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 細胞による取り込み測定のための、標識用試薬としての、キノンでマスクされたプローブ |
| WO2017142852A1 (en) * | 2016-02-15 | 2017-08-24 | Promega Corporation | Coelenterazine analogues |
| CN105968114B (zh) * | 2016-05-27 | 2018-11-09 | 山东大学 | 一种腔肠素类似物及其制备方法与应用 |
-
2017
- 2017-04-28 EP EP17168838.5A patent/EP3395803A1/en not_active Withdrawn
-
2018
- 2018-04-30 EP EP18722450.6A patent/EP3615516B1/en active Active
- 2018-04-30 ES ES18722450T patent/ES2904366T3/es active Active
- 2018-04-30 CA CA3061245A patent/CA3061245A1/en active Pending
- 2018-04-30 US US16/607,058 patent/US11938199B2/en active Active
- 2018-04-30 EP EP21200585.4A patent/EP3964501A1/en active Pending
- 2018-04-30 WO PCT/EP2018/061050 patent/WO2018197727A1/en active Application Filing
- 2018-04-30 DK DK18722450.6T patent/DK3615516T3/da active
- 2018-04-30 JP JP2019558501A patent/JP7366752B2/ja active Active
-
2023
- 2023-10-11 JP JP2023176076A patent/JP2024009933A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3061245A1 (en) | 2018-11-01 |
| WO2018197727A1 (en) | 2018-11-01 |
| EP3964501A1 (en) | 2022-03-09 |
| ES2904366T3 (es) | 2022-04-04 |
| US11938199B2 (en) | 2024-03-26 |
| EP3395803A1 (en) | 2018-10-31 |
| JP7366752B2 (ja) | 2023-10-23 |
| JP2024009933A (ja) | 2024-01-23 |
| JP2020521724A (ja) | 2020-07-27 |
| EP3615516A1 (en) | 2020-03-04 |
| EP3615516B1 (en) | 2021-11-17 |
| US20200129644A1 (en) | 2020-04-30 |
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