DK3483163T3 - Triazolo[4,5-d]pyrimidinderivater som cb2-receptorantagonister - Google Patents

Triazolo[4,5-d]pyrimidinderivater som cb2-receptorantagonister Download PDF

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Publication number
DK3483163T3
DK3483163T3 DK18206943.5T DK18206943T DK3483163T3 DK 3483163 T3 DK3483163 T3 DK 3483163T3 DK 18206943 T DK18206943 T DK 18206943T DK 3483163 T3 DK3483163 T3 DK 3483163T3
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DK
Denmark
Prior art keywords
triazolo
receptor antagonists
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
DK18206943.5T
Other languages
English (en)
Inventor
Stephan Roever
Mark Rogers-Evans
Matthias Nettekoven
Sebastien Schmitt
Uwe Grether
Atsushi Kimbara
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of DK3483163T3 publication Critical patent/DK3483163T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
DK18206943.5T 2013-09-06 2014-09-03 Triazolo[4,5-d]pyrimidinderivater som cb2-receptorantagonister DK3483163T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13183385 2013-09-06
EP14761320.2A EP3041843B1 (en) 2013-09-06 2014-09-03 Triazolo[4,5-d]pyrimidine derivatives as cb2 receptor antagonists

Publications (1)

Publication Number Publication Date
DK3483163T3 true DK3483163T3 (da) 2021-08-30

Family

ID=49111076

Family Applications (2)

Application Number Title Priority Date Filing Date
DK18206943.5T DK3483163T3 (da) 2013-09-06 2014-09-03 Triazolo[4,5-d]pyrimidinderivater som cb2-receptorantagonister
DK14761320.2T DK3041843T3 (da) 2013-09-06 2014-09-03 Triazolo[4,5-d]pyrimidinderivater som CB2-receptorantagonister

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK14761320.2T DK3041843T3 (da) 2013-09-06 2014-09-03 Triazolo[4,5-d]pyrimidinderivater som CB2-receptorantagonister

Country Status (32)

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US (1) US9593123B2 (da)
EP (3) EP3943497A1 (da)
JP (1) JP6441356B2 (da)
KR (3) KR102349567B1 (da)
CN (1) CN105555788B (da)
AR (1) AR097553A1 (da)
AU (1) AU2014317229B2 (da)
CA (1) CA2915766C (da)
CL (1) CL2016000495A1 (da)
CR (1) CR20160076A (da)
DK (2) DK3483163T3 (da)
EA (1) EA028335B1 (da)
ES (2) ES2883923T3 (da)
HK (1) HK1219277A1 (da)
HR (2) HRP20190361T1 (da)
HU (2) HUE041760T2 (da)
IL (1) IL243092B (da)
LT (2) LT3483163T (da)
MA (1) MA38826B1 (da)
MX (2) MX367084B (da)
MY (1) MY191628A (da)
PE (2) PE20160691A1 (da)
PH (1) PH12016500250A1 (da)
PL (2) PL3041843T3 (da)
PT (2) PT3483163T (da)
RS (2) RS58390B1 (da)
SG (1) SG11201601714UA (da)
SI (2) SI3041843T1 (da)
TR (1) TR201900662T4 (da)
TW (1) TWI705966B (da)
UA (1) UA116395C2 (da)
WO (1) WO2015032769A1 (da)

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WO2016071375A1 (en) 2014-11-07 2016-05-12 F. Hoffmann-La Roche Ag Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2
WO2017004133A1 (en) * 2015-06-29 2017-01-05 Nimbus Iris, Inc. Irak inhibitors and uses thereof
WO2017076266A1 (zh) * 2015-11-06 2017-05-11 江苏恒瑞医药股份有限公司 制备坎格雷洛中间体的方法
CN109311886B (zh) 2016-06-23 2021-11-09 豪夫迈·罗氏有限公司 [1,2,3]三唑并[4,5-d]嘧啶衍生物
SG10202113286RA (en) * 2016-06-23 2021-12-30 Hoffmann La Roche [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor
JP7090037B2 (ja) * 2016-06-23 2022-06-23 エフ．ホフマン－ラ ロシュ アーゲー 新規な［１，２，３］トリアゾロ［４，５－ｄ］ピリミジン誘導体
EP3475283B1 (en) 2016-06-23 2021-08-11 F. Hoffmann-La Roche AG Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives
CN106478639B (zh) * 2016-09-05 2018-09-18 郑州大学 嘧啶并1,2,4–三氮唑类的lsd1抑制剂、其制备方法及应用
CN106432247B (zh) * 2016-09-27 2018-06-29 郑州大学 含有腙键的嘧啶并三氮唑类化合物、制备方法及其应用
CN106432248B (zh) * 2016-09-27 2018-11-27 郑州大学 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用
CN106928296A (zh) * 2017-02-06 2017-07-07 上海华升生物科技有限公司 一种2‑(3,3,3‑三氟丙硫基)腺苷的合成方法
CN106928235A (zh) * 2017-05-03 2017-07-07 郑州大学 含嘧啶并三氮唑类lsd1抑制剂、其制备方法及应用
CN107033148B (zh) * 2017-05-03 2018-10-26 郑州大学 含嘧啶并三氮唑—巯基四氮唑类lsd1抑制剂、其制备方法及应用
CN109516990B (zh) * 2017-09-19 2021-06-01 天津药物研究院有限公司 嘧啶并三氮唑类化合物、其制备方法和用途
CN113582935A (zh) * 2021-08-27 2021-11-02 中国医学科学院放射医学研究所 一种炎症小体核苷酸结合寡聚化结构域样受体蛋白3抑制剂及其制备方法和应用
CN115246832A (zh) * 2022-06-15 2022-10-28 深圳湾实验室 一类去泛素化酶usp25和usp28靶向抑制剂及制备和应用

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KR20210145303A (ko) 2013-05-02 2021-12-01 에프. 호프만-라 로슈 아게 Cb2 수용체 작용제로서의 퓨린 유도체
CA2907691A1 (en) 2013-05-02 2014-11-06 F. Hoffmann-La Roche Ag Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists
EP3008055B1 (en) 2013-06-11 2017-07-19 F. Hoffmann-La Roche AG Tetrazolone derivatives

Also Published As

Publication number Publication date
LT3483163T (lt) 2021-09-10
MA38826B1 (fr) 2016-12-30
CN105555788B (zh) 2018-11-23
RS58390B1 (sr) 2019-04-30
AU2014317229A1 (en) 2016-01-07
TW201542551A (zh) 2015-11-16
DK3041843T3 (da) 2019-03-25
NZ756513A (en) 2021-05-28
TWI705966B (zh) 2020-10-01
PE20191528A1 (es) 2019-10-23
RS62234B1 (sr) 2021-09-30
PL3483163T3 (pl) 2021-11-22
SG11201601714UA (en) 2016-04-28
MX2019009100A (es) 2019-09-16
MY191628A (en) 2022-07-04
KR102349567B1 (ko) 2022-01-11
SI3041843T1 (sl) 2019-04-30
IL243092B (en) 2019-06-30
US20160168158A1 (en) 2016-06-16
EA201690478A1 (ru) 2016-06-30
LT3041843T (lt) 2019-03-12
KR20220140651A (ko) 2022-10-18
ES2714094T3 (es) 2019-05-27
CR20160076A (es) 2016-04-01
KR20160050061A (ko) 2016-05-10
KR20210074404A (ko) 2021-06-21
HK1219277A1 (zh) 2017-03-31
HUE055201T2 (hu) 2021-11-29
CA2915766C (en) 2023-09-26
NZ715085A (en) 2021-05-28
ES2883923T3 (es) 2021-12-09
AR097553A1 (es) 2016-03-23
EP3041843A1 (en) 2016-07-13
PT3041843T (pt) 2019-02-26
CN105555788A (zh) 2016-05-04
JP6441356B2 (ja) 2018-12-19
EP3943497A1 (en) 2022-01-26
HUE041760T2 (hu) 2019-05-28
PH12016500250B1 (en) 2016-05-16
TR201900662T4 (tr) 2019-02-21
MX367084B (es) 2019-08-05
PL3041843T3 (pl) 2019-06-28
PH12016500250A1 (en) 2016-05-16
UA116395C2 (uk) 2018-03-12
MA38826A1 (fr) 2016-05-31
HRP20211322T1 (hr) 2021-11-26
EP3483163A2 (en) 2019-05-15
US9593123B2 (en) 2017-03-14
EP3483163A3 (en) 2019-07-24
EP3483163B1 (en) 2021-06-23
EP3041843B1 (en) 2019-01-02
CA2915766A1 (en) 2015-03-12
SI3483163T1 (sl) 2021-11-30
IL243092A0 (en) 2016-02-01
AU2014317229B2 (en) 2018-11-08
KR102454344B1 (ko) 2022-10-14
WO2015032769A1 (en) 2015-03-12
HRP20190361T1 (hr) 2019-04-05
CL2016000495A1 (es) 2016-10-07
PE20160691A1 (es) 2016-07-28
PT3483163T (pt) 2021-08-24
JP2016532707A (ja) 2016-10-20
MX2016002117A (es) 2016-07-05
EA028335B1 (ru) 2017-11-30

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