SG10202113286RA - [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor - Google Patents
[1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptorInfo
- Publication number
- SG10202113286RA SG10202113286RA SG10202113286RA SG10202113286RA SG10202113286RA SG 10202113286R A SG10202113286R A SG 10202113286RA SG 10202113286R A SG10202113286R A SG 10202113286RA SG 10202113286R A SG10202113286R A SG 10202113286RA SG 10202113286R A SG10202113286R A SG 10202113286RA
- Authority
- SG
- Singapore
- Prior art keywords
- triazolo
- affinity
- type
- pyrimidine derivatives
- cannabinoid receptor
- Prior art date
Links
- GIIGHSIIKVOWKZ-UHFFFAOYSA-N 2h-triazolo[4,5-d]pyrimidine Chemical class N1=CN=CC2=NNN=C21 GIIGHSIIKVOWKZ-UHFFFAOYSA-N 0.000 title 1
- 102000018208 Cannabinoid Receptor Human genes 0.000 title 1
- 108050007331 Cannabinoid receptor Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
- G01N33/948—Sedatives, e.g. cannabinoids, barbiturates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16175924 | 2016-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10202113286RA true SG10202113286RA (en) | 2021-12-30 |
Family
ID=56203225
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202113286RA SG10202113286RA (en) | 2016-06-23 | 2017-06-20 | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
| SG11201809678VA SG11201809678VA (en) | 2016-06-23 | 2017-06-20 | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201809678VA SG11201809678VA (en) | 2016-06-23 | 2017-06-20 | [1,2,3]triazolo[4,5-d]pyrimidine derivatives with affinity for the type-2 cannabinoid receptor |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US10457685B2 (en) |
| EP (2) | EP4108665A1 (en) |
| JP (2) | JP6962942B2 (en) |
| KR (2) | KR102530131B1 (en) |
| CN (4) | CN113943297A (en) |
| AR (1) | AR108845A1 (en) |
| AU (2) | AU2017283136C1 (en) |
| BR (1) | BR112018075143A2 (en) |
| CA (2) | CA3023043A1 (en) |
| CL (1) | CL2018003610A1 (en) |
| CO (1) | CO2018011231A2 (en) |
| CR (2) | CR20220661A (en) |
| IL (2) | IL292015B1 (en) |
| MA (1) | MA45442A (en) |
| MX (1) | MX2018014684A (en) |
| MY (1) | MY197244A (en) |
| PE (1) | PE20190109A1 (en) |
| PH (1) | PH12018502733A1 (en) |
| RU (1) | RU2741597C2 (en) |
| SG (2) | SG10202113286RA (en) |
| TW (2) | TWI824380B (en) |
| UA (1) | UA123834C2 (en) |
| WO (1) | WO2017220517A1 (en) |
| ZA (1) | ZA201807133B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017220516A1 (en) | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| CN109311886B (en) | 2016-06-23 | 2021-11-09 | 豪夫迈·罗氏有限公司 | [1,2,3] triazolo [4,5-d ] pyrimidine derivatives |
| EP3475283B1 (en) | 2016-06-23 | 2021-08-11 | F. Hoffmann-La Roche AG | Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| CN113387845B (en) * | 2021-07-16 | 2022-12-20 | 国药集团化学试剂有限公司 | Preparation method of phenylmethylsulfonyl fluoride |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003512326A (en) * | 1999-10-18 | 2003-04-02 | ユニヴァーシティ オブ コネチカット | Similar indole derivatives of cannabinoids |
| JPWO2006051704A1 (en) * | 2004-11-15 | 2008-05-29 | 大正製薬株式会社 | Imine compounds |
| EP1863778B1 (en) | 2005-03-31 | 2015-12-30 | Merck Sharp & Dohme Corp. | Spirocyclic thrombin receptor antagonists |
| FR2887550A1 (en) | 2005-06-24 | 2006-12-29 | Sanofi Aventis Sa | New 1-benzylpyrazole-3-acetamide compounds are cannabinoids receptor antagonists useful to treat/prevent immune disorders, pain, gastrointestinal disturbances, cardiovascular/kidney disorders and in cancer chemotherapy |
| MX2008012400A (en) * | 2006-03-30 | 2008-10-10 | Irm Llc | Azolopyrimidines as inhibitors of cannabinoid 1 activity. |
| US8629157B2 (en) * | 2009-01-05 | 2014-01-14 | Boehringer Ingelheim International Gmbh | Pyrrolidine compounds which modulate the CB2 receptor |
| EP2311443A1 (en) | 2009-10-15 | 2011-04-20 | Rheinische Friedrich-Wilhelms-Universität | Pharmaceutical composition containing cannabinoid-receptor 2 antagonists |
| CN102924457A (en) * | 2011-08-12 | 2013-02-13 | 上海恒瑞医药有限公司 | Triazolopyrimidine derivatives, preparation method and uses thereof |
| UA111640C2 (en) * | 2011-11-08 | 2016-05-25 | Ф. Хоффманн-Ля Рош Аг | DERIVATIVES [1,2,3] TRIAZOLO [4,5-d] PYRIMIDINE AS A cannabinoid receptor agonist 2 |
| US9067943B2 (en) | 2011-11-25 | 2015-06-30 | Hoffmann-La Roche Inc. | [1,2,3]triazolo[4,5-D]pyrimidine derivatives |
| PE20151539A1 (en) | 2013-03-07 | 2015-10-28 | Hoffmann La Roche | NEW DERIVATIVES OF PIRAZOLE |
| EP2991988B1 (en) | 2013-05-02 | 2017-05-31 | F. Hoffmann-La Roche AG | Pyrrolo[2,3-d]pyrimidine derivatives as cb2 receptor agonists |
| KR102330794B1 (en) | 2013-05-02 | 2021-11-26 | 에프. 호프만-라 로슈 아게 | Purine derivatives as cb2 receptor agonists |
| EP3483163B1 (en) * | 2013-09-06 | 2021-06-23 | F. Hoffmann-La Roche AG | Triazolo[4,5-d]pyrimidine derivatives as cb2 receptor antagonists |
| EP3215506B1 (en) | 2014-11-07 | 2019-01-02 | F.Hoffmann-La Roche Ag | Triazolo[4,5-d]pyrimidines as agonists of the cannabinoid receptor 2 |
| WO2017220516A1 (en) | 2016-06-23 | 2017-12-28 | F. Hoffmann-La Roche Ag | Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives |
| CN109311886B (en) | 2016-06-23 | 2021-11-09 | 豪夫迈·罗氏有限公司 | [1,2,3] triazolo [4,5-d ] pyrimidine derivatives |
| EP3475283B1 (en) | 2016-06-23 | 2021-08-11 | F. Hoffmann-La Roche AG | Novel[1,2,3]triazolo[4,5-d]pyrimidine derivatives |
-
2017
- 2017-06-20 MY MYPI2018002797A patent/MY197244A/en unknown
- 2017-06-20 PE PE2018003112A patent/PE20190109A1/en unknown
- 2017-06-20 SG SG10202113286RA patent/SG10202113286RA/en unknown
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- 2017-06-20 SG SG11201809678VA patent/SG11201809678VA/en unknown
- 2017-06-20 UA UAA201900294A patent/UA123834C2/en unknown
- 2017-06-20 KR KR1020187037004A patent/KR102530131B1/en active IP Right Grant
- 2017-06-20 IL IL292015A patent/IL292015B1/en unknown
- 2017-06-20 KR KR1020237014572A patent/KR20230062680A/en not_active Application Discontinuation
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- 2017-06-20 RU RU2018146657A patent/RU2741597C2/en active
- 2017-06-20 AU AU2017283136A patent/AU2017283136C1/en active Active
- 2017-06-20 CN CN202111184338.3A patent/CN113943297A/en active Pending
- 2017-06-20 CN CN202210799583.3A patent/CN115073476A/en active Pending
- 2017-06-20 CN CN202210807089.7A patent/CN115093418A/en active Pending
- 2017-06-20 JP JP2018566249A patent/JP6962942B2/en active Active
- 2017-06-20 MA MA045442A patent/MA45442A/en unknown
- 2017-06-20 WO PCT/EP2017/064994 patent/WO2017220517A1/en active Application Filing
- 2017-06-20 MX MX2018014684A patent/MX2018014684A/en unknown
- 2017-06-20 CA CA3206921A patent/CA3206921A1/en active Pending
- 2017-06-20 EP EP22174808.0A patent/EP4108665A1/en active Pending
- 2017-06-20 CR CR20220661A patent/CR20220661A/en unknown
- 2017-06-20 EP EP17731149.5A patent/EP3475282B1/en active Active
- 2017-06-20 CN CN201780036295.XA patent/CN109348716A/en active Pending
- 2017-06-20 CR CR20180615A patent/CR20180615A/en unknown
- 2017-06-21 AR ARP170101708A patent/AR108845A1/en unknown
- 2017-06-22 TW TW111101354A patent/TWI824380B/en active
- 2017-06-22 TW TW106120830A patent/TWI764908B/en active
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2018
- 2018-10-19 CO CONC2018/0011231A patent/CO2018011231A2/en unknown
- 2018-10-25 ZA ZA2018/07133A patent/ZA201807133B/en unknown
- 2018-11-01 IL IL262711A patent/IL262711B2/en unknown
- 2018-12-14 CL CL2018003610A patent/CL2018003610A1/en unknown
- 2018-12-20 US US16/228,539 patent/US10457685B2/en active Active
- 2018-12-21 PH PH12018502733A patent/PH12018502733A1/en unknown
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2021
- 2021-07-26 AU AU2021206925A patent/AU2021206925B2/en active Active
- 2021-10-14 JP JP2021168709A patent/JP7308246B2/en active Active
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