DK3350180T3 - 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-onderivater som selektive modulatorer af ataxia telangiectasia muteret (atm) kinase til behandling af cancer - Google Patents

8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-onderivater som selektive modulatorer af ataxia telangiectasia muteret (atm) kinase til behandling af cancer Download PDF

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DK3350180T3
DK3350180T3 DK16770461.8T DK16770461T DK3350180T3 DK 3350180 T3 DK3350180 T3 DK 3350180T3 DK 16770461 T DK16770461 T DK 16770461T DK 3350180 T3 DK3350180 T3 DK 3350180T3
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underivatives
muttered
quinolin
imidazo
propoxy
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DK16770461.8T
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Kurt Gordon Pike
Bernard Christophe Barlaam
Thomas Anthony Hunt
Andrew John Eatherton
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Astrazeneca Ab
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK16770461.8T 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-onderivater som selektive modulatorer af ataxia telangiectasia muteret (atm) kinase til behandling af cancer DK3350180T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1516504.6A GB201516504D0 (en) 2015-09-17 2015-09-17 Imadazo(4,5-c)quinolin-2-one Compounds and their use in treating cancer
PCT/EP2016/071782 WO2017046216A1 (en) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1 -isopropyl-imidazo[4,5-c]quinolin-2-one derivatives as selective modulators of ataxia telangiectasia mutated (atm) kinase for the treatment of cancer

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DK16770461.8T DK3350180T3 (da) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropyl-imidazo[4,5-c]quinolin-2-onderivater som selektive modulatorer af ataxia telangiectasia muteret (atm) kinase til behandling af cancer
DK20156172.7T DK3683220T3 (da) 2015-09-17 2016-09-15 8-[6-[3-(amino)propoxy]-3-pyridyl]-1-isopropylimidazo[4,5-c]quinolin-2-on-derivater som selektive modulatorer af ataxia telangiectasia muteret (atm) kinase til behandling af huntingtons sygdom

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US (5) US9856255B2 (https=)
EP (2) EP3683220B1 (https=)
JP (1) JP6605130B2 (https=)
KR (2) KR102028848B1 (https=)
CN (1) CN108137576B (https=)
AR (1) AR106053A1 (https=)
AU (1) AU2016323399B2 (https=)
BR (1) BR112018004325B1 (https=)
CA (1) CA2997399C (https=)
CL (1) CL2018000677A1 (https=)
CO (1) CO2018002829A2 (https=)
CR (1) CR20180172A (https=)
CY (1) CY1124680T1 (https=)
DK (2) DK3350180T3 (https=)
DO (1) DOP2018000065A (https=)
EA (1) EA033284B1 (https=)
ES (2) ES2920876T3 (https=)
GB (1) GB201516504D0 (https=)
HR (1) HRP20210149T1 (https=)
HU (2) HUE058884T2 (https=)
IL (1) IL257847B (https=)
LT (1) LT3350180T (https=)
MX (1) MX384930B (https=)
MY (2) MY198813A (https=)
NI (1) NI201800033A (https=)
PE (1) PE20181078A1 (https=)
PH (1) PH12018500532A1 (https=)
PL (2) PL3683220T3 (https=)
PT (2) PT3683220T (https=)
RS (1) RS61435B1 (https=)
SI (1) SI3350180T1 (https=)
SM (1) SMT202100071T1 (https=)
SV (1) SV2018005655A (https=)
TN (1) TN2018000078A1 (https=)
TW (2) TWI762109B (https=)
WO (1) WO2017046216A1 (https=)
ZA (1) ZA202209171B (https=)

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