DK3138581T3 - Omdirigeret immunterapi - Google Patents

Omdirigeret immunterapi Download PDF

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Publication number
DK3138581T3
DK3138581T3 DK16191609.3T DK16191609T DK3138581T3 DK 3138581 T3 DK3138581 T3 DK 3138581T3 DK 16191609 T DK16191609 T DK 16191609T DK 3138581 T3 DK3138581 T3 DK 3138581T3
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Prior art keywords
cell
peptidase
cells
leu
subfamily
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DK16191609.3T
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English (en)
Inventor
Mark Cobbold
David Millar
Original Assignee
Univ Birmingham
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Priority claimed from GBGB1104514.3A external-priority patent/GB201104514D0/en
Priority claimed from GBGB1203434.4A external-priority patent/GB201203434D0/en
Application filed by Univ Birmingham filed Critical Univ Birmingham
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Publication of DK3138581T3 publication Critical patent/DK3138581T3/da

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    • C07—ORGANIC CHEMISTRY
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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Claims (16)

1. Middel omfattende: (i) en målretningsdel, der kan rette sig mod faste cancertumorceller, hvor målretningsdelen er et antistof eller et antigen-bindende fragment deraf; (ii) en peptid-linker omfattende et proteasespaltningssted; og (iii) et T-celle antigen, hvor T-celleantigenet er et virusafledt peptid, der kan binde til et MHC klasse l-molekyle og/eller et MHC klasse Il-molekyle; hvor T-celleantigenet kan frigives fra målretningsdelen ved spaltning af spaltningsstedet i den linker, der kan spaltes af en protease selektivt i nærheden af de faste cancertumorceller; hvor selektiv spaltning af proteasespaltningsstedet muliggør frigivelse af T-celleantigenet i nærheden af, og uden for, de faste cancertumorceller, og hvor midlet er til forebyggelse eller behandling af en fast cancertumor.
2. Middel ifølge krav 1, hvor T-celleantigenet kan fremkalde et eksisterende T-cellerespons hos et individ.
3. Middel ifølge krav 1 eller 2, hvor den faste cancertumor er valgt blandt en epitelial tumor, prostatatumor, ovarietumor, renalcelletumor, tumor i mave-tarm-kanalen, levertumor, kolorektal tumor, tumorvaskulatur, mesotheliom-tu-mor, pancreastumor, brysttumor, sarkom-tumor, lungetumor, colontumor, hjernetumor, melanomtumor, småcellet lungetumor, neuroblastom-tumor, testikeltumor, karcinom-tumor, adenokarcinom-tumor, gliom-tumor, seminom-tumor eller osteosarkom-tumor.
4. Middel ifølge et hvilket som helst af kravene 1-3, hvor selektiv spaltning af spaltningsstedet muliggør frigivelse af T-celleantigenet ved eller tæt på celleoverfladen af de faste cancertumorceller.
5. Middel ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf er specifikt for en hvilken som helst af Her2/Neu; EpCAM (CD326); EGFR; PMSA; CA125; ku I syrean hydrase IX; c-met/HGFR; TRAIL-R1; DR5; IGF-1 R; VEGF-R2; prostatastamcelleantigen (PSCA); MUC1; CanAg; me-sothelin; P-cadherin; myostatin (GDF8); Cripto (TDGF1); MUC5AC; CEACAM; SLC44A4; neuropilin 1; glypican; HER3/EGFR; og EphA2.
6. Middel ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf er specifikt for CEACAM.
7. Middel ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf er et anti-epidermal vækstfaktorreceptor-antistof, cetuximab, et anti-Her2-antistof, et anti-MUC1-antistof, GP1.4, SM3, et anti-P-cadherin-antistof, et anti-EpCAM-antistof, et anti-E-cadherin-antistof, et anti-CEA-antistof eller et anti-FGFR3-antistof.
8. Middel ifølge krav 1, hvor antistoffet eller det antigenbindende fragment deraf er specifikt for CEA.
9. Middel ifølge et hvilket som helst af kravene 1-8, hvor antigenet er fra Varicella Zoster-virus, Herpes simplex-virus, cytomegalovirus, Epstein-Barr-virus, adenovirus, rhinovirus eller influenzavirus.
10. Middel ifølge et hvilket som helst af kravene 1-9, hvor enzymet selektivt i nærheden af de faste cancertumorceller er en tumorassocieret protease.
11. Middel ifølge et hvilket som helst af kravene 1-10 til anvendelse i medicin.
12. Farmaceutisk sammensætning omfattende et middel ifølge et hvilket som helst af kravene 1-11 og et farmaceutisk acceptabelt bærestof, fortyndingsmiddel eller hjælpestof.
13. Middel ifølge krav 1-11 til anvendelse til forebyggelse eller behandling af en fast cancertumor hos et individ; eventuelt hvor individet får indgivet et yderligere terapeutisk middel.
14. Sammensætning omfattende (i) et middel ifølge et hvilket som helst af kravene 1-11 og (ii) et yderligere terapeutisk middel, der er egnet til forebyggelse eller behandling af en fast cancertumor.
15. Sammensætning ifølge krav 14 til anvendelse til forebyggelse eller behandling af en fast cancertumor.
16. Middel ifølge et hvilket som helst af kravene 1-11 eller 13 eller sammensætning ifølge et hvilket som helst af kravene 12,14 eller 15, hvor målretningsdelen og T-celleantigenet kodes af en enkelt polypeptidkæde.
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