DK3110961T3 - Modulering af cellevækst og glycosylering i rekombinant glycoproteinproduktion - Google Patents

Modulering af cellevækst og glycosylering i rekombinant glycoproteinproduktion Download PDF

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Publication number
DK3110961T3
DK3110961T3 DK15709430.1T DK15709430T DK3110961T3 DK 3110961 T3 DK3110961 T3 DK 3110961T3 DK 15709430 T DK15709430 T DK 15709430T DK 3110961 T3 DK3110961 T3 DK 3110961T3
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DK
Denmark
Prior art keywords
glycosylation
modulation
cell growth
recombinant glycoprotein
glycoprotein production
Prior art date
Application number
DK15709430.1T
Other languages
Danish (da)
English (en)
Inventor
Nicola Beaucamp
Georg Drabner
Stephanie Esslinger
Oliver Popp
Original Assignee
Hoffmann La Roche
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50184787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK3110961(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
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Publication of DK3110961T3 publication Critical patent/DK3110961T3/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK15709430.1T 2014-02-27 2015-02-24 Modulering af cellevækst og glycosylering i rekombinant glycoproteinproduktion DK3110961T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14157030 2014-02-27
PCT/EP2015/053804 WO2015128314A1 (en) 2014-02-27 2015-02-24 Modulation of cell growth and glycosylation in recombinant glycoprotein production

Publications (1)

Publication Number Publication Date
DK3110961T3 true DK3110961T3 (da) 2020-02-03

Family

ID=50184787

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15709430.1T DK3110961T3 (da) 2014-02-27 2015-02-24 Modulering af cellevækst og glycosylering i rekombinant glycoproteinproduktion

Country Status (20)

Country Link
US (3) US20170058309A1 (https=)
EP (1) EP3110961B1 (https=)
JP (2) JP6831702B2 (https=)
KR (1) KR102280638B1 (https=)
CN (1) CN106133146B (https=)
BR (1) BR112016017660B1 (https=)
CA (1) CA2937611C (https=)
DK (1) DK3110961T3 (https=)
ES (1) ES2769003T3 (https=)
HR (1) HRP20200100T1 (https=)
HU (1) HUE047575T2 (https=)
LT (1) LT3110961T (https=)
MX (1) MX369395B (https=)
PL (1) PL3110961T3 (https=)
PT (1) PT3110961T (https=)
RS (1) RS59881B1 (https=)
RU (1) RU2712562C2 (https=)
SG (1) SG11201606856SA (https=)
SI (1) SI3110961T1 (https=)
WO (1) WO2015128314A1 (https=)

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Publication number Priority date Publication date Assignee Title
AU2012340849B2 (en) 2011-11-21 2017-11-02 Innovation Hammer Llc Methods and systems for growing plants using silicate-based substrates, cultivation of enhanced photosynthetic productivity and photosafening by utilization of exogenous glycopyranosides for endogenous glycopyranosyl-protein derivatives, and formulations, processes and systems for the same
BR112016017660B1 (pt) * 2014-02-27 2022-04-19 F. Hoffmann-La Roche Ag Método para a produção de uma glicoproteína recombinante
CA2969225C (en) 2014-12-01 2023-08-22 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
BR112018072235B1 (pt) 2016-04-29 2023-01-17 Innovation Hammer Llc Método para intensificar o crescimento respiratório de um organismo fotossintético que compreende aplicar uma formulação de compósito de glicano
CA3056011A1 (en) 2017-03-14 2018-09-20 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
MX2020009605A (es) * 2018-03-16 2021-01-08 Genzyme Corp Metodos para mejorar la viabilidad celular en un biorreactor de produccion.
US12325737B2 (en) * 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
AU2019274782A1 (en) * 2018-05-24 2020-12-03 Ares Trading S.A. Method for controlling the afucosylation level of a glycoprotein composition
HU231514B1 (hu) 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
EA202191352A1 (ru) * 2018-11-13 2021-08-11 Янссен Байотек, Инк. Контроль содержания микроэлементов-металлов во время продукции антител к cd38
JP2020188737A (ja) * 2019-05-23 2020-11-26 東ソー株式会社 抗体依存性細胞傷害活性が向上した抗体の製造方法
US20230265204A1 (en) * 2020-04-24 2023-08-24 Hoffmann-La Roche Inc. Enzyme and pathway modulation with sulfhydryl compounds and their derivatives
CN121712803A (zh) * 2023-08-16 2026-03-20 葛兰素史密斯克莱知识产权有限公司 控制抗体糖基化谱的方法

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US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
US6030945A (en) 1996-01-09 2000-02-29 Genentech, Inc. Apo-2 ligand
AU4330597A (en) 1996-08-30 1998-03-19 Life Technologies, Inc. Serum-free mammalian cell culture medium, and uses thereof
DE69929198T2 (de) * 1998-05-29 2006-08-10 Genentech, Inc., South San Francisco Zellkulturverfahren für die produktion von glycoproteinen
JP2001120262A (ja) * 1999-10-26 2001-05-08 Welfide Corp 生理活性物質の産生増強方法
EP1360314B1 (en) 2001-02-15 2009-01-14 Centocor, Inc. Chemically defined medium for cultured mammalian cells
US20050287666A1 (en) * 2004-06-29 2005-12-29 Invitrogen Corporation Cell culture medium comprising transition metals or trace elements
TWI384069B (zh) 2004-08-27 2013-02-01 Pfizer Ireland Pharmaceuticals 多胜肽之製法
ES2361559T3 (es) 2004-11-02 2011-06-20 Ares Trading S.A. Medio de cultivo de células exento de suero para mamíferos.
US20070231895A1 (en) 2005-11-02 2007-10-04 Lee Gene W Methods for adapting mammalian cells
EP2495308A1 (en) * 2005-12-08 2012-09-05 Amgen Inc. Improved production of glycoproteins using manganese
EP3255141B1 (en) * 2006-07-13 2021-12-01 Wyeth LLC Production of antibodies with improved glycosylation pattern
ES2541546T3 (es) 2006-11-03 2015-07-21 Wyeth Llc Sustancias que inhiben la glucólisis en cultivo celular
AU2008223133A1 (en) 2007-03-02 2008-09-12 Wyeth Use of copper and glutamate in cell culture for production of polypeptides
US20110053223A1 (en) * 2009-08-14 2011-03-03 Robert Bayer Cell culture methods to make antibodies with enhanced adcc function
EP2531592A1 (en) * 2010-02-04 2012-12-12 Vivalis Fed-batch process using concentrated cell culture medium for the efficient production of biologics in eb66 cells
PL2563906T3 (pl) 2010-04-26 2018-04-30 Novartis Ag Sposób hodowli komórek cho
US9062106B2 (en) 2011-04-27 2015-06-23 Abbvie Inc. Methods for controlling the galactosylation profile of recombinantly-expressed proteins
CN105189735B (zh) 2011-04-29 2019-04-12 拜康研究有限公司 在培养期间减少乳酸累积的方法和生产多肽的方法
EP2809773B1 (en) * 2012-01-30 2020-09-02 Dr. Reddy's Laboratories Limited Process of modulating man5 and/or afucosylation content of glycoprotein composition
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BR112016017660B1 (pt) * 2014-02-27 2022-04-19 F. Hoffmann-La Roche Ag Método para a produção de uma glicoproteína recombinante

Also Published As

Publication number Publication date
SG11201606856SA (en) 2016-09-29
LT3110961T (lt) 2020-02-10
CN106133146B (zh) 2021-05-04
MX2016010236A (es) 2016-10-13
HUE047575T2 (hu) 2020-04-28
RS59881B1 (sr) 2020-03-31
PT3110961T (pt) 2020-01-29
RU2016138176A3 (https=) 2018-10-29
KR20160125514A (ko) 2016-10-31
WO2015128314A1 (en) 2015-09-03
MX369395B (es) 2019-11-07
PL3110961T3 (pl) 2020-04-30
JP2020054351A (ja) 2020-04-09
US20210222220A1 (en) 2021-07-22
US20240327890A1 (en) 2024-10-03
RU2712562C2 (ru) 2020-01-29
RU2016138176A (ru) 2018-03-29
US20170058309A1 (en) 2017-03-02
ES2769003T3 (es) 2020-06-24
JP2017506515A (ja) 2017-03-09
CA2937611C (en) 2023-01-03
BR112016017660B1 (pt) 2022-04-19
HRP20200100T1 (hr) 2020-04-03
CN106133146A (zh) 2016-11-16
SI3110961T1 (sl) 2020-03-31
JP6934507B2 (ja) 2021-09-15
CA2937611A1 (en) 2015-09-03
KR102280638B1 (ko) 2021-07-22
BR112016017660A2 (https=) 2017-08-08
EP3110961B1 (en) 2019-11-27
JP6831702B2 (ja) 2021-02-17
EP3110961A1 (en) 2017-01-04

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