JP6831702B2 - 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法 - Google Patents

細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法 Download PDF

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JP6831702B2
JP6831702B2 JP2016554322A JP2016554322A JP6831702B2 JP 6831702 B2 JP6831702 B2 JP 6831702B2 JP 2016554322 A JP2016554322 A JP 2016554322A JP 2016554322 A JP2016554322 A JP 2016554322A JP 6831702 B2 JP6831702 B2 JP 6831702B2
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zinc
manganese
copper
iron
glycoprotein
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JP2017506515A (ja
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オリバー ポップ
オリバー ポップ
ニコラ ブカン
ニコラ ブカン
ジョージ ドラブナー
ジョージ ドラブナー
ステファニー エスリンガー
ステファニー エスリンガー
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/38—Chemical stimulation of growth or activity by addition of chemical compounds which are not essential growth factors; Stimulation of growth by removal of a chemical compound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation

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  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2016554322A 2014-02-27 2015-02-24 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法 Active JP6831702B2 (ja)

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Application Number Priority Date Filing Date Title
JP2019214046A JP6934507B2 (ja) 2014-02-27 2019-11-27 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14157030.9 2014-02-27
EP14157030 2014-02-27
PCT/EP2015/053804 WO2015128314A1 (en) 2014-02-27 2015-02-24 Modulation of cell growth and glycosylation in recombinant glycoprotein production

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JP2019214046A Division JP6934507B2 (ja) 2014-02-27 2019-11-27 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法

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JP2017506515A JP2017506515A (ja) 2017-03-09
JP6831702B2 true JP6831702B2 (ja) 2021-02-17

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JP2016554322A Active JP6831702B2 (ja) 2014-02-27 2015-02-24 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法
JP2019214046A Active JP6934507B2 (ja) 2014-02-27 2019-11-27 細胞増殖および組換え糖タンパク質産生におけるグリコシル化のモジュレーションの方法

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US (3) US20170058309A1 (https=)
EP (1) EP3110961B1 (https=)
JP (2) JP6831702B2 (https=)
KR (1) KR102280638B1 (https=)
CN (1) CN106133146B (https=)
BR (1) BR112016017660B1 (https=)
CA (1) CA2937611C (https=)
DK (1) DK3110961T3 (https=)
ES (1) ES2769003T3 (https=)
HR (1) HRP20200100T1 (https=)
HU (1) HUE047575T2 (https=)
LT (1) LT3110961T (https=)
MX (1) MX369395B (https=)
PL (1) PL3110961T3 (https=)
PT (1) PT3110961T (https=)
RS (1) RS59881B1 (https=)
RU (1) RU2712562C2 (https=)
SG (1) SG11201606856SA (https=)
SI (1) SI3110961T1 (https=)
WO (1) WO2015128314A1 (https=)

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AU2012340849B2 (en) 2011-11-21 2017-11-02 Innovation Hammer Llc Methods and systems for growing plants using silicate-based substrates, cultivation of enhanced photosynthetic productivity and photosafening by utilization of exogenous glycopyranosides for endogenous glycopyranosyl-protein derivatives, and formulations, processes and systems for the same
BR112016017660B1 (pt) * 2014-02-27 2022-04-19 F. Hoffmann-La Roche Ag Método para a produção de uma glicoproteína recombinante
CA2969225C (en) 2014-12-01 2023-08-22 Amgen Inc. Process for manipulating the level of glycan content of a glycoprotein
BR112018072235B1 (pt) 2016-04-29 2023-01-17 Innovation Hammer Llc Método para intensificar o crescimento respiratório de um organismo fotossintético que compreende aplicar uma formulação de compósito de glicano
CA3056011A1 (en) 2017-03-14 2018-09-20 Amgen Inc. Control of total afucosylated glycoforms of antibodies produced in cell culture
WO2019077628A1 (en) * 2017-10-16 2019-04-25 Council Of Scientific & Industrial Research ZINC SUPPLEMENTATION TO DECREASE GALACTOSYLATION OF RECOMBINANT GLYCOPROTEINS
MX2020009605A (es) * 2018-03-16 2021-01-08 Genzyme Corp Metodos para mejorar la viabilidad celular en un biorreactor de produccion.
US12325737B2 (en) * 2018-03-26 2025-06-10 Amgen Inc. Total afucosylated glycoforms of antibodies produced in cell culture
AU2019274782A1 (en) * 2018-05-24 2020-12-03 Ares Trading S.A. Method for controlling the afucosylation level of a glycoprotein composition
HU231514B1 (hu) 2018-11-07 2024-07-28 Richter Gedeon Nyrt. Sejttenyészetben előállított rekombináns glikoprotein glikozilációs mintázatának megváltoztatására szolgáló módszer
EA202191352A1 (ru) * 2018-11-13 2021-08-11 Янссен Байотек, Инк. Контроль содержания микроэлементов-металлов во время продукции антител к cd38
JP2020188737A (ja) * 2019-05-23 2020-11-26 東ソー株式会社 抗体依存性細胞傷害活性が向上した抗体の製造方法
US20230265204A1 (en) * 2020-04-24 2023-08-24 Hoffmann-La Roche Inc. Enzyme and pathway modulation with sulfhydryl compounds and their derivatives
CN121712803A (zh) * 2023-08-16 2026-03-20 葛兰素史密斯克莱知识产权有限公司 控制抗体糖基化谱的方法

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US4767704A (en) 1983-10-07 1988-08-30 Columbia University In The City Of New York Protein-free culture medium
IL87737A (en) 1987-09-11 1993-08-18 Genentech Inc Method for culturing polypeptide factor dependent vertebrate recombinant cells
US5705364A (en) * 1995-06-06 1998-01-06 Genentech, Inc. Mammalian cell culture process
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DE69929198T2 (de) * 1998-05-29 2006-08-10 Genentech, Inc., South San Francisco Zellkulturverfahren für die produktion von glycoproteinen
JP2001120262A (ja) * 1999-10-26 2001-05-08 Welfide Corp 生理活性物質の産生増強方法
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BR112016017660B1 (pt) * 2014-02-27 2022-04-19 F. Hoffmann-La Roche Ag Método para a produção de uma glicoproteína recombinante

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Publication number Publication date
SG11201606856SA (en) 2016-09-29
LT3110961T (lt) 2020-02-10
CN106133146B (zh) 2021-05-04
MX2016010236A (es) 2016-10-13
HUE047575T2 (hu) 2020-04-28
RS59881B1 (sr) 2020-03-31
PT3110961T (pt) 2020-01-29
RU2016138176A3 (https=) 2018-10-29
KR20160125514A (ko) 2016-10-31
WO2015128314A1 (en) 2015-09-03
MX369395B (es) 2019-11-07
PL3110961T3 (pl) 2020-04-30
JP2020054351A (ja) 2020-04-09
US20210222220A1 (en) 2021-07-22
US20240327890A1 (en) 2024-10-03
RU2712562C2 (ru) 2020-01-29
RU2016138176A (ru) 2018-03-29
US20170058309A1 (en) 2017-03-02
ES2769003T3 (es) 2020-06-24
JP2017506515A (ja) 2017-03-09
CA2937611C (en) 2023-01-03
BR112016017660B1 (pt) 2022-04-19
DK3110961T3 (da) 2020-02-03
HRP20200100T1 (hr) 2020-04-03
CN106133146A (zh) 2016-11-16
SI3110961T1 (sl) 2020-03-31
JP6934507B2 (ja) 2021-09-15
CA2937611A1 (en) 2015-09-03
KR102280638B1 (ko) 2021-07-22
BR112016017660A2 (https=) 2017-08-08
EP3110961B1 (en) 2019-11-27
EP3110961A1 (en) 2017-01-04

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