DK2968503T3 - Anti-hepcidin-antistoffer og anvendelser deraf - Google Patents

Anti-hepcidin-antistoffer og anvendelser deraf Download PDF

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Publication number
DK2968503T3
DK2968503T3 DK14771150.1T DK14771150T DK2968503T3 DK 2968503 T3 DK2968503 T3 DK 2968503T3 DK 14771150 T DK14771150 T DK 14771150T DK 2968503 T3 DK2968503 T3 DK 2968503T3
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Prior art keywords
hepcidin
antibody
antigen
binding
mab
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DK14771150.1T
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English (en)
Inventor
Mark Westerman
Keith Westerman
Vaughn Ostland
Huiling Han
Patrick Gutschow
Gordana Olbina
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Intrinsic Lifesciences Llc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Claims (10)

1. Antistof eller antigenbindende fragment deraf, der binder specifikt til hepcidin (Hep) eller et hepcidinpeptid med en dissociationskonstant på mindre end 500 pM, hvilket antistof eller antigenbindende fragment deraf omfatter en variabel tung kæde, der omfatter en aminosyresekvens som vist i SEQ ID NO: 44, og en variabel let kæde, der omfatter en aminosyresekvens som vist i SEQ ID NO: 50.
2. Antistof eller antigenbindende fragment deraf, der binder specifikt til hepcidin (Hep) eller et hepcidinpeptid med en dissociationskonstant på mindre end 500 pM, hvilket antistof eller antigenbindende fragment deraf omfatter en variabel tung kæde, der omfatter en aminosyresekvens som vist i SEQ ID NO: 46, og en variabel let kæde, der omfatter en aminosyresekvens som vist i SEQ ID NO: 52.
3. Isoleret nukleinsyremolekyle, der omfatter en nukleotidsekvens, der koder for et antistof eller et antigenbindende fragment deraf ifølge krav 1 eller 2.
4. Ekspressionsvektor, der omfatter nukleinsyremolekylet ifølge krav 3, der er operabelt koblet til en regulatorisk kontrolsekvens.
5. Værtscelle, der omfatter vektoren ifølge krav 4 eller et nukleinsyremolekyle ifølge krav 3.
6. Fremgangsmåde til anvendelse af værtscellen ifølge krav 5 til fremstilling af et antistof eller et antigenbindende fragment deraf, som omfatter dyrkning af værtscellen under egnede betingelser, således at nukleinsyren udtrykkes til fremstilling af antistoffet eller det antigenbindende fragment deraf.
7. Sammensætning, der omfatter et antistof eller et antigenbindende fragment ifølge krav 1 eller 2 og et acceptabelt bæremateriale eller excipiens.
8. Antistof eller antigenbindende fragment ifølge krav 1 eller 2 eller sammensætning ifølge krav 7 til anvendelse som et medikament; eller til anvendelse i en fremgangsmåde til behandling af: en forstyrrelse med jernhomøostase ; hæmokromatose; jernrefraktær jerndeficiens-anæmi (IRIDA); anæmi ved inflammation; en inflammationssygdom; Alzheimers sygdom; en kronisk nyresygdom; Parkinsons sygdom; intermediær talassæmi; en bakterieinfektion; en svampeinfektion; en virusinfektion; anæmi; eller alfa-talassæmi.
9. Antistof eller antigenbindende fragment eller sammensætning til anvendelse ifølge krav 8, der yderligere omfatter administrering af en erytropoiese-stimulator, hvor erytropoiese-stimulatoren er valgt fra gruppen, der består af erythropoietin, hypoksi-inducerbar faktor prolylhydroxylaseinhibitor, et erytropoiese-stimulerende middel og erytroferron.
10. Antistof eller antigenbindende fragment ifølge et hvilket som helst af kravene 1 eller 2 eller sammensætning ifølge krav 7 til anvendelser ifølge krav 8 eller 9, hvor antistoffet eller det antigenbindende fragment eller sammensætningen administreres ved hjælp af intravenøs injektion, subkutan injektion, intramuskulær injektion eller ved hjælp af spinal injektion i en cerebrospinal væske.
DK14771150.1T 2013-03-15 2014-03-13 Anti-hepcidin-antistoffer og anvendelser deraf DK2968503T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361791953P 2013-03-15 2013-03-15
PCT/US2014/026804 WO2014152006A2 (en) 2013-03-15 2014-03-13 Anti-hepcidin antibodies and uses thereof

Publications (1)

Publication Number Publication Date
DK2968503T3 true DK2968503T3 (da) 2018-12-03

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US (3) US9657098B2 (da)
EP (1) EP2968503B1 (da)
JP (2) JP6463331B2 (da)
KR (1) KR102218494B1 (da)
CN (2) CN105263514B (da)
AU (2) AU2014236677B2 (da)
BR (1) BR112015022123B1 (da)
CA (1) CA2904357C (da)
DK (1) DK2968503T3 (da)
ES (1) ES2695166T3 (da)
HK (1) HK1220379A1 (da)
IL (2) IL241079A0 (da)
MX (1) MX359794B (da)
NZ (1) NZ631098A (da)
RU (1) RU2668391C2 (da)
WO (1) WO2014152006A2 (da)

Families Citing this family (17)

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DK2968503T3 (da) 2013-03-15 2018-12-03 Intrinsic Lifesciences Llc Anti-hepcidin-antistoffer og anvendelser deraf
US10323088B2 (en) 2014-09-22 2019-06-18 Intrinsic Lifesciences Llc Humanized anti-hepcidin antibodies and uses thereof
US11517540B2 (en) 2015-01-09 2022-12-06 The Board Of Trustees Of The University Of Illinois Restoring physiology in iron-deficient organisms using small molecules
WO2016146587A1 (en) 2015-03-13 2016-09-22 INSERM (Institut National de la Santé et de la Recherche Médicale) Hepcidin antagonists for use in the treatment of inflammation
EP3329018B1 (en) 2015-07-31 2021-03-31 Medimmune Limited Il-6 antagonists for use in treating hepcidin-mediated disorders
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