DK2924047T3 - Vaccinebærer - Google Patents
Vaccinebærer Download PDFInfo
- Publication number
- DK2924047T3 DK2924047T3 DK15161237.1T DK15161237T DK2924047T3 DK 2924047 T3 DK2924047 T3 DK 2924047T3 DK 15161237 T DK15161237 T DK 15161237T DK 2924047 T3 DK2924047 T3 DK 2924047T3
- Authority
- DK
- Denmark
- Prior art keywords
- ala
- glu
- lys
- leu
- asp
- Prior art date
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/415—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from plants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/35—Allergens
- A61K39/36—Allergens from pollen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/32011—Picornaviridae
- C12N2770/32711—Rhinovirus
- C12N2770/32734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Botany (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Virology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Claims (10)
1. A Hypoallergent molekyle, der er afledt af Phl p 5 og består af amino-syresekvens GAASNKAFAEGLSGEPKGAAESSSKAALTSK, ADLGYGPAT-PAAPAAGYTPATPAAPAEAAPAGK eller TVATAPEVKYTVFETALKKAI-TAMSEAQKAAK.
2. Hypoallergent fusionsprotein omfattende et hypoallergent molekyle ifølge krav 1 fusioneret på mindst et viruscapsidprotein, hvor det hypoallergene molekyle er fusioneret på N-terminus og/eller C-terminus af det mindst ene viruscapsidprotein.
3. Hypoallergent protein ifølge krav 2, kendetegnet ved, at det mindst ene viruscapsidprotein er afledt fra en human patogen virus.
4. Hypoallergent protein ifølge krav 3, kendetegnet ved, at den humane patogene virus er en virus af familien picornaviridae.
5. Hypoallergent protein ifølge krav 4, kendetegnet ved, at virussen af familien picornaviridae er af arten af rhinovira, fortrinsvis af arten af humane rhino-vira, især human rhinovirus 89 eller 14.
6. Nukleinsyremolekyle, der koder for et hypoallergent molekyle ifølge krav 1 eller et hypoallergent fusionsprotein ifølge et hvilket som helst af kravene 2 til 5.
7. Vektor omfattende et nukleinsyremolekyle ifølge krav 6, hvor vektoren med hensyn til en nukleinsyre, der koder for Phl p5, består af en nukleinsyrese-kvens, der koder for det hypoallergene molekyle bestående af aminosyrese-kvensen defineret i krav 1.
8. Vaccineformulering omfattende et hypoallergent molekyle ifølge krav 1 eller et hypoallergent fusionsprotein ifølge et hvilket som helst af kravene 2 til 5.
9. Formulering ifølge krav 8, kendetegnet ved, at formuleringen yderligere omfatter mindst en adjuvans, et farmaceutisk acceptabelt hjælpestof og/eller konserveringsmiddel.
10. Hypoallergent molekyle ifølge krav 1 eller hypoallergent fusionsprotein ifølge et hvilket som helst af kravene 2 til 5 til anvendelse ved behandling eller forebyggelse af en allergi hos et menneske eller et dyr.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0099406A AT503690A1 (de) | 2006-06-09 | 2006-06-09 | Hypoallergene moleküle |
| EP07718492.7A EP2035457B1 (en) | 2006-06-09 | 2007-06-11 | Vaccine carrier |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2924047T3 true DK2924047T3 (da) | 2018-12-03 |
Family
ID=38650124
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15161237.1T DK2924047T3 (da) | 2006-06-09 | 2007-06-11 | Vaccinebærer |
| DK07718492.7T DK2035457T3 (da) | 2006-06-09 | 2007-06-11 | Vaccinebærer |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07718492.7T DK2035457T3 (da) | 2006-06-09 | 2007-06-11 | Vaccinebærer |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9296828B2 (da) |
| EP (2) | EP2924047B1 (da) |
| JP (3) | JP5399895B2 (da) |
| CN (3) | CN101466738A (da) |
| AT (1) | AT503690A1 (da) |
| AU (1) | AU2007257308B2 (da) |
| BR (1) | BR122019004393B1 (da) |
| CA (1) | CA2657971C (da) |
| DK (2) | DK2924047T3 (da) |
| ES (2) | ES2541311T3 (da) |
| PL (1) | PL2035457T3 (da) |
| PT (1) | PT2035457E (da) |
| RU (1) | RU2486206C2 (da) |
| WO (1) | WO2007140505A2 (da) |
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| SI2190473T1 (sl) * | 2007-08-15 | 2013-05-31 | Circassia Limited | Peptid z zmanjšano tvorbo dimerov |
| SI2153841T2 (sl) * | 2008-08-15 | 2016-02-29 | Circassia Limited | Cepivo, ki obsega peptide Amb a 1, za uporabo pri zdravljenju alergije na ambrozijo |
| WO2010076583A1 (en) * | 2008-12-30 | 2010-07-08 | Kaw Yan Chua | A variant of mite allergen and uses thereof |
| CO6260019A1 (es) | 2009-01-30 | 2011-03-22 | Fundacion Universidad Del Norte | Metodo y composicion inmunoquimica para la deteccion de alergenos de acaros usando anticuerpos policlonales igy |
| AU2013202362B2 (en) * | 2009-02-05 | 2015-09-17 | Circassia Limited | Grass Peptides for Vaccine |
| CN103784952B (zh) * | 2009-02-05 | 2016-08-17 | 切尔卡西亚有限公司 | 用于疫苗的草肽 |
| EP2316481A1 (en) * | 2009-10-30 | 2011-05-04 | Biomay Ag | Pharmaceutical composition for the treatment and prevention of a rhinovirus infection |
| CA2838217C (en) * | 2011-06-09 | 2022-11-01 | Biomay Ag | Peptide carrier fusion proteins as allergy vaccines |
| WO2013001362A2 (en) * | 2011-06-27 | 2013-01-03 | Anergis S.A. | Contiguous overlapping peptides for treatment of ragweed pollen allergy |
| EP2543725A1 (en) * | 2011-07-08 | 2013-01-09 | Biomay Ag | Polysaccharide lyases |
| JO3820B1 (ar) * | 2012-05-03 | 2021-01-31 | Regeneron Pharma | أجسام مضادة بشرية لـ fel d1وطرق لاستخدامها |
| GB201209868D0 (en) * | 2012-06-01 | 2012-07-18 | Circassia Ltd | Alternaria peptides |
| US9163069B2 (en) | 2012-09-20 | 2015-10-20 | Universidad De Cartagena | Fusion proteins representing different allergens and a vaccine against allergy to mites |
| JP2014231500A (ja) * | 2013-05-29 | 2014-12-11 | 元晴 植原 | シラカンバ花粉症の免疫療法に用いるペプチド混合物 |
| WO2015027154A2 (en) | 2013-08-23 | 2015-02-26 | Regeneron Pharmaceuticals, Inc. | Diagnostic tests and methods for assessing safety, efficacy or outcome of allergen-specific immunotherapy (sit) |
| WO2017004561A1 (en) * | 2015-07-01 | 2017-01-05 | Alk-Abelló A/S | Peptide combinations and uses thereof for treating grass allergy |
| US11352417B2 (en) | 2016-12-22 | 2022-06-07 | Regeneron Pharmaceuticals, Inc. | Method of treating an allergy with allergen-specific monoclonal antibodies |
| US11408895B1 (en) | 2018-04-09 | 2022-08-09 | Hob Biotech Group Corp., Ltd. | Allergen characterization, potent allergen product formulation, comprehensive allergen reagent, and allergy assay |
| EP3569612A1 (en) * | 2018-05-18 | 2019-11-20 | Biomay Ag | Treatment and prevention of house dust mite allergies |
| RU2761431C9 (ru) | 2020-10-26 | 2022-04-18 | Федеральное государственное бюджетное учреждение "Государственный научный центр "Институт иммунологии" Федерального медико-биологического агентства России (ФГБУ "ГНЦ Институт иммунологии" ФМБА России) | Рекомбинантный полипептид на основе аллергена пыльцы березы и аллергена яблока в качестве вакцины от аллергии |
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| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
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| US6019972A (en) * | 1989-11-03 | 2000-02-01 | Immulogic Pharmaceutical Corporation | Peptides of human T cell reactive feline protein (TRFP) |
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| ES2209563B1 (es) | 2000-07-28 | 2005-10-01 | Universidad Complutense De Madrid | Produccion en la levadurapipchia pastoris y sistema de purificacion del alergeno recombinante de olea europaea ole e 1 para uso en diagnosis y tratamiento de alergias. |
| ATE414773T1 (de) * | 2000-11-16 | 2008-12-15 | Alk Abello As | Mutante allergene |
| EP1221317A1 (en) * | 2000-12-28 | 2002-07-10 | SHAN-Beteiligungsgesellschaft m.b.H. | Vaccines containing hybrid polypeptides consisting of at least two different allergenic proteins |
| US7264810B2 (en) * | 2001-01-19 | 2007-09-04 | Cytos Biotechnology Ag | Molecular antigen array |
| PL206709B1 (pl) * | 2002-02-27 | 2010-09-30 | Merck Patent Gmbh | Sposób wytwarzania i sposób obniżania aktywności IgE głównego hipoalergicznego alergenu pyłku brzozy rBet v 1, główny hipoalergiczny alergen pyłku brzozy rBet v 1uzyskiwany takim sposobem i jego zastosowanie jako leku oraz kompozycja farmaceutyczna zawierająca taki główny alergen |
| CA2490866A1 (en) * | 2002-06-26 | 2004-01-08 | Advanced Bionutrition Corporation | Viruses and virus-like particles for multiple antigen and target display |
| BR0312474A (pt) | 2002-07-05 | 2005-04-26 | Denis Leclerc | Partìcula viral adjuvante |
| EP1440979B1 (en) | 2003-01-21 | 2005-10-19 | BIOMAY Produktions- und Handels- Aktiengesellschaft | Process for the preparation of hypoallergenic mosaic proteins |
| GB0308988D0 (en) * | 2003-04-17 | 2003-05-28 | Univ Singapore | Molecule |
| JP4782671B2 (ja) * | 2003-06-04 | 2011-09-28 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | 低減したアレルギー誘発性および保持されたＴ細胞反応性を有するＰｈｌｐ５ａ誘導体 |
| US20050053615A1 (en) * | 2003-07-16 | 2005-03-10 | Best Elaine A. | Variants of mite group 1 allergens for the treatment of house dust mite allergy |
| DE10351471A1 (de) * | 2003-11-04 | 2005-06-09 | Ursula Prof. Dr. Wiedermann-Schmidt | Polyvalente Allergievakzine |
| MXPA06006221A (es) * | 2003-12-01 | 2008-02-13 | Dow Global Technologies Inc | Produccion de particula tipo virus icosaedrico recombinante en organismos del genero pseudomonas. |
| ITRM20040103A1 (it) * | 2004-02-27 | 2004-05-27 | Consiglio Nazionale Ricerche | Proteine di fusione comprendenti allergeni della famiglia delle ns-ltps, loro usi e composizioni farmaceutiche che le comprendono. |
| EP1720990A4 (en) * | 2004-02-27 | 2008-04-30 | Dow Global Technologies Inc | HIGHLY EFFICIENT PEPTIDE PRODUCTION IN PLANT CELLS |
| US20060088549A1 (en) * | 2004-07-08 | 2006-04-27 | Arnold Gail F | Chimeric virus vaccine |
| DE102004035337A1 (de) | 2004-07-21 | 2006-03-16 | Merck Patent Gmbh | Varianten der Gruppe 1-Allergene aus Poaceae mit reduzierter Allergenität und erhaltener T-Zellreaktivität |
| AU2005286475A1 (en) * | 2004-09-21 | 2006-03-30 | Cytos Biotechnology Ag | Virus-like particles comprising a fusion protein of the coat protein of AP205 and an antigenic polypeptide |
| AT501101B1 (de) * | 2004-12-02 | 2008-01-15 | Biomay Ag | Protein-allergen-derivat |
| CA2599218C (en) * | 2005-03-18 | 2015-08-11 | Cytos Biotechnology Ag | Cat allergen conjugates and uses thereof |
| EP2228656B1 (en) * | 2005-09-15 | 2013-10-23 | Alk-Abelló A/S | Quantification of allergens |
-
2006
- 2006-06-09 AT AT0099406A patent/AT503690A1/de not_active Application Discontinuation
-
2007
- 2007-06-11 BR BR122019004393-0A patent/BR122019004393B1/pt active IP Right Grant
- 2007-06-11 RU RU2008152045/10A patent/RU2486206C2/ru active
- 2007-06-11 AU AU2007257308A patent/AU2007257308B2/en active Active
- 2007-06-11 ES ES07718492.7T patent/ES2541311T3/es active Active
- 2007-06-11 PT PT77184927T patent/PT2035457E/pt unknown
- 2007-06-11 CA CA2657971A patent/CA2657971C/en active Active
- 2007-06-11 PL PL07718492T patent/PL2035457T3/pl unknown
- 2007-06-11 EP EP15161237.1A patent/EP2924047B1/en active Active
- 2007-06-11 US US12/304,267 patent/US9296828B2/en active Active
- 2007-06-11 CN CNA200780021374XA patent/CN101466738A/zh active Pending
- 2007-06-11 EP EP07718492.7A patent/EP2035457B1/en active Active
- 2007-06-11 WO PCT/AT2007/000281 patent/WO2007140505A2/en active Application Filing
- 2007-06-11 CN CN2013102084632A patent/CN103319601A/zh active Pending
- 2007-06-11 DK DK15161237.1T patent/DK2924047T3/da active
- 2007-06-11 JP JP2009513514A patent/JP5399895B2/ja active Active
- 2007-06-11 ES ES15161237T patent/ES2698525T3/es active Active
- 2007-06-11 DK DK07718492.7T patent/DK2035457T3/da active
- 2007-06-11 CN CN201310209988.8A patent/CN103319602B/zh active Active
-
2013
- 2013-10-24 JP JP2013221629A patent/JP2014087341A/ja active Pending
- 2013-10-24 JP JP2013221630A patent/JP2014064573A/ja active Pending
-
2015
- 2015-12-17 US US14/972,685 patent/US20160257722A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007257308B2 (en) | 2013-06-06 |
| EP2035457B1 (en) | 2015-04-01 |
| CN101466738A (zh) | 2009-06-24 |
| JP2014087341A (ja) | 2014-05-15 |
| AT503690A1 (de) | 2007-12-15 |
| US9296828B2 (en) | 2016-03-29 |
| EP2924047A1 (en) | 2015-09-30 |
| US20160257722A1 (en) | 2016-09-08 |
| WO2007140505A2 (en) | 2007-12-13 |
| CN103319602A (zh) | 2013-09-25 |
| US20090324501A1 (en) | 2009-12-31 |
| PT2035457E (pt) | 2015-07-28 |
| JP2009539354A (ja) | 2009-11-19 |
| CN103319602B (zh) | 2016-09-07 |
| BRPI0712421A2 (pt) | 2012-06-19 |
| JP5399895B2 (ja) | 2014-01-29 |
| ES2698525T3 (es) | 2019-02-05 |
| JP2014064573A (ja) | 2014-04-17 |
| RU2486206C2 (ru) | 2013-06-27 |
| CA2657971C (en) | 2018-01-23 |
| RU2008152045A (ru) | 2010-07-20 |
| EP2924047B1 (en) | 2018-08-22 |
| EP2035457A2 (en) | 2009-03-18 |
| CN103319601A (zh) | 2013-09-25 |
| AU2007257308A1 (en) | 2007-12-13 |
| DK2035457T3 (da) | 2015-06-15 |
| CA2657971A1 (en) | 2007-12-13 |
| BR122019004393B1 (pt) | 2023-10-17 |
| PL2035457T3 (pl) | 2015-10-30 |
| WO2007140505A3 (en) | 2008-03-20 |
| ES2541311T3 (es) | 2015-07-17 |
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