DK2922528T3 - Topikale dapson og dapson/adapalen-sammensætninger og fremgangsmåder til anvendelse deraf - Google Patents

Topikale dapson og dapson/adapalen-sammensætninger og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK2922528T3
DK2922528T3 DK13795979.7T DK13795979T DK2922528T3 DK 2922528 T3 DK2922528 T3 DK 2922528T3 DK 13795979 T DK13795979 T DK 13795979T DK 2922528 T3 DK2922528 T3 DK 2922528T3
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composition
concentration
present
acne
solvent
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DK13795979.7T
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English (en)
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Kevin S Warner
Ajay P Parashar
Varsha Bhatt
Vijaya Swaminathan
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Allergan Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49667632&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2922528(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/145—Amines having sulfur, e.g. thiurams (>N—C(S)—S—C(S)—N< and >N—C(S)—S—S—C(S)—N<), Sulfinylamines (—N=SO), Sulfonylamines (—N=SO2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/12—Keratolytics, e.g. wart or anti-corn preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (14)

1. Sammensætning omfattende dapson, et første opløsningsmiddel, hvilket er diethylen-glycol-monoethyl-ether, eventuelt mindst et andet opløsningsmiddel, en polymerisk viskositetsbygger og vand, hvor dapson er til stede i sammensætningen i en koncentration på 3 % vægt/vægt til 10 % vægt/vægt, hvor den polymeriske viskositetsbygger omfatter en akrylamid/natrium-akryloyldimethyltaurat copolymer.
2. Sammensætningen ifølge krav 1, hvor diethylene-glycol-monoethyl-etheren er til stede i en koncentration på 20 % vægt/vægt til 30 % vægt/vægt, fortrinsvis i en koncentration på 25 % vægt/vægt.
3. Sammensætningen ifølge krav 1, yderligere omfattende adapalen, eventuelt i en koncentration på 0,1 % vægt/vægt til 0,3 % vægt/vægt.
4. Sammensætningen ifølge krav 1, hvor det andet opløsningsmiddel er PEG 400, mælkesyre, dimethyl-isosorbid, propylen-glycol, propylen-karbonat, hexylen-glycol, isostearyl-alkohol, diethyl-sebacat eller ethanol.
5. Sammensætningen ifølge krav 1, hvor det andet opløsningsmiddel er propylen-glycol.
6. Sammensætningen ifølge krav 1, hvor det andet opløsningsmiddel er propylen-karbonat.
7. Sammensætningen ifølge krav 1, hvor det andet opløsningsmiddel er ethanol.
8. Sammensætningen ifølge krav 1, hvor den polymeriske viskositetsbygger er til stede i en koncentration på 2 % vægt/vægt til 6 % vægt/vægt, fortrinsvis i en koncentration på 4 % vægt/vægt.
9. Sammensætningen ifølge krav 1, yderligere omfattende methylparaben.
10. Sammensætningen ifølge krav 1, yderligere omfattende carbomer interpolymer type A, carbomer interpolymer type B, eller carbomer homopolymer type C.
11. Sammensætningen ifølge krav 1, yderligere omfattende et neutraliseringsmiddel, hvor neutraliseringsmidlet fortrinsvis er NaOH eller triethanolamin.
12. Sammensætningen ifølge krav 1 yderligere omfattende ethylen-diamin-tetraeddikesyre.
13. Sammensætningen ifølge krav 1 til anvendelse i en fremgangsmåde til behandling af en dermatologisk tilstand omfattende at administrere en terapeutisk effektiv mængde af sammensætningen til et individ med behov derfor.
14. Sammensætningen til anvendelse ifølge krav 13, hvor tilstanden er acne vulgaris, rosacea, atopisk dermatitis, behandling af kroniske sår, liggesår, keratose pilaris, cystis sebacea, inflammatoriske dermatoser, post-inflammatorisk hyperpigmentering, eksem, xerose, pruritus, lichen planus, nodular prurigo, dermatitis, eksem, eller miliaria, og hvor tilstanden er fortrinsvis acne vulgaris.
DK13795979.7T 2012-11-20 2013-11-18 Topikale dapson og dapson/adapalen-sammensætninger og fremgangsmåder til anvendelse deraf DK2922528T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261728403P 2012-11-20 2012-11-20
US201361770768P 2013-02-28 2013-02-28
PCT/US2013/070613 WO2014081674A1 (en) 2012-11-20 2013-11-18 Topical dapsone and dapsone/adapalene compositions and methods for use thereof

Publications (1)

Publication Number Publication Date
DK2922528T3 true DK2922528T3 (da) 2017-09-18

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ID=49667632

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Application Number Title Priority Date Filing Date
DK13795979.7T DK2922528T3 (da) 2012-11-20 2013-11-18 Topikale dapson og dapson/adapalen-sammensætninger og fremgangsmåder til anvendelse deraf

Country Status (16)

Country Link
US (9) US9161926B2 (da)
EP (1) EP2922528B1 (da)
JP (2) JP6285946B2 (da)
KR (2) KR20150085069A (da)
CN (1) CN105246457B (da)
AU (2) AU2013348247A1 (da)
BR (1) BR112015011673B1 (da)
CA (1) CA2890224C (da)
DK (1) DK2922528T3 (da)
ES (1) ES2644342T3 (da)
HK (1) HK1214516A1 (da)
HU (1) HUE035940T2 (da)
MX (1) MX362520B (da)
PL (1) PL2922528T3 (da)
RU (1) RU2638815C2 (da)
WO (1) WO2014081674A1 (da)

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EP3370711A1 (en) * 2015-11-04 2018-09-12 Allergan, Inc. Methods of treatment of acne vulgaris using topical dapsone compositions
CN105769892A (zh) * 2016-04-21 2016-07-20 蔡敏 一种治疗水痘的皮肤护理液及其制备方法
JP2020508993A (ja) * 2017-02-15 2020-03-26 ボタニクス ファーマシューティカルズ リミテッド ざ瘡を処置するための組成物
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KR101959524B1 (ko) * 2018-09-19 2019-03-18 주식회사 우신라보타치 리도카인을 포함한 이온토포레시스용 점착성 카타플라스마 시스템
CN116723864A (zh) * 2020-11-23 2023-09-08 德玛万科学有限责任公司 Tapinarof的凝胶、软膏和泡沫配制剂及使用方法
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WO2014081674A1 (en) 2014-05-30
AU2018214139A1 (en) 2018-08-30
US20180263931A1 (en) 2018-09-20
US20170087102A1 (en) 2017-03-30
AU2018214139B2 (en) 2020-03-05
RU2015123207A (ru) 2017-01-10
JP6285946B2 (ja) 2018-02-28
MX2015006396A (es) 2015-08-05
US20160030580A1 (en) 2016-02-04
US11273132B2 (en) 2022-03-15
JP2018083847A (ja) 2018-05-31
US20180243240A1 (en) 2018-08-30
EP2922528B1 (en) 2017-05-31
KR20150085069A (ko) 2015-07-22
JP2016500072A (ja) 2016-01-07
ES2644342T3 (es) 2017-11-28
BR112015011673B1 (pt) 2021-03-09
US20160243065A1 (en) 2016-08-25
US20140142184A1 (en) 2014-05-22
EP2922528A1 (en) 2015-09-30
US9517219B2 (en) 2016-12-13
KR20210049968A (ko) 2021-05-06
CA2890224A1 (en) 2014-05-30
US20170360729A1 (en) 2017-12-21
MX362520B (es) 2019-01-21
JP6644817B2 (ja) 2020-02-12
RU2638815C2 (ru) 2017-12-15
HUE035940T2 (en) 2018-05-28
US11116733B2 (en) 2021-09-14
CN105246457A (zh) 2016-01-13
CN105246457B (zh) 2019-06-07
KR102291448B1 (ko) 2021-08-18
CA2890224C (en) 2021-03-09
BR112015011673A2 (pt) 2017-07-11
US9161926B2 (en) 2015-10-20
HK1214516A1 (zh) 2016-07-29
US20170367999A1 (en) 2017-12-28
PL2922528T3 (pl) 2017-12-29
US20220184002A1 (en) 2022-06-16
AU2013348247A1 (en) 2015-05-21

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