DK2848625T3 - Fremgangsmåder til fjernelse af en kontaminant under anvendelse af ion bytningsmembrankromatografi med forskydning af naturligt forekommende proteiner - Google Patents
Fremgangsmåder til fjernelse af en kontaminant under anvendelse af ion bytningsmembrankromatografi med forskydning af naturligt forekommende proteiner Download PDFInfo
- Publication number
- DK2848625T3 DK2848625T3 DK14189582.1T DK14189582T DK2848625T3 DK 2848625 T3 DK2848625 T3 DK 2848625T3 DK 14189582 T DK14189582 T DK 14189582T DK 2848625 T3 DK2848625 T3 DK 2848625T3
- Authority
- DK
- Denmark
- Prior art keywords
- contaminant
- displacement
- methods
- ion exchange
- naturally occurring
- Prior art date
Links
- 239000000356 contaminant Substances 0.000 title 1
- 238000006073 displacement reaction Methods 0.000 title 1
- 239000003014 ion exchange membrane Substances 0.000 title 1
- 238000011140 membrane chromatography Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08797895.3A EP2321337B2 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using protein displacement ion exchange membrane chromatography |
| EP14189582.1A EP2848625B1 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
| PCT/US2008/073179 WO2010019148A1 (en) | 2008-08-14 | 2008-08-14 | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2848625T3 true DK2848625T3 (da) | 2019-10-07 |
Family
ID=39899038
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19181531.5T DK3604324T3 (da) | 2008-08-14 | 2008-08-14 | Fremgangsmåder til at fjerne en kontaminant under anvendelse af ionbytningskromatografi med forskydning af iboende proteiner |
| DK14189582.1T DK2848625T3 (da) | 2008-08-14 | 2008-08-14 | Fremgangsmåder til fjernelse af en kontaminant under anvendelse af ion bytningsmembrankromatografi med forskydning af naturligt forekommende proteiner |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK19181531.5T DK3604324T3 (da) | 2008-08-14 | 2008-08-14 | Fremgangsmåder til at fjerne en kontaminant under anvendelse af ionbytningskromatografi med forskydning af iboende proteiner |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US10927144B2 (enExample) |
| EP (3) | EP3604324B1 (enExample) |
| JP (1) | JP5666447B2 (enExample) |
| KR (3) | KR20180033311A (enExample) |
| CN (1) | CN102149724B (enExample) |
| AU (1) | AU2008360625C1 (enExample) |
| BR (1) | BRPI0823046B1 (enExample) |
| CA (1) | CA2731943C (enExample) |
| CY (1) | CY1122221T1 (enExample) |
| DK (2) | DK3604324T3 (enExample) |
| ES (3) | ES2749190T3 (enExample) |
| FI (1) | FI3604324T3 (enExample) |
| HR (2) | HRP20240472T1 (enExample) |
| HU (2) | HUE066562T2 (enExample) |
| IL (2) | IL210912B (enExample) |
| LT (2) | LT3604324T (enExample) |
| MX (1) | MX2011001506A (enExample) |
| PL (2) | PL2848625T3 (enExample) |
| PT (2) | PT3604324T (enExample) |
| RS (1) | RS59232B1 (enExample) |
| SI (2) | SI2848625T1 (enExample) |
| WO (1) | WO2010019148A1 (enExample) |
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| US10927144B2 (en) | 2008-08-14 | 2021-02-23 | Genentech, Inc. | Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography |
| SG10201702951RA (en) | 2008-10-20 | 2017-06-29 | Abbvie Inc | Viral inactivation during purification of antibodies |
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| SG10201710439UA (en) † | 2010-05-25 | 2018-01-30 | Genentech Inc | Methods of purifying polypeptides |
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| KR20140092227A (ko) * | 2010-12-10 | 2014-07-23 | 트레이시 톰슨 | 분리 방법용 조성물 |
| US9062106B2 (en) | 2011-04-27 | 2015-06-23 | Abbvie Inc. | Methods for controlling the galactosylation profile of recombinantly-expressed proteins |
| PL2794635T3 (pl) | 2011-12-22 | 2019-02-28 | F.Hoffmann-La Roche Ag | Membranowa chromatografia jonowymienna |
| US9067990B2 (en) | 2013-03-14 | 2015-06-30 | Abbvie, Inc. | Protein purification using displacement chromatography |
| US9181572B2 (en) | 2012-04-20 | 2015-11-10 | Abbvie, Inc. | Methods to modulate lysine variant distribution |
| US9505833B2 (en) | 2012-04-20 | 2016-11-29 | Abbvie Inc. | Human antibodies that bind human TNF-alpha and methods of preparing the same |
| US9150645B2 (en) | 2012-04-20 | 2015-10-06 | Abbvie, Inc. | Cell culture methods to reduce acidic species |
| US9512214B2 (en) | 2012-09-02 | 2016-12-06 | Abbvie, Inc. | Methods to control protein heterogeneity |
| EP2961759A4 (en) * | 2013-02-26 | 2016-09-28 | Agency Science Tech & Res | PROTEIN CLEANING IN THE PRESENCE OF NON-ORGANIC POLYMERS AND ELECTROPOSITIVE SURFACES |
| US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
| US9017687B1 (en) | 2013-10-18 | 2015-04-28 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same using displacement chromatography |
| US9499614B2 (en) | 2013-03-14 | 2016-11-22 | Abbvie Inc. | Methods for modulating protein glycosylation profiles of recombinant protein therapeutics using monosaccharides and oligosaccharides |
| US10400007B2 (en) * | 2013-04-16 | 2019-09-03 | Asahi Kasei Medical Co., Ltd. | Method for purifying antibody protein |
| EP3052640A2 (en) | 2013-10-04 | 2016-08-10 | AbbVie Inc. | Use of metal ions for modulation of protein glycosylation profiles of recombinant proteins |
| US9181337B2 (en) | 2013-10-18 | 2015-11-10 | Abbvie, Inc. | Modulated lysine variant species compositions and methods for producing and using the same |
| US9085618B2 (en) | 2013-10-18 | 2015-07-21 | Abbvie, Inc. | Low acidic species compositions and methods for producing and using the same |
| US20150139988A1 (en) | 2013-11-15 | 2015-05-21 | Abbvie, Inc. | Glycoengineered binding protein compositions |
| US9546208B2 (en) | 2014-01-03 | 2017-01-17 | Bio-Rad Laboratories, Inc. | Removal of impurities from protein A eluates |
| EP4389757A3 (en) * | 2016-09-07 | 2025-01-01 | GlaxoSmithKline Intellectual Property Development Limited | Methods for purifying antibodies |
| JP7085533B2 (ja) | 2016-09-09 | 2022-06-16 | スリーエム イノベイティブ プロパティズ カンパニー | 官能化コポリマー及びその使用 |
| US10053368B1 (en) * | 2017-09-07 | 2018-08-21 | Chevron U.S.A. Inc. | Synthesis of AFX framework type molecular sieves |
| EP3546475A1 (en) * | 2018-03-27 | 2019-10-02 | Sanofi | Full flow-through process for purifying recombinant proteins |
| TWI814812B (zh) * | 2018-05-02 | 2023-09-11 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| EP3810650A1 (en) * | 2018-06-19 | 2021-04-28 | Bristol-Myers Squibb Company | Methods of purifying proteins using chromatography |
| CN109324143B (zh) * | 2018-10-19 | 2021-10-29 | 张骐 | 利用二维液相分离制备抗体类产品相关杂质的方法 |
| CN109806916B (zh) * | 2019-03-15 | 2021-12-21 | 中科森辉微球技术(苏州)有限公司 | 高性能阴离子交换介质及其制备方法 |
| GB201911685D0 (en) * | 2019-08-15 | 2019-10-02 | Fujifilm Diosynth Biotechnologies Uk Ltd | Process for purifying monoclonal antibodies |
| KR20220112014A (ko) | 2021-02-03 | 2022-08-10 | 고인석 | 십전대보탕을 이용하여 만든 오리목뼈 간식 |
| JP2024537490A (ja) * | 2021-10-27 | 2024-10-10 | プラズマ テクノロジーズ エルエルシー | タンパク質を単離するための構成及び方法 |
| CN118290514B (zh) * | 2024-06-05 | 2025-04-04 | 东曜药业有限公司 | 基于阴离子膜的抗体偶联药物的纯化方法及抗体偶联药物 |
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2008
- 2008-08-14 US US13/058,796 patent/US10927144B2/en active Active
- 2008-08-14 DK DK19181531.5T patent/DK3604324T3/da active
- 2008-08-14 SI SI200832092T patent/SI2848625T1/sl unknown
- 2008-08-14 PT PT191815315T patent/PT3604324T/pt unknown
- 2008-08-14 RS RSP20191119 patent/RS59232B1/sr unknown
- 2008-08-14 ES ES14189582T patent/ES2749190T3/es active Active
- 2008-08-14 SI SI200832219T patent/SI3604324T1/sl unknown
- 2008-08-14 PT PT141895821T patent/PT2848625T/pt unknown
- 2008-08-14 PL PL14189582T patent/PL2848625T3/pl unknown
- 2008-08-14 HR HRP20240472TT patent/HRP20240472T1/hr unknown
- 2008-08-14 MX MX2011001506A patent/MX2011001506A/es active IP Right Grant
- 2008-08-14 CA CA2731943A patent/CA2731943C/en active Active
- 2008-08-14 KR KR1020187008461A patent/KR20180033311A/ko not_active Ceased
- 2008-08-14 HU HUE19181531A patent/HUE066562T2/hu unknown
- 2008-08-14 KR KR1020117005824A patent/KR101843915B1/ko active Active
- 2008-08-14 CN CN200880131059.7A patent/CN102149724B/zh active Active
- 2008-08-14 AU AU2008360625A patent/AU2008360625C1/en active Active
- 2008-08-14 FI FIEP19181531.5T patent/FI3604324T3/fi active
- 2008-08-14 WO PCT/US2008/073179 patent/WO2010019148A1/en not_active Ceased
- 2008-08-14 DK DK14189582.1T patent/DK2848625T3/da active
- 2008-08-14 ES ES19181531T patent/ES2978373T3/es active Active
- 2008-08-14 PL PL19181531.5T patent/PL3604324T3/pl unknown
- 2008-08-14 HU HUE14189582A patent/HUE047316T2/hu unknown
- 2008-08-14 BR BRPI0823046-3A patent/BRPI0823046B1/pt active IP Right Grant
- 2008-08-14 ES ES08797895T patent/ES2527943T5/es active Active
- 2008-08-14 EP EP19181531.5A patent/EP3604324B1/en active Active
- 2008-08-14 JP JP2011522953A patent/JP5666447B2/ja active Active
- 2008-08-14 LT LTEP19181531.5T patent/LT3604324T/lt unknown
- 2008-08-14 EP EP08797895.3A patent/EP2321337B2/en active Active
- 2008-08-14 EP EP14189582.1A patent/EP2848625B1/en active Active
- 2008-08-14 LT LTEP14189582.1T patent/LT2848625T/lt unknown
- 2008-08-14 KR KR1020187036563A patent/KR102196883B1/ko active Active
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2011
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2021
- 2021-01-20 US US17/153,826 patent/US20210284685A1/en active Pending
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