DK2824183T3 - Fremgangsmåde til fremstilling af bispecifikke antistoffer - Google Patents
Fremgangsmåde til fremstilling af bispecifikke antistoffer Download PDFInfo
- Publication number
- DK2824183T3 DK2824183T3 DK14176527.1T DK14176527T DK2824183T3 DK 2824183 T3 DK2824183 T3 DK 2824183T3 DK 14176527 T DK14176527 T DK 14176527T DK 2824183 T3 DK2824183 T3 DK 2824183T3
- Authority
- DK
- Denmark
- Prior art keywords
- production
- bispecific antibodies
- bispecific
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005112514 | 2005-04-08 | ||
EP06730769.4A EP1876236B9 (en) | 2005-04-08 | 2006-03-31 | Antibody substituting for function of blood coagulation factor viii |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2824183T3 true DK2824183T3 (da) | 2020-09-28 |
Family
ID=37086871
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK14176527.1T DK2824183T3 (da) | 2005-04-08 | 2006-03-31 | Fremgangsmåde til fremstilling af bispecifikke antistoffer |
DK06730769.4T DK1876236T3 (da) | 2005-04-08 | 2006-03-31 | Antistof som funktionel erstatning for blodkoagulationsfaktor VIII |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK06730769.4T DK1876236T3 (da) | 2005-04-08 | 2006-03-31 | Antistof som funktionel erstatning for blodkoagulationsfaktor VIII |
Country Status (13)
Country | Link |
---|---|
US (12) | US20100003254A1 (da) |
EP (2) | EP1876236B9 (da) |
JP (3) | JP4917024B2 (da) |
CA (2) | CA2603264C (da) |
CY (1) | CY1115702T1 (da) |
DK (2) | DK2824183T3 (da) |
ES (1) | ES2494921T3 (da) |
NO (1) | NO20075699L (da) |
PL (1) | PL1876236T3 (da) |
PT (1) | PT1876236E (da) |
SI (1) | SI1876236T1 (da) |
TW (1) | TW200714313A (da) |
WO (1) | WO2006109592A1 (da) |
Families Citing this family (75)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8597911B2 (en) | 2003-06-11 | 2013-12-03 | Chugai Seiyaku Kabushiki Kaisha | Process for producing antibodies |
AU2003271174A1 (en) | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
JPWO2005035754A1 (ja) * | 2003-10-14 | 2006-12-21 | 中外製薬株式会社 | 機能蛋白質を代替する二種特異性抗体 |
EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
EP3345616A1 (en) | 2006-03-31 | 2018-07-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
IN2014DN10515A (da) | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
PL3059246T3 (pl) | 2007-09-26 | 2018-11-30 | Chugai Seiyaku Kabushiki Kaisha | Zmodyfikowany region stały przeciwciała |
ES2834741T3 (es) | 2007-12-05 | 2021-06-18 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-NR10 y uso del mismo |
SG189775A1 (en) | 2008-04-11 | 2013-05-31 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
TWI440469B (zh) * | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
EP2409991B1 (en) | 2009-03-19 | 2017-05-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody constant region variant |
TWI646193B (zh) | 2009-03-19 | 2019-01-01 | 中外製藥股份有限公司 | 抗體恆定區域改變體 |
CN102459344A (zh) | 2009-05-15 | 2012-05-16 | 中外制药株式会社 | 抗axl抗体 |
WO2011037158A1 (ja) | 2009-09-24 | 2011-03-31 | 中外製薬株式会社 | 抗体定常領域改変体 |
US8518405B2 (en) | 2009-10-08 | 2013-08-27 | The University Of North Carolina At Charlotte | Tumor specific antibodies and uses therefor |
ES2777901T3 (es) | 2009-12-25 | 2020-08-06 | Chugai Pharmaceutical Co Ltd | Método de modificación de polipéptidos para purificar multímeros polipeptídicos |
TWI505838B (zh) | 2010-01-20 | 2015-11-01 | Chugai Pharmaceutical Co Ltd | Stabilized antibody solution containing |
EP2530109A4 (en) | 2010-01-29 | 2013-08-28 | Toray Industries | RESIN SHEET BASED ON POLYLACTIC ACID |
JP5889181B2 (ja) | 2010-03-04 | 2016-03-22 | 中外製薬株式会社 | 抗体定常領域改変体 |
US9845362B2 (en) | 2010-10-08 | 2017-12-19 | The University Of North Carolina At Charlotte | Compositions comprising chimeric antigen receptors, T cells comprising the same, and methods of using the same |
RS57038B1 (sr) | 2010-11-17 | 2018-05-31 | Chugai Pharmaceutical Co Ltd | Multi-specifičan antigen-vezujući molekul koji ima alternativnu funkciju funkciji faktora viii koagulacije krvi |
CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
EP4303237A3 (en) | 2010-11-30 | 2024-03-27 | Chugai Seiyaku Kabushiki Kaisha | Cytotoxicity-inducing therapeutic agent |
JP6043629B2 (ja) | 2011-01-07 | 2016-12-14 | 中外製薬株式会社 | 抗体の物性を改善させる方法 |
SG192945A1 (en) | 2011-02-25 | 2013-09-30 | Chugai Pharmaceutical Co Ltd | Fcgriib-specific fc antibody |
EP3939996A1 (en) | 2011-09-30 | 2022-01-19 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之FcRn結合域的治療性抗原結合分子 |
KR102398736B1 (ko) | 2011-10-31 | 2022-05-16 | 추가이 세이야쿠 가부시키가이샤 | 중쇄와 경쇄의 회합이 제어된 항원 결합 분자 |
UA114108C2 (uk) * | 2012-07-10 | 2017-04-25 | Борд Оф Ріджентс, Дзе Юніверсіті Оф Техас Сістем | Моноклональне антитіло для застосування в діагностиці і терапії злоякісних пухлин і аутоімунного захворювання |
CA2886326C (en) * | 2012-09-28 | 2021-11-02 | Chugai Seiyaku Kabushiki Kaisha | Method for evaluating blood coagulation reaction |
US9908944B2 (en) * | 2013-07-15 | 2018-03-06 | Novo Nordisk A/S | Antibodies that bind urokinase plasminogen activator |
SG10201803449VA (en) | 2013-09-27 | 2018-05-30 | Chugai Pharmaceutical Co Ltd | Method for producing polypeptide heteromultimer |
WO2015153765A1 (en) * | 2014-04-01 | 2015-10-08 | Adimab, Llc | Multispecific antibody analogs comprising a common light chain, and methods of their preparation and use |
TW201625299A (zh) | 2014-06-20 | 2016-07-16 | Chugai Pharmaceutical Co Ltd | 用於因第viii凝血因子及/或活化的第viii凝血因子的活性降低或欠缺而發病及/或進展的疾病之預防及/或治療之醫藥組成物 |
US11554181B2 (en) | 2014-09-05 | 2023-01-17 | The University Of North Carolina At Charlotte | Tumor specific antibody conjugates and uses therefor |
TWI701435B (zh) * | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定fviii的反應性之方法 |
TWI700300B (zh) * | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第viii凝血因子(fviii)機能替代活性的物質之抗體 |
MA40764A (fr) * | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
US9765135B2 (en) | 2014-12-19 | 2017-09-19 | Chugai Seiyaku Kabushiki Kaisha | Anti-C5 antibodies |
CR20170326A (es) | 2014-12-19 | 2017-08-22 | Chugai Pharmaceutical Co Ltd | Anticuerpos antimiostatina, polipéptidos que contienen regiones fc variantes, y métodos de uso |
WO2016125495A1 (en) | 2015-02-05 | 2016-08-11 | Chugai Seiyaku Kabushiki Kaisha | Antibodies comprising an ion concentration dependent antigen-binding domain, fc region variants, il-8-binding antibodies, and uses therof |
WO2016136933A1 (ja) | 2015-02-27 | 2016-09-01 | 中外製薬株式会社 | Il-6関連疾患治療用組成物 |
JP7082484B2 (ja) | 2015-04-01 | 2022-06-08 | 中外製薬株式会社 | ポリペプチド異種多量体の製造方法 |
US10787500B2 (en) | 2015-04-10 | 2020-09-29 | Adimab, Llc | Methods for purifying heterodimeric multispecific antibodies from parental homodimeric antibody species |
AU2016248817A1 (en) | 2015-04-17 | 2017-08-17 | F. Hoffmann-La Roche Ag | Combination therapy with coagulation factors and multispecific antibodies |
JP2018123055A (ja) * | 2015-04-24 | 2018-08-09 | 公立大学法人奈良県立医科大学 | 血液凝固第viii因子(fviii)の機能を代替する多重特異性抗原結合分子を含有する、血液凝固第xi因子(fxi)異常症の予防および/または治療に用いられる医薬組成物 |
US10723793B2 (en) * | 2015-06-12 | 2020-07-28 | Ludwig Institute For Cancer Research, Ltd. | TGF-β3 specific antibodies and methods and uses thereof |
PL3337817T3 (pl) * | 2015-08-21 | 2022-01-17 | F. Hoffmann-La Roche Ag | Sposób zmniejszania zawartości białek komórek gospodarza w chromatografii powinowactwa |
EP3395835B1 (en) | 2015-12-25 | 2021-02-03 | Chugai Seiyaku Kabushiki Kaisha | Antibody having enhanced activity, and method for modifying same |
WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
WO2017159287A1 (ja) | 2016-03-14 | 2017-09-21 | 中外製薬株式会社 | 癌の治療に用いるための細胞傷害誘導治療剤 |
BR112018067792A2 (pt) | 2016-04-28 | 2019-02-12 | Chugai Seiyaku Kabushiki Kaisha | preparação contendo o anticorpo |
JP7084878B2 (ja) * | 2016-05-16 | 2022-06-15 | 武田薬品工業株式会社 | 抗第IX因子Padua抗体 |
US20190185578A1 (en) * | 2016-07-29 | 2019-06-20 | Chugai Seiyaku Kabushiki Kaisha | Bispecific antibody exhibiting increased alternative fviii-cofactor-function activity |
KR20230079499A (ko) | 2016-08-05 | 2023-06-07 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
SG11201901961SA (en) | 2016-09-06 | 2019-04-29 | Chugai Pharmaceutical Co Ltd | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
TW201836636A (zh) | 2017-03-31 | 2018-10-16 | 公立大學法人奈良縣立醫科大學 | 含有替代凝血因子viii功能之多特異性抗原結合分子之用於預防和/或治療凝血因子ix異常症的醫藥組合物 |
EP3620531A4 (en) | 2017-05-02 | 2021-03-17 | National Center of Neurology and Psychiatry | METHOD OF PREDICTION AND EVALUATION OF THERAPEUTIC EFFECT IN DISEASES RELATING TO IL-6 AND NEUTROPHILS |
GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
JP2020533016A (ja) | 2017-08-01 | 2020-11-19 | エービー ストゥーディオ インコーポレイテッド | 二重特異性抗体およびその使用 |
JP6496095B1 (ja) | 2017-09-29 | 2019-04-03 | 中外製薬株式会社 | 血液凝固第viii因子(fviii)補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤 |
MX2020003472A (es) | 2017-11-01 | 2020-08-03 | Chugai Pharmaceutical Co Ltd | Variante e isoforma de anticuerpos con actividad biologica reducida. |
EP3710486A1 (en) | 2017-11-15 | 2020-09-23 | Novo Nordisk A/S | Factor x binders enhancing fx activation |
WO2019235420A1 (ja) | 2018-06-04 | 2019-12-12 | 中外製薬株式会社 | 複合体を検出する方法 |
FR3082427B1 (fr) | 2018-06-14 | 2020-09-25 | Lab Francais Du Fractionnement | Combinaison de facteur vii et d'un anticorps bispecifique anti-facteurs ix et x |
US11220554B2 (en) | 2018-09-07 | 2022-01-11 | Novo Nordisk A/S | Procoagulant antibodies |
KR102382743B1 (ko) * | 2018-08-01 | 2022-04-12 | 노보 노르디스크 에이/에스 | 개선된 응혈 촉진 항체 |
PL3723858T3 (pl) | 2018-12-21 | 2022-03-07 | Kymab Limited | Przeciwciało dwuswoiste fixaxfx o wspólnym łańcuchu lekkim |
CA3125303A1 (en) * | 2019-01-21 | 2020-07-30 | Aronora Inc. | Novel humanized antibodies against factor xi having anti-thrombotic and anti-inflammatory effects and uses thereof |
TW202207984A (zh) | 2019-10-11 | 2022-03-01 | 日商中外製藥股份有限公司 | 用於後天性血友病a之預防及/或治療之醫藥組成物、及包含該醫藥組成物之製品 |
IL292106A (en) | 2019-10-11 | 2022-06-01 | Chugai Pharmaceutical Co Ltd | A pharmaceutical composition that can be used to prevent and/or treat acquired hemophilia a, and a product that includes this pharmaceutical composition |
JP2023106635A (ja) | 2020-04-17 | 2023-08-02 | 中外製薬株式会社 | 二重特異性抗原結合分子ならびに、それに関連する組成物、組成物の製造のための使用、キット、および方法 |
US20230183376A1 (en) | 2020-05-22 | 2023-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antibody for neutralizing substance having coagulation factor viii (f.viii) function-substituting activity |
Family Cites Families (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US55092A (en) * | 1866-05-29 | Improvement in rotary steam-engines | ||
US111406A (en) * | 1871-01-31 | Pctehs | ||
US76275A (en) * | 1868-03-31 | Tuttle | ||
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
JPS5837636B2 (ja) * | 1980-07-31 | 1983-08-17 | 富士通株式会社 | 半導体記憶装置 |
IE52535B1 (en) | 1981-02-16 | 1987-12-09 | Ici Plc | Continuous release pharmaceutical compositions |
US4474893A (en) * | 1981-07-01 | 1984-10-02 | The University of Texas System Cancer Center | Recombinant monoclonal antibodies |
US4444878A (en) * | 1981-12-21 | 1984-04-24 | Boston Biomedical Research Institute, Inc. | Bispecific antibody determinants |
HUT35524A (en) | 1983-08-02 | 1985-07-29 | Hoechst Ag | Process for preparing pharmaceutical compositions containing regulatory /regulative/ peptides providing for the retarded release of the active substance |
US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US6010902A (en) * | 1988-04-04 | 2000-01-04 | Bristol-Meyers Squibb Company | Antibody heteroconjugates and bispecific antibodies for use in regulation of lymphocyte activity |
DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
TW212184B (da) * | 1990-04-02 | 1993-09-01 | Takeda Pharm Industry Co Ltd | |
WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
EP0546073B1 (en) | 1990-08-29 | 1997-09-10 | GenPharm International, Inc. | production and use of transgenic non-human animals capable of producing heterologous antibodies |
DE69233528T2 (de) | 1991-11-25 | 2006-03-16 | Enzon, Inc. | Verfahren zur Herstellung von multivalenten antigenbindenden Proteinen |
AU3328493A (en) | 1991-12-17 | 1993-07-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5667988A (en) * | 1992-01-27 | 1997-09-16 | The Scripps Research Institute | Methods for producing antibody libraries using universal or randomized immunoglobulin light chains |
JP3881689B2 (ja) | 1992-03-11 | 2007-02-14 | パウダージェクト ヴァクシンズ,インコーポレイテッド | 免疫不全ウイルス用の遺伝子ワクチン |
EP0652950B1 (en) | 1992-07-24 | 2007-12-19 | Amgen Fremont Inc. | Generation of xenogeneic antibodies |
US5945311A (en) * | 1994-06-03 | 1999-08-31 | GSF--Forschungszentrumfur Umweltund Gesundheit | Method for producing heterologous bi-specific antibodies |
CA2194907A1 (en) | 1994-07-13 | 1996-02-01 | Kouji Matsushima | Reshaped human antibody against human interleukin-8 |
JP4312259B2 (ja) | 1995-04-27 | 2009-08-12 | アムジェン フレモント インク. | 免疫したゼノマウス(XenoMouse)に由来するヒト抗体 |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
DK0979281T3 (da) * | 1997-05-02 | 2005-11-21 | Genentech Inc | Fremgangsmåde til fremstilling af multispecifikke antistoffer med heteromultimere og fælles bestanddele |
US20030207346A1 (en) * | 1997-05-02 | 2003-11-06 | William R. Arathoon | Method for making multispecific antibodies having heteromultimeric and common components |
US20020062010A1 (en) * | 1997-05-02 | 2002-05-23 | Genentech, Inc. | Method for making multispecific antibodies having heteromultimeric and common components |
DE19725586C2 (de) * | 1997-06-17 | 1999-06-24 | Gsf Forschungszentrum Umwelt | Verfahren zur Herstellung von Zellpräparaten zur Immunisierung mittels heterologer intakter bispezifischer und/oder trispezifischer Antikörper |
HUP0101160A2 (hu) | 1998-04-03 | 2001-08-28 | Chugai Seiyaku Kabushiki Kaisha | Humán szöveti faktor (TF) elleni humanizált antitest és eljárás előállítására |
AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
DE10156482A1 (de) * | 2001-11-12 | 2003-05-28 | Gundram Jung | Bispezifisches Antikörper-Molekül |
US8030461B2 (en) * | 2002-04-15 | 2011-10-04 | Chugai Seiyaku Kabushiki Kaisha | Methods for constructing scDb libraries |
US7732149B2 (en) * | 2002-04-26 | 2010-06-08 | Chugai Seiyaku Kabushiki Kaisha | Methods of screening agonistic antibodies |
EP1510943A4 (en) * | 2002-05-31 | 2007-05-09 | Celestar Lexico Sciences Inc | INTERACTION PREDICTION DEVICE |
ATE514717T1 (de) * | 2002-07-18 | 2011-07-15 | Merus B V | Rekombinante produktion von antikörpermischungen |
ATE431423T1 (de) * | 2003-01-21 | 2009-05-15 | Chugai Pharmaceutical Co Ltd | Verfahren zum screening der leichten kette eines antikörpers |
GB2400851B (en) * | 2003-04-25 | 2004-12-15 | Bioinvent Int Ab | Identifying binding of a polypeptide to a polypeptide target |
US8597911B2 (en) * | 2003-06-11 | 2013-12-03 | Chugai Seiyaku Kabushiki Kaisha | Process for producing antibodies |
AU2003271174A1 (en) * | 2003-10-10 | 2005-04-27 | Chugai Seiyaku Kabushiki Kaisha | Double specific antibodies substituting for functional protein |
JPWO2005035754A1 (ja) * | 2003-10-14 | 2006-12-21 | 中外製薬株式会社 | 機能蛋白質を代替する二種特異性抗体 |
TWI263461B (en) * | 2003-12-26 | 2006-10-01 | Ind Tech Res Inst | Enhanced flexible copper foil structure and fabrication method thereof |
US20050266425A1 (en) * | 2003-12-31 | 2005-12-01 | Vaccinex, Inc. | Methods for producing and identifying multispecific antibodies |
EP3050963B1 (en) * | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
KR101367544B1 (ko) * | 2005-06-10 | 2014-02-26 | 추가이 세이야쿠 가부시키가이샤 | 메글루민을 함유하는 단백질 제제의 안정화제, 및 그의이용 |
IN2014DN10515A (da) * | 2006-03-31 | 2015-08-21 | Chugai Pharmaceutical Co Ltd | |
EP3345616A1 (en) * | 2006-03-31 | 2018-07-11 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
-
2006
- 2006-03-31 DK DK14176527.1T patent/DK2824183T3/da active
- 2006-03-31 WO PCT/JP2006/306821 patent/WO2006109592A1/ja active Application Filing
- 2006-03-31 US US11/910,836 patent/US20100003254A1/en not_active Abandoned
- 2006-03-31 SI SI200631839T patent/SI1876236T1/sl unknown
- 2006-03-31 ES ES06730769.4T patent/ES2494921T3/es active Active
- 2006-03-31 EP EP06730769.4A patent/EP1876236B9/en active Active
- 2006-03-31 DK DK06730769.4T patent/DK1876236T3/da active
- 2006-03-31 TW TW095111592A patent/TW200714313A/zh unknown
- 2006-03-31 CA CA2603264A patent/CA2603264C/en active Active
- 2006-03-31 CA CA2957144A patent/CA2957144C/en active Active
- 2006-03-31 JP JP2007512906A patent/JP4917024B2/ja active Active
- 2006-03-31 PL PL06730769T patent/PL1876236T3/pl unknown
- 2006-03-31 PT PT67307694T patent/PT1876236E/pt unknown
- 2006-03-31 EP EP14176527.1A patent/EP2824183B1/en active Active
-
2007
- 2007-11-07 NO NO20075699A patent/NO20075699L/no unknown
-
2011
- 2011-11-11 JP JP2011247507A patent/JP5912436B2/ja active Active
-
2012
- 2012-03-29 US US13/434,643 patent/US20120237517A1/en not_active Abandoned
-
2014
- 2014-10-28 JP JP2014218881A patent/JP6055808B2/ja active Active
- 2014-11-06 CY CY20141100921T patent/CY1115702T1/el unknown
-
2017
- 2017-01-10 US US15/402,580 patent/US20170145111A1/en not_active Abandoned
- 2017-09-12 US US15/701,630 patent/US20180002443A1/en not_active Abandoned
-
2018
- 2018-04-26 US US15/963,345 patent/US20180244800A1/en not_active Abandoned
- 2018-12-20 US US16/226,798 patent/US20190112390A1/en not_active Abandoned
-
2019
- 2019-08-09 US US16/536,385 patent/US20190359728A1/en not_active Abandoned
-
2020
- 2020-03-20 US US16/825,513 patent/US20200277402A1/en not_active Abandoned
- 2020-12-22 US US17/130,736 patent/US20210107995A1/en not_active Abandoned
-
2021
- 2021-07-30 US US17/389,534 patent/US20210380717A1/en not_active Abandoned
-
2022
- 2022-03-21 US US17/699,293 patent/US20220213217A1/en not_active Abandoned
-
2023
- 2023-07-05 US US18/346,920 patent/US20230348621A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2824183T3 (da) | Fremgangsmåde til fremstilling af bispecifikke antistoffer | |
DK1795576T3 (da) | Fremgangsmåde til fremstilling af carbonhydrider | |
DK1877192T3 (da) | Fremgangsmåde til fremstilling af fibermateriale | |
DK1741768T4 (da) | Fremgangsmåde til fremstilling af dieselcarbonhydrider | |
DK3461875T3 (da) | Fremgangsmåde til fremstillling af en kulbrintekomponent | |
DK1893586T3 (da) | Fremgangsmåde til fremstilling af 1-alkyl-3-phenyluraciler | |
DK1828164T3 (da) | Fremgangsmåde til fremstilling af N-phenylpyrazol-1-carboxamider | |
DK1778668T3 (da) | Fremgangsmåde til fremstilling af dihydropteridion | |
DK2086944T3 (da) | Fremgangsmåde til fremstilling af difluormethylpyrazolylcarboxylater | |
DK2292607T3 (da) | Fremgangsmåde til syntese af organiske forbindelser | |
DK2431359T3 (da) | Fremgangsmåde til fremstilling af diaminophenothiaziniumforbindelser | |
DK3336073T3 (da) | Fremgangsmåde til fremstilling af fluorerede organiske forbindelser | |
DK1945271T3 (da) | Fremgangsmåde til fremstilling af polymerbelagte mikropartikler | |
DE602006002935D1 (de) | Verfahren zur Tonerherstellung | |
NO20076030L (no) | Fremgangsmåte for fremstilling av hydroklorsilaner | |
DK2029567T3 (da) | Fremgangsmåde til frembringelse af benzopyran-2-ol-derivater | |
DK2160225T3 (da) | Fremgangsmåde til fremstilling af krystaller | |
DK2311970T3 (da) | Fremgangsmåde til fremstillingen af bioprodukter | |
DK2082054T3 (da) | Fremgangsmåde til forbedring af udbyttet af celluloseomdannelsesprocesser | |
DE602006016683D1 (de) | Tonerherstellungsverfahren | |
DK1831223T3 (da) | Fremgangsmåde til fremstilling af L-biopterin | |
FI20055666A0 (fi) | Prosessi hiilivetykomponentin valmistamiseksi | |
DK2094728T3 (da) | Fremgangsmåder til anvendelse for human-adapterende monoklonale antistoffer | |
DK1866297T3 (da) | Fremgangsmåde til fremstilling af en aminomethyl-thiazolforbindelse | |
DK1805316T3 (da) | Fremgangsmåde til fremstilling af de enantiomere former af cis-3-hydroxycy- |