DK2632400T3 - Kredsløb til påføring af varme og elektrisk stimulering - Google Patents

Kredsløb til påføring af varme og elektrisk stimulering Download PDF

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DK2632400T3
DK2632400T3 DK11776005.8T DK11776005T DK2632400T3 DK 2632400 T3 DK2632400 T3 DK 2632400T3 DK 11776005 T DK11776005 T DK 11776005T DK 2632400 T3 DK2632400 T3 DK 2632400T3
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substrate
heating element
circuit
electrodes
heat
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DK11776005.8T
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Ole Brix
Bård Henriksen
Inge Klepsvik
Louise Mohn
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Louise Mohn
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/3603—Control systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36017—External stimulators, e.g. with patch electrodes with leads or electrodes penetrating the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0408—Use-related aspects
    • A61N1/0456—Specially adapted for transcutaneous electrical nerve stimulation [TENS]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/0404—Electrodes for external use
    • A61N1/0472—Structure-related aspects
    • A61N1/0492—Patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/372—Arrangements in connection with the implantation of stimulators
    • A61N1/37211—Means for communicating with stimulators
    • A61N1/37235—Aspects of the external programmer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N5/067—Radiation therapy using light using laser light
    • G—PHYSICS
    • G08—SIGNALLING
    • G08B—SIGNALLING OR CALLING SYSTEMS; ORDER TELEGRAPHS; ALARM SYSTEMS
    • G08B5/00—Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied
    • G08B5/22—Visible signalling systems, e.g. personal calling systems, remote indication of seats occupied using electric transmission; using electromagnetic transmission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00022—Sensing or detecting at the treatment site
    • A61B2017/00084—Temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00988—Means for storing information, e.g. calibration constants, or for preventing excessive use, e.g. usage, service life counter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0054—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water
    • A61F2007/0056—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling
    • A61F2007/0058—Heating or cooling appliances for medical or therapeutic treatment of the human body with a closed fluid circuit, e.g. hot water for cooling evaporating on or near the spot to be cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0071—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a resistor, e.g. near the spot to be heated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/007—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating
    • A61F2007/0075—Heating or cooling appliances for medical or therapeutic treatment of the human body characterised by electric heating using a Peltier element, e.g. near the spot to be heated or cooled
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0093—Heating or cooling appliances for medical or therapeutic treatment of the human body programmed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F2007/0095—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator
    • A61F2007/0096—Heating or cooling appliances for medical or therapeutic treatment of the human body with a temperature indicator with a thermometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F7/00—Heating or cooling appliances for medical or therapeutic treatment of the human body
    • A61F7/02—Compresses or poultices for effecting heating or cooling
    • A61F2007/0295—Compresses or poultices for effecting heating or cooling for heating or cooling or use at more than one temperature
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36014—External stimulators, e.g. with patch electrodes
    • A61N1/36021—External stimulators, e.g. with patch electrodes for treatment of pain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/06—Radiation therapy using light
    • A61N2005/0626—Monitoring, verifying, controlling systems and methods

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  • Health & Medical Sciences (AREA)
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  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Thermal Sciences (AREA)
  • Biophysics (AREA)
  • Electromagnetism (AREA)
  • General Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pathology (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Electrotherapy Devices (AREA)
  • Finger-Pressure Massage (AREA)
  • Resistance Heating (AREA)
  • Materials For Medical Uses (AREA)

Claims (19)

1. Kredsløb til påføring af varme og elektrisk stimulering, hvor kredsløbet (51) omfatter et plant substrat (500), hvor substratet omfatter et varmeelement (502), hvor kredsløbet omfatter mindst to elektroder (514a, 514b) til påføring af elektrisk stimulering, hvor de mindst to elektroder og varmeelementet omfatter et elektrisk ledende område (511, 512), der er forbundet med en overflade af substratet ved hjælp af en ætsningsproces eller afsat på en overflade af substratet ved hjælp af en additiv proces, hvor substratet omfatter en første overflade (53) og en anden overflade (52), hvor den første overflade er på en bagside af substratet i forhold til den anden overflade, hvor de mindst to elektroder (514a, 514b) er tilvejebragt på den første overflade (53), og varmeelementet (502) er tilvejebragt på den anden overflade (52).
2. Kredsløb ifølge krav 1, hvor positionen på den anden overflade (52) af mindst en del af varmeelementet (502) svarer til positionen på den første overflade (53) af elektroden (514a, 514b), således at den mindst en del af varmeelementet kan anvendes til at opvarme elektroden.
3. Kredsløb ifølge krav 2, hvor varmeelementet (502) omfatter et eller flere modstandslegemer (503), hvor positionen af det ene eller flere modstandslegemer på den anden overflade (52) svarer til positionen på den første overflade (53) af elektroden (514a, 514b).
4. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor varmeelementet (502) omfatter et eller flere modstandslegemer (503), der er monteret på en overflade (53) af substratet (500).
5. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor varmeelementet 25 (502) omfatter en flerhed af modstandslegemer (503), og hvor modstandslegemerne er anbragt til at frembringe en forudbestemt varmefordeling, når en strøm påføres varmeelementet.
6. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor varmeelementet (502) omfatter en flerhed af modstandslegemer (503), hvor hvert modstandslegeme har en respektive modstands-30-værdi, hvor modstandsværdierne er udvalgt til at frembringe en forudbestemt varmefordeling, når en strøm påføres varmeelementet.
7. Kredsløb ifølge et hvilket som helst af kravene 3 til 6, hvor modstandslegemerne (503) er elektrisk forbundne med et elektrisk ledende område (512a, 512b), der er forbundet med eller afsat på en overflade (52) af substratet (500), som udgør en del af varmeelementet (502).
8. Kredsløb ifølge krav 7, hvor det elektrisk ledende område (512a, 512b), som udgør en del af varmeelementet (502), er udformet således, at modstanden deraf er ubetydelig i forhold til modstanden af hvert modstandslegeme (503).
9. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor både elektroden (514a, 514b) og varmeelementet (502) omfatter et elektrisk ledende område (511,512), der er forbundet med eller afsat på en overflade (52, 53) af substratet (500).
10. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor en temperatursensor (510) er monteret på en overflade (52) af substratet (500).
11. Kredsløb ifølge krav 10, hvor varmeelementet (502) omfatter et eller flere modstandslegemer (503), der er monteret på den samme overflade (52) af substratet (500) som temperatursensoren (510).
12. Kredsløb ifølge krav 10 eller krav 11, hvor temperatursensoren (510) er anbragt mellem de mindst to elektroder.
13. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor substratet (500) er fleksibelt.
14. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor varmeelementet (502) er anbragt på den anden overflade, således at det befinder sig både over og mellem de mindst to elektroder.
15. Kredsløb ifølge et hvilket som helst af de foregående krav, hvor det elektrisk ledende område (511,512) er et lag af kobber, der er forbundet med overfladen (52, 53) af substratet (500).
16. Kredsløb ifølge et hvilket som helst af kravene 1 til 14, hvor det elektrisk ledende område (511,512) er et ledende materiale, som er afsat på overfladen (52, 53) af substratet (500).
17. Fremgangsmåde til fremstilling af en varmestimuleringspude, omfattende: tilvejebringelse af et plant substrat (500), som omfatter en første overflade (53) og en anden overflade (52), hvor den første overflade er på en bagside af substratet i forhold til den anden plane overflade; tilvejebringelse af elektriske ledere (511,512) på enhver af de plane overflader (52, 53); anvendelse afen ætsende eller additiv struktureringsproces for at tilvejebringe mindst to elektroder (514a, 514b), som er elektrisk forbundne med de elektriske ledere (511, 512) til påføring af elektrisk stimulering på den første plane overflade (53); og anvendelse af en struktureringsproces for at tilvejebringe et varmeelement (502) på den anden plane overflade (52).
18. Fremgangsmåde ifølge krav 17, hvor struktureringsprocessen, som anvendes til at tilvejebringe mindst ét af varmeelementerne (502) og de mindst to elektroder (514a, 514b), omfatter: at forbinde et lag af kobber med til en overflade (52, 53) af substratet (500); og at fjerne en del af kobberlaget ved hjælp af ætsning, således at resten af det ledende lag danner et mønster med en foruddefineret form.
19. Fremgangsmåde ifølge krav 17, hvor struktureringsprocessen, som anvendes til at tilvejebringe mindst én af varmeelementet (502) og de mindst to elektroder (514a, 514b), omfatter inkjet-printing af et elektrisk ledende materiale på en overflade (52, 53) af substratet (500).
DK11776005.8T 2010-10-28 2011-10-28 Kredsløb til påføring af varme og elektrisk stimulering DK2632400T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10189306A EP2446865A1 (en) 2010-10-28 2010-10-28 Thermostimulation apparatus
PCT/EP2011/069047 WO2012056025A2 (en) 2010-10-28 2011-10-28 Circuit for applying heat and electrical stimulation

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DK2632400T3 true DK2632400T3 (da) 2018-08-06

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US (4) US20120109232A1 (da)
EP (5) EP2446865A1 (da)
JP (6) JP5806321B2 (da)
KR (2) KR20140060459A (da)
CN (4) CN103298434A (da)
DK (1) DK2632400T3 (da)
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US20140052199A1 (en) 2014-02-20
US9082273B2 (en) 2015-07-14
JP2013540543A (ja) 2013-11-07
CN103228238B (zh) 2015-05-06
GB2498913A (en) 2013-07-31
JP2015180351A (ja) 2015-10-15
WO2012056028A2 (en) 2012-05-03
JP2013540545A (ja) 2013-11-07
WO2012056025A2 (en) 2012-05-03
WO2012056027A1 (en) 2012-05-03
US9082272B2 (en) 2015-07-14
KR20140057471A (ko) 2014-05-13
GB201309491D0 (en) 2013-07-10
CN103228238A (zh) 2013-07-31
EP2632403A1 (en) 2013-09-04
JP5815721B2 (ja) 2015-11-17
GB2499162A (en) 2013-08-07
GB2499162B (en) 2016-04-20
EP2632400B1 (en) 2018-05-02
JP2013540542A (ja) 2013-11-07
CN103237529A (zh) 2013-08-07
WO2012056026A1 (en) 2012-05-03
EP2632403B1 (en) 2015-10-14
EP2632400A2 (en) 2013-09-04
GB201309492D0 (en) 2013-07-10
CN103237529B (zh) 2015-06-17
CN103298434A (zh) 2013-09-11
CN103228237B (zh) 2016-05-25
GB2485002A (en) 2012-05-02
JP2015180352A (ja) 2015-10-15
KR20140060459A (ko) 2014-05-20
US20120109232A1 (en) 2012-05-03
JP5972886B2 (ja) 2016-08-17
EP2632402A2 (en) 2013-09-04
EP2632401A1 (en) 2013-09-04
US20140055239A1 (en) 2014-02-27
WO2012056025A3 (en) 2012-06-28
GB201101498D0 (en) 2011-03-16
JP2013540544A (ja) 2013-11-07
EP2446865A1 (en) 2012-05-02
JP5806321B2 (ja) 2015-11-10
WO2012056028A3 (en) 2012-08-23
CN103228237A (zh) 2013-07-31
HK1184358A1 (zh) 2014-01-24

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