DK2591363T3 - Diagnose og behandling af brystcancer - Google Patents

Diagnose og behandling af brystcancer Download PDF

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DK2591363T3
DK2591363T3 DK11804337.1T DK11804337T DK2591363T3 DK 2591363 T3 DK2591363 T3 DK 2591363T3 DK 11804337 T DK11804337 T DK 11804337T DK 2591363 T3 DK2591363 T3 DK 2591363T3
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ctc
expression
ctcs
positive
breast cancer
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DK11804337.1T
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Daniel Hayes
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Univ Michigan Regents
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    • G01N33/57407—Specifically defined cancers
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Claims (8)

1. fremgangsmåde til bestemmelse af et behandlingsforløb, omfattende a) at detektere niveauet af cirkulerende tumorceller (CTC) i en prøve fra et individ med metastatisk brystcancer; b) at bestemme antalllet af CTC, der er positive for ekspression af østrogenreceptor, HER-2, bcl-2 og ki67; c) at beregne et numerisk CTC-endokrin terapi-indeks (CTC-ETI) baseret på antallet af CTC, der er positive for ekspression af østrogenreceptoren (ER), HER-2, bcl-2, ki67, og det samlede antal af CTC ved at tildele point på basis af antallet af CTC, der er positive for ekspression of ER, HER-2, bcl-2 og ki67 på CTC'erne, hvor CTC-ETI'et beregnes ved i) at tildele nul point, når antallet af CTC er 0-4 pr. 7,5 ml, 1 point, når antallet af CTC er 5-10 pr. 7,5 ml, og 2 point, når antallet af CTC er større end 10 pr. 7,5 ml; ii) at tildele nul point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er større end 10 %, at tildele 2 point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er 1-10 %, og at tildele 6 point, når antallet af CTC, der er positive for ekspression af østrogenreceptor, er nul; iii) at tildele nul point, når antallet af CTC, der er positive for ekspression af HER-2, er 0 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af HER-2, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af HER-2, er større end 10 %; iv) at tildele nul point, når antallet af CTC, der er positive for ekspression af bcl-2, er større end 10 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af bcl-2, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af bcl-2, er 0 %; v) at tildele nul point, når antallet af CTC, der er positive for ekspression af ki67, er 0 %, at tildele 1 point, når antallet af CTC, der er positive for ekspression af ki-67, er 1-10 %, og at tildele 2 point, når antallet af CTC, der er positive for ekspression af ki-67, er større end 10 %; og vi) at addere pointene til opnåelse af CTC-ETI'et; og d) at anbefale indgivelse af antiøstrogen-terapi til individet, når CTC-ETI'et er 0-3, og indgivelse af kemoterapi til individet, når CTC-ETI'et er 7-14, hvor et CTC-ETI på 0-3 indikerer et gunstigt respons på antiøstrogen-terapi, et CTC- ETI på 4-6 indikerer et moderat respons på antiøstrogen-terapi, og et CTC-ETI på 7-14 indikerer et dårligt respons på antiøstrogen-terapi.
2. Fremgangsmåde ifølge krav 1, hvor behandlingsforløbet omfatter antiøstrogen-terapi.
3. Fremgangsmåde ifølge krav 2, hvor antiøstrogen-terapien omfatter tamoxifen.
4. Fremgangsmåde ifølge krav 2, hvor antiøstrogen-terapien er udvalgt fra gruppen bestående af letrozol, anastrozol og exemestan.
5. Fremgangsmåde ifølge krav 1, hvor behandlingsforløbet omfatter kemoterapi.
6. Fremgangsmåde ifølge krav 1, hvor en eller flere af tumormarkørerne de-tekteres under anvendelse af en multiplex-PCR-fremgangsmåde.
7. Fremgangsmåde ifølge krav 1, hvor tumormarkørerne detekteres under anvendelse af et immunomagnetisk assay.
8. Fremgangsmåde ifølge krav 1, hvor brystcanceren er østrogenreceptor-positiv.
DK11804337.1T 2010-07-07 2011-07-07 Diagnose og behandling af brystcancer DK2591363T3 (da)

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US36202110P 2010-07-07 2010-07-07
US201161469890P 2011-03-31 2011-03-31
PCT/US2011/043189 WO2012006421A2 (en) 2010-07-07 2011-07-07 Diagnosis and treatment of breast cancer

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DK2591363T3 true DK2591363T3 (da) 2017-12-11

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US (3) US8790878B2 (da)
EP (2) EP3306321A1 (da)
JP (1) JP5951603B2 (da)
CN (1) CN103109187B (da)
AU (1) AU2011274789B2 (da)
BR (1) BR112013000433A2 (da)
CA (1) CA2804269A1 (da)
DK (1) DK2591363T3 (da)
ES (1) ES2652600T3 (da)
RU (1) RU2550925C2 (da)
WO (1) WO2012006421A2 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2011274789B2 (en) 2010-07-07 2014-04-10 The Regents Of The University Of Michigan Diagnosis and treatment of breast cancer
WO2012097820A1 (en) * 2011-01-20 2012-07-26 Syddansk Universitet Method and assay for predicting long-term efficacy of tamoxifen treatment in estrogen receptor-positive breast cancer patients
US20120252038A1 (en) * 2011-04-01 2012-10-04 Chianese David A Steroid receptor assays
RU2646498C2 (ru) * 2012-01-24 2018-03-05 Пфайзер Инк. Способы детектирования 5Т4-положительных циркулирующих опухолевых клеток и способы диагностики 5Т4-положительного рака у млекопитающего
CN105209489B (zh) * 2013-03-05 2019-06-14 得克萨斯州大学系统董事会 针对间质和上皮-间质转化的循环肿瘤细胞的特异性检测工具
ES2729638T3 (es) * 2013-10-11 2019-11-05 Ventana Med Syst Inc Ensayos múltiplex de tinción conjunta de receptores de HER2 y de estrógenos para detectar heterogeneidad tumoral
CA2934618A1 (en) * 2013-12-20 2015-06-25 Optipharm. Co., Ltd. Quantitative reverse transcription polymerase chain reaction kit using tissue and blood for early diagnosis and screening test for therapeutic agent of breast cancer
CA2934344A1 (en) 2013-12-20 2015-06-25 David T. TING Methods and assays relating to circulating tumor cells
JP6582486B2 (ja) * 2015-03-27 2019-10-02 コニカミノルタ株式会社 血液中の稀少細胞検出方法
CN104892759B (zh) * 2015-06-18 2018-04-03 福州迈新生物技术开发有限公司 由杂交瘤细胞系分泌的抗Ki67单克隆抗体及其应用
CN104991010B (zh) * 2015-07-29 2017-10-13 中国药科大学 一种区分乳腺癌亚型生物标志物的组合物
RU2641158C2 (ru) * 2016-02-03 2018-01-16 Федеральное государственное бюджетное образовательное учреждение высшего образования "Нижегородская государственная медицинская академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НижГМА Минздрава России) Способ оценки эффективности неоадъювантной полихимиотерапии злокачественной опухоли молочной железы
RU2624367C1 (ru) * 2016-05-12 2017-07-03 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ выбора объема локорегионарной лучевой терапии после хирургической операции по поводу рака молочной железы
SG10202100951SA (en) 2016-11-21 2021-03-30 Nanostring Technologies Inc Chemical compositions and methods of using same
RU2637859C1 (ru) * 2017-02-13 2017-12-07 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии имени Н.Н. Петрова" Министерства здравоохранения Российской Федерации Способ дифференцированного лечения больных локализованным раком молочной железы
CA3099909A1 (en) 2018-05-14 2019-11-21 Nanostring Technologies, Inc. Chemical compositions and methods of using same
RU2706029C1 (ru) * 2018-10-09 2019-11-13 Государственное бюджетное учреждение здравоохранения Московской области "Московский областной научно-исследовательский клинический институт им. М.Ф. Владимирского" (ГБУЗ МО МОНИКИ им. М.Ф. Владимирского) Способ лечения люминального подтипа рака молочной железы
CN111661161B (zh) 2020-06-08 2021-06-08 浙江联控技术有限公司 一种用于车辆的拖车装置及车辆
RU2760168C1 (ru) * 2021-02-05 2021-11-22 федеральное государственное бюджетное учреждение «Национальный медицинский исследовательский центр онкологии» Министерства здравоохранения Российской Федерации Способ прогнозирования результатов лечения эмбриональных опухолей

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US4965188A (en) 1986-08-22 1990-10-23 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
EP0232967B1 (en) 1986-01-10 1993-04-28 Amoco Corporation Competitive homogeneous assay
US4800159A (en) 1986-02-07 1989-01-24 Cetus Corporation Process for amplifying, detecting, and/or cloning nucleic acid sequences
US5283174A (en) 1987-09-21 1994-02-01 Gen-Probe, Incorporated Homogenous protection assay
US5130238A (en) 1988-06-24 1992-07-14 Cangene Corporation Enhanced nucleic acid amplification process
US5225326A (en) 1988-08-31 1993-07-06 Research Development Foundation One step in situ hybridization assay
US5480784A (en) 1989-07-11 1996-01-02 Gen-Probe Incorporated Nucleic acid sequence amplification methods
CA2020958C (en) 1989-07-11 2005-01-11 Daniel L. Kacian Nucleic acid sequence amplification methods
US5455166A (en) 1991-01-31 1995-10-03 Becton, Dickinson And Company Strand displacement amplification
US5270184A (en) 1991-11-19 1993-12-14 Becton, Dickinson And Company Nucleic acid target generation
US5545524A (en) 1991-12-04 1996-08-13 The Regents Of The University Of Michigan Compositions and methods for chromosome region-specific probes
US5925517A (en) 1993-11-12 1999-07-20 The Public Health Research Institute Of The City Of New York, Inc. Detectably labeled dual conformation oligonucleotide probes, assays and kits
US5648211A (en) 1994-04-18 1997-07-15 Becton, Dickinson And Company Strand displacement amplification using thermophilic enzymes
JP3189000B2 (ja) 1994-12-01 2001-07-16 東ソー株式会社 特定核酸配列の検出方法
US5710029A (en) 1995-06-07 1998-01-20 Gen-Probe Incorporated Methods for determining pre-amplification levels of a nucleic acid target sequence from post-amplification levels of product
US6121489A (en) 1996-03-05 2000-09-19 Trega Biosciences, Inc. Selectively N-alkylated peptidomimetic combinatorial libraries and compounds therein
DE69738687D1 (de) 1996-04-12 2008-06-26 Phri Properties Inc Sonden, kits und assays
US20020172987A1 (en) * 1998-02-12 2002-11-21 Terstappen Leon W.M.M. Methods and reagents for the rapid and efficient isolation of circulating cancer cells
AU762728B2 (en) 1998-07-02 2003-07-03 Gen-Probe Incorporated Molecular torches
US6573043B1 (en) 1998-10-07 2003-06-03 Genentech, Inc. Tissue analysis and kits therefor
US6303305B1 (en) 1999-03-30 2001-10-16 Roche Diagnostics, Gmbh Method for quantification of an analyte
DE60014762T2 (de) 1999-05-24 2005-10-13 Tosoh Corp., Shinnanyo Methode zum Nachweis von Ribonukleinsäuren
KR20030080002A (ko) * 2001-02-16 2003-10-10 이뮤니베스트 코포레이션 순환 암 세포를 신속하고 효과적으로 분리하기 위한 방법및 시약
US7863012B2 (en) * 2004-02-17 2011-01-04 Veridex, Llc Analysis of circulating tumor cells, fragments, and debris
US20050079557A1 (en) * 2002-03-13 2005-04-14 Bio Merieux Method for the detection and/or characterisation of circulating tumour cells and the use thereof in the early diagnosis, prognosis and diagnosis of relapses and in the selection and evaluation of therapeutic treatments
EP1400806A1 (en) * 2002-09-18 2004-03-24 G2M Cancer Drugs AG The use of molecular markers for the preclinical and clinical profiling of inhibitors of enzymes having histone deacetylase activity
JP4593557B2 (ja) * 2003-02-27 2010-12-08 ベリデックス・リミテッド・ライアビリティ・カンパニー 循環腫瘍細胞（ｃｔｃ）：転移癌患者における増悪までの時間、生存および療法に対する応答の早期評価
AU2004235747B2 (en) 2003-05-01 2009-05-28 Gen-Probe Incorporated Oligonucleotides comprising a molecular switch
AU2005280162B2 (en) 2004-08-27 2012-04-26 Gen-Probe Incorporated Single-primer nucleic acid amplification methods
EP1797431B1 (en) * 2004-10-06 2011-01-26 Wellstat Biologics Corporation Detection of elevated levels of her-2/neu protein on circulating cancer cells and treatment
WO2006121991A2 (en) * 2005-05-06 2006-11-16 Diadexus, Inc. Compositions and methods for detection, prognosis and treatment of breast cancer
US20080275652A1 (en) * 2005-05-13 2008-11-06 Universite Libre De Bruxelles Gene-based algorithmic cancer prognosis
US20070037173A1 (en) * 2005-08-12 2007-02-15 Allard Jeffrey W Circulating tumor cells (CTC's): early assessment of time to progression, survival and response to therapy in metastatic cancer patients
CN104673903B (zh) * 2005-06-20 2018-11-13 领先细胞医疗诊断有限公司 检测单个细胞中的核酸和鉴定异质大细胞群中罕见细胞的方法
KR20080066663A (ko) * 2005-09-21 2008-07-16 씨씨씨 디아그노스틱스 엘엘씨 맞춤화된 항암 화학요법（ｐａｃ）을 위한 종합적인 진단테스트 방법
US20090317836A1 (en) * 2006-01-30 2009-12-24 The Scripps Research Institute Methods for Detection of Circulating Tumor Cells and Methods of Diagnosis of Cancer in Mammalian Subject
US20070231822A1 (en) * 2006-02-28 2007-10-04 Michael Mitas Methods for the detection and treatment of cancer
MX2008013331A (es) * 2006-04-18 2008-11-10 Wellstat Biologics Corp Deteccion de receptores de esteroides en celulas de carcinoma circulantes y tratamiento.
US20080113350A1 (en) 2006-11-09 2008-05-15 Terstappen Leon W M M Blood test to monitor the genetic changes of progressive cancer using immunomagnetic enrichment and fluorescence in situ hybridization (FISH)
EP2155905A1 (en) * 2007-05-31 2010-02-24 Dako Denmark A/S Methods for utilizing esr copy number changes in breast cancer treatments and prognoses
US20090061456A1 (en) * 2007-08-30 2009-03-05 Allard William J Method for predicting progression free and overall survival at each follow-up time point during therapy of metastatic breast cancer patients using circulating tumor cells
CN102016581B (zh) * 2008-02-25 2014-07-30 雀巢产品技术援助有限公司 用抗体阵列选择乳腺癌治疗药物
US20130178383A1 (en) * 2008-11-12 2013-07-11 David Spetzler Vesicle isolation methods
US20100311601A1 (en) * 2009-05-01 2010-12-09 Nuvera Biosciences, Inc. Index of genomic expression of estrogen receptor (er) and er-related genes
JP5808349B2 (ja) * 2010-03-01 2015-11-10 カリス ライフ サイエンシズ スウィッツァーランド ホールディングスゲーエムベーハー セラノーシスのためのバイオマーカー
CA2795776A1 (en) * 2010-04-06 2011-10-13 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers for disease
AU2011274789B2 (en) 2010-07-07 2014-04-10 The Regents Of The University Of Michigan Diagnosis and treatment of breast cancer

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