DK2584920T3 - Hypokaloriske, proteinrige ernæringssammensætninger og fremgangsmåder til anvendelse deraf - Google Patents
Hypokaloriske, proteinrige ernæringssammensætninger og fremgangsmåder til anvendelse deraf Download PDFInfo
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- DK2584920T3 DK2584920T3 DK11730513.6T DK11730513T DK2584920T3 DK 2584920 T3 DK2584920 T3 DK 2584920T3 DK 11730513 T DK11730513 T DK 11730513T DK 2584920 T3 DK2584920 T3 DK 2584920T3
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/11—Lactobacillus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/21—Streptococcus, lactococcus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/31—Leuconostoc
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/41—Pediococcus
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- A—HUMAN NECESSITIES
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- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/51—Bifidobacterium
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2400/00—Lactic or propionic acid bacteria
- A23V2400/61—Propionibacterium
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- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
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Claims (18)
1. Komplet daglig sondeernæringsformulering, med en kalorietæthed på fra 0,5 til 0,8 kilokalorier pr. ml, omfattende: en forarbejdet helkostkomponent; en kilde af vitaminer eller mineraler; og en proteinkilde der tilvejebringer energi fra protein i en mængde fra ca. 18% til ca. 35% af formuleringens samlede energi, og med en osmolaritet der er mindre end eller lig med 400 mOsm/kg vand.
2. Sondeernæringsformuleringen ifølge krav 1, hvor den forarbejdede helkostkomponent er valgt fra gruppen bestående af en forarbejdet frugt, en forarbejdet grønsag, et forarbejdet kød, et forarbejdet korn, og kombinationer deraf.
3. Sondeernæringsformuleringen ifølge et hvilket som helst af de foregående krav, hvor proteinet er valgt fra gruppen bestående af mælkebaserede proteiner, plantebaserede proteiner, dyrebaserede proteiner, kunstige proteiner, og kombinationer deraf.
4. Sondeernæringsformuleringen ifølge krav 3, hvor de mælkebaserede proteiner er valgt fra gruppen bestående af kasein, kaseinater, kasein hydrolysat, valle, vallehydrolysater, vallekoncentrater, valleisolater, mælkeproteinkoncentrat, mælkeproteinisolat, og kombinationer deraf.
5. Sondeernæringsformuleringen ifølge krav 3, hvor de plantebaserede proteiner er valgt fra gruppen bestående af sojaprotein, ærteprotein, rapsprotein, hvede-og fraktionerede hvedeproteiner, majsproteiner, zeinproteiner, ridsproteiner, havreproteiner, kartoffel proteiner, peanutproteiner, grøn-ærtepulver, grøn-bønnepulver, spirulina, proteiner afledt fra grønsager, bønner, boghvede, linser, bælgfrugter, enkeltcelleproteiner, og kombinationer deraf.
6. Sondeernæringsformuleringen ifølge et hvilket som helst af de foregående krav yderligere omfattende et phytonæringsstof valgt fra gruppen bestående af flavanoider, beslægtede phenoliske forbindelser, polyphenoliske forbindelser, terpenoider, alkaloider, svovl-indeholdende forbindelser, og kombinationer deraf.
7. Sondeernæringsformuleringen ifølge et hvilket som helst af de foregående krav yderligere omfattende et nukleotid valgt fra gruppen bestående af en underenhed af deoxyribonukleinsyre, en underenhed af ribonukleinsyre, polymeriske former af DNA og RNA, og kombinationer deraf, hvor nukleotidet er tilvejebragt i en mængde på mindst ca. 10 mg/100 kcal.
8. Fremgangsmåde til fremstilling af en sondemadssammensætning, fremgangsmåden omfattende: kombinere en helkostkomponent, en kilde af vitaminer eller mineraler og en proteinkilde der tilvejebringer energi fra protein i en mængde fra ca. 18% til ca. 35% for at danne en blanding; og forarbejde blandingen for at danne en sondemadssammensætning der er en komplet daglig ernæring, og sondeernæringsformuleringen har en kalorietæthed på 0,5 til 0,8 kilokalorier pr. ml og en osmolalitet der er mindre end eller lig med 400 mOsm/kg vand.
9. Fremgangsmåden ifølge krav 8, hvor helkostkomponenten er valgt fra gruppen bestående af en frugt, en grønsag, et kød, et korn, og kombinationer deraf.
10. Fremgangsmåden ifølge kravene 8 eller 9, hvor forarbejdningen omfatter blendning.
11. Fremgangsmåden ifølge et hvilket som helst af kravene 8 til 10, hvor helkostkomponenten er en kilde af phytokemikalier og/eller nukleotider.
12. Fremgangsmåden ifølge et hvilket som helst af kravene 8 til 11, hvor sondeernæringsformuleringen har en kalorietæthed på fra ca. 0,5 til ca. 0,8 kilokalorier pr. ml.
13. Fremgangsmåden ifølge et hvilket som helst af kravene 8 til 12, hvor kilden af vitaminer eller mineraler omfatter en kilde af vitamin D der tilvejebringer mindst 500 IU.
14. Fremgangsmåden ifølge et hvilket som helst af kravene 8 til 13, hvor sondeernæringsformuleringen omfatter nukleotider i en mængde på mindst ca. 10 mg/100 kcal.
15. En hypokalorisk komplet daglig sondeernæringsformulering, med en kalorietæthed på fra ca. 0,5 til ca. 0,8 kilokalorier pr. ml, omfattende en forarbejdet helkostkomponent, en kilde af vitaminer eller mineraler, og en proteinkilde der tilvejebringer fra ca. 18% til ca. 35% energi fra protein, og med en osmolaritet der er mindre end eller lig med 400 mOsm/kg vand, til anvendelse i forbedring af den totale sundhedstilstand hos en sondemads-tilført pædiatrisk patient med en underliggende medicinsk tilstand.
16. Sondeernæringsformuleringen ifølge krav 15, hvor den underliggende medicinske tilstand er valgt fra gruppen bestående af cerebral palsi, mistrivsel, neuromuskulære lidelser, hjerneskade, udviklingsmæssig forsinkelse, immunodeficiens, lav knoglemassefylde, tryksår, kroniske sår, langtids-sondemads-patienter, og kombinationer deraf.
17. Sondeernæringsformuleringen ifølge kravene 15 eller 16, hvor kilden af vitaminer eller mineraler omfatter en kilde af vitamin D der tilvejebringer mindst 500 IU af vitamin D pr. liter af formuleringen eller pr. 600 kcal.
18. Sondeernæringsformuleringen ifølge et hvilket som helst af kravene 15 til 17, hvor sondeernæringsformuleringen omfatter nukleotider i en mængde på mindst ca. 10 mg/100 kcal.
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Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2801208C (en) | 2010-06-28 | 2016-10-04 | Nestec S.A. | Hypocaloric, high protein nutritional compositions and methods of using same |
CA3021845C (en) * | 2011-04-20 | 2022-03-29 | Amgen Inc. | Autoinjector apparatus |
AU2013240271A1 (en) | 2012-03-26 | 2014-10-02 | Axcella Health Inc. | Nutritive fragments, proteins and methods |
WO2013148329A1 (en) | 2012-03-26 | 2013-10-03 | Pronutria, Inc. | Charged nutritive proteins and methods |
WO2013148328A1 (en) | 2012-03-26 | 2013-10-03 | Pronutria, Inc. | Nutritive proteins and methods |
CN104364259A (zh) | 2012-03-26 | 2015-02-18 | 普罗努塔利亚公司 | 营养性片段、蛋白质和方法 |
WO2014055905A1 (en) | 2012-10-04 | 2014-04-10 | Abbott Laboratories | Methods for enhancing the effect of egcg on mitigating skeletal muscle loss |
FR2996419B1 (fr) * | 2012-10-09 | 2015-05-29 | Internat Nutrition Res Company | Produit dietetique destine a etre administre aux personnes obeses recemment operees en chirurgie bariatrique |
PL2988617T3 (pl) * | 2013-03-27 | 2024-02-19 | Nutritional Growth Solutions Ltd | Suplement odżywczy do poprawy wzrostu |
MX2016003945A (es) | 2013-09-25 | 2016-12-09 | Pronutria Biosciences Inc | Composiciones y formulaciones para la prevencion y tratamiento de la diabetes y la obesidad y los metodos de produccion y uso en el control de la glucosa y calorias. |
CZ2014164A3 (cs) | 2014-03-19 | 2015-10-14 | Zlkl, S.R.O. | Výsuvná spojovací tyč řízení |
CN105212042A (zh) * | 2014-06-30 | 2016-01-06 | 罗汉斐 | 一种小麦发酵营养食品及其制作方法 |
US9446100B2 (en) * | 2015-02-13 | 2016-09-20 | Eastern Vision Limited | Dietary supplements and formulations |
CN105901144A (zh) * | 2015-12-14 | 2016-08-31 | 威海百合生物技术股份有限公司 | 一种具有抑菌作用的高蛋白食品的制备方法 |
TWI634845B (zh) * | 2016-12-27 | 2018-09-11 | 信元製藥股份有限公司 | 均質泥狀寵物膳食及其製造方法 |
EP3609347A1 (en) * | 2017-04-10 | 2020-02-19 | Société des Produits Nestlé S.A. | Method of preparing a composition comprising ferulic acid |
US11197917B2 (en) | 2017-12-01 | 2021-12-14 | ByHeart, Inc. | Formulations for nutritional support in subjects in need thereof |
WO2019147692A1 (en) * | 2018-01-26 | 2019-08-01 | Abbott Laboratories | Tube feeding composition and method for preparation thereof |
CN110742266B (zh) * | 2019-11-11 | 2022-11-01 | 江南大学 | 一种辅助调节肠道免疫功能的全营养配方食品 |
CN112568444A (zh) * | 2020-11-20 | 2021-03-30 | 格乐瑞(无锡)营养科技有限公司 | 一种缓解肌肉流失的组合物及其制备方法 |
Family Cites Families (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57110176A (en) | 1980-12-27 | 1982-07-08 | Snow Brand Milk Prod Co Ltd | Nutrious food composition for tube feeding |
US5268365A (en) | 1988-03-11 | 1993-12-07 | Rudolph Frederick B | Nucleotides, nucleosides, and nucleobases in immune function restoration enhancement or maintenance |
SE463593B (sv) * | 1988-05-27 | 1990-12-17 | Semper Ab | Sondnaering innehaallande betfibrer och foerfarande foer framstaellning daerav |
US5571783A (en) * | 1993-03-09 | 1996-11-05 | Clintec Nutrition Company | Composition and method for treating patients with hepatic disease |
US5723446A (en) * | 1993-12-23 | 1998-03-03 | Nestec Ltd. | Enteral formulation designed for optimized nutrient absorption and wound healing |
NZ331481A (en) * | 1994-01-10 | 2000-02-28 | Abbott Lab | Infant formula with a specific fat blend of soy, coconut, and high oleic safflower oil (HOSO), or a specified fatty acid profile of lauric, palmitic, oleic, or linleic acid |
BG548Y1 (bg) * | 1997-03-31 | 2002-07-31 | Тошка Й. Масларска | Хранителен продукт за ентерално хранене |
US6288116B1 (en) | 1998-05-13 | 2001-09-11 | Novartis Nutrition Ag | Method of administration of a nutritional product to a person having renal failure |
CN1257731A (zh) * | 1999-12-22 | 2000-06-28 | 王爱民 | 一种适用于管饲病人的全能营养素及其生产工艺 |
CA2405377C (en) | 2000-04-18 | 2014-04-01 | Societe Des Produits Nestle S.A. | Nutritional modules |
CN1330881A (zh) * | 2000-06-29 | 2002-01-16 | 王爱民 | 一种全营养膳 |
JP3907098B2 (ja) | 2001-02-13 | 2007-04-18 | 株式会社大塚製薬工場 | 栄養飲料またはゼリー |
US20030104033A1 (en) | 2001-07-13 | 2003-06-05 | Lai Chon-Si | Enteral formulations |
EP1281325A1 (en) | 2001-07-30 | 2003-02-05 | Societe Des Produits Nestle S.A. | Nutritional composition preventing bacterial overgrowth |
JP3724740B2 (ja) * | 2002-06-20 | 2005-12-07 | 日清キョーリン製薬株式会社 | コエンザイムq10を含有する経管経腸栄養剤 |
ES2282880T3 (es) * | 2003-05-22 | 2007-10-16 | N.V. Nutricia | Metodo para tratar o prevenir heridas cronicas y composicion nutritiv a completa comprendiendo glicina y/o leucina para usar en este. |
WO2005110124A1 (en) * | 2004-04-15 | 2005-11-24 | Abbott Laboratories | Composition and methods for nutritional management of patients with hepatic disease |
JP2006033349A (ja) * | 2004-07-15 | 2006-02-02 | Nippon Dempa Kogyo Co Ltd | 逓倍型の水晶発振器 |
CN101027074B (zh) * | 2004-09-22 | 2010-06-16 | 味之素株式会社 | 复合肠内营养组合物 |
JP2006104147A (ja) | 2004-10-07 | 2006-04-20 | Otsuka Pharmaceut Factory Inc | 経口・経腸栄養組成物 |
US20100094246A1 (en) * | 2006-10-19 | 2010-04-15 | Herve Le-Henand | Long-term feed - elderly |
JP2010507157A (ja) | 2006-10-19 | 2010-03-04 | ネステク ソシエテ アノニム | 長期栄養を供給する方法 |
WO2009013559A1 (en) | 2007-07-23 | 2009-01-29 | Cellectis | Meganuclease variants cleaving a dna target sequence from the human hemoglobin beta gene and uses thereof |
MX2010006199A (es) | 2007-12-05 | 2010-08-18 | Nutricia Nv | Composicion nutricional enterica liquida basada en caseina micelar, densa en cuanto a proteina. |
WO2009113845A1 (en) | 2008-03-12 | 2009-09-17 | N.V. Nutricia | High protein liquid enteral nutritional composition |
US20090264520A1 (en) | 2008-04-21 | 2009-10-22 | Asha Lipid Sciences, Inc. | Lipid-containing compositions and methods of use thereof |
JP5341601B2 (ja) * | 2008-04-22 | 2013-11-13 | 三栄源エフ・エフ・アイ株式会社 | 液状食品用ゲル化剤及びゲル状食品の製造方法 |
WO2009135959A1 (es) * | 2008-05-07 | 2009-11-12 | Katry Inversiones, S.L. | Producto alimenticio para la nutrición por vía enteral u oral del paciente diabético |
DK2409575T3 (da) | 2008-10-17 | 2017-04-03 | Nestec Sa | Fremgangsmåde til fremstilling af valleprotein-sammensætninger |
CA2801208C (en) | 2010-06-28 | 2016-10-04 | Nestec S.A. | Hypocaloric, high protein nutritional compositions and methods of using same |
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AU2015202897B2 (en) | 2016-06-02 |
ZA201300690B (en) | 2016-11-30 |
CA2801208C (en) | 2016-10-04 |
AU2015202897A1 (en) | 2015-06-18 |
RU2013103517A (ru) | 2014-08-10 |
SG186086A1 (en) | 2013-01-30 |
CN102958386A (zh) | 2013-03-06 |
BR112012033422B8 (pt) | 2021-05-11 |
MX2012015080A (es) | 2013-02-12 |
AU2011276545A1 (en) | 2012-12-13 |
US20130203664A1 (en) | 2013-08-08 |
EP2584920A1 (en) | 2013-05-01 |
CA2801208A1 (en) | 2012-01-12 |
CN105747218A (zh) | 2016-07-13 |
BR112012033422A2 (pt) | 2015-09-08 |
US9486003B2 (en) | 2016-11-08 |
BR112012033422B1 (pt) | 2018-08-21 |
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