DK2509991T3 - MODULATION OF HSP47 EXPRESSION - Google Patents
MODULATION OF HSP47 EXPRESSION Download PDFInfo
- Publication number
- DK2509991T3 DK2509991T3 DK10836656.8T DK10836656T DK2509991T3 DK 2509991 T3 DK2509991 T3 DK 2509991T3 DK 10836656 T DK10836656 T DK 10836656T DK 2509991 T3 DK2509991 T3 DK 2509991T3
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- nucleic acid
- nucleotide
- nucleotides
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
- C12N2310/531—Stem-loop; Hairpin
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28514909P | 2009-12-09 | 2009-12-09 | |
| US30741210P | 2010-02-23 | 2010-02-23 | |
| US37207210P | 2010-08-09 | 2010-08-09 | |
| PCT/US2010/059578 WO2011072082A2 (en) | 2009-12-09 | 2010-12-08 | Modulation of hsp47 expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2509991T3 true DK2509991T3 (en) | 2015-12-21 |
Family
ID=44146170
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10836656.8T DK2509991T3 (en) | 2009-12-09 | 2010-12-08 | MODULATION OF HSP47 EXPRESSION |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US8710209B2 (https=) |
| EP (3) | EP2509991B1 (https=) |
| JP (3) | JP5685267B2 (https=) |
| KR (3) | KR101718534B1 (https=) |
| CN (3) | CN106701758B (https=) |
| AU (1) | AU2010328104B2 (https=) |
| CA (1) | CA2781896C (https=) |
| DK (1) | DK2509991T3 (https=) |
| ES (1) | ES2562499T3 (https=) |
| IL (2) | IL219804A (https=) |
| PL (1) | PL2509991T3 (https=) |
| PT (1) | PT2509991E (https=) |
| TW (3) | TWI611021B (https=) |
| WO (1) | WO2011072082A2 (https=) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009221164A (ja) | 2008-03-17 | 2009-10-01 | Nitto Denko Corp | 肺線維症処置剤 |
| US9572886B2 (en) | 2005-12-22 | 2017-02-21 | Nitto Denko Corporation | Agent for treating myelofibrosis |
| DK2504435T3 (da) | 2009-11-26 | 2019-12-09 | Quark Pharmaceuticals Inc | Sirna-forbindelser omfattende terminale substitutioner |
| WO2011084193A1 (en) | 2010-01-07 | 2011-07-14 | Quark Pharmaceuticals, Inc. | Oligonucleotide compounds comprising non-nucleotide overhangs |
| CA2802414C (en) * | 2010-06-17 | 2018-01-09 | Nitto Denko Corporation | Agent for treating renal fibrosis |
| JP5950428B2 (ja) | 2010-08-05 | 2016-07-13 | 日東電工株式会社 | 線維化組織から正常組織を再生するための組成物 |
| AU2011337658A1 (en) | 2010-12-02 | 2013-07-04 | Daiichi Sankyo Company, Limited | Modified single-strand polynucleotide |
| US10196637B2 (en) | 2011-06-08 | 2019-02-05 | Nitto Denko Corporation | Retinoid-lipid drug carrier |
| TWI658830B (zh) | 2011-06-08 | 2019-05-11 | 日東電工股份有限公司 | Hsp47表現調控強化用類視色素脂質體 |
| KR20140047141A (ko) * | 2011-08-03 | 2014-04-21 | 쿠아크 파마수티칼스 인코퍼레이티드 | 청력 및 균형 장애를 치료하기 위한 이중-가닥 올리고뉴클레오티드 화합물들 |
| EP2780454A2 (en) | 2011-11-18 | 2014-09-24 | Alnylam Pharmaceuticals, Inc. | Modified rnai agents |
| IN2014MN00908A (https=) * | 2011-11-18 | 2015-04-17 | Nitto Denko Corp | |
| JP2015502365A (ja) * | 2011-12-12 | 2015-01-22 | オンコイミューニン,インコーポレイティド | オリゴヌクレオチドのイン−ビボ送達 |
| EP2802657B1 (en) | 2012-01-12 | 2018-05-02 | Quark Pharmaceuticals, Inc. | Combination therapy for treating hearing and balance disorders |
| US10260089B2 (en) | 2012-10-29 | 2019-04-16 | The Research Foundation Of The State University Of New York | Compositions and methods for recognition of RNA using triple helical peptide nucleic acids |
| JP6340162B2 (ja) | 2012-12-20 | 2018-06-06 | 日東電工株式会社 | アポトーシス誘導剤 |
| CA2951816A1 (en) * | 2013-06-12 | 2014-12-18 | Oncoimmunin, Inc. | Systemic in vivo delivery of oligonucleotides |
| JP6694811B2 (ja) * | 2013-10-04 | 2020-05-20 | ノバルティス アーゲー | RNA干渉に使用するためのRNAi剤用の3’末端キャップ |
| EP3052627B1 (en) * | 2013-10-04 | 2018-08-22 | Novartis AG | Novel formats for organic compounds for use in rna interference |
| CA2944417A1 (en) | 2014-04-02 | 2015-10-08 | Nitto Denko Corporation | A targeting molecule and a use thereof |
| EP3129425B1 (en) | 2014-04-07 | 2019-04-10 | Nitto Denko Corporation | Polymer-based hydrotropes for hydrophobic drug delivery |
| US10676737B2 (en) | 2014-12-17 | 2020-06-09 | Proqr Therapeutics Ii B.V. | Targeted RNA editing |
| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| US10792299B2 (en) | 2014-12-26 | 2020-10-06 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| US11045488B2 (en) | 2014-12-26 | 2021-06-29 | Nitto Denko Corporation | RNA interference agents for GST-π gene modulation |
| US20180002702A1 (en) | 2014-12-26 | 2018-01-04 | Nitto Denko Corporation | Methods and compositions for treating malignant tumors associated with kras mutation |
| JP6457704B2 (ja) | 2015-12-13 | 2019-01-23 | 日東電工株式会社 | 高活性及びオフターゲット削減のためのsiRNA構造 |
| EP3475424A1 (en) | 2016-06-22 | 2019-05-01 | ProQR Therapeutics II B.V. | Single-stranded rna-editing oligonucleotides |
| US10941402B2 (en) | 2016-09-01 | 2021-03-09 | Proqr Therapeutics Ii B.V. | Chemically modified single-stranded RNA-editing oligonucleotides |
| JP6833456B2 (ja) | 2016-11-02 | 2021-02-24 | 日東電工株式会社 | 皮膚線維症処置剤 |
| EP4035659A1 (en) | 2016-11-29 | 2022-08-03 | PureTech LYT, Inc. | Exosomes for delivery of therapeutic agents |
| US11274300B2 (en) | 2017-01-19 | 2022-03-15 | Proqr Therapeutics Ii B.V. | Oligonucleotide complexes for use in RNA editing |
| GB201808146D0 (en) | 2018-05-18 | 2018-07-11 | Proqr Therapeutics Ii Bv | Stereospecific Linkages in RNA Editing Oligonucleotides |
| WO2020198556A2 (en) * | 2019-03-27 | 2020-10-01 | Phoenix Tissue Repair, Inc. | Systems and methods for producing collagen 7 compositions |
| CN110237235B (zh) * | 2019-06-04 | 2023-03-28 | 徐州医科大学 | 华支睾吸虫重组蛋白CsHscB在胆汁淤积性肝纤维化治疗药物中的应用 |
| CN111135300A (zh) * | 2020-01-09 | 2020-05-12 | 南京大学 | 一种蛋白抑制剂在制备减轻雾霾引起肺炎的药物中的用途 |
| JP2023517963A (ja) * | 2020-03-11 | 2023-04-27 | プロダ・バイオテック・リミテッド・ライアビリティ・カンパニー | Pkm2活性化剤を使用して線維症を治療する方法 |
| KR102404883B1 (ko) | 2020-11-30 | 2022-06-07 | (주)이노보테라퓨틱스 | 벤즈브로마론을 포함하는 켈로이드 또는 비대흉터 예방 또는 치료용 약학 조성물 |
| WO2022154123A1 (ja) * | 2021-01-15 | 2022-07-21 | 国立大学法人 東京大学 | Rna分子、キメラ型na分子、二本鎖rna分子、および二本鎖キメラ型na分子 |
| KR20240161967A (ko) | 2022-03-16 | 2024-11-13 | 다이이찌 산쿄 가부시키가이샤 | 트랜스페린 수용체 2 의 발현을 억제하는 siRNA |
| JPWO2023176863A1 (https=) | 2022-03-16 | 2023-09-21 |
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