DK249086A - 4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse - Google Patents
4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse Download PDFInfo
- Publication number
- DK249086A DK249086A DK249086A DK249086A DK249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A DK 249086 A DK249086 A DK 249086A
- Authority
- DK
- Denmark
- Prior art keywords
- methyl
- ethyl
- amino
- methylpyridinium
- pyridyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
- C07D213/20—Quaternary compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pyridine Compounds (AREA)
- Dental Preparations (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/738,805 US4623486A (en) | 1985-05-29 | 1985-05-29 | [4-substituted benzoyloxy]-N-substituted-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides having anti-arthritic activity |
Publications (2)
Publication Number | Publication Date |
---|---|
DK249086D0 DK249086D0 (da) | 1986-05-28 |
DK249086A true DK249086A (da) | 1986-11-30 |
Family
ID=24969564
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK249086A DK249086A (da) | 1985-05-29 | 1986-05-28 | 4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse |
Country Status (25)
Country | Link |
---|---|
US (1) | US4623486A (ru) |
EP (1) | EP0208404B1 (ru) |
JP (1) | JPS61277683A (ru) |
KR (1) | KR870000913B1 (ru) |
CN (1) | CN1004628B (ru) |
AT (1) | ATE56010T1 (ru) |
AU (1) | AU557396B1 (ru) |
CA (1) | CA1270485A (ru) |
DD (1) | DD247451A5 (ru) |
DE (1) | DE3673710D1 (ru) |
DK (1) | DK249086A (ru) |
EG (1) | EG17811A (ru) |
ES (1) | ES8707211A1 (ru) |
FI (1) | FI86065C (ru) |
GR (1) | GR861389B (ru) |
HU (2) | HU199839B (ru) |
IL (1) | IL78912A (ru) |
NO (1) | NO165240C (ru) |
NZ (1) | NZ216310A (ru) |
PH (1) | PH23146A (ru) |
PL (1) | PL147843B1 (ru) |
PT (1) | PT82649B (ru) |
SU (2) | SU1538896A3 (ru) |
YU (1) | YU44576B (ru) |
ZA (1) | ZA863986B (ru) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2650589A1 (fr) * | 1989-08-04 | 1991-02-08 | Esteve Labor Dr | Derives benzothiaziniques, leur preparation et leurs applications comme medicaments ou comme intermediaires de synthese de medicaments |
JPH069600A (ja) * | 1992-05-06 | 1994-01-18 | Bristol Myers Squibb Co | タクソールのベンゾエート誘導体 |
FR2795412B1 (fr) * | 1999-06-23 | 2001-07-13 | Adir | Nouveaux derives d'ammonium quaternaire, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
GB0031107D0 (en) * | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
FR2818641B1 (fr) * | 2000-12-21 | 2004-03-05 | Servier Lab | Nouveaux derives de 1,1-dioxo-2h-1,2-benzothiazine 3-carboxamides, leur procede de preparation et les compositions pharmaceutiques que les contiennent |
GB0202873D0 (en) * | 2002-02-07 | 2002-03-27 | Novartis Ag | Organic compounds |
WO2008044095A1 (en) | 2006-10-11 | 2008-04-17 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of oxicams and related compounds with very high skin penetration rate |
US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
US20090221703A1 (en) * | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
US20100322858A1 (en) * | 2006-08-23 | 2010-12-23 | Board Of Regents, The University Of Texas System | Radiohaloimatinibs and Methods of Their Synthesis and Use in PET Imaging of Cancers |
CN103980228B (zh) * | 2006-10-11 | 2020-03-17 | 于崇曦 | 具有快速皮肤穿透速度的带正电荷的水溶性的昔康及其相关化合物的前药 |
US20080103305A1 (en) * | 2006-10-26 | 2008-05-01 | Macdonald Peter | Process for the preparation of imatinib |
WO2008070350A2 (en) | 2006-10-27 | 2008-06-12 | The Board Of Regents Of The University Of Texas System | Methods and compositions related to wrapping of dehydrons |
JP5235423B2 (ja) * | 2007-01-25 | 2013-07-10 | 株式会社 資生堂 | 皮膚外用組成物 |
CN101687792B (zh) | 2007-06-04 | 2016-03-02 | 于崇曦 | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 |
CN108191846B (zh) | 2008-12-04 | 2021-08-20 | 于崇曦 | 高穿透性组合物及其应用 |
CN101665472B (zh) * | 2009-06-15 | 2011-08-24 | 威海迪素制药有限公司 | 2-甲基-3,4-二氢-4-氧代-2h-1,2-苯并噻嗪-3-羧酸乙酯-1,1-二氧化物的制备方法 |
WO2011130918A1 (zh) | 2010-04-23 | 2011-10-27 | 上海百灵医药科技有限公司 | 一种伊马替尼的合成方法 |
WO2013008242A1 (en) | 2011-07-12 | 2013-01-17 | Natco Pharma Limited | A process for the preparation of highly pure 4-(4-methyl piperazinomethyl) benzoic acid dihydrochloride |
WO2013035102A1 (en) | 2011-09-05 | 2013-03-14 | Natco Pharma Limited | Processes for the preparation of imatinib base and intermediates thereof |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH93751A (de) * | 1921-02-24 | 1922-04-01 | Hoffmann La Roche | Verfahren zur Darstellung des p-Diäthylaminomethylbenzoesäurebenzylesters. |
CH93438A (de) * | 1921-02-24 | 1922-04-01 | Hoffmann La Roche | Verfahren zur Darstellung des p-Dimethylaminomethylbenzoesäurebenzylesters. |
US2406627A (en) * | 1942-04-16 | 1946-08-27 | American Cyanamid Co | Alkamine derivatives of para aminomethyl benzoic acid |
US3591584A (en) * | 1968-08-27 | 1971-07-06 | Pfizer | Benzothiazine dioxides |
US3787324A (en) * | 1971-03-01 | 1974-01-22 | Warner Lambert Co | 4-hydroxy-3-(3-isoxazolocarbamyl)-2h-1,2-benzothiazine 1,dioxides and process for their production |
JPS4810078U (ru) * | 1971-06-17 | 1973-02-03 | ||
US3788324A (en) * | 1972-05-05 | 1974-01-29 | P Lim | External catheter device |
JPS5070888A (ru) * | 1973-10-27 | 1975-06-12 | ||
US3925371A (en) * | 1974-09-23 | 1975-12-09 | Mcneilab Inc | Benzothiazine-1,1-dioxides |
US3900470A (en) * | 1974-09-23 | 1975-08-19 | Mcneilab Inc | Esters of benzothiazine-1,1-dioxides derivatives |
AU518216B2 (en) * | 1977-09-06 | 1981-09-17 | Hafslund Nycomed Pharma Aktiengesellschaft | Thienothiazine derivatives |
IT1126509B (it) * | 1979-12-07 | 1986-05-21 | Medea Res Srl | Benzimidi ad attivita' anestetica locale e antiaritmica,processo per la loro preparazione e composizioni farmaceutiche che le contengono |
JPS5714589A (en) * | 1980-06-27 | 1982-01-25 | Mitsui Toatsu Chem Inc | Benzothiazine derivative, its preparation and drug composition |
JPS5770888A (en) * | 1980-10-18 | 1982-05-01 | Shinichi Ito | Benzothiazine derivative, its preparation and medicinal composition |
US4309427A (en) * | 1981-01-15 | 1982-01-05 | Pfizer Inc. | Benzothiazine dioxide derivatives |
US4434164A (en) * | 1981-06-01 | 1984-02-28 | Pfizer Inc. | Crystalline benzothiazine dioxide salts |
IT1168064B (it) * | 1981-11-12 | 1987-05-20 | Prodotti Antibiotici Spa | Composto ad azione antinfiammatoria |
IT8219486A0 (it) * | 1982-02-05 | 1982-02-05 | Chiesi Farma Spa | Nuovi composti ad attivita'antiinfiammatoria, procedimento per la loro preparazione e relative composizioni farmaceutiche. |
JPS59193879A (ja) * | 1983-03-31 | 1984-11-02 | Fujisawa Pharmaceut Co Ltd | トロポン誘導体 |
US4551452A (en) * | 1983-12-21 | 1985-11-05 | Pfizer Inc. | Anti-inflammatory 2-methyl-2H-1,2-benzo-(or -thieno-)thiazine-3-carboxamide 1,1-dioxide derivatives, compositions, and method of use therefor |
JPS60184077A (ja) * | 1984-02-23 | 1985-09-19 | フアイザー・インコーポレーテツド | 抗炎症性オキシム前駆薬 |
-
1985
- 1985-05-29 US US06/738,805 patent/US4623486A/en not_active Expired - Lifetime
-
1986
- 1986-05-26 IL IL78912A patent/IL78912A/xx unknown
- 1986-05-27 EP EP86304017A patent/EP0208404B1/en not_active Expired - Lifetime
- 1986-05-27 DE DE8686304017T patent/DE3673710D1/de not_active Expired - Fee Related
- 1986-05-27 CA CA000510033A patent/CA1270485A/en not_active Expired - Fee Related
- 1986-05-27 PT PT82649A patent/PT82649B/pt not_active IP Right Cessation
- 1986-05-27 PL PL1986259740A patent/PL147843B1/pl unknown
- 1986-05-27 NZ NZ216310A patent/NZ216310A/xx unknown
- 1986-05-27 AT AT86304017T patent/ATE56010T1/de not_active IP Right Cessation
- 1986-05-27 ES ES555374A patent/ES8707211A1/es not_active Expired
- 1986-05-28 SU SU864027578A patent/SU1538896A3/ru active
- 1986-05-28 CN CN86103603.4A patent/CN1004628B/zh not_active Expired
- 1986-05-28 HU HU872418A patent/HU199839B/hu unknown
- 1986-05-28 FI FI862252A patent/FI86065C/fi not_active IP Right Cessation
- 1986-05-28 JP JP61123215A patent/JPS61277683A/ja active Granted
- 1986-05-28 PH PH33823A patent/PH23146A/en unknown
- 1986-05-28 KR KR1019860004181A patent/KR870000913B1/ko not_active IP Right Cessation
- 1986-05-28 NO NO862124A patent/NO165240C/no not_active IP Right Cessation
- 1986-05-28 GR GR861389A patent/GR861389B/el unknown
- 1986-05-28 HU HU862250A patent/HU200178B/hu not_active IP Right Cessation
- 1986-05-28 YU YU906/86A patent/YU44576B/xx unknown
- 1986-05-28 DD DD86290676A patent/DD247451A5/de not_active IP Right Cessation
- 1986-05-28 EG EG318/86A patent/EG17811A/xx active
- 1986-05-28 ZA ZA863986A patent/ZA863986B/xx unknown
- 1986-05-28 AU AU58013/86A patent/AU557396B1/en not_active Ceased
- 1986-05-28 DK DK249086A patent/DK249086A/da not_active Application Discontinuation
-
1987
- 1987-04-24 SU SU874202427A patent/SU1531855A3/ru active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK249086D0 (da) | 4-(p-aminomethylbenzoyloxy)-2-methyl-n-heteroaryl-2h-1,2-benzothiazin-3-carboxamid-1,1-dioxid-forbindelser og farmaceutiske praeparater indeholdende disse | |
IL81483A0 (en) | Piperazine derivatives and pharmaceutical compositions containing them | |
FI102175B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten piperatsiinijohdannaisten valmistamiseksi | |
IE820054L (en) | Benzothiazine dioxide anti-inflammatory agents | |
IE821287L (en) | Water-soluble benzothiazine salts | |
FI901761A0 (fi) | Menetelmä lääkeaineina käyttökelpoisten pyridiinijohdannaisten valmistamiseksi | |
GB1466493A (en) | 1-h-tetrazole derivatives | |
ES2016305B3 (es) | Compuestos de piperazina, procedimiento para prepararlos y composicion farmaceutica y su uso. | |
FI854512A0 (fi) | Ny kristallform av benzotiazin-dioxidsaltet. | |
SE8503109D0 (sv) | Cyclic prodrugs of antiinflammatory oxicams | |
DK0430114T3 (da) | Hexahydro-1H-quino 4,3,2-ef 1,4 -benzoxazepiner og beslægtede forbindelser, en fremgangsmåde og mellemprodukter til deres fremstilling og deres anvendelse som lægemidler |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |