DK2454255T3 - Pyridin-4-ylderivater som s1p1/edg1-agonister - Google Patents
Pyridin-4-ylderivater som s1p1/edg1-agonisterInfo
- Publication number
- DK2454255T3 DK2454255T3 DK10742897.1T DK10742897T DK2454255T3 DK 2454255 T3 DK2454255 T3 DK 2454255T3 DK 10742897 T DK10742897 T DK 10742897T DK 2454255 T3 DK2454255 T3 DK 2454255T3
- Authority
- DK
- Denmark
- Prior art keywords
- yld
- pyridin
- derivatives
- edg1
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Endocrinology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Transplantation (AREA)
- Emergency Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IB2009053089 | 2009-07-16 | ||
PCT/IB2010/053224 WO2011007324A1 (en) | 2009-07-16 | 2010-07-15 | Pyridin-4-yl derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2454255T3 true DK2454255T3 (da) | 2013-12-16 |
Family
ID=42734812
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK10742897.1T DK2454255T3 (da) | 2009-07-16 | 2010-07-15 | Pyridin-4-ylderivater som s1p1/edg1-agonister |
Country Status (27)
Country | Link |
---|---|
US (1) | US8658675B2 (da) |
EP (1) | EP2454255B1 (da) |
JP (1) | JP5036923B1 (da) |
KR (1) | KR101409131B1 (da) |
CN (1) | CN102471328B (da) |
AR (1) | AR077413A1 (da) |
AU (1) | AU2010272219B2 (da) |
BR (1) | BR112012000763B8 (da) |
CA (1) | CA2767585C (da) |
CY (1) | CY1114759T1 (da) |
DK (1) | DK2454255T3 (da) |
ES (1) | ES2441845T3 (da) |
HK (1) | HK1170479A1 (da) |
HR (1) | HRP20140098T1 (da) |
IL (1) | IL217490A (da) |
MA (1) | MA33528B1 (da) |
MX (1) | MX2012000414A (da) |
MY (1) | MY153617A (da) |
NZ (1) | NZ598173A (da) |
PL (1) | PL2454255T3 (da) |
PT (1) | PT2454255E (da) |
RU (1) | RU2547098C2 (da) |
SG (1) | SG178042A1 (da) |
SI (1) | SI2454255T1 (da) |
TW (1) | TWI410421B (da) |
WO (1) | WO2011007324A1 (da) |
ZA (1) | ZA201201125B (da) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CL2007002593A1 (es) * | 2006-09-07 | 2008-06-13 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer. |
NZ580454A (en) * | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
ATE502938T1 (de) * | 2007-08-17 | 2011-04-15 | Actelion Pharmaceuticals Ltd | Pyridinderivate als s1p1/edg1-rezeptormodulatoren |
JP5517944B2 (ja) * | 2007-11-01 | 2014-06-11 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピリミジン誘導体 |
ES2389042T3 (es) * | 2008-03-06 | 2012-10-22 | Actelion Pharmaceuticals Ltd. | Compuestos de piridina |
ES2389469T3 (es) * | 2008-03-07 | 2012-10-26 | Actelion Pharmaceuticals Ltd. | Derivados novedosos de aminometilbeceno |
NZ588438A (en) * | 2008-03-07 | 2012-05-25 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl oxadiazole derivatives as immunomodulating agents |
AR084883A1 (es) * | 2011-01-19 | 2013-07-10 | Actelion Pharmaceuticals Ltd | Derivados de 2-metoxi-piridin-4-ilo |
CA2873439A1 (en) * | 2012-05-22 | 2013-11-28 | Actelion Pharmaceuticals Ltd | New process for the preparation of 2-cyclopentyl-6-methoxy-isonicotinic acid |
SI2970236T1 (sl) | 2013-03-15 | 2017-11-30 | Idorsia Pharmaceuticals Ltd | Derivati piridil-4-ila |
CN107667104B (zh) * | 2015-05-20 | 2022-03-22 | 爱杜西亚药品有限公司 | (s)-3-{4-[5-(2-环戊基-6-甲氧基-吡啶-4-基)-[1,2,4]噁二唑-3-基]-2-乙基-6-甲基-苯氧基}-丙烷-1,2-二醇的结晶形式 |
EP3590929B1 (en) * | 2017-02-28 | 2021-09-15 | Medshine Discovery Inc. | Spiro compound and use thereof |
CN107382965A (zh) * | 2017-08-14 | 2017-11-24 | 河南科技大学第附属医院 | 具有抗肿瘤活性的新型s1p‑1受体激动剂药物分子的合成方法 |
CN107445941A (zh) * | 2017-08-14 | 2017-12-08 | 河南科技大学第附属医院 | 具有免疫抑制活性的三氮唑类化合物的制备方法及应用 |
CN107311994A (zh) * | 2017-08-14 | 2017-11-03 | 淄博职业学院 | 一种s1p‑1受体激动剂药物分子的新型合成方法 |
US11014940B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Thiazolidinone and oxazolidinone compounds and formulations |
US11013723B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms of a thiazolidinone compound, compositions and methods of use thereof |
US11014897B1 (en) | 2018-10-16 | 2021-05-25 | Celgene Corporation | Solid forms comprising a thiazolidinone compound, compositions and methods of use thereof |
US11186556B1 (en) | 2018-10-16 | 2021-11-30 | Celgene Corporation | Salts of a thiazolidinone compound, solid forms, compositions and methods of use thereof |
CN109369620B (zh) * | 2018-12-22 | 2020-04-14 | 山东大学 | 吡啶类化合物及其制备方法与抗胃癌应用 |
AU2020372647A1 (en) | 2019-10-31 | 2022-06-16 | Idorsia Pharmaceuticals Ltd | Combination of a CXCR7 antagonist with an S1P1 receptor modulator |
WO2021148314A1 (en) | 2020-01-20 | 2021-07-29 | Idorsia Pharmaceuticals Ltd | Accelerated elimination of (s)-3-{4-[5-(2-cyclopentyl-6-methoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methyl-phenoxy}-propane-1,2-diol |
US20230055568A1 (en) | 2020-02-06 | 2023-02-23 | Mitsubishi Tanabe Pharma Corporation | Therapeutic agent for myalgic encephalomyelitis/chronic fatigue syndrome |
EP4116294A1 (en) * | 2020-03-04 | 2023-01-11 | Helioeast Pharmaceutical Co., Ltd. | Benzo 2-azaspiro[4.4]nonane compound and use thereof |
JP2024510647A (ja) * | 2021-04-09 | 2024-03-08 | ヒーリオイースト ファーマシューティカル カンパニー リミテッド | オキサジアゾール置換スピロ環系化合物とその使用 |
EP4212156A1 (en) | 2022-01-13 | 2023-07-19 | Abivax | Combination of 8-chloro-n-(4-(trifluoromethoxy)phenyl)quinolin-2-amine and its derivatives with a s1p receptor modulator |
WO2024056631A1 (en) | 2022-09-14 | 2024-03-21 | Idorsia Pharmaceuticals Ltd | S1p 1 receptor modulators for use in the treatment of type 1 ifn mediated diseases |
Family Cites Families (61)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL31990A (en) | 1968-04-26 | 1974-05-16 | Chinoin Gyogyszer Es Vegyeszet | Pyridyl 1,2,4-oxadiazole derivatives,process for the preparation thereof and pharmaceutical compositions containing same |
WO1991015583A1 (en) | 1990-04-05 | 1991-10-17 | The American National Red Cross | A protein family related to immediate-early protein expressed by human endothelial cells during differentiation |
CA2051494C (en) | 1990-09-20 | 2006-03-14 | Robert J. Dinerstein | 1-aryl-3-pyridinyl-2-propene-1-ones as calcium uptake inhibitors |
DE4429465A1 (de) | 1994-08-19 | 1996-02-22 | Bayer Ag | Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde |
EP1070080A4 (en) | 1998-03-09 | 2004-12-29 | Smithkline Beecham Corp | HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND THEIR APPLICATIONS |
DE19904389A1 (de) | 1999-02-04 | 2000-08-10 | Bayer Ag | Verwendung von substituierten Isoxazolcarbonsäuren und Derivate und neue Stoffe |
CZ2002599A3 (cs) | 1999-08-19 | 2002-06-12 | Nps Pharmaceuticals Inc. | Heteropolycyklické sloučeniny a jejich pouľití jako antagonistů metabotropního receptoru glutamátu |
ES2292830T3 (es) | 2001-02-21 | 2008-03-16 | Astrazeneca Ab | Compuestos heteropoliciclicos y su uso como antagonistas del receptor metabotropico de glutamato. |
CA2472715A1 (en) | 2002-01-18 | 2003-07-31 | Merck & Co., Inc. | Edg receptor agonists |
DE60330047D1 (en) | 2002-01-18 | 2009-12-24 | Merck & Co Inc | "n-(benzyl)aminoalkyl carboxylate, phosphinate, phosphonate und tetrazole als edg rezeptoragonisten" |
CA2488117A1 (en) | 2002-06-17 | 2003-12-24 | Merck & Co., Inc. | 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists |
DE10237883A1 (de) | 2002-08-19 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie |
RU2331639C2 (ru) * | 2002-08-23 | 2008-08-20 | Райджел Фармасьютикалз, Инк. | Пиридилзамещенные гетероциклы, пригодные для лечения или профилактики инфекции, вызванной вирусом гепатита с |
AU2003279915A1 (en) | 2002-10-15 | 2004-05-04 | Merck And Co., Inc. | Process for making azetidine-3-carboxylic acid |
US20050004186A1 (en) | 2002-12-20 | 2005-01-06 | Pfizer Inc | MEK inhibiting compounds |
CA2524867A1 (en) | 2003-05-15 | 2004-12-02 | Merck & Co., Inc. | 3-(2-amino-1-azacyclyl)-5-aryl-1,2,4-oxadiazoles as s1p receptor agonists |
WO2005014525A2 (en) | 2003-08-12 | 2005-02-17 | Mitsubishi Pharma Corporation | Bi-aryl compound having immunosuppressive activity |
EP1670463A2 (en) | 2003-10-01 | 2006-06-21 | Merck & Co., Inc. | 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as s1p receptor agonists |
EP1697333A4 (en) * | 2003-12-17 | 2009-07-08 | Merck & Co Inc | 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG) |
US8022063B2 (en) | 2004-05-29 | 2011-09-20 | 7Tm Pharma A/S | CRTH2 receptor ligands for medicinal uses |
WO2006010379A1 (en) | 2004-07-29 | 2006-02-02 | Actelion Pharmaceuticals Ltd. | Novel thiophene derivatives as immunosuppressive agents |
AU2005299851B2 (en) | 2004-10-22 | 2011-03-17 | Merck Sharp & Dohme Corp. | 2-(aryl)azacyclylmethyl carboxylates, sulfonates, phosphonates, phosphinates and heterocycles as S1P receptor agonists |
WO2006064757A1 (ja) | 2004-12-13 | 2006-06-22 | Ono Pharmaceutical Co., Ltd. | アミノカルボン酸誘導体およびその医薬用途 |
JP5072825B2 (ja) | 2005-03-23 | 2012-11-14 | アクテリオン ファーマシューティカルズ リミテッド | スフィンゴシン−1−ホスフェート−1受容体アゴニストとしての新規チオフェン誘導体 |
NZ562562A (en) | 2005-03-23 | 2010-11-26 | Actelion Pharmaceuticals Ltd | Hydrogenated benzo(C)thiophene derivatives as immunomodulators |
BRPI0609665A2 (pt) | 2005-03-23 | 2010-04-20 | Actelion Pharmaceuticals Ltd | composto, composição farmacêutica, e, uso de um composto |
EP1874772A1 (en) | 2005-04-05 | 2008-01-09 | Pharmacopeia, Inc. | Purine and imidazopyridine derivatives for immunosuppression |
CA2605594A1 (en) | 2005-04-22 | 2006-11-02 | Daiichi Sankyo Company, Limited | Heterocyclic compound |
MX2007013263A (es) | 2005-04-26 | 2008-01-22 | Neurosearch As | Novedosos derivados oxadiazol y su uso medico. |
BRPI0612028A2 (pt) | 2005-06-08 | 2010-10-13 | Novartis Ag | oxadiazóis ou isodiazóis policìclicos e uso dos mesmos como ligantes de receptor s1p |
US20070043104A1 (en) | 2005-06-10 | 2007-02-22 | Luthman Ingrid K | UII-modulating compounds and their use |
JP2008546758A (ja) | 2005-06-24 | 2008-12-25 | アクテリオン ファーマシューティカルズ リミテッド | 新規チオフェン誘導体 |
WO2007001973A1 (en) | 2005-06-28 | 2007-01-04 | Astrazeneca Ab | New use |
AR057894A1 (es) | 2005-11-23 | 2007-12-26 | Actelion Pharmaceuticals Ltd | Derivados de tiofeno |
TWI404706B (zh) | 2006-01-11 | 2013-08-11 | Actelion Pharmaceuticals Ltd | 新穎噻吩衍生物 |
EP1979345B1 (en) | 2006-01-24 | 2009-11-04 | Actelion Pharmaceuticals Ltd. | Novel pyridine derivatives |
GB0601744D0 (en) | 2006-01-27 | 2006-03-08 | Novartis Ag | Organic compounds |
WO2007098474A1 (en) | 2006-02-21 | 2007-08-30 | University Of Virginia Patent Foundation | Phenyl-cycloalkyl and phenyl-heterocyclic derivatives as s1p receptor agonists |
RS20080525A (en) | 2006-05-09 | 2009-09-08 | Pfizer Products Inc., | Cycloalkylamino acid derivatives and pharmaceutical compositions thereof |
AR061841A1 (es) | 2006-09-07 | 2008-09-24 | Actelion Pharmaceuticals Ltd | Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores. |
CL2007002593A1 (es) * | 2006-09-07 | 2008-06-13 | Actelion Pharmaceuticals Ltd | Compuestos derivados de 4-heteroaril-piridina; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como rechazo de organos transplantados, sindromes autoinmunes y cancer. |
KR101454937B1 (ko) | 2006-09-08 | 2014-10-27 | 액테리온 파마슈티칼 리미티드 | 면역조절제로서 피리딘-3-일 유도체 |
RU2442780C2 (ru) | 2006-09-21 | 2012-02-20 | Актелион Фармасьютиклз Лтд | Фенильные производные и их применение в качестве иммуномодуляторов |
BRPI0717656A2 (pt) | 2006-09-29 | 2014-04-29 | Novartis Ag | Derivados de diaril oxadiazol |
JP2008120794A (ja) | 2006-10-16 | 2008-05-29 | Daiichi Sankyo Co Ltd | ヘテロ環化合物を含有する医薬組成物 |
EP2109364A4 (en) | 2006-12-15 | 2010-04-14 | Abbott Lab | NOVEL OXADIAZONE COMPOUNDS |
US20110207704A1 (en) | 2006-12-15 | 2011-08-25 | Abbott Laboratories | Novel Oxadiazole Compounds |
WO2008091967A1 (en) | 2007-01-26 | 2008-07-31 | Smithkline Beecham Corporation | Chemical compounds |
NZ580454A (en) * | 2007-03-16 | 2011-05-27 | Actelion Pharmaceuticals Ltd | Amino- pyridine derivatives as s1p1 /edg1 receptor agonists |
ATE502938T1 (de) | 2007-08-17 | 2011-04-15 | Actelion Pharmaceuticals Ltd | Pyridinderivate als s1p1/edg1-rezeptormodulatoren |
AU2008306886B2 (en) | 2007-10-04 | 2014-01-16 | Merck Serono S.A. | Oxadiazole diaryl compounds |
EA201070422A1 (ru) | 2007-10-04 | 2010-12-30 | Мерк Сероно С.А. | Производные оксадиазола |
JP5517944B2 (ja) * | 2007-11-01 | 2014-06-11 | アクテリオン ファーマシューティカルズ リミテッド | 新規なピリミジン誘導体 |
AU2008326184A1 (en) | 2007-11-08 | 2009-05-14 | Pfizer Inc. | Cyclobutyl carboxylic acid derivatives |
CA2706834A1 (en) | 2007-12-10 | 2009-06-18 | Actelion Pharmaceuticals Ltd | Thiophene derivatives as agonists of s1p1/edg1 |
CN101965346A (zh) | 2008-03-06 | 2011-02-02 | 埃科特莱茵药品有限公司 | 新颖嘧啶-吡啶衍生物 |
ES2389042T3 (es) | 2008-03-06 | 2012-10-22 | Actelion Pharmaceuticals Ltd. | Compuestos de piridina |
NZ588438A (en) | 2008-03-07 | 2012-05-25 | Actelion Pharmaceuticals Ltd | Pyridin-2-yl oxadiazole derivatives as immunomodulating agents |
ES2389469T3 (es) | 2008-03-07 | 2012-10-26 | Actelion Pharmaceuticals Ltd. | Derivados novedosos de aminometilbeceno |
MY172105A (en) | 2008-05-14 | 2019-11-14 | Scripps Research Inst | Novel modulators of sphingosine phosphate receptors |
UY32734A (es) | 2009-06-26 | 2010-11-30 | Glaxo Group Ltd | Compuestos agonistas del receptor esfingosina 1-fosfato |
-
2010
- 2010-07-15 KR KR1020127003855A patent/KR101409131B1/ko active IP Right Grant
- 2010-07-15 JP JP2012520145A patent/JP5036923B1/ja active Active
- 2010-07-15 CN CN201080030606.XA patent/CN102471328B/zh active Active
- 2010-07-15 TW TW099123317A patent/TWI410421B/zh active
- 2010-07-15 SG SG2012003372A patent/SG178042A1/en unknown
- 2010-07-15 AR ARP100102565A patent/AR077413A1/es active IP Right Grant
- 2010-07-15 EP EP10742897.1A patent/EP2454255B1/en active Active
- 2010-07-15 CA CA2767585A patent/CA2767585C/en active Active
- 2010-07-15 PL PL10742897T patent/PL2454255T3/pl unknown
- 2010-07-15 MY MYPI2012000167A patent/MY153617A/en unknown
- 2010-07-15 US US13/383,619 patent/US8658675B2/en active Active
- 2010-07-15 SI SI201030453T patent/SI2454255T1/sl unknown
- 2010-07-15 AU AU2010272219A patent/AU2010272219B2/en active Active
- 2010-07-15 ES ES10742897.1T patent/ES2441845T3/es active Active
- 2010-07-15 PT PT107428971T patent/PT2454255E/pt unknown
- 2010-07-15 MX MX2012000414A patent/MX2012000414A/es active IP Right Grant
- 2010-07-15 RU RU2012105134/04A patent/RU2547098C2/ru active
- 2010-07-15 WO PCT/IB2010/053224 patent/WO2011007324A1/en active Application Filing
- 2010-07-15 NZ NZ598173A patent/NZ598173A/en unknown
- 2010-07-15 DK DK10742897.1T patent/DK2454255T3/da active
- 2010-07-15 BR BR112012000763A patent/BR112012000763B8/pt active IP Right Grant
-
2012
- 2012-01-12 IL IL217490A patent/IL217490A/en active IP Right Grant
- 2012-02-14 MA MA34631A patent/MA33528B1/fr unknown
- 2012-02-15 ZA ZA2012/01125A patent/ZA201201125B/en unknown
- 2012-11-06 HK HK12111159.0A patent/HK1170479A1/xx unknown
-
2014
- 2014-01-16 CY CY20141100036T patent/CY1114759T1/el unknown
- 2014-02-04 HR HRP20140098AT patent/HRP20140098T1/hr unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2454255T3 (da) | Pyridin-4-ylderivater som s1p1/edg1-agonister | |
DK2125797T3 (da) | Aminopyridinderivater som s1p1/edg1-receptoragonister | |
DK2421825T3 (da) | Azetidinyldiamider som monoacylglycerollipase-inhibitorer | |
DK2435409T3 (da) | Substituerede aminopropionsyrederivater som neprilysininhibitorer | |
BRPI1006128A2 (pt) | derivados de sulfonamida | |
DK2069322T3 (da) | THIOPHENDERIVATER SOM S1P1/EDG1-receptoragonister | |
DK2364293T3 (da) | Hidtil ukendte pyrazol-4-N-alkoxycarboxamider som mikrobiocider | |
DK2616102T3 (da) | Prodrugs, som omfatter et exendin-linker-konjugat | |
DK3124483T3 (da) | Pyrazolaminopyrimidin-derivater som LRRK2-modulatorer | |
BRPI1015921A2 (pt) | agonistas de gpr119 | |
DK2513105T3 (da) | 2-arylimidazolderivater som pde10a-enzyminhibitorer | |
DK3070091T3 (da) | Benzodioxolderivater som phosphodiesterasehæmmere | |
DK2858986T3 (da) | Piperidinderivater som gpr119-agonister | |
DK2513106T3 (da) | Heteroaromatiske aryltriazol-derivater som pde10a-enzyminhibitorer | |
BR112012000762A2 (pt) | enxerto de uma peça para bifurcação | |
DK2571405T3 (da) | Drikfremstillingssystem som anvender kapsler | |
DK2448968T3 (da) | ANTISTOFFER SOM ER SELEKTIVE FOR N-TERMINAL-TRUNKEREDE AMYLOID-ß PROTOFIBRILLER/OLIGOMERER | |
BRPI1011416A2 (pt) | derivados de antraquinova novos | |
BR112012002824A2 (pt) | agonistas de receptor de esfingosina-1-fosfato | |
DK2342182T3 (da) | Isoquinolinonderivater som nk3-antagonister | |
IL208519A0 (en) | Substituted sulfonamide derivatives | |
FR2965843B1 (fr) | Rotor pour turbomachine | |
DK2519503T3 (da) | Sekundære 8-hydroxyquinolin-7-carboxamidderivater til anvendelse som antisvampemidler | |
DK2456765T3 (da) | Imidazolderivater som mglur5-antagonister | |
DE112011100717A5 (de) | Betriebsgerät für Leuchtmittel |