DK2450041T3 - Forbedret testosterongel til anvendelse i behandlingen af hypogonadisme - Google Patents

Forbedret testosterongel til anvendelse i behandlingen af hypogonadisme Download PDF

Info

Publication number
DK2450041T3
DK2450041T3 DK11181638.5T DK11181638T DK2450041T3 DK 2450041 T3 DK2450041 T3 DK 2450041T3 DK 11181638 T DK11181638 T DK 11181638T DK 2450041 T3 DK2450041 T3 DK 2450041T3
Authority
DK
Denmark
Prior art keywords
testosterone
formulation
gel
skin
dose
Prior art date
Application number
DK11181638.5T
Other languages
English (en)
Inventor
Ramana Malladi
Jodi Miller
Original Assignee
Unimed Pharmaceuticals Llc
Besins Healthcare Lu Sarl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37943593&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2450041(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Unimed Pharmaceuticals Llc, Besins Healthcare Lu Sarl filed Critical Unimed Pharmaceuticals Llc
Application granted granted Critical
Publication of DK2450041T3 publication Critical patent/DK2450041T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26—Androgens

Claims (9)

1. Testosterongelsformulering bestående af: i. fra 1,50 til 1,70 % (w/w) testosteron; ii. fra 0,6 til 1,2 % (w/w) isopropylmyristat; iii. fra 60 til 80 % (w/w) af en alkohol valgt fra gruppen bestående af ethanol og isopropanol; iv. en tilstrækkelig mængde af fortykkelsesmiddel til at give sammensætningen en viskositet der overstiger 9000 cps; og v. vand; til anvendelse i behandling af hypogonadisme hos et individ ved perkutan administration.
2. Testosterongelsformuleringen til anvendelse ifølge krav 1, hvor nævnte formulering omfatter: i. fra 1,50 % til 1,70 % (w/w) testosteron; ii. fra 0,6 % til 1,2 % (w/w) isopropylmyristat; iii. fra 67 % til 74 % (w/w) afen alkohol valgt fra gruppen bestående af ethanol og isopropanol; iv. en tilstrækkelig mængde af fortykkelsesmiddel til at give sammensætningen en viskositet der overstiger 9000 cps; og v. vand.
3. Testosterongelsformuleringen til anvendelse ifølge krav 1 eller 2, hvor sammensætningen er opnåelig ved at kombinere: i. 1,62 % (w/w) testosteron; ii. 1,00 % (w/w) isopropylmyristat; iii. 73,5 % (w/w) alkohol (95 % v/v)* iv. 1,00 % (w/w) carbopol® 980; v. 7,00 % (w/w) 0,1 N natriumhydroxid; og vi. 15,9 % (w/w) oprenset vand *svarende til omkring 68,1 % absolut alkohol i formuleringen.
4. Testosterongelsformuleringen til anvendelse ifølge krav 1 eller 2, hvor sammensætningen omfatter omkring 1,62 % (w/w) testosteron.
5. Testosterongelsformuleringen til anvendelse ifølge krav 1 eller 2, hvor fortykkelsesmidlet er en neutraliseret carbomer.
6. Testosterongelsformuleringen til anvendelse ifølge krav 1 eller 2, hvor sammensætningen har en viskositet på 13000 cps til 33000 cps.
7. Testosterongelsformuleringen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor individet har en serumtestosteronkoncentration før behandling på mindre end 300 ng/dl.
8. Testosterongelsformuleringen til anvendelse ifølge et hvilket som helst af de foregående krav, hvor en terapeutisk effektiv dosis af sammensætningen administreres en, to eller tre gange om dagen i mindst omkring 7 dage.
9. Fremgangsmåde til at opnå en testosterongelsformulering ved at kombinere: i. 1,62 % (w/w) testosteron; ii. 1,00 % (w/w) isopropylmyristat; iii. 73,5 % (w/w) alkohol (95% v/v)* iv. 1,00 % (w/w) carbopol® 980; v. 7,00 % (w/w) 0,1 N natriumhydroxid; og vi. 15,9 % (w/w) oprenset vand *svarende til omkring 68,1 % absolut alkohol i formuleringen.
DK11181638.5T 2005-10-12 2006-10-12 Forbedret testosterongel til anvendelse i behandlingen af hypogonadisme DK2450041T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72527605P 2005-10-12 2005-10-12
EP06836341A EP1937276B1 (en) 2005-10-12 2006-10-12 Improved testosterone gel and method of use

Publications (1)

Publication Number Publication Date
DK2450041T3 true DK2450041T3 (da) 2018-11-19

Family

ID=37943593

Family Applications (2)

Application Number Title Priority Date Filing Date
DK11181638.5T DK2450041T3 (da) 2005-10-12 2006-10-12 Forbedret testosterongel til anvendelse i behandlingen af hypogonadisme
DK06836341.5T DK1937276T3 (da) 2005-10-12 2006-10-12 Forbedret testosterongel og fremgangsmåde til anvendelse deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK06836341.5T DK1937276T3 (da) 2005-10-12 2006-10-12 Forbedret testosterongel og fremgangsmåde til anvendelse deraf

Country Status (30)

Country Link
US (11) US20070237822A1 (da)
EP (3) EP2450041B1 (da)
JP (2) JP5584415B2 (da)
KR (1) KR101342357B1 (da)
CN (1) CN101287470B (da)
AU (1) AU2006299833B2 (da)
BR (1) BRPI0617294B8 (da)
CA (1) CA2624788C (da)
CY (1) CY1120904T1 (da)
DK (2) DK2450041T3 (da)
EA (1) EA012754B1 (da)
EC (1) ECSP088363A (da)
ES (2) ES2693745T3 (da)
GE (1) GEP20125432B (da)
HK (1) HK1117417A1 (da)
HR (1) HRP20130071T1 (da)
IL (1) IL190522A (da)
LT (1) LT2450041T (da)
MA (1) MA29941B1 (da)
NO (2) NO346660B1 (da)
NZ (1) NZ567056A (da)
PL (2) PL2450041T3 (da)
PT (2) PT1937276E (da)
RS (1) RS52671B (da)
SI (2) SI2450041T1 (da)
TN (1) TNSN08167A1 (da)
TR (1) TR201815853T4 (da)
UA (1) UA87627C2 (da)
WO (1) WO2007044976A2 (da)
ZA (1) ZA200803087B (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6503894B1 (en) * 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
ZA200407403B (en) * 2002-03-15 2007-09-26 Unimed Pharmaceuticals Inc Androgen pharmaceutical composition and method for treating depression
EP1634583A1 (en) * 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
WO2007044976A2 (en) 2005-10-12 2007-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
AU2008231781B2 (en) * 2007-03-23 2012-09-20 Besins Healthcare Luxembourg Sarl Compositions and method for treating pediatric hypogonadism
US20100279988A1 (en) * 2007-11-02 2010-11-04 Acrux Dds Pty Ltd. Transdermal delivery system for hormones and steroids
AU2010237596A1 (en) * 2009-04-01 2011-10-27 Wirra Ip Pty Ltd A multidose package, course and method of treatment for delivering predetermined multiple doses of a pharmaceutical
AR086400A1 (es) 2011-05-13 2013-12-11 Trimel Pharmaceuticals Corp Formulaciones en gel intranasal de testosterona en dosis de menor potencia y uso de las mismas para el tratamiento de la anorgasmia o el trastorno de deseo sexual hipoactivo
US20130045958A1 (en) 2011-05-13 2013-02-21 Trimel Pharmaceuticals Corporation Intranasal 0.15% and 0.24% testosterone gel formulations and use thereof for treating anorgasmia or hypoactive sexual desire disorder
US9757388B2 (en) 2011-05-13 2017-09-12 Acerus Pharmaceuticals Srl Intranasal methods of treating women for anorgasmia with 0.6% and 0.72% testosterone gels
US9987213B2 (en) * 2012-06-13 2018-06-05 Edward Dunne Corboy, JR. Topical dihydrotestosterone (DHT) for promoting hair growth—containing formulations
US20140058339A1 (en) * 2012-08-22 2014-02-27 Mark L. Baum Method and apparatus for self-dosing and self-administering pharmaceutical compositions
US11744838B2 (en) 2013-03-15 2023-09-05 Acerus Biopharma Inc. Methods of treating hypogonadism with transnasal testosterone bio-adhesive gel formulations in male with allergic rhinitis, and methods for preventing an allergic rhinitis event
WO2015054213A1 (en) 2013-10-07 2015-04-16 Wotton Paul K Hematocrit modulation through needle assisted jet injection of testosterone
US8785426B1 (en) 2013-12-13 2014-07-22 Upsher-Smith Laboratories, Inc. Testosterone gel compositions and related methods
WO2015128876A2 (en) * 2014-02-25 2015-09-03 Intas Pharmaceuticals Limited Stable transdermal testosterone gel
US20170014417A1 (en) 2015-07-14 2017-01-19 Lipp Life Sciences Llc Pharmaceutical administration system for the transdermal application of vardenafil
CN107949389A (zh) * 2015-09-30 2018-04-20 富士胶片株式会社 经皮吸收用组合物
JP6838952B2 (ja) * 2016-12-07 2021-03-03 川崎重工業株式会社 ロボット及びロボットに使用される袋体

Family Cites Families (295)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2155658A (en) 1936-01-08 1939-04-25 Chemische Forschungs Gmbh Surgical and medical preparations
US2232508A (en) 1938-10-21 1941-02-18 Lionel Corp Accessory control circuits for toy electric railroads and apparatus therefor
BE565269A (da) 1957-03-27
US3121042A (en) 1959-05-04 1964-02-11 Ercoli Alberto Oral compositions containing 3-enolethers of methyltestosterone
GB916778A (en) 1959-10-15 1963-01-30 Vismara Francesco Spa Oral compositions containing 3-substituted 17-ª--methyl testosterones
GB941634A (en) 1960-11-16 1963-11-13 Upjohn Co Improvements in or relating to steroids and the manufacture thereof
US3218283A (en) 1962-07-26 1965-11-16 Monsanto Co Novel solutions of poly-(acrylic anhydride) and poly-(methacrylic anhydride) polymers
US3164520A (en) 1962-10-29 1965-01-05 Olin Mathieson Injectable steroid compositions containing at least 75% benzyl benzoate
GB1158283A (en) 1965-10-21 1969-07-16 Foster Milburn Company Composition to be Applied to Skin and Process for Preparing Same.
US3888995A (en) 1968-07-19 1975-06-10 Syntex Corp Fatty alcohol-propylene glycol vehicle
US3887699A (en) 1969-03-24 1975-06-03 Seymour Yolles Biodegradable polymeric article for dispensing drugs
US3913789A (en) 1974-02-13 1975-10-21 United States Banknote Corp Fluid container of the flexible wall capsule type
US4009254A (en) 1974-05-06 1977-02-22 Colgate-Palmolive Company Topical compositions
US3939111A (en) 1974-07-01 1976-02-17 The B. F. Goodrich Company Stable polyurethane solutions
US3989816A (en) 1975-06-19 1976-11-02 Nelson Research & Development Company Vehicle composition containing 1-substituted azacycloheptan-2-ones
US4197316A (en) 1975-07-23 1980-04-08 Scott Eugene J Van Treatment of dry skin
NL7510104A (nl) 1975-08-27 1977-03-01 Akzo Nv Werkwijze ter bereiding van een oraal werkzaam farmaceutisch preparaat.
US4078060A (en) 1976-05-10 1978-03-07 Richardson-Merrell Inc. Method of inducing an estrogenic response
CH625702A5 (da) 1977-01-18 1981-10-15 Delalande Sa
DE2747531A1 (de) 1977-10-22 1979-04-26 Basf Ag Substituierte 3-aminopyrazole
US4954487A (en) 1979-01-08 1990-09-04 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4299826A (en) 1979-10-12 1981-11-10 The Procter & Gamble Company Anti-acne composition
CA1165240A (en) 1980-07-09 1984-04-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions
US4346709A (en) 1980-11-10 1982-08-31 Alza Corporation Drug delivery devices comprising erodible polymer and erosion rate modifier
US4442094A (en) 1980-12-23 1984-04-10 Merck & Co., Inc. (3-Aralkylamino-2-or-propoxy)heterocyclic compounds
US4440777A (en) 1981-07-07 1984-04-03 Merck & Co., Inc. Use of eucalyptol for enhancing skin permeation of bio-affecting agents
US4447562A (en) 1981-07-15 1984-05-08 Ivani Edward J Amino-polysaccharides and copolymers thereof for contact lenses and ophthalmic compositions
FR2515041A1 (fr) 1981-10-26 1983-04-29 Besins Jean Medicament a base de progesterone pour le traitement des affections mammaires
FR2518879A1 (fr) 1981-12-30 1983-07-01 Besins Jean Medicament a base d'oestradiol pour le traitement de la pathologie menopausique
FR2519252A1 (fr) 1982-01-07 1983-07-08 Besins Jean Medicament a base de dihydrotestosterone pour le traitement des deficits des secretions androgeniques testiculaires
US4496556A (en) 1982-08-16 1985-01-29 Norman Orentreich Topical applications for preventing dry skin
DE3315654A1 (de) 1983-04-29 1984-10-31 Bosch Gmbh Robert Polarographischer messfuehler fuer die bestimmung des sauerstoff-gehaltes in gasen
NL8301550A (nl) 1983-05-03 1984-12-03 Gist Brocades Nv Imidazolethanol esters.
US4478822A (en) 1983-05-16 1984-10-23 Merck & Co., Inc. Drug delivery system utilizing thermosetting gels
US4557934A (en) 1983-06-21 1985-12-10 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing 1-dodecyl-azacycloheptan-2-one
US4631188A (en) 1983-08-31 1986-12-23 S.K.Y. Polymers, Ltd. (Kingston Technologies) Injectable physiologically-acceptable polymeric composition
DE3333240A1 (de) 1983-09-12 1985-03-28 Schering AG, 1000 Berlin und 4709 Bergkamen Mittel zur transdermalen applikation von arzneimittelwirkstoffen
US4690775A (en) 1983-09-30 1987-09-01 Research Corporation Emulsion-based gel and process for preparing same
ATE151286T1 (de) 1983-11-14 1997-04-15 Columbia Lab Inc Bioadhäsive mittel
FR2558373B1 (fr) 1984-01-20 1987-07-03 Mauvais Jarvis Pierre Medicament antioestrogene a base de 4-hydroxytamoxifene pour administration percutanee
GB8508404D0 (en) 1985-03-30 1985-05-09 Baylor College Medicine Therapeutic compositions
CA1248450A (en) 1984-04-05 1989-01-10 Kazuo Kigasawa Soft patch
GB8416234D0 (en) 1984-06-26 1984-08-01 Ici Plc Biodegradable amphipathic copolymers
US4725439A (en) 1984-06-29 1988-02-16 Alza Corporation Transdermal drug delivery device
US4704282A (en) 1984-06-29 1987-11-03 Alza Corporation Transdermal therapeutic system having improved delivery characteristics
US4791099A (en) 1984-10-29 1988-12-13 Chaovanee Aroonsakul Method of treatment for central nervous system diseases such as Alzheimer's's disease
GB2167408B (en) 1984-11-23 1988-05-25 Farmos Oy Substituted imidazole derivatives and their preparation and use
EP0189861A3 (en) 1985-01-26 1988-02-17 Showa Denko Kabushiki Kaisha Percutaneous absorption accelerator for ionic water-soluble medicine
DE3685895T2 (de) 1985-02-25 1992-12-24 Univ Rutgers Dosierungssystem fuer transdermale absorption von arzneimittelwirkstoffen.
US4663157A (en) 1985-02-28 1987-05-05 The Proctor & Gamble Company Sunscreen compositions
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4994265A (en) 1985-09-06 1991-02-19 Aloe Scientific Labs Shaving composition
US4683242A (en) 1985-10-28 1987-07-28 A. H. Robins Company, Incorporated Transdermal treatment for pain and inflammation with 2-amino-3-aroylbenzeneacetic acids, salts and esters
EP0222385B1 (en) 1985-11-13 1993-02-03 Research Development Corporation of Japan Sex hormones for the treatment of immunodeficiency diseases
US5023252A (en) 1985-12-04 1991-06-11 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery of drugs
KR940011209B1 (ko) 1985-12-04 1994-11-29 시에 딘 약물의 경피 투여
US5731303A (en) 1985-12-04 1998-03-24 Conrex Pharmaceutical Corporation Transdermal and trans-membrane delivery compositions
US4699779A (en) 1986-02-18 1987-10-13 Victor Palinczar Waterproof sunscreen compositions
US4820724A (en) 1986-03-31 1989-04-11 University Of Southern California Dual phase solvent carrier system
US4780320A (en) 1986-04-29 1988-10-25 Pharmetrix Corp. Controlled release drug delivery system for the periodontal pocket
US4946870A (en) 1986-06-06 1990-08-07 Union Carbide Chemicals And Plastics Company Inc. Delivery systems for pharmaceutical or therapeutic actives
US4863911A (en) 1986-08-04 1989-09-05 University Of Florida Method for treating male sexual dysfunction
MY102980A (en) 1986-10-31 1993-03-31 Pfizer Transdermal flux enhancing compositions
US4863970A (en) 1986-11-14 1989-09-05 Theratech, Inc. Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols
US4861764A (en) 1986-11-17 1989-08-29 Macro Chem. Corp. Percutaneous absorption enhancers, compositions containing same and method of use
US5326790A (en) 1986-11-19 1994-07-05 Dermatologic Research Corporation Administration of skin medications by use of dicarboxylic acids and derivatives
AU601528B2 (en) 1986-12-22 1990-09-13 Ortho-Mcneil Pharmaceutical, Inc. Resilient transdermal drug-delivery device and compositions and devices employing fatty acid esters/ethers of alkanediols and percutaneous absorption enhancers
US4981696A (en) 1986-12-22 1991-01-01 E. I. Du Pont De Nemours And Company Polylactide compositions
US4906169A (en) 1986-12-29 1990-03-06 Rutgers, The State University Of New Jersey Transdermal estrogen/progestin dosage unit, system and process
US4788062A (en) 1987-02-26 1988-11-29 Alza Corporation Transdermal administration of progesterone, estradiol esters, and mixtures thereof
BE1000381A4 (fr) 1987-03-13 1988-11-16 Pharlyse Sa Preparation pharmaceutique a base d'indometacine.
US4855305A (en) 1987-03-23 1989-08-08 Applied Medical Research Compositions and methods of effecting contraception utilizing melatonin
JPS6479103A (en) 1987-06-09 1989-03-24 Lion Corp External preparation
US5013553A (en) 1987-06-30 1991-05-07 Vipont Pharmaceutical, Inc. Drug delivery devices
US5256652A (en) 1987-11-12 1993-10-26 Pharmedic Co. Topical compositions and methods for treatment of male impotence
US4920203A (en) 1987-12-17 1990-04-24 Allied-Signal Inc. Medical devices fabricated from homopolymers and copolymers having recurring carbonate units
US5223261A (en) 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US5656286A (en) 1988-03-04 1997-08-12 Noven Pharmaceuticals, Inc. Solubility parameter based drug delivery system and method for altering drug saturation concentration
US5446070A (en) 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5719197A (en) 1988-03-04 1998-02-17 Noven Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
IE62871B1 (en) 1988-03-08 1995-03-08 Warner Lambert Co Compositions with enhanced penetration
US5231087A (en) 1988-03-16 1993-07-27 Cellegy Pharmaceuticals, Inc. Treatment of skin diseases and tumors with esters and amides of monocarboxylic acids
US5641504A (en) 1988-06-09 1997-06-24 Alza Corporation Skin permeation enhancer compositions using glycerol monolinoleate
CA2000401C (en) 1988-10-11 1996-05-28 Masato Azuma Percutaneous pharmaceutical preparation
DE58909570D1 (de) 1988-10-27 1996-02-22 Schering Ag Mittel zur transdermalen applikation enthaltend gestoden
DE3836862A1 (de) 1988-10-27 1990-05-03 Schering Ag Mittel zur transdermalen applikation von steroidhormonen
US5238944A (en) 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US5332577A (en) 1988-12-27 1994-07-26 Dermamed Transdermal administration to humans and animals
CA2011423A1 (en) 1989-03-07 1990-09-07 Peter M. Taylor Pharmaceutical compositions useful as drug delivery vehicles and/or as wound dressings
ZA901847B (en) 1989-03-10 1991-10-30 Endorecherche Inc Combination therapy for the treatment of estrogen sensitive diseases
US4917882A (en) 1989-03-16 1990-04-17 Amway Corporation Gel-type sunscreen composition
US5053227A (en) 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
EP0399432B1 (en) 1989-05-25 1994-06-22 Takeda Chemical Industries, Ltd. Transdermal therapeutic composition
US5059603A (en) 1989-06-12 1991-10-22 Centuries Laboratories, Inc. Method and composition for treating impotence
US5122519A (en) 1989-06-27 1992-06-16 American Cyanamid Company Stable, cosmetically acceptable topical gel formulation and method of treatment for acne
EP0595796B1 (en) 1989-07-07 2003-01-15 Endorecherche Inc. Method of treatment of androgen-related diseases
US5232703A (en) 1989-07-21 1993-08-03 Izhak Blank Estradiol compositions and methods for topical application
US5116828A (en) 1989-10-26 1992-05-26 Nippon Zoki Pharmaceutical Co., Ltd. Pharmaceutical composition for treatment of osteoporosis
US5324521A (en) 1989-12-18 1994-06-28 Dermamed Systems for transdermal administration of medicaments
JP2893803B2 (ja) 1990-02-27 1999-05-24 日本電気株式会社 プラズマディスプレイの駆動方法
ES2099747T3 (es) 1990-06-01 1997-06-01 Population Council Inc Aplicacion topica terapeuticamente eficaz de la st1435.
US5250534A (en) 1990-06-20 1993-10-05 Pfizer Inc. Pyrazolopyrimidinone antianginal agents
US5202125A (en) 1990-12-10 1993-04-13 Theratech, Inc. Method and systems for administering nitroglycerin transdermally at enhanced transdermal fluxes
US5152997A (en) 1990-12-11 1992-10-06 Theratech, Inc. Method and device for transdermally administering testosterone across nonscrotal skin at therapeutically effective levels
EP0491076A1 (en) 1990-12-19 1992-06-24 Theratech, Inc. Penetration enhancement with multi-component system of N-aliphatic pyrrolidones with lower alcohols
JPH04261119A (ja) 1991-02-13 1992-09-17 Lintec Corp 経皮吸収型貼付剤
US5340586A (en) 1991-04-12 1994-08-23 University Of Southern California Methods and formulations for use in treating oophorectomized women
US5211952A (en) 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
US5340585A (en) 1991-04-12 1994-08-23 University Of Southern California Method and formulations for use in treating benign gynecological disorders
US5326566A (en) 1991-05-17 1994-07-05 Bristol-Myers Squibb Company Use of dibutyl adipate and isopropyl myristate in topical and transdermal products
TW218849B (da) 1991-05-17 1994-01-11 Bristol Myers Squibb Co
US5208013A (en) 1991-06-03 1993-05-04 Olympus International, Inc. Composition for skin care and protection
US5252338A (en) 1991-06-27 1993-10-12 Alza Corporation Therapy delayed
US5487898A (en) 1991-08-26 1996-01-30 Abbott Laboratories Compositions and method for the sublingual or buccal administration therapeutic agents
US5238933A (en) 1991-10-28 1993-08-24 Sri International Skin permeation enhancer compositions
JP3202777B2 (ja) 1992-01-24 2001-08-27 リンテック株式会社 経皮吸収促進剤及びテープ製剤
US5629019A (en) 1992-02-27 1997-05-13 Alza Corporation Formulations with hydrophobic permeation enhancers
TW224048B (da) 1992-03-30 1994-05-21 Hoechst Roussel Pharma
JP2960832B2 (ja) 1992-05-08 1999-10-12 ペルマテック テクノロジー アクチェンゲゼルシャフト エストラジオールの投与システム
US5446025A (en) 1992-06-12 1995-08-29 Abbott Laboratories Formulations and method of the percutaneous administration of leuprolide
US5607691A (en) 1992-06-12 1997-03-04 Affymax Technologies N.V. Compositions and methods for enhanced drug delivery
BR9306564A (pt) 1992-06-19 1999-01-12 Univ California Processo para o tratamento da epiderme de um mamífero terrestre sofrendo de uma condição constitída por uma função de barreira epidérmica perturbada
DE4223004A1 (de) 1992-07-13 1994-01-20 Liedtke Pharmed Gmbh Einzeldosierte halbfeste topische Arzneiform zur Transdermaltherapie
EP0651993B1 (en) 1992-07-23 2002-10-09 Hisamitsu Pharmaceutical Co., Inc. Percutaneously administrable base composition and drug composition prepared therefrom
JP3276406B2 (ja) 1992-07-24 2002-04-22 富士通株式会社 プラズマディスプレイの駆動方法
CA2101496A1 (en) 1992-07-31 1994-02-01 Masao Kobayashi Base for transdermal administration
DE4227989A1 (de) 1992-08-21 1994-06-09 Schering Ag Mittel zur transdermalen Applikation enthaltend 3-Keto-desogestrel
US5883115A (en) 1992-11-09 1999-03-16 Pharmetrix Division Technical Chemicals & Products, Inc. Transdermal delivery of the eutomer of a chiral drug
US5639743A (en) 1992-11-13 1997-06-17 University Of Georgia Research Foundation Compositions and methods for treating exocrine gland atrophy
WO1994013257A1 (en) 1992-12-16 1994-06-23 Creative Products Resource Associates, Ltd. Occlusive/semi-occlusive lotion for treatment of a skin disease or disorder
PT1382340E (pt) 1993-01-19 2006-07-31 Endorech Inc Utilizacoes terapeuticas de desidroepiandrosterona para tratar libido diminuida e osteoporose
US5776923A (en) 1993-01-19 1998-07-07 Endorecherche, Inc. Method of treating or preventing osteoporosis by adminstering dehydropiandrosterone
US5881926A (en) 1993-03-11 1999-03-16 Taro Pharmaceutical Industries, Ltd. Pharmaceutical compositions in semisolid form and a device for administration thereof
US5723114A (en) 1993-03-19 1998-03-03 Cellegy Pharmaceuticals Inc. Penetration enhancing compositions and methods of their use
JP3204510B2 (ja) 1993-04-05 2001-09-04 コンペティティブ テクノロジーズ，インク． 勃起不全の診断および治療
KR100201424B1 (ko) 1993-05-19 1999-06-15 나카토미 히로타카 용해제 및 이 용해제를 함유하는 외용제제
US5648350A (en) 1993-05-25 1997-07-15 Laboratoires Besins Iscovesco Dihydrotestosterone for use in androgenotherapy
US5460820B1 (en) 1993-08-03 1999-08-03 Theratech Inc Method for providing testosterone and optionally estrogen replacement therapy to women
US5362886A (en) 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis
CZ187796A3 (en) 1993-12-27 1997-01-15 Akzo Nobel Nv Pharmaceutical preparation
GB9401090D0 (en) 1994-01-21 1994-03-16 Glaxo Lab Sa Chemical compounds
US6143746A (en) 1994-01-21 2000-11-07 Icos Corporation Tetracyclic cyclic GMP-specific phosphodiesterase inhibitors, process of preparation and use
CN1106259A (zh) 1994-02-05 1995-08-09 日东制药株式会社 含有作为有效成分的丙酸类非类固醇性药物的新颖消炎镇痛外用凝胶制剂
FR2718372B1 (fr) 1994-04-08 1996-06-28 Sofab Dispensateur de produits fluides.
US6395744B1 (en) 1994-04-22 2002-05-28 Queen's University At Kingston Method and compositions for the treatment or amelioration of female sexual dysfunction
DE10199068I2 (de) 1994-04-22 2004-05-06 Pentech Pharmaceuticals Inc Sublinguale Dosierungsformen enthaltend apomorphinzur Verwendung bei der Behandlung von erektiler D ysfunktion.
US5540934A (en) 1994-06-22 1996-07-30 Touitou; Elka Compositions for applying active substances to or through the skin
PT781122E (pt) 1994-09-14 2000-11-30 Minnesota Mining & Mfg Matriz para a distribuicao transdermica de farmacos
WO1996019205A1 (en) 1994-12-21 1996-06-27 Theratech, Inc. Transdermal delivery system with adhesive overlay and peel seal disc
US5807568A (en) 1994-12-27 1998-09-15 Mcneil-Ppc, Inc. Enhanced delivery of topical compositions containing flurbiprofen
US6024974A (en) 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
US5629021A (en) 1995-01-31 1997-05-13 Novavax, Inc. Micellar nanoparticles
AT408067B (de) 1995-03-17 2001-08-27 Gebro Pharma Gmbh Pharmazeutische zusammensetzung zur topischen applizierung und verfahren zu ihrer herstellung
US5654337A (en) 1995-03-24 1997-08-05 II William Scott Snyder Topical formulation for local delivery of a pharmaceutically active agent
US5844103A (en) 1995-03-24 1998-12-01 Lever Brothers Company, Division Of Conopco, Inc. Anionic glycasuccinamide sufactants and a process for their manufacture
FR2732223B1 (fr) 1995-03-30 1997-06-13 Sanofi Sa Composition pharmaceutique pour administration transdermique
US5731339A (en) 1995-04-28 1998-03-24 Zonagen, Inc. Methods and formulations for modulating the human sexual response
DE19517145C2 (de) 1995-05-10 2000-02-24 Hexal Pharmaforschung Gmbh Transdermales therapeutisches System (TTS) zur Verabreichung von Testosteron
US5882676A (en) 1995-05-26 1999-03-16 Alza Corporation Skin permeation enhancer compositions using acyl lactylates
DE69625483T3 (de) 1995-06-07 2012-05-10 Ortho-Mcneil Pharmaceutical, Inc. Transdermales pflaster zur verabreichung von 17-deacetyl norgestimat in kombination mit einem östrogen
US5785991A (en) 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
GB9512670D0 (en) 1995-06-21 1995-08-23 Sod Conseils Rech Applic Camptothecin analogues
US5780050A (en) 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
WO1997004752A1 (en) 1995-07-26 1997-02-13 Duramed Pharmaceuticals, Inc. Pharmaceutical compositions of conjugated estrogens and methods for their use
US5906830A (en) 1995-09-08 1999-05-25 Cygnus, Inc. Supersaturated transdermal drug delivery systems, and methods for manufacturing the same
US5902603A (en) 1995-09-14 1999-05-11 Cygnus, Inc. Polyurethane hydrogel drug reservoirs for use in transdermal drug delivery systems, and associated methods of manufacture and use
US6251436B1 (en) 1995-09-29 2001-06-26 L.A.M. Pharmaceutical Corporation Drug preparations for treating sexual dysfunction
US6036977A (en) 1995-09-29 2000-03-14 L.A.M. Pharmaceutical Corp. Drug preparations for treating sexual dysfunction
US5849729A (en) 1995-12-26 1998-12-15 Hershey Foods Corporation Use of hydrolyzed cocoa butter for percutaneous absorption
US5643587A (en) 1996-02-15 1997-07-01 Avon Products, Inc. Composition and method for under-eye skin lightening
AUPN814496A0 (en) 1996-02-19 1996-03-14 Monash University Dermal penetration enhancer
US5898038A (en) 1996-03-19 1999-04-27 Board Of Regents, The University Of Texas System Treatment of osteoporosis and metabolic bone disorders with nitric oxide substrate and/or donors
DE19619045C1 (de) 1996-05-02 1997-11-13 Jenapharm Gmbh Verwendung von Kombinationspräparaten zur Behandlung hypogonadaler Männer sowie Männern mit Hypophysenerkrankungen
IT1283102B1 (it) 1996-06-06 1998-04-07 Permatec Nv Composizione terapeutica per la somministrazione transdermica di un principio attivo estrogeno o progestinico o di loro miscele
US5730987A (en) 1996-06-10 1998-03-24 Omar; Lotfy Ismail Medication for impotence containing lyophilized roe and a powdered extract of Ginkgo biloba
US5708038A (en) 1996-06-13 1998-01-13 Univera Pharmaceuticals, Inc. Method of using aloe vera as a biological vehicle
US6007837A (en) 1996-07-03 1999-12-28 Alza Corporation Drug delivery devices and process of manufacture
US6139873A (en) 1996-07-10 2000-10-31 Cedars-Sinai Medical Center Combined pharmaceutical estrogen-androgen-progestin
US5770226A (en) 1996-07-10 1998-06-23 Wake Forest University Combined pharmaceutical estrogen-androgen-progestin oral contraceptive
RU2122396C1 (ru) 1996-07-12 1998-11-27 Валентина Александровна Андрюшина Биологически-активная добавка в косметические изделия
US6228852B1 (en) 1996-07-12 2001-05-08 Carolyn V. Shaak Transdermal application of naturally occurring steroid hormones
US5783208A (en) 1996-07-19 1998-07-21 Theratech, Inc. Transdermal drug delivery matrix for coadministering estradiol and another steroid
US5837289A (en) 1996-07-23 1998-11-17 Grasela; John C. Transdermal delivery of medications using a combination of penetration enhancers
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
US6225299B1 (en) 1996-09-16 2001-05-01 Jenapharm Gmbh & Co. Kg Hormonal agent for skin treatment
US5760096A (en) 1996-10-18 1998-06-02 Thornfeldt; Carl R. Potent penetration enhancers
CA2263300A1 (en) 1996-10-30 1998-05-07 David Fikstad Fatty acid esters of glycolic acid and its salts as permeation enhancers
US6331543B1 (en) 1996-11-01 2001-12-18 Nitromed, Inc. Nitrosated and nitrosylated phosphodiesterase inhibitors, compositions and methods of use
US6019988A (en) 1996-11-18 2000-02-01 Bristol-Myers Squibb Company Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage
US5855920A (en) 1996-12-13 1999-01-05 Chein; Edmund Y. M. Total hormone replacement therapy
US5807957A (en) 1996-12-23 1998-09-15 Macrochem Corporation Cationic film-forming polymer compositions, and use thereof in topical agents delivery system and method of delivering agents to the skin
US5908619A (en) 1997-01-09 1999-06-01 Minnesota Mining And Manufacturing Company Hydroalcoholic compositions thickened using surfactant/polymer complexes
US6019997A (en) 1997-01-09 2000-02-01 Minnesota Mining And Manufacturing Hydroalcoholic compositions for transdermal penetration of pharmaceutical agents
DE19701949A1 (de) 1997-01-13 1998-07-16 Jenapharm Gmbh Transdermales therapeutisches System
GB9700878D0 (en) 1997-01-17 1997-03-05 Scherer Ltd R P Dosage forms and method for ameliorating male erectile dysfunction
US20010023261A1 (en) 1997-01-27 2001-09-20 Lg Chemical Limited. Novel composition for the transdermal administration of drugs
TR199902104T2 (xx) 1997-02-28 2000-04-21 Minnesota Mining And Manufacturing Company Testosteronun verilmesine y�nelik transdermal d�zenek.
US6103765A (en) 1997-07-09 2000-08-15 Androsolutions, Inc. Methods for treating male erectile dysfunction
US6342250B1 (en) 1997-09-25 2002-01-29 Gel-Del Technologies, Inc. Drug delivery devices comprising biodegradable protein for the controlled release of pharmacologically active agents and method of making the drug delivery devices
US5968919A (en) 1997-10-16 1999-10-19 Macrochem Corporation Hormone replacement therapy drug formulations for topical application to the skin
JP2001520999A (ja) 1997-10-28 2001-11-06 アシビ， エルエルシー 女性の性的機能不全の処置
US6127363A (en) 1997-10-28 2000-10-03 Vivus, Inc. Local administration of Type IV phosphodiesterase inhibitors for the treatment of erectile dysfunction
US5877216A (en) 1997-10-28 1999-03-02 Vivus, Incorporated Treatment of female sexual dysfunction
US6156753A (en) 1997-10-28 2000-12-05 Vivus, Inc. Local administration of type III phosphodiesterase inhibitors for the treatment of erectile dysfunction
US6037346A (en) 1997-10-28 2000-03-14 Vivus, Inc. Local administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction
US20020013304A1 (en) 1997-10-28 2002-01-31 Wilson Leland F. As-needed administration of an androgenic agent to enhance female sexual desire and responsiveness
US6472425B1 (en) 1997-10-31 2002-10-29 Nitromed, Inc. Methods for treating female sexual dysfunctions
US6046244A (en) 1997-11-05 2000-04-04 Nexmed Holdings, Inc. Topical compositions for prostaglandin E1 delivery
AU747041B2 (en) * 1997-11-10 2002-05-09 Strakan International Limited Penetration enhancing and irritation reducing systems
CA2309855A1 (en) 1997-11-24 1999-06-03 Katherine D. Gordon Testosterone inhibitors and use for the protection of neurons
WO1999032153A1 (en) 1997-12-22 1999-07-01 Alza Corporation Monoglyceride and ethyl palmitate permeation enhancer compositions
AU1689999A (en) 1997-12-25 1999-07-19 Daiichi Pharmaceutical Co., Ltd. Medicinal composition for percutaneous administration
US5935949A (en) 1998-03-20 1999-08-10 Trustees Of Dartmouth College Use of androgen therapy in fibromyalgia and chronic fatigue syndrome
EP1071428A2 (en) 1998-04-17 2001-01-31 Ortho-Mcneil Pharmaceutical, Inc. Folic acid-containing pharmaceutical compositions, and related methods and delivery systems
FR2777784B1 (fr) 1998-04-27 2004-03-19 Arepa Composition pharmaceutique a base d'estrogene et de progesterone
US6124461A (en) 1998-05-26 2000-09-26 Saint Louis University, Health Services Center, Research Administration Compounds, compositions, and methods for treating erectile dysfunction
US5847128A (en) 1998-05-29 1998-12-08 Virginia Commonwealth University Water soluble derivatives of cannabinoids
US6277884B1 (en) 1998-06-01 2001-08-21 Nitromed, Inc. Treatment of sexual dysfunction with N-hydroxyguanidine compounds
US6087368A (en) 1998-06-08 2000-07-11 Bristol-Myers Squibb Company Quinazolinone inhibitors of cGMP phosphodiesterase
DE19825856A1 (de) 1998-06-10 1999-12-16 Labtec Gmbh Topische Arzneimittelzubereitung
US5942545A (en) 1998-06-15 1999-08-24 Macrochem Corporation Composition and method for treating penile erectile dysfunction
AU4696499A (en) 1998-06-19 2000-01-05 Genetronics, Inc. Electrically assisted transdermal method and apparatus for the treatment of erectile dysfunction
US6200591B1 (en) 1998-06-25 2001-03-13 Anwar A. Hussain Method of administration of sildenafil to produce instantaneous response for the treatment of erectile dysfunction
US5880117A (en) 1998-07-13 1999-03-09 Arnold; Patrick Use of 4-androstenediol to increase testosterone levels in humans
US6207694B1 (en) 1998-07-27 2001-03-27 Howard Murad Pharmaceutical compositions and methods for managing scalp conditions
US6284234B1 (en) 1998-08-04 2001-09-04 Johnson & Johnson Consumer Companies, Inc. Topical delivery systems for active agents
US6436950B1 (en) 1998-08-14 2002-08-20 Nastech Pharmaceutical Company, Inc. Nasal delivery of apomorphine
US6077841A (en) 1998-09-04 2000-06-20 Janssen Pharmaceutica, N.V. 5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction
US6323242B1 (en) 1998-12-02 2001-11-27 Peter Sterling Mueller Treatment of disorders secondary to organic impairments
EP1005831A3 (en) 1998-12-04 2001-05-30 Eisai Co., Ltd. A method for measurement of a penile diameter
US6224573B1 (en) 1999-01-15 2001-05-01 Nexmed Holdings, Inc. Medicament dispenser
US6117446A (en) 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
JP2000212080A (ja) 1999-01-26 2000-08-02 Hiroshi Azuma 勃起機能不全改善剤
DE19903087A1 (de) 1999-01-27 2000-08-10 Forssmann Wolf Georg Behandlung von erektilen Dysfunktionen mit C-Typ Natriuretischem Polypeptid (CNP) als Monotherapie oder in Kombination mit Phosphodiesterasehemmern
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
US6267985B1 (en) 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
US6294192B1 (en) 1999-02-26 2001-09-25 Lipocine, Inc. Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents
US6087362A (en) 1999-03-16 2000-07-11 Pentech Pharmaceuticals, Inc. Apomorphine and sildenafil composition
US6309663B1 (en) 1999-08-17 2001-10-30 Lipocine Inc. Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents
US6187750B1 (en) 1999-08-25 2001-02-13 Everyoung Technologies, Inc. Method of hormone treatment for patients with symptoms consistent with multiple sclerosis
US6075028A (en) 1999-09-23 2000-06-13 Graham; Richard Method of treating Tourette's syndrome and related CNS disorders
US6980566B2 (en) 2000-03-10 2005-12-27 Lightwaves Systems, Inc. Method for routing data packets using an IP address based in GEO position
US6586000B2 (en) * 1999-12-16 2003-07-01 Dermatrends, Inc. Hydroxide-releasing agents as skin permeation enhancers
US6582724B2 (en) 1999-12-16 2003-06-24 Dermatrends, Inc. Dual enhancer composition for topical and transdermal drug delivery
US6562369B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of androgenic drugs hydroxide-releasing agents as permeation enhancers
US6562370B2 (en) * 1999-12-16 2003-05-13 Dermatrends, Inc. Transdermal administration of steroid drugs using hydroxide-releasing agents as permeation enhancers
AU3104301A (en) 2000-01-20 2001-07-31 Noven Pharmaceuticals, Inc. Compositions and methods to effect the release profile in the transdermal administration of active agents
JP3596464B2 (ja) * 2000-02-10 2004-12-02 セイコーエプソン株式会社 計時装置および計時装置の制御方法
DE10015783C2 (de) 2000-03-30 2003-12-04 Lohmann Therapie Syst Lts Transdermales therapeutisches System zur Abgabe von Lerisetron und seine Verwendung
CZ20023637A3 (cs) 2000-04-07 2003-02-12 Tap Pharmaceutical Products, Inc. Deriváty apomorfinu a způsoby jejich použití
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
US20030139384A1 (en) 2000-08-30 2003-07-24 Dudley Robert E. Method for treating erectile dysfunction and increasing libido in men
AU2001285367B2 (en) 2000-08-30 2006-05-18 Besins Healthcare Luxembourg Sarl Method of increasing testosterone and related steroid concentrations in women
US20040002482A1 (en) * 2000-08-30 2004-01-01 Dudley Robert E. Androgen pharmaceutical composition and method for treating depression
US20040092494A9 (en) * 2000-08-30 2004-05-13 Dudley Robert E. Method of increasing testosterone and related steroid concentrations in women
CN1473047A (zh) 2000-08-30 2004-02-04 ������ҩ�����޹�˾ 治疗男性勃起功能障碍和增强性冲动的方法
JP5039252B2 (ja) 2000-08-31 2012-10-03 ユニメッド ファーマシューティカルズ，リミティド ライアビリティ カンパニー 性機能低下を治療するための医薬組成物及び方法
FR2814074B1 (fr) 2000-09-15 2003-03-07 Theramex Nouvelles compositions estro-progestatives topiques a effet systemique
ES2283446T3 (es) 2000-12-22 2007-11-01 DR. AUGUST WOLFF GMBH & CO. KG ARZNEIMITTEL Composicion de gel basada en alcohol para el tratamiento del hipogonadismo por administracion transescrotal.
JP2002212105A (ja) 2001-01-22 2002-07-31 Lion Corp 水性皮膚外用剤組成物
US20030018085A1 (en) 2001-05-11 2003-01-23 Raoof Araz A. Isostearic acid salts as permeation enhancers
US20030027804A1 (en) 2001-06-27 2003-02-06 Van Der Hoop Roland Gerritsen Therapeutic combinations for the treatment of hormone deficiencies
AU2002340120A1 (en) 2001-10-04 2003-04-14 Cellegy Pharmaceuticals, Inc. Semisolid topical hormonal compositions and methods for treatment
EP1317921B1 (fr) 2001-12-07 2009-08-19 Besins International Belgique Composition pharmaceutique sous forme de gel ou de solution à base de dihydrotestostérone, son procédé de préparation et ses utilisations
US20040072810A1 (en) * 2001-11-07 2004-04-15 Besins International Belgique Pharmaceutical composition in the form of a gel or a solution based on dihydrotestosterone, process for preparing it and uses thereof
AU2003212962A1 (en) 2002-02-07 2003-09-02 Massachusetts Institute Of Technology Transdermal drug delivery systems
ZA200407403B (en) 2002-03-15 2007-09-26 Unimed Pharmaceuticals Inc Androgen pharmaceutical composition and method for treating depression
MY139721A (en) * 2002-04-19 2009-10-30 Cpex Pharmaceuticals Inc Pharmaceutical composition
CN1470239A (zh) 2002-07-28 2004-01-28 王怀秀 睾酮经皮缓释制剂
FR2848112B1 (fr) 2002-12-10 2007-02-16 Besins Int Belgique Composition pharmaceutique pour administration transdermique ou transmuqueuse comprenant au moins un progestatif et/ou au moins un oestrogene, son procede de preparation et ses utilisations
FR2851470B1 (fr) 2003-02-20 2007-11-16 Besins Int Belgique Composition pharmaceutique pour administration transdermique ou transmuqueuse
US20050042268A1 (en) 2003-07-16 2005-02-24 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050025833A1 (en) 2003-07-16 2005-02-03 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US20050020552A1 (en) * 2003-07-16 2005-01-27 Chaim Aschkenasy Pharmaceutical composition and method for transdermal drug delivery
US7968532B2 (en) 2003-12-15 2011-06-28 Besins Healthcare Luxembourg Treatment of gynecomastia with 4-hydroxy tamoxifen
RU2275930C2 (ru) 2004-04-26 2006-05-10 ООО "РусГен" Композиция для коррекции возрастных изменений эндокринной системы человека (варианты) и способ получения фармацевтической формы на основе такой композиции
US20070196453A1 (en) 2004-06-07 2007-08-23 Jie Zhang Two or more non-volatile solvent-containing compositions and methods for dermal delivery of drugs
US20070196323A1 (en) 2004-06-07 2007-08-23 Jie Zhang Polyvinyl alcohol-containing compositions and methods for dermal delivery of drugs
US20070189977A1 (en) 2004-06-07 2007-08-16 Jie Zhang Spray-on formulations and methods for dermal delivery of drugs
US20070190124A1 (en) 2004-06-07 2007-08-16 Jie Zhang Two or more solidifying agent-containing compositions and methods for dermal delivery of drugs
US8907153B2 (en) 2004-06-07 2014-12-09 Nuvo Research Inc. Adhesive peel-forming formulations for dermal delivery of drugs and methods of using the same
EP1634583A1 (en) 2004-09-09 2006-03-15 Laboratoires Besins International Testosterone gels comprising propylene glycol as penetration enhancer
US20070082039A1 (en) 2004-10-18 2007-04-12 Jones Gerald S Jr Synthesis of fatty alcohol esters of alpha-hydroxy carboxylic acids, the use of the same as percutaneous permeation enhancers, and topical gels for the transdermal delivery of steroids
US20070088012A1 (en) * 2005-04-08 2007-04-19 Woun Seo Method of treating or preventing type-2 diabetes
JP2008538753A (ja) 2005-04-12 2008-11-06 ユニメド ファーマスーティカルズ インク 骨の老化または骨粗しょう症の治療または予防方法
KR20080016552A (ko) 2005-04-13 2008-02-21 유니메드 파마슈티칼스, 인크. 여성의 테스토스테론 및 관련된 스테로이드의 농도를증가시키는 방법
EP2979699A1 (en) 2005-04-15 2016-02-03 Clarus Therapeutics, Inc. Pharmaceutical delivery systems for hydrophobic drugs and compositions comprising same
NZ563946A (en) 2005-06-03 2012-02-24 Acrux Dds Pty Ltd Testosterone containing non-occlusive transdermal drug delivery composition for application to the arm pit / axilla
US20070065494A1 (en) 2005-08-03 2007-03-22 Watson Laboratories, Inc. Formulations and Methods for Enhancing the Transdermal Penetration of a Drug
WO2007044976A2 (en) 2005-10-12 2007-04-19 Unimed Pharmaceuticals, Llc Improved testosterone gel and method of use
US20070254036A1 (en) 2006-04-13 2007-11-01 Besins Healthcare Sa Treatment of menopause associated symptoms
US20080220068A1 (en) 2006-07-31 2008-09-11 Laboratories Besins International Treatment and prevention of excessive scarring
US20090258063A1 (en) 2006-09-11 2009-10-15 Sekisui Chemical Co., Ltd. Transdermal patch
US20080261937A1 (en) 2007-03-23 2008-10-23 Dudley Robert E Pharmaceutical compositions and method for treating pediatric hypogonadism

Also Published As

Publication number Publication date
NO344564B1 (no) 2020-02-03
AU2006299833A1 (en) 2007-04-19
NO20082170L (no) 2008-05-09
US8754070B2 (en) 2014-06-17
US20070237822A1 (en) 2007-10-11
JP5584415B2 (ja) 2014-09-03
US20130210791A1 (en) 2013-08-15
US8466137B2 (en) 2013-06-18
ZA200803087B (en) 2009-11-25
US20130210790A1 (en) 2013-08-15
UA87627C2 (ru) 2009-07-27
EP1937276B1 (en) 2012-11-21
TNSN08167A1 (fr) 2009-10-30
US20110269729A1 (en) 2011-11-03
JP2013064028A (ja) 2013-04-11
US20120028948A1 (en) 2012-02-02
US20120028946A1 (en) 2012-02-02
SI2450041T1 (sl) 2019-02-28
WO2007044976A3 (en) 2007-09-07
JP2009511602A (ja) 2009-03-19
US8466138B2 (en) 2013-06-18
US20140329788A1 (en) 2014-11-06
JP5728508B2 (ja) 2015-06-03
CN101287470A (zh) 2008-10-15
US20110306583A1 (en) 2011-12-15
SI1937276T1 (sl) 2013-04-30
IL190522A (en) 2015-04-30
DK1937276T3 (da) 2013-02-11
NO346660B1 (no) 2022-11-21
LT2450041T (lt) 2018-12-27
PT2450041T (pt) 2018-11-16
EP1937276A2 (en) 2008-07-02
US8466136B2 (en) 2013-06-18
AU2006299833B2 (en) 2012-04-12
US8729057B2 (en) 2014-05-20
GEP20125432B (en) 2012-03-26
CA2624788A1 (en) 2007-04-19
PL1937276T3 (pl) 2013-07-31
IL190522A0 (en) 2008-11-03
PT1937276E (pt) 2013-02-21
PL2450041T3 (pl) 2019-02-28
CA2624788C (en) 2011-04-19
ES2399763T3 (es) 2013-04-03
EA012754B1 (ru) 2009-12-30
TR201815853T4 (tr) 2018-11-21
US8741881B2 (en) 2014-06-03
CN101287470B (zh) 2012-10-17
RS52671B (en) 2013-06-28
US20130210789A1 (en) 2013-08-15
NO20200014A1 (no) 2008-05-09
CY1120904T1 (el) 2019-12-11
US20160228355A1 (en) 2016-08-11
HK1117417A1 (en) 2009-01-16
MA29941B1 (fr) 2008-11-03
KR20080068654A (ko) 2008-07-23
EP3456329A1 (en) 2019-03-20
US8486925B2 (en) 2013-07-16
ECSP088363A (es) 2008-10-31
BRPI0617294A2 (pt) 2011-07-19
EA200801049A1 (ru) 2008-08-29
US8759329B2 (en) 2014-06-24
WO2007044976A2 (en) 2007-04-19
EP2450041A2 (en) 2012-05-09
HRP20130071T1 (hr) 2013-03-31
ES2693745T3 (es) 2018-12-13
EP2450041B1 (en) 2018-09-26
US20130203720A1 (en) 2013-08-08
BRPI0617294B8 (pt) 2021-05-25
BRPI0617294B1 (pt) 2020-12-01
EP2450041A3 (en) 2012-08-01
NZ567056A (en) 2012-02-24
KR101342357B1 (ko) 2013-12-20

Similar Documents

Publication Publication Date Title
DK2450041T3 (da) Forbedret testosterongel til anvendelse i behandlingen af hypogonadisme
CN101018542B (zh) 含有渗透促进剂丙二醇的睾丸激素凝胶
BRPI0515040B1 (pt) Géis de testosterona compreendendo propileno glicol como intensificador de penetração