DK2439284T3 - Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor - Google Patents
Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor Download PDFInfo
- Publication number
- DK2439284T3 DK2439284T3 DK11178194.4T DK11178194T DK2439284T3 DK 2439284 T3 DK2439284 T3 DK 2439284T3 DK 11178194 T DK11178194 T DK 11178194T DK 2439284 T3 DK2439284 T3 DK 2439284T3
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- Prior art keywords
- reactivity
- cancer
- procedure
- determining
- growth factor
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Links
- 102000001301 EGF receptor Human genes 0.000 title 1
- 108060006698 EGF receptor Proteins 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 230000009257 reactivity Effects 0.000 title 1
- 238000011282 treatment Methods 0.000 title 1
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
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- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
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- C12Q2600/136—Screening for pharmacological compounds
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
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- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
- G01N2333/485—Epidermal growth factor [EGF] (urogastrone)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Pathology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
Applications Claiming Priority (8)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US55821804P | 2004-03-31 | 2004-03-31 | |
| US56109504P | 2004-04-09 | 2004-04-09 | |
| US56575304P | 2004-04-27 | 2004-04-27 | |
| US56598504P | 2004-04-27 | 2004-04-27 | |
| US57403504P | 2004-05-25 | 2004-05-25 | |
| US57791604P | 2004-06-07 | 2004-06-07 | |
| US59228704P | 2004-07-29 | 2004-07-29 | |
| EP05757467.5A EP1733056B1 (en) | 2004-03-31 | 2005-03-31 | Method to determine responsiveness of cancer to epidermal growth factor receptor targeting treatments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2439284T3 true DK2439284T3 (da) | 2019-07-29 |
Family
ID=35064318
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11178202.5T DK2439285T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| DK11178194.4T DK2439284T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| DK11178200.9T DK2423331T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| DK05757467.5T DK1733056T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål |
| DK11178198.5T DK2447375T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11178202.5T DK2439285T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11178200.9T DK2423331T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| DK05757467.5T DK1733056T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål |
| DK11178198.5T DK2447375T3 (da) | 2004-03-31 | 2005-03-31 | Fremgangsmåde til bestemmelse af responsiviteten af en tumor på behandlinger med den epidermale vækstfaktor-receptor som mål |
Country Status (14)
| Country | Link |
|---|---|
| US (8) | US7294468B2 (enExample) |
| EP (6) | EP1733056B1 (enExample) |
| JP (6) | JP4350148B2 (enExample) |
| KR (3) | KR101289774B1 (enExample) |
| CN (6) | CN107794302B (enExample) |
| AU (4) | AU2012202668B9 (enExample) |
| BR (1) | BRPI0508286B8 (enExample) |
| CA (1) | CA2556227C (enExample) |
| DK (5) | DK2439285T3 (enExample) |
| ES (5) | ES2741573T3 (enExample) |
| HK (1) | HK1254906A1 (enExample) |
| PT (1) | PT1733056E (enExample) |
| SI (1) | SI1733056T1 (enExample) |
| WO (1) | WO2005094357A2 (enExample) |
Families Citing this family (183)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7219016B2 (en) | 2001-04-20 | 2007-05-15 | Yale University | Systems and methods for automated analysis of cells and tissues |
| US20100056762A1 (en) | 2001-05-11 | 2010-03-04 | Old Lloyd J | Specific binding proteins and uses thereof |
| JP4414142B2 (ja) | 2001-05-11 | 2010-02-10 | ルードヴィッヒ インスティテュート フォー キャンサー リサーチ | 特異的結合タンパク質およびその使用 |
| DK2439285T3 (da) | 2004-03-31 | 2019-07-29 | Massachusetts Gen Hospital | Fremgangsmåde til at bestemme reaktivitet af cancer på behandlinger målrettet mod epidermal vækstfaktor-receptor |
| WO2005118876A2 (en) | 2004-06-04 | 2005-12-15 | Genentech, Inc. | Egfr mutations |
| TW200617396A (en) * | 2004-10-06 | 2006-06-01 | Astrazeneca Ab | Method |
| EP2927238B1 (en) * | 2004-10-18 | 2018-01-17 | Brandeis University | Methods for LATE amplification and sequencing of a nucleic acid |
| JPWO2006070667A1 (ja) * | 2004-12-28 | 2008-06-12 | タカラバイオ株式会社 | Egfr遺伝子変異の検出法ならびに検出キット |
| ZA200706804B (en) * | 2005-02-03 | 2008-10-29 | Gen Hospital Corp | Method for treating gefitinib resistant cancer |
| CN101193905B (zh) | 2005-02-11 | 2014-06-25 | 纪念斯隆-凯特林癌症中心 | 用于检测抗药egfr突变体的方法和组合物 |
| EA013617B1 (ru) | 2005-02-24 | 2010-06-30 | Амген Инк. | Мутации рецептора эпидермального фактора роста |
| GB0506670D0 (en) * | 2005-04-01 | 2005-05-11 | Astrazeneca Ab | Method |
| GB2424886A (en) * | 2005-04-04 | 2006-10-11 | Dxs Ltd | Polynucleotide primers against epidermal growth factor receptor and method of detecting gene mutations |
| EP2594631A1 (en) | 2005-04-05 | 2013-05-22 | Cellpoint Diagnostics | Devices and method for detecting circulating tumor cells and other particles |
| CA2646257A1 (en) * | 2005-04-14 | 2006-10-26 | Wyeth | Use of an epidermal growth factor receptor kinase inhibitor (egfr) in gefitinib resistant patients |
| US20090202989A1 (en) * | 2005-06-28 | 2009-08-13 | Hillan Kenneth J | Egfr and kras mutations |
| WO2007039705A1 (en) * | 2005-10-05 | 2007-04-12 | Astrazeneca Uk Limited | Method to predict or monitor the response of a patient to an erbb receptor drug |
| CA2626326C (en) | 2005-11-04 | 2021-02-16 | Wyeth | Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272 |
| PT1948180E (pt) * | 2005-11-11 | 2013-05-10 | Boehringer Ingelheim Int | Tratamento de combinação de cancro compreendendo inibidores de egfr/her2 |
| JP5688877B2 (ja) | 2005-11-11 | 2015-03-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 癌疾患の治療用キナゾリン誘導体 |
| WO2007099852A1 (ja) * | 2006-02-23 | 2007-09-07 | National University Corporation Kanazawa University | 固形癌のチロシンキナーゼ阻害剤に対する感受性を検査する方法及び検査キット |
| US7736905B2 (en) * | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
| US7906342B2 (en) | 2006-03-31 | 2011-03-15 | Biodesix, Inc. | Monitoring treatment of cancer patients with drugs targeting EGFR pathway using mass spectrometry of patient samples |
| US7867775B2 (en) * | 2006-03-31 | 2011-01-11 | Biodesix, Inc. | Selection of head and neck cancer patients for treatment with drugs targeting EGFR pathway |
| EP2032982B1 (en) | 2006-05-05 | 2012-08-29 | Yale University | Use of subcellular localization profiles as prognostic or predictive indicators |
| CN103424541B (zh) * | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
| US12366585B2 (en) | 2006-05-18 | 2025-07-22 | Caris Mpi, Inc. | Molecular profiling of tumors |
| US8768629B2 (en) * | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| AU2007260676A1 (en) | 2006-06-14 | 2007-12-21 | Artemis Health, Inc. | Rare cell analysis using sample splitting and DNA tags |
| EP2589668A1 (en) | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| CA2657324A1 (en) * | 2006-07-13 | 2008-01-17 | Yale University | Methods for making cancer prognoses based on subcellular localization of biomarkers |
| CA2663599A1 (en) * | 2006-09-18 | 2008-03-27 | Boehringer Ingelheim International Gmbh | Method for treating cancer harboring egfr mutations |
| EP2063265B1 (en) * | 2006-09-28 | 2022-12-14 | Shimadzu Corporation | Method of preparing sample for matrix-assisted laser desorption ionization mass spectrometry and matrix-assisted laser desorption ionization mass spectrometry |
| JP4795203B2 (ja) * | 2006-11-13 | 2011-10-19 | シスメックス株式会社 | アンスラサイクリン系抗癌剤の感受性判定方法及びそのシステム |
| CN104013956B (zh) | 2007-01-25 | 2018-12-18 | 达娜-法勃肿瘤研究所公司 | 抗egfr抗体在治疗egfr突变体介导的疾病中的用途 |
| BRPI0808055A2 (pt) * | 2007-02-16 | 2013-07-30 | Merrimack Pharmaceuticals Inc | anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, composiÇço, Ácido nucleico isolado, vetor de expressço, cÉlula hospedeira, hibridoma, kit, uso de um anticorpo monoclonal isolado ou porÇço do mesmo que se liga ao antÍgeno, mÉtodo para diagnosticar um cÂncer associado com erbb3 em um paciente, e, anticorpo |
| LT2465950T (lt) | 2007-03-13 | 2017-10-10 | Amgen Inc. | K-ras mutacijos ir anti-egfr antikūnų terapija |
| SI2412828T1 (sl) * | 2007-03-13 | 2013-10-30 | Amgen Inc. | Mutacije k-ras in b-raf ter terapija s protitelesom anti-egfr |
| CA2680854C (en) | 2007-03-15 | 2017-02-14 | Ludwig Institute For Cancer Research | Treatment method using egfr antibodies and src inhibitors and related formulations |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US8999634B2 (en) | 2007-04-27 | 2015-04-07 | Quest Diagnostics Investments Incorporated | Nucleic acid detection combining amplification with fragmentation |
| EA200971049A1 (ru) * | 2007-05-11 | 2010-04-30 | Сантарис Фарма А/С | Антагонисты phk и их применение для модуляции her3 |
| WO2009005715A1 (en) * | 2007-06-29 | 2009-01-08 | Yale University | Methods for a predictive diagnostic test for tamoxifen |
| CN108424454B (zh) | 2007-08-14 | 2022-05-31 | 路德维格癌症研究所有限公司 | 靶向egf受体的单克隆抗体175及其衍生物和用途 |
| US8022216B2 (en) | 2007-10-17 | 2011-09-20 | Wyeth Llc | Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof |
| DK2245199T3 (da) | 2008-02-01 | 2014-02-03 | Gen Hospital Corp | Anvendelse af mikrovesikler i diagnosticering, prognosticering og behandling af medicinske sygdomme og tilstande |
| CN102066573A (zh) * | 2008-04-03 | 2011-05-18 | 哈森阿尔法生物技术研究院 | 用于扩增多个靶标的扩增子拯救多重聚合酶链式反应 |
| US8137919B2 (en) * | 2008-04-10 | 2012-03-20 | Montefiore Medical Center | Method of determining the sensitivity of cancer cells to EGFR inhibitors including cetuximab, panitumumab and erlotinib |
| CN101445829B (zh) * | 2008-04-23 | 2013-06-05 | 广州益善生物技术有限公司 | Egfr基因突变位点的检测探针、液相芯片及其检测方法 |
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