DK2379734T3 - Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A - Google Patents
Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A Download PDFInfo
- Publication number
- DK2379734T3 DK2379734T3 DK09795862.3T DK09795862T DK2379734T3 DK 2379734 T3 DK2379734 T3 DK 2379734T3 DK 09795862 T DK09795862 T DK 09795862T DK 2379734 T3 DK2379734 T3 DK 2379734T3
- Authority
- DK
- Denmark
- Prior art keywords
- fermentation culture
- streptococcus pneumoniae
- molecular weight
- fermentation
- hours
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Claims (11)
1
1. Fremgangsmåde til fremstilling af en opløsning indeholdende isolerede kapselpolysaccharider med høj molekylvægt af typen Streptococcus pneumoniae serotype 19A, hvor fremgangsmåden omfatter: a) at fremstille en fermenteringskultur af Streptococcus pneumoniae-bakterieceller, der producerer kapselpolysaccharider serotype 19A; b) at fermentere fermenteringskulturen i mindre end 6 timer; c) at lysere bakteriecellerne i fermenteringskulturen; og d) at isolere kapselpolysaccharider af typen Streptococcus pneumoniae serotype 19A fra fermenteringskulturen, hvor det isolerede kapselpolysaccharid med høj molekylvægt af typen Streptococcus pneumoniae serotype 19A har en molekylvægt på mindst 480 kD.
2. Fremgangsmåde ifølge krav 1, der yderligere omfatter tilførsel af CO2 til fermenteringskulturen.
3. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter tilsætning af bicarbonation (HCO3') til fermenteringskulturen.
4. Fremgangsmåde ifølge krav 3, hvor tilsætningen af HCO3' til fermenteringskulturen omfatter tilsætning af NaHC03.
5. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter tilsætning af bicarbonation (CO32') til fermenteringskulturen.
6. Fremgangsmåde ifølge krav 5, hvor tilsætningen af CO32' til fermenteringskulturen omfatter tilsætning af Na2CC>3.
7. Fremgangsmåde ifølge krav 2, hvor tilsætning af CO2 til fermenteringskulturen omfatter en første tilsætning af NaHCC>3 og en anden tilsætning af Na2CC>3.
8. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter overdækning af fermenteringskulturen med CO2. 2
9. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mindre end 5 timer.
10. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mindre end 4 timer.
11. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mellem 3 timer og mindre end 6 timer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13856308P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2379734T3 true DK2379734T3 (da) | 2018-04-23 |
Family
ID=42266457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09795862.3T DK2379734T3 (da) | 2008-12-18 | 2009-12-17 | Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8795689B2 (da) |
| EP (1) | EP2379734B1 (da) |
| JP (1) | JP5843612B2 (da) |
| KR (2) | KR20110091546A (da) |
| CN (1) | CN102257155B (da) |
| AU (1) | AU2009335826B2 (da) |
| BR (1) | BRPI0922981A8 (da) |
| CA (1) | CA2743710C (da) |
| DK (1) | DK2379734T3 (da) |
| ES (1) | ES2666698T3 (da) |
| HK (1) | HK1163750A1 (da) |
| HU (1) | HUE037465T2 (da) |
| IL (1) | IL213169A (da) |
| MX (1) | MX2011006432A (da) |
| PL (1) | PL2379734T3 (da) |
| PT (1) | PT2379734T (da) |
| RU (1) | RU2511404C2 (da) |
| SI (1) | SI2379734T1 (da) |
| WO (1) | WO2010080486A2 (da) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE046859T2 (hu) * | 2008-12-18 | 2020-03-30 | Wyeth Llc | Eljárás Streptococcus pneumoniae poliszacharid molekulatömegének szabályozására szén alkalmazásával |
| BRPI1014494A2 (pt) | 2009-04-30 | 2016-08-02 | Coley Pharm Group Inc | vacina pneumocócica e usos da mesma |
| MX348547B (es) * | 2011-12-15 | 2017-06-19 | Serum Inst India Ltd | Nuevo proceso para cultivar bacterias para el mejoramiento del rendimiento de las poliosas capsulares. |
| EP2894225B1 (en) | 2012-09-07 | 2017-11-22 | SK Chemicals Co., Ltd. | Production method for capsular polysaccharide having pneumococcal serotype |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN118662649A (zh) | 2016-12-30 | 2024-09-20 | Vaxcyte公司 | 具有非天然氨基酸的多肽-抗原缀合物 |
| US11197921B2 (en) | 2017-01-31 | 2021-12-14 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
| WO2018156491A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| US10688170B2 (en) | 2017-06-10 | 2020-06-23 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| JP7218358B2 (ja) | 2017-09-07 | 2023-02-06 | メルク・シャープ・アンド・ドーム・エルエルシー | 肺炎球菌多糖体および免疫原性多糖体－キャリアタンパク質コンジュゲートでのその使用 |
| CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| TWI725359B (zh) | 2017-12-06 | 2021-04-21 | 美商默沙東藥廠 | 包含肺炎鏈球菌多醣-蛋白結合物之組合物及其使用方法 |
| KR20190121713A (ko) * | 2018-04-18 | 2019-10-28 | 에스케이바이오사이언스(주) | 스트렙토코커스 뉴모니애 협막 다당류 및 그의 면역원성 접합체 |
| EP3788143B1 (en) | 2018-04-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
| US20210252125A1 (en) | 2018-04-30 | 2021-08-19 | Merck Sharp & Dohme Corp. | Methods for producing streptococcus pneumoniae capsular polysaccharide carrier protein conjugates |
| JOP20210148A1 (ar) | 2018-12-19 | 2023-01-30 | Merck Sharp & Dohme | تركيبات تشتمل على متقارنات بولي سكاريد-بروتين للمكورات العقدية الرئوية وطرق استخدامها |
| JP2023537945A (ja) | 2020-08-10 | 2023-09-06 | インベントプライズ・インコーポレイテッド | 出現血清型２４ｆを含む多価肺炎球菌複合糖質ワクチン |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US4686102A (en) | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| CA2059693C (en) * | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| US5314822A (en) * | 1992-10-15 | 1994-05-24 | Merck & Co., Inc. | Method of clonal growth of Streptococcus pneumoniae |
| US5714354A (en) | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
| US6146902A (en) | 1998-12-29 | 2000-11-14 | Aventis Pasteur, Inc. | Purification of polysaccharide-protein conjugate vaccines by ultrafiltration with ammonium sulfate solutions |
| PT1268844E (pt) * | 2000-03-16 | 2009-11-03 | Philadelphia Children Hospital | Modulação da produção de polissacáridos capsulares de pneumococos |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ITTS20010013A1 (it) | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| ATE460498T1 (de) | 2003-09-11 | 2010-03-15 | Staat Der Nederlanden Vert Doo | Verfahren zur herstellung eines kapselpolysaccharids zur verwendung in konjugat- impfstoffen |
| EP2425855A1 (en) | 2005-04-08 | 2012-03-07 | Wyeth LLC | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7709001B2 (en) | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| US7955605B2 (en) | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| DK3466982T3 (da) * | 2005-04-08 | 2020-08-03 | Wyeth Llc | Separation af forurenende kontaminanter fra streptococcus pneumoniae-polysaccharid ved ph-manipulation |
| US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| ATE473289T1 (de) | 2006-10-10 | 2010-07-15 | Wyeth Llc | Verbesserte verfahren zur trennung von streptococcus pneumoniae-3-polysacchariden |
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| CA2681570C (en) * | 2007-03-23 | 2016-05-03 | Wyeth | Shortened purification process for the production of capsular streptococcus pneumoniae polysaccharides |
| HUE046859T2 (hu) | 2008-12-18 | 2020-03-30 | Wyeth Llc | Eljárás Streptococcus pneumoniae poliszacharid molekulatömegének szabályozására szén alkalmazásával |
-
2009
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en active Application Filing
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Application Discontinuation
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active IP Right Grant
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/da active
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
-
2012
- 2012-04-24 HK HK12104021.1A patent/HK1163750A1/zh not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2743710C (en) | 2017-01-24 |
| IL213169A (en) | 2015-02-26 |
| EP2379734A2 (en) | 2011-10-26 |
| ES2666698T3 (es) | 2018-05-07 |
| IL213169A0 (en) | 2011-07-31 |
| WO2010080486A3 (en) | 2010-11-04 |
| PL2379734T3 (pl) | 2018-08-31 |
| EP2379734B1 (en) | 2018-03-21 |
| PT2379734T (pt) | 2018-04-27 |
| HUE037465T2 (hu) | 2018-09-28 |
| RU2511404C2 (ru) | 2014-04-10 |
| MX2011006432A (es) | 2011-09-29 |
| BRPI0922981A8 (pt) | 2019-11-26 |
| AU2009335826A1 (en) | 2010-07-15 |
| KR20130136011A (ko) | 2013-12-11 |
| JP5843612B2 (ja) | 2016-01-13 |
| KR20110091546A (ko) | 2011-08-11 |
| CA2743710A1 (en) | 2010-07-15 |
| BRPI0922981A2 (pt) | 2015-08-25 |
| SI2379734T1 (en) | 2018-05-31 |
| RU2011128564A (ru) | 2013-01-27 |
| CN102257155B (zh) | 2016-03-02 |
| KR101593770B1 (ko) | 2016-02-15 |
| US20100158953A1 (en) | 2010-06-24 |
| WO2010080486A2 (en) | 2010-07-15 |
| US8795689B2 (en) | 2014-08-05 |
| CN102257155A (zh) | 2011-11-23 |
| JP2012512660A (ja) | 2012-06-07 |
| AU2009335826B2 (en) | 2013-10-31 |
| HK1163750A1 (zh) | 2012-09-14 |
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