DK2379734T3 - Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A - Google Patents
Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A Download PDFInfo
- Publication number
- DK2379734T3 DK2379734T3 DK09795862.3T DK09795862T DK2379734T3 DK 2379734 T3 DK2379734 T3 DK 2379734T3 DK 09795862 T DK09795862 T DK 09795862T DK 2379734 T3 DK2379734 T3 DK 2379734T3
- Authority
- DK
- Denmark
- Prior art keywords
- fermentation culture
- streptococcus pneumoniae
- molecular weight
- fermentation
- hours
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Claims (11)
1
1. Fremgangsmåde til fremstilling af en opløsning indeholdende isolerede kapselpolysaccharider med høj molekylvægt af typen Streptococcus pneumoniae serotype 19A, hvor fremgangsmåden omfatter: a) at fremstille en fermenteringskultur af Streptococcus pneumoniae-bakterieceller, der producerer kapselpolysaccharider serotype 19A; b) at fermentere fermenteringskulturen i mindre end 6 timer; c) at lysere bakteriecellerne i fermenteringskulturen; og d) at isolere kapselpolysaccharider af typen Streptococcus pneumoniae serotype 19A fra fermenteringskulturen, hvor det isolerede kapselpolysaccharid med høj molekylvægt af typen Streptococcus pneumoniae serotype 19A har en molekylvægt på mindst 480 kD.
2. Fremgangsmåde ifølge krav 1, der yderligere omfatter tilførsel af CO2 til fermenteringskulturen.
3. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter tilsætning af bicarbonation (HCO3') til fermenteringskulturen.
4. Fremgangsmåde ifølge krav 3, hvor tilsætningen af HCO3' til fermenteringskulturen omfatter tilsætning af NaHC03.
5. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter tilsætning af bicarbonation (CO32') til fermenteringskulturen.
6. Fremgangsmåde ifølge krav 5, hvor tilsætningen af CO32' til fermenteringskulturen omfatter tilsætning af Na2CC>3.
7. Fremgangsmåde ifølge krav 2, hvor tilsætning af CO2 til fermenteringskulturen omfatter en første tilsætning af NaHCC>3 og en anden tilsætning af Na2CC>3.
8. Fremgangsmåde ifølge krav 2, hvor tilførslen af CO2 til fermenteringskulturen omfatter overdækning af fermenteringskulturen med CO2. 2
9. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mindre end 5 timer.
10. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mindre end 4 timer.
11. Fremgangsmåde ifølge et af kravene 1 til 8, hvor fermenteringskulturen fermenteres i mellem 3 timer og mindre end 6 timer.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13856308P | 2008-12-18 | 2008-12-18 | |
| PCT/US2009/068429 WO2010080486A2 (en) | 2008-12-18 | 2009-12-17 | Method for controlling streptococcus pneumoniae serotype 19a polysaccharide molecular weight |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2379734T3 true DK2379734T3 (da) | 2018-04-23 |
Family
ID=42266457
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09795862.3T DK2379734T3 (da) | 2008-12-18 | 2009-12-17 | Fremgangsmåde til at styre molekylvægten af polysaccharid af streptococcus pneumoniae serotype 19A |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8795689B2 (da) |
| EP (1) | EP2379734B1 (da) |
| JP (1) | JP5843612B2 (da) |
| KR (2) | KR101593770B1 (da) |
| CN (1) | CN102257155B (da) |
| AU (1) | AU2009335826B2 (da) |
| BR (1) | BRPI0922981A8 (da) |
| CA (1) | CA2743710C (da) |
| DK (1) | DK2379734T3 (da) |
| ES (1) | ES2666698T3 (da) |
| HK (1) | HK1163750A1 (da) |
| HU (1) | HUE037465T2 (da) |
| IL (1) | IL213169A (da) |
| MX (1) | MX2011006432A (da) |
| PL (1) | PL2379734T3 (da) |
| PT (1) | PT2379734T (da) |
| RU (1) | RU2511404C2 (da) |
| SI (1) | SI2379734T1 (da) |
| WO (1) | WO2010080486A2 (da) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102257127B (zh) * | 2008-12-18 | 2014-01-01 | 惠氏有限责任公司 | 使用二氧化碳控制肺炎链球菌多糖分子量的方法 |
| KR101450958B1 (ko) | 2009-04-30 | 2014-10-15 | 콜레이 파마시티컬 그룹, 인코포레이티드 | 폐렴구균 백신 및 그의 용도 |
| BR112014014656B1 (pt) * | 2011-12-15 | 2020-03-17 | Serum Institute Of India Ltd. | Método de cultivo de bactérias para produção volumétrica superior de polioses capsulares em comparação com a fermentação em batelada |
| JP5905649B2 (ja) | 2012-09-07 | 2016-04-20 | エスケー ケミカルズ カンパニー, リミテッドSk Chemicals Co., Ltd. | 肺炎球菌血清型を有する莢膜多糖類の製造方法 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| CN110225764A (zh) | 2017-01-31 | 2019-09-10 | 默沙东公司 | 制备多糖-蛋白缀合物的方法 |
| WO2018156491A1 (en) | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Enhancing immunogenicity of streptococcus pneumoniae polysaccharide-protein conjugates |
| WO2018227177A1 (en) | 2017-06-10 | 2018-12-13 | Inventprise, Llc | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| MX2020002556A (es) * | 2017-09-07 | 2020-07-13 | Merck Sharp & Dohme | Polisacaridos neumococicos y su uso en conjugados de polisacarido inmunogenico con proteina transportadora. |
| US11395849B2 (en) | 2017-09-07 | 2022-07-26 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
| CN111683678B (zh) | 2017-12-06 | 2024-01-26 | 默沙东有限责任公司 | 包含肺炎链球菌多糖蛋白缀合物的组合物及其使用方法 |
| CA3096358A1 (en) * | 2018-04-18 | 2019-10-24 | Sk Bioscience Co., Ltd. | Streptococcus pneumoniae capsular polysaccharide and immunogenic conjugate thereof |
| KR20210002641A (ko) | 2018-04-30 | 2021-01-08 | 머크 샤프 앤드 돔 코포레이션 | 디메틸술폭시드 중의 동결건조된 돌연변이체 디프테리아 독소의 균질 용액을 제공하는 방법 |
| TWI788610B (zh) | 2018-12-19 | 2023-01-01 | 美商默沙東有限責任公司 | 包含肺炎鏈球菌多醣-蛋白質結合物之組合物及其使用方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CA1115210A (en) | 1977-11-28 | 1981-12-29 | Dennis J. Carlo | Pneumococcal vaccine |
| US4221906A (en) * | 1979-03-19 | 1980-09-09 | American Cyanamid Company | Stabilization of pneumococcal polysaccharides |
| US4242501A (en) | 1979-08-08 | 1980-12-30 | American Cyanamid Company | Purification of pneumococcal capsular polysaccharides |
| FR2495939B1 (fr) | 1980-12-11 | 1985-10-11 | Merieux Inst | Procede de purification de polyosides de streptococcus pneumoniae et vaccin a base de polyosides ainsi purifies |
| BE889979A (fr) | 1981-08-14 | 1982-02-15 | Smith Kline Rit | Procede de preparation de polysaccharides bacteriens capsulaires antigeniques purifies, produits obtenus et leur utilisation |
| US4686102A (en) * | 1984-04-12 | 1987-08-11 | American Cyanamid Company | Multivalent pneumococcal vaccine and preparation thereof |
| CA2059693C (en) | 1991-01-28 | 2003-08-19 | Peter J. Kniskern | Polysaccharide antigens from streptococcus pneumoniae |
| CA2059692C (en) * | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
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| US5714354A (en) * | 1995-06-06 | 1998-02-03 | American Home Products Corporation | Alcohol-free pneumococcal polysaccharide purification process |
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| PT1268844E (pt) * | 2000-03-16 | 2009-11-03 | Philadelphia Children Hospital | Modulação da produção de polissacáridos capsulares de pneumococos |
| US6743610B2 (en) * | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| ITTS20010013A1 (it) | 2001-06-04 | 2002-12-04 | Ct Ricerche Poly Tec H A R L S | Nuovi derivati di ialuronano. |
| CA2538691C (en) * | 2003-09-11 | 2014-01-14 | Nederlands Vaccininstituut | Process for producing polysaccharide for conjugate vaccine |
| US7709001B2 (en) * | 2005-04-08 | 2010-05-04 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
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| US7955605B2 (en) * | 2005-04-08 | 2011-06-07 | Wyeth Llc | Multivalent pneumococcal polysaccharide-protein conjugate composition |
| EP3466982B1 (en) | 2005-04-08 | 2020-06-17 | Wyeth LLC | Separation of contaminants from streptococcus pneumoniae polysaccharide by ph manipulation |
| KR20150061019A (ko) * | 2005-04-08 | 2015-06-03 | 와이어쓰 엘엘씨 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| GB0522303D0 (en) * | 2005-11-01 | 2005-12-07 | Chiron Srl | Culture method |
| PT2074221E (pt) * | 2006-10-10 | 2010-09-06 | Wyeth Llc | Métodos melhorados para a separação de polissacáridos tipo 3 de streptococcus pneumoniae |
| US7860500B2 (en) * | 2006-10-27 | 2010-12-28 | Motorola, Inc. | Method and apparatus for determining appropriate channels for communication |
| PL3406635T3 (pl) * | 2007-03-23 | 2022-08-22 | Wyeth Llc | Skrócony sposób oczyszczania do wytwarzania polisacharydów otoczkowych Streptococcus pneumoniae |
| CN102257127B (zh) * | 2008-12-18 | 2014-01-01 | 惠氏有限责任公司 | 使用二氧化碳控制肺炎链球菌多糖分子量的方法 |
-
2009
- 2009-12-17 PT PT97958623T patent/PT2379734T/pt unknown
- 2009-12-17 EP EP09795862.3A patent/EP2379734B1/en active Active
- 2009-12-17 BR BRPI0922981-7 patent/BRPI0922981A8/pt not_active Application Discontinuation
- 2009-12-17 RU RU2011128564/10A patent/RU2511404C2/ru active
- 2009-12-17 CN CN200980150879.5A patent/CN102257155B/zh active Active
- 2009-12-17 ES ES09795862.3T patent/ES2666698T3/es active Active
- 2009-12-17 HU HUE09795862A patent/HUE037465T2/hu unknown
- 2009-12-17 PL PL09795862T patent/PL2379734T3/pl unknown
- 2009-12-17 JP JP2011542425A patent/JP5843612B2/ja active Active
- 2009-12-17 AU AU2009335826A patent/AU2009335826B2/en active Active
- 2009-12-17 US US12/640,769 patent/US8795689B2/en active Active
- 2009-12-17 KR KR1020137031507A patent/KR101593770B1/ko active IP Right Grant
- 2009-12-17 DK DK09795862.3T patent/DK2379734T3/da active
- 2009-12-17 SI SI200931830T patent/SI2379734T1/en unknown
- 2009-12-17 KR KR1020117013836A patent/KR20110091546A/ko not_active Application Discontinuation
- 2009-12-17 WO PCT/US2009/068429 patent/WO2010080486A2/en active Application Filing
- 2009-12-17 MX MX2011006432A patent/MX2011006432A/es active IP Right Grant
- 2009-12-17 CA CA2743710A patent/CA2743710C/en active Active
-
2011
- 2011-05-26 IL IL213169A patent/IL213169A/en active IP Right Grant
-
2012
- 2012-04-24 HK HK12104021.1A patent/HK1163750A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0922981A8 (pt) | 2019-11-26 |
| SI2379734T1 (en) | 2018-05-31 |
| WO2010080486A3 (en) | 2010-11-04 |
| MX2011006432A (es) | 2011-09-29 |
| CN102257155B (zh) | 2016-03-02 |
| ES2666698T3 (es) | 2018-05-07 |
| JP2012512660A (ja) | 2012-06-07 |
| CN102257155A (zh) | 2011-11-23 |
| KR20110091546A (ko) | 2011-08-11 |
| IL213169A (en) | 2015-02-26 |
| US8795689B2 (en) | 2014-08-05 |
| EP2379734B1 (en) | 2018-03-21 |
| AU2009335826B2 (en) | 2013-10-31 |
| CA2743710C (en) | 2017-01-24 |
| KR20130136011A (ko) | 2013-12-11 |
| KR101593770B1 (ko) | 2016-02-15 |
| EP2379734A2 (en) | 2011-10-26 |
| RU2011128564A (ru) | 2013-01-27 |
| BRPI0922981A2 (pt) | 2015-08-25 |
| PT2379734T (pt) | 2018-04-27 |
| RU2511404C2 (ru) | 2014-04-10 |
| PL2379734T3 (pl) | 2018-08-31 |
| IL213169A0 (en) | 2011-07-31 |
| JP5843612B2 (ja) | 2016-01-13 |
| HK1163750A1 (zh) | 2012-09-14 |
| HUE037465T2 (hu) | 2018-09-28 |
| WO2010080486A2 (en) | 2010-07-15 |
| CA2743710A1 (en) | 2010-07-15 |
| US20100158953A1 (en) | 2010-06-24 |
| AU2009335826A1 (en) | 2010-07-15 |
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