DK2341937T3 - Composition for the treatment of a disease - Google Patents
Composition for the treatment of a disease Download PDFInfo
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- DK2341937T3 DK2341937T3 DK09782400.7T DK09782400T DK2341937T3 DK 2341937 T3 DK2341937 T3 DK 2341937T3 DK 09782400 T DK09782400 T DK 09782400T DK 2341937 T3 DK2341937 T3 DK 2341937T3
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| JP5604311B2 (ja) * | 2008-03-13 | 2014-10-08 | バイオテスト・アクチエンゲゼルシヤフト | 疾患治療剤 |
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| EP3019193B1 (en) * | 2013-07-10 | 2019-09-25 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Apoptotic cell-mediated induction of antigen specific regulatory t-cells for the therapy of autoimmune diseases in animals and humans |
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| US20020068057A1 (en) * | 1994-03-10 | 2002-06-06 | Marc Feldmann | Treatment of autoimmune and inflammatory disorders |
| US20010056066A1 (en) * | 1996-07-26 | 2001-12-27 | Smithkline Beecham Corporation | Method of treating immune cell mediated systemic diseases |
| DE19722888A1 (de) * | 1997-05-28 | 1998-12-03 | Thomas Prof Dr Huenig | Human-CD28 spezifische monoklonale Antikörper zur antigenunspezifischen Aktivierung von T-Lymphozyten |
| WO2000074718A1 (en) * | 1999-06-09 | 2000-12-14 | Immunomedics, Inc. | Immunotherapy of autoimmune disorders using antibodies which target b-cells |
| AU2001275186A1 (en) * | 2000-06-02 | 2001-12-17 | Nicole Kirchhof | Immunotherapeutic method to prevent islet cell rejection |
| CN1592645A (zh) * | 2000-09-18 | 2005-03-09 | 拜奥根Idec公司 | 使用b细胞耗尽/免疫调节抗体组合治疗自身免疫病的联合疗法 |
| DE10050935A1 (de) * | 2000-10-11 | 2002-05-02 | Tegenero Gmbh | Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen |
| EP2314293B1 (en) * | 2001-01-16 | 2017-01-04 | Vascular Therapies, LLC | Implantable device containing resorbable matrix material and rapamycin for preventing or treating vasuloproliferative diseases |
| EP1372721A4 (en) * | 2001-03-07 | 2008-04-02 | Childrens Medical Center | METHOD FOR SCREENING PEPTIDE DISPLAY LIBRARIES WITH A MINIMUM DISPLAY |
| AU2002316855B2 (en) * | 2001-04-24 | 2008-03-13 | Merck Patent Gmbh | Combination therapy using anti-angiogenic agents and TNFalpha |
| US7541443B2 (en) * | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
| EP1451224B1 (de) * | 2001-12-04 | 2012-08-15 | TheraMAB LLC | Peptid oder protein enthaltend ein c'-d loop der cd28 rezeptorfamilie |
| DE10212108A1 (de) * | 2002-03-13 | 2003-10-02 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung |
| DE10230223A1 (de) * | 2002-07-04 | 2004-01-22 | Tegenero Ag | Mikropartikel mit CD28-spezifischen monoklonalen Antikörpern |
| US7501494B2 (en) * | 2003-01-15 | 2009-03-10 | United Biomedical, Inc. | Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection |
| EP1460088A1 (en) * | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
| HRP20090325T1 (en) * | 2003-04-09 | 2009-07-31 | Genentech | Therapy of autoimmune disease in a patient with an inadequate response to a tnf-alpha inhibitor |
| GB0314461D0 (en) * | 2003-06-20 | 2003-07-23 | Isis Innovation | Suppression of transplant rejection |
| EP1600164A3 (de) * | 2003-09-22 | 2006-05-17 | TeGenero AG | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer Pharmazeutischen Zusammensetzung mit dosisabhängiger Wirkung |
| DE10352900A1 (de) * | 2003-11-11 | 2005-06-16 | Tegenero Ag | Verwendung einer an CD28 bindenden Wirksubstanz zur Herstellung einer pharmazeutischen Zusammensetzung zur Behandlung von B-CLL |
| EP1797882A4 (en) * | 2004-09-29 | 2009-11-18 | Kowa Co | PREVENTIVE AND / OR THERAPEUTIC MEDICAMENT FOR RHEUMATOID ARTHRITIS |
| DE102004063494A1 (de) * | 2004-12-23 | 2006-07-13 | Tegenero Ag | Antikörper |
| JP4730733B2 (ja) * | 2005-05-02 | 2011-07-20 | 国立大学法人京都大学 | ４型葉酸受容体の発現を指標とした制御性ｔ細胞の検出方法、及び免疫賦活剤 |
| SG163615A1 (en) * | 2005-07-11 | 2010-08-30 | Macrogenics Inc | Methods for the treatment of autoimmune disorders using immunosuppressive monoclonal antibodies with reduced toxicity |
| WO2007031875A2 (en) * | 2005-08-26 | 2007-03-22 | Glycart Biotechnology Ag | Modified antigen binding molecules with altered cell signaling activity |
| KR20080112300A (ko) * | 2006-03-16 | 2008-12-24 | 제넨테크, 인크. | Ｃｄ4 항체를 사용하여 루푸스를 치료하는 방법 |
| JP5604311B2 (ja) | 2008-03-13 | 2014-10-08 | バイオテスト・アクチエンゲゼルシヤフト | 疾患治療剤 |
| KR20100135807A (ko) * | 2008-03-13 | 2010-12-27 | 바이오테스트 아게 | 질병 치료제 |
| CA2718184A1 (en) * | 2008-03-13 | 2009-10-08 | Biotest Ag | Agent for treating disease |
| ES2351456B1 (es) * | 2009-06-24 | 2011-11-28 | Fundacio Institut De Recerca De L'hospital Universitari Vall D'hebron | Metodo in vitro para el pronostico o prediccion de la respuesta por parte de pacientes con artritis reumatoide al tratamiento con agentes que reconocen el receptor de membrana cd20 de los linfocitos b |
-
2009
- 2009-08-31 RU RU2011117293/10A patent/RU2531548C2/ru not_active IP Right Cessation
- 2009-08-31 KR KR1020117009215A patent/KR20110061630A/ko not_active Ceased
- 2009-08-31 ES ES09782400.7T patent/ES2528419T3/es active Active
- 2009-08-31 CA CA2738598A patent/CA2738598C/en active Active
- 2009-08-31 CN CN200980143326.7A patent/CN102215867B/zh not_active Expired - Fee Related
- 2009-08-31 AU AU2009296078A patent/AU2009296078B2/en not_active Ceased
- 2009-08-31 PT PT97824007T patent/PT2341937E/pt unknown
- 2009-08-31 DK DK09782400.7T patent/DK2341937T3/en active
- 2009-08-31 SG SG2013070859A patent/SG194362A1/en unknown
- 2009-08-31 JP JP2011528278A patent/JP2012504110A/ja active Pending
- 2009-08-31 BR BRPI0919489A patent/BRPI0919489A2/pt not_active IP Right Cessation
- 2009-08-31 WO PCT/EP2009/061210 patent/WO2010034590A1/en not_active Ceased
- 2009-08-31 MX MX2011003335A patent/MX2011003335A/es active IP Right Grant
-
2011
- 2011-03-24 IL IL211904A patent/IL211904A/en not_active IP Right Cessation
- 2011-03-29 US US13/074,357 patent/US20110229465A1/en not_active Abandoned
- 2011-04-29 CR CR20110226A patent/CR20110226A/es not_active Application Discontinuation
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2015
- 2015-05-13 JP JP2015097888A patent/JP6154847B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010034590A1 (en) | 2010-04-01 |
| CA2738598A1 (en) | 2010-04-01 |
| BRPI0919489A2 (pt) | 2015-12-01 |
| CN102215867B (zh) | 2017-04-19 |
| AU2009296078A1 (en) | 2010-04-01 |
| IL211904A (en) | 2016-03-31 |
| JP2012504110A (ja) | 2012-02-16 |
| CA2738598C (en) | 2017-11-21 |
| CR20110226A (es) | 2011-12-05 |
| KR20110061630A (ko) | 2011-06-09 |
| AU2009296078B2 (en) | 2015-08-20 |
| HK1154797A1 (en) | 2012-05-04 |
| JP6154847B2 (ja) | 2017-06-28 |
| JP2015172060A (ja) | 2015-10-01 |
| ES2528419T3 (es) | 2015-02-09 |
| RU2531548C2 (ru) | 2014-10-20 |
| MX2011003335A (es) | 2011-04-27 |
| US20110229465A1 (en) | 2011-09-22 |
| PT2341937E (pt) | 2015-02-18 |
| RU2011117293A (ru) | 2012-11-10 |
| CN102215867A (zh) | 2011-10-12 |
| SG194362A1 (en) | 2013-11-29 |
| IL211904A0 (en) | 2011-06-30 |
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