DK2263653T3 - Anvendelse af en dual asymmetrisk centrifuge (DAZ) til fremstilling af lipidbaserede nanopartikler - Google Patents

Anvendelse af en dual asymmetrisk centrifuge (DAZ) til fremstilling af lipidbaserede nanopartikler

Info

Publication number
DK2263653T3
DK2263653T3 DK10178676.2T DK10178676T DK2263653T3 DK 2263653 T3 DK2263653 T3 DK 2263653T3 DK 10178676 T DK10178676 T DK 10178676T DK 2263653 T3 DK2263653 T3 DK 2263653T3
Authority
DK
Denmark
Prior art keywords
mixing container
lipid
substances
above method
axis
Prior art date
Application number
DK10178676.2T
Other languages
English (en)
Inventor
Ulrich Massing
Original Assignee
Ktb Tumorforschungs Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=34930147&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2263653(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ktb Tumorforschungs Gmbh filed Critical Ktb Tumorforschungs Gmbh
Application granted granted Critical
Publication of DK2263653T3 publication Critical patent/DK2263653T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6905Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
    • A61K47/6911Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
    • A61K47/6913Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/02Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/14Liposomes; Vesicles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1277Processes for preparing; Proliposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5192Processes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01FMIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F29/00Mixers with rotating receptacles
    • B01F29/10Mixers with rotating receptacles with receptacles rotated about two different axes, e.g. receptacles having planetary motion
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
DK10178676.2T 2004-12-23 2005-12-23 Anvendelse af en dual asymmetrisk centrifuge (DAZ) til fremstilling af lipidbaserede nanopartikler DK2263653T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04106939A EP1674081A1 (de) 2004-12-23 2004-12-23 Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge
EP05823526.8A EP1838286B2 (de) 2004-12-23 2005-12-23 Herstellung von lipidbasierten nanopartikeln unter einsatz einer dualen asymmetrischen zentrifuge

Publications (1)

Publication Number Publication Date
DK2263653T3 true DK2263653T3 (da) 2013-05-21

Family

ID=34930147

Family Applications (2)

Application Number Title Priority Date Filing Date
DK05823526.8T DK1838286T3 (da) 2004-12-23 2005-12-23 Fremstilling af lipidbaserede nanopartikler ved anvendelse af en dobbelt asymmetrisk centrifuge
DK10178676.2T DK2263653T3 (da) 2004-12-23 2005-12-23 Anvendelse af en dual asymmetrisk centrifuge (DAZ) til fremstilling af lipidbaserede nanopartikler

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK05823526.8T DK1838286T3 (da) 2004-12-23 2005-12-23 Fremstilling af lipidbaserede nanopartikler ved anvendelse af en dobbelt asymmetrisk centrifuge

Country Status (6)

Country Link
US (1) US10662060B2 (da)
EP (3) EP1674081A1 (da)
AT (1) ATE545409T1 (da)
DK (2) DK1838286T3 (da)
PL (2) PL2263653T3 (da)
WO (1) WO2006069985A2 (da)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020106511A1 (en) * 2000-12-01 2002-08-08 Novozymes A/S Encapsulation of compounds in vesicles
JP5571380B2 (ja) * 2006-07-24 2014-08-13 ルミナス バイオサイエンシズ,インコーポレイテッド オストワルド熟成を減少させた水不溶性の医薬品物質の固体ナノ粒子処方物
AR072777A1 (es) * 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
EP2601934A1 (en) 2009-01-22 2013-06-12 Ludwig-Maximilians-Universität München Vesicular phospholipid gels comprising proteinaceous substances
US20100273730A1 (en) * 2009-04-27 2010-10-28 Innopharmax, Inc. Self-emulsifying pharmaceutical compositions of hydrophilic drugs and preparation thereof
WO2011005714A2 (en) * 2009-07-07 2011-01-13 Alan Saven Bendamustine liposomal compositions
WO2012059936A1 (en) 2010-11-03 2012-05-10 Padma Venkitachalam Devarajan Pharmaceutical compositions for colloidal drug delivery
GB201021937D0 (en) 2010-12-24 2011-02-02 Reckitt & Colman Overseas Skin sanitizer compositions comprising alcohol based emulsion
US8871811B2 (en) 2011-02-07 2014-10-28 Professional Compounding Centers of America, Ltd Permeation enhancers for topical formulations
US8906397B2 (en) 2011-02-07 2014-12-09 Professional Compounding Centers of America, Ltd Permeation enhancers for topical formulations
US20120201871A1 (en) * 2011-02-07 2012-08-09 Professional Compounding Centers Of America, Ltd. Permeation enhancers with liposomes for topical formulations
JP6061343B2 (ja) * 2011-04-04 2017-01-18 学校法人早稲田大学 小胞体の製造方法
GB201116248D0 (en) * 2011-09-20 2011-11-02 Glaxosmithkline Biolog Sa Liposome production using isopropanol
US20130272963A1 (en) * 2012-04-12 2013-10-17 The Ohio State University Cholesterol Efflux Assay Probe Formulations, Methods of Making and Using
US20140120157A1 (en) * 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
DE102013000586B4 (de) * 2012-12-11 2014-12-04 Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh Zusammensetzung für die topische Anwendung
DE102012223340A1 (de) 2012-12-17 2014-06-18 Beiersdorf Ag Individuell auf den einzelnen Anwender zugeschnittene kosmetische Zubereitung und das Verfahren zur Herstellung derselben
BR112015022415A2 (pt) * 2013-03-13 2017-07-18 Mallinckrodt Llc composições de cisplatina lipossômica para terapia contra câncer
DE102013212642A1 (de) 2013-06-28 2014-12-31 Beiersdorf Ag Individuell zugeschnittene kosmetische Zubereitung mit Coenzym Q10 und das Verfahren zur Herstellung derselben
US9724657B2 (en) * 2013-10-22 2017-08-08 Tyme, Inc. High-speed centrifugal mixing devices and methods of use
WO2015148483A1 (en) * 2014-03-24 2015-10-01 University Of Mississippi Systems and methods for preparing solid lipid nanoparticles
US20170143629A1 (en) 2014-06-13 2017-05-25 Gert Fricker Matrix Stabilized Liposomes
WO2016045732A1 (en) * 2014-09-25 2016-03-31 Biontech Rna Pharmaceuticals Gmbh Stable formulations of lipids and liposomes
DE102015100613A1 (de) * 2015-01-16 2016-07-21 Andreas Hettich Gmbh & Co. Kg Rotor einer Dualen Zentrifuge
WO2017004518A1 (en) * 2015-07-02 2017-01-05 The Regents Of The University Of California Site-targeted nano-liposomal nitroglycerin therapeutics
AU2016298606A1 (en) 2015-07-27 2018-02-22 Augustus Biotarget, Inc. Immunotherapies for malignant, neurodegenerative and demyelinating diseases by the use of targeted nanocarriers
EP3372223B1 (en) * 2015-11-02 2024-04-17 FUJIFILM Corporation Liposome composition and method for producing same
CZ307681B6 (cs) 2016-02-29 2019-02-13 Ústav makromolekulární chemie AV ČR, v. v. i. Fotoaktivovatelná nanočástice pro fotodynamické aplikace, způsob její přípravy, farmaceutická kompozice ji obsahující a jejich použití
US10434084B2 (en) * 2016-11-29 2019-10-08 Scientific Holdings, Llc Cannabinoid blends and formulations, related methods
WO2019010521A1 (en) * 2017-07-14 2019-01-17 Flinders University Of South Australia THIN FILM VORTEX FLUID MANUFACTURING OF LIPOSOMES
CN109966250A (zh) * 2019-04-10 2019-07-05 浙江工业大学 一种羟基喜树碱类衍生物脂质体的制备方法
CA3136500A1 (en) * 2019-05-10 2020-11-19 Xellia Pharmaceuticals Aps Daptomycin aqueous formulations
NO20211141A1 (en) * 2019-05-10 2021-09-23 Landmark Graphics Corp Enhanced centrifuge for core sample analysis
US11534420B2 (en) 2019-05-14 2022-12-27 Tyme, Inc. Compositions and methods for treating cancer
EP4121011A1 (en) * 2020-03-20 2023-01-25 University Of Heidelberg Method for producing polymersomes
US10905698B1 (en) 2020-05-14 2021-02-02 Tyme, Inc. Methods of treating SARS-COV-2 infections
EP4046720A1 (en) 2021-02-22 2022-08-24 Bia Separations D.O.O. Centrifuge rotor, centrifuge or ultracentrifuge comprising centrifuge rotor, sample retraction needle, method for in-situ sample retraction from a centrifuge tube
WO2023275648A1 (en) 2021-06-30 2023-01-05 Novocure Gmbh Compositions and methods for using alternating electric fields to disrupt lipid capsules

Family Cites Families (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US300545A (en) * 1884-06-17 Centrifugal drainer
US895173A (en) * 1908-08-04 Frederic Ecaubert Mixing or separating machine.
US1011929A (en) * 1908-12-12 1911-12-19 Frederic Ecaubert Mixing and separating machine.
US1343091A (en) * 1919-10-11 1920-06-08 Richard Harry Niehuus Machine for making butter
US2313045A (en) * 1941-11-25 1943-03-09 Edward A Brown Mixer
DE1151718B (de) 1960-03-25 1963-07-18 Netzsch Maschinenfabrik Zentrifugal-Kugelmuehle
US3679184A (en) * 1969-01-14 1972-07-25 Woodham Cecil H Mixing devices
GB1387402A (en) * 1971-03-02 1975-03-19 Techno Med Ltd Mixing process and apparatus
US4497581A (en) * 1979-11-15 1985-02-05 Miller Paint Equipment, Inc. Paint shaker
US4814282A (en) * 1984-05-03 1989-03-21 Abbott Laboratories Centrifuge for two-dimensional centrifugation
US4776832A (en) * 1985-03-21 1988-10-11 Abbott Laboratories Centrifuge having multiple induction motors for rotating objects about a second axis
CH666413A5 (de) * 1985-06-20 1988-07-29 Peter Reinhard Geraet zur herstellung von abdruckmassen.
JPH01199159A (ja) * 1988-02-04 1989-08-10 Kosumitsuku:Kk 遠心チューブ
FR2631826B1 (fr) * 1988-05-27 1992-06-19 Centre Nat Rech Scient Vecteur particulaire utile notamment pour le transport de molecules a activite biologique et procede pour sa preparation
DE3825374A1 (de) 1988-07-26 1990-02-01 Schwendener Reto Dipl Apotheke Komplex aus mindestens einer lipophilen saeure und mitoxantron und/oder bisantren
DE8907335U1 (da) * 1989-06-15 1990-10-18 Espe Stiftung & Co Produktions- Und Vertriebs Kg, 8031 Seefeld, De
FR2668079B1 (fr) * 1990-10-18 1992-12-31 Jouvin Jean Luc Godet melangeur pour un malaxeur centrifuge planetaire, et malaxeur recevant de tels godets.
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
DE4131562A1 (de) 1991-09-18 1993-03-25 Medac Klinische Spezialpraep Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln)
US5620703A (en) 1991-10-11 1997-04-15 Max-Delbruck-Centrum Fur Molekulare Medizin Stimulating hematopoietic activity with carboplatin or lobaplatin
IT1256134B (it) * 1992-09-09 1995-11-29 Luigi Boltri Sali lipofili contenenti isotopi neutron attivabili e composizioni che li contengono
DE4239284A1 (de) * 1992-11-23 1994-05-26 Hilti Ag Mischgerät für fließfähige Massen
DE4430592A1 (de) 1994-08-20 1996-02-22 Max Delbrueck Centrum Liposomale Zubereitung, ihre Herstellung und ihre Verwendung
DE4443140A1 (de) * 1994-12-03 1996-06-05 Hilti Ag Mischgerät
US20050031679A1 (en) * 1998-03-27 2005-02-10 Clemens Unger Method for producing liposomal formulations of active ingredients
DE19813773A1 (de) 1998-03-27 1999-09-30 Clemens Unger Verfahren zur Herstellung von liposomalen Wirkstoffformulierungen
US6099160A (en) * 1999-03-23 2000-08-08 Flacktek, Inc. Mixing system for mixing and dispensing reactive materials
MXPA01011347A (es) * 1999-05-07 2004-06-03 Pharmasol Gmbh Portador de farmaco producido a partir de conjugados de matriz lipida-farmaco (particula lak) para la aplicacion controlada de un agente activo.
EP1070509A3 (en) * 1999-07-23 2002-04-24 Medtronic, Inc. Safety device for vacuum-assisted venous drainage
US6126097A (en) * 1999-08-21 2000-10-03 Nanotek Instruments, Inc. High-energy planetary ball milling apparatus and method for the preparation of nanometer-sized powders
AU2001247951A1 (en) * 2000-02-07 2001-08-14 Roche Diagnostics Corporation Novel cationic amphiphiles
US6361486B1 (en) * 2000-02-29 2002-03-26 Agilent Technologies, Inc. Coaxial-drive centrifuge providing tilt control relative to centrifugal force
EP1343507A2 (en) 2000-08-02 2003-09-17 Virocell Inc. Method to treat infectious diseases and/or to enhance antimicrobial efficacy of drugs
JP3805642B2 (ja) * 2001-05-15 2006-08-02 ジャパンホームサプライ株式会社 飲食物材料の加工装置
DE10143439A1 (de) 2001-09-05 2003-03-20 Hauschild & Co Kg Mischvorrichtung zum Vermischen von flüssigen, fließfähigen oder pulverförmigen Materialien
EP1300161A1 (en) 2001-10-08 2003-04-09 Rubitec Gesellschaft für Innovation und Technologie der Ruhr-Universität Bochum mbH Cationic lipids suitable for gene transfer
US7261860B1 (en) * 2001-10-16 2007-08-28 Space Hardware Optimization Technology, Inc. Apparatus and method for centrifugation and robotic manipulation of samples
JP3468367B2 (ja) * 2001-12-03 2003-11-17 株式会社ジーシー 歯牙修復材用カプセル用練和装置
US6767126B2 (en) * 2002-03-19 2004-07-27 Fluid Management, Inc. Fluid mixer for accommodating containers of varying sizes
US20040082521A1 (en) * 2002-03-29 2004-04-29 Azaya Therapeutics Inc. Novel formulations of digitalis glycosides for treating cell-proliferative and other diseases
US6755565B2 (en) * 2002-04-17 2004-06-29 Flacktek, Inc. Deep holder for dual asymmetric centrifugal mixing system
CA2428185C (en) * 2002-05-13 2007-07-24 The Sherwin-Williams Company Apparatus and method for mixing a fluid dispersion disposed in a container having either a cylindrical or a square shape
DE10255285A1 (de) 2002-11-26 2004-06-03 Mcs Micro Carrier Systems Gmbh Selbst formende Phospholipid-Gele
DE10302743A1 (de) * 2003-01-24 2004-07-29 Goldschmidt Ag Verwendung von Siliconharzen als Dispergiermittel
EP1457483A1 (en) 2003-03-11 2004-09-15 Ruhr-Universität Bochum Cationic lipids with serine backbone
DE102004005783A1 (de) 2003-05-09 2004-12-02 Novosom Ag Injizierbare liposomale Depots zum Peptid- und Proteindelivery
US7097348B2 (en) * 2003-07-24 2006-08-29 Fluid Management, Inc. Methods and apparatuses for mixing cosmetic preparations at a point of sale
EP1512393A1 (de) * 2003-09-08 2005-03-09 BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG Verfahren zur Herstellung von homogenen Liposomen und Lipoplexen
JP4422683B2 (ja) * 2003-09-11 2010-02-24 株式会社シンキー 撹拌脱泡装置
CA2461269A1 (en) * 2004-03-16 2005-09-16 Plastiques Gyf Ltee Bladeless mixer
US7520660B2 (en) * 2004-06-30 2009-04-21 Red Devil Equipment Company Mixer suspension
US20070002681A1 (en) * 2005-06-29 2007-01-04 Bausch & Lomb Incorporated Mixing and deaeration of viscous materials
US20070002680A1 (en) * 2005-06-29 2007-01-04 Bausch & Lomb Incorporated Method of producing mixtures of thermally labile materials
US20070002682A1 (en) * 2005-06-29 2007-01-04 Bausch & Lomb Incorporated Method of producing liquid solutions comprising fusible solid materials
US7495054B2 (en) * 2005-09-19 2009-02-24 3M Innovative Properties Company Curable compositions containing dithiane monomers
DE102006025643A1 (de) * 2006-05-24 2007-11-29 Hauschild & Co Kg Mischvorrichtung mit Vakuum-Box
US7850775B2 (en) * 2006-11-09 2010-12-14 Sun Chemical Corporation Multi-colored lustrous pearlescent pigments
US8211224B2 (en) * 2006-11-09 2012-07-03 Sun Chemical Corp. Multi-colored lustrous pearlescent pigments and process for making
US8906154B2 (en) * 2006-11-09 2014-12-09 Sun Chemical Corporation Coating, ink, or article comprising multi-colored lustrous pearlescent pigments
US8349067B2 (en) * 2006-11-09 2013-01-08 Sun Chemical Corp. Multi-colored lustrous pearlescent pigments
US8221536B2 (en) * 2006-11-09 2012-07-17 Sun Chemical Corp. Cosmetic comprising multi-colored lustrous pearlescent pigments
US8629172B2 (en) * 2008-04-18 2014-01-14 Warsaw Orthopedic, Inc. Methods and compositions for treating post-operative pain comprising clonidine
US20090281663A1 (en) * 2008-05-06 2009-11-12 Boston Scientific Scimed, Inc. Device and method for mixing materials
WO2010059389A2 (en) * 2008-10-30 2010-05-27 Osteotech, Inc. Bone/polyurethane composites and methods thereof

Also Published As

Publication number Publication date
ATE545409T1 (de) 2012-03-15
DK1838286T3 (da) 2012-05-29
EP1838286B1 (de) 2012-02-15
EP2263653A2 (de) 2010-12-22
WO2006069985A3 (de) 2006-10-26
EP1838286B2 (de) 2017-11-01
EP2263653B1 (de) 2013-02-13
US10662060B2 (en) 2020-05-26
EP2263653A3 (de) 2010-12-29
WO2006069985A2 (de) 2006-07-06
PL1838286T3 (pl) 2012-08-31
PL2263653T3 (pl) 2013-08-30
EP1674081A1 (de) 2006-06-28
EP1838286A2 (de) 2007-10-03
US20080193511A1 (en) 2008-08-14

Similar Documents

Publication Publication Date Title
DK2263653T3 (da) Anvendelse af en dual asymmetrisk centrifuge (DAZ) til fremstilling af lipidbaserede nanopartikler
Kim et al. Simple, miniaturized blood plasma extraction method
US20110244595A1 (en) Biomedical chip for blood coagulation test, method of production and use thereof
WO2008052143A3 (en) Mixing device and output fluids of same
WO2009069656A1 (ja) マイクロチップおよび血液観測装置
AU2019278927A1 (en) Devices and systems for gastrointestinal microbiome detection and manipulation
NO20065872L (no) Forskjellig konfigurerbar roterende biologisk kontaktor og prefabrikkerte komponenter for denne
JP2005523065A5 (da)
JP4689665B2 (ja) 液体均一化装置およびそれを用いた分析装置
RU2013135283A (ru) Липосомная композиция и способ ее получения
Goshisht et al. Surface adsorption and molecular modeling of biofunctional gold nanoparticles for systemic circulation and biological sustainability
EA201170597A1 (ru) Смесительный узел
Maria-Hormigos et al. Biocompatible micromotors for biosensing
WO2009129472A3 (en) Methods of labeling biological samples
JP2010032446A (ja) 分析用デバイスと分析方法
CN106309408B (zh) 酪素基SiO2双载药复合微胶囊及其制备方法
ATE517343T1 (de) Bestimmung von konzentrationsänderungen
JP2014235065A (ja) チップおよびその利用
ATE507769T1 (de) Kinderfreundliches blutglucosemessgerät
CN208780540U (zh) 消化道多重病原体液相芯片检测试剂盒
JPS601432A (ja) トルクコンバ−タ
Lu et al. Vortex-Enhanced Microfluidic Chip for Efficient Mixing and Particle Capturing Combining Acoustics with Inertia
CN103145832B (zh) 一种头孢类药物通用人工抗原的合成方法
Zhang et al. Urine Self-Sampling Kit Combined with an Automated Preparation-Sampler Device for Convenient and Reliable Analysis of Arsenic Metabolites by HPLC–ICPMS
Cimaschi et al. A case of amputation neuroma of the bile duct following video-laparoscopic cholecystectomy