ES2034891B1 - Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. - Google Patents
Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.Info
- Publication number
- ES2034891B1 ES2034891B1 ES9101859A ES9101859A ES2034891B1 ES 2034891 B1 ES2034891 B1 ES 2034891B1 ES 9101859 A ES9101859 A ES 9101859A ES 9101859 A ES9101859 A ES 9101859A ES 2034891 B1 ES2034891 B1 ES 2034891B1
- Authority
- ES
- Spain
- Prior art keywords
- nanocapsules
- nanoparticles
- chemically
- preparing
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5138—Organic macromolecular compounds; Dendrimers obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5192—Processes
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/778—Nanostructure within specified host or matrix material, e.g. nanocomposite films
- Y10S977/783—Organic host/matrix, e.g. lipid
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
- Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/832—Nanostructure having specified property, e.g. lattice-constant, thermal expansion coefficient
- Y10S977/835—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial
- Y10S977/836—Chemical or nuclear reactivity/stability of composition or compound forming nanomaterial having biological reactive capability
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/90—Manufacture, treatment, or detection of nanostructure having step or means utilizing mechanical or thermal property, e.g. pressure, heat
Abstract
PROCEDIMIENTO DE ELABORACION EN CONTINUO DE SISTEMAS COLOIDALES DISPERSOS, EN FORMA DE NANOCAPSULAS O NANOPARTICULAS. COMPRENDE: (1) PREPARAR UNA FASE ACUOSA CONTENIENDO AGENTES TENSOACTIVOS, SUSPENSORES Y, OPCIONALMENTE, UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA; (2) PREPARAR UNA FASE ORGANICA CONTENIENDO UN POLIMERO O MONOMERO BIOCMPATIBLE Y, OPCIONALMENTE, UN LIPIDO O UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA; (3) MEZCLAR AMBAS FASES EN FORMA CONTINUA EN UNA RELACION DE FASES Y VOLUMEN MEDIO CONSTANTE, RETIRANDO CONTINUAMENTE A SUSPENSION COLOIDAL RECIEN FORMADA; (4) ELIMINAR DE FORMA CONTINUA EL DISOLVENTE DE LA SUSPENSION COLOIDAL; Y (5) ELIMINAR POR COMPLETO EL DISOLVENTE ORGANICO Y PARTE O TODA EL AGUA PARA OBTENER LA CONCENTRACION DESEADA DE NANOESFERAS O EL PRODUCTO SECO. APLICACION EN BIOMEDICINA, FARMACIA, MEDICINA, COSMETICA, INDUSTRIA QUIMICA, AGRICULTURA Y VETERINARIA, ETC.
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101859A ES2034891B1 (es) | 1991-08-08 | 1991-08-08 | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
DE4128910A DE4128910A1 (de) | 1991-08-08 | 1991-08-30 | Verfahren zur kontinuierlichen herstellung feinverteilter kolloidsysteme in form von nanokapseln oder nanopartikeln |
AT92202434T ATE150642T1 (de) | 1991-08-08 | 1992-08-05 | Verfahren zur kontinuierlichen herstellung von dispersen kolloide-systemen in form von nanokapseln oder nanopartikeln |
EP92202434A EP0529711B1 (en) | 1991-08-08 | 1992-08-05 | Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles |
JP4212681A JP2542149B2 (ja) | 1991-08-08 | 1992-08-10 | ナノカプセルあるいはナノ粒子の分散コロイダル系の連続製造方法 |
US08/309,797 US5705196A (en) | 1991-08-08 | 1994-09-21 | Process of continuous preparation of disperse colloidal systems in the form of nanocapsules or nanoparticles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES9101859A ES2034891B1 (es) | 1991-08-08 | 1991-08-08 | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2034891A1 ES2034891A1 (es) | 1993-04-01 |
ES2034891B1 true ES2034891B1 (es) | 1993-12-16 |
Family
ID=8273277
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES9101859A Expired - Lifetime ES2034891B1 (es) | 1991-08-08 | 1991-08-08 | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
Country Status (6)
Country | Link |
---|---|
US (1) | US5705196A (es) |
EP (1) | EP0529711B1 (es) |
JP (1) | JP2542149B2 (es) |
AT (1) | ATE150642T1 (es) |
DE (1) | DE4128910A1 (es) |
ES (1) | ES2034891B1 (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5981719A (en) | 1993-03-09 | 1999-11-09 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
US6090925A (en) | 1993-03-09 | 2000-07-18 | Epic Therapeutics, Inc. | Macromolecular microparticles and methods of production and use |
ES2078190B1 (es) * | 1994-05-20 | 1996-08-01 | Cusi Lab | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
WO1996020698A2 (en) * | 1995-01-05 | 1996-07-11 | The Board Of Regents Acting For And On Behalf Of The University Of Michigan | Surface-modified nanoparticles and method of making and using same |
ES2177592T3 (es) * | 1995-07-05 | 2002-12-16 | Europ Economic Community | Nanoparticulas biocompatibles y biodegradables para la absorcion y administracion de medicamentos proteinicos. |
US5766629A (en) | 1995-08-25 | 1998-06-16 | Sangstat Medical Corporation | Oral cyclosporin formulations |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
EP1135682B1 (en) | 1998-11-30 | 2007-07-11 | Nanosphere, Inc. | Nanoparticles with polymer shells |
EP1144105B1 (de) * | 1998-12-11 | 2002-09-25 | Henkel Kommanditgesellschaft auf Aktien | Verfahren zur herstellung von nanopartikeldispersionen |
GB9919693D0 (en) * | 1999-08-19 | 1999-10-20 | Rhone Poulenc Rorer Ltd | Process |
FR2805761B1 (fr) | 2000-03-02 | 2002-08-30 | Mainelab | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
CA2309575A1 (en) * | 2000-05-26 | 2001-11-26 | James E. Guillet | Internally cross-linked macromolecules |
EP1401399A2 (en) * | 2001-06-22 | 2004-03-31 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
CN1688275B (zh) * | 2002-09-11 | 2012-05-30 | 田边三菱制药株式会社 | 微球的制备方法 |
US7112620B2 (en) * | 2002-10-18 | 2006-09-26 | Albright Robert L | Hemocompatible polymer systems & related methods |
JP4341238B2 (ja) * | 2002-12-16 | 2009-10-07 | 日油株式会社 | 繊維加工方法および繊維 |
WO2005016976A2 (en) * | 2003-05-27 | 2005-02-24 | Albright Robert L | Hemocompatible polymer systems and related methods |
EP1652515A1 (en) * | 2003-08-06 | 2006-05-03 | Eisai Co., Ltd. | Process for producing drug ultramicroparticle and apparatus therefor |
US7714015B2 (en) * | 2003-08-07 | 2010-05-11 | Lil Brat Pharmaceuticals Of Marlette, Mi | Method and composition for treating sunburned skin |
EP1730516A1 (en) * | 2004-03-30 | 2006-12-13 | Pfizer Products Incorporated | Method and device for evaluation of pharmaceutical compositions |
EP1674081A1 (de) * | 2004-12-23 | 2006-06-28 | KTB Tumorforschungsgesellschaft mbH | Herstellung von lipidbasierten Nanopartikeln unter Einsatz einer dualen asymmetrischen Zentrifuge |
US20100062073A1 (en) * | 2006-11-29 | 2010-03-11 | Ronald Arthur Beyerinck | Pharmaceutical compositions comprising nanoparticles comprising enteric polymers casein |
US20100119612A1 (en) * | 2007-04-17 | 2010-05-13 | Bend Research, Inc | Nanoparticles comprising non-crystalline drug |
US20100080852A1 (en) * | 2007-05-03 | 2010-04-01 | Ronald Arthur Beyerinck | Phamaceutical composition comprising nanoparticles and casein |
WO2008135855A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a cholesteryl ester transfer protein inhibitor and a nonionizable polymer |
WO2008135828A2 (en) * | 2007-05-03 | 2008-11-13 | Pfizer Products Inc. | Nanoparticles comprising a drug, ethylcellulose, and a bile salt |
US8974827B2 (en) * | 2007-06-04 | 2015-03-10 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable cellulosic polymer and an amphiphilic non-ionizable block copolymer |
US9545384B2 (en) | 2007-06-04 | 2017-01-17 | Bend Research, Inc. | Nanoparticles comprising drug, a non-ionizable cellulosic polymer and tocopheryl polyethylene glocol succinate |
US20100215747A1 (en) * | 2007-07-13 | 2010-08-26 | Corey Jay Bloom | Nanoparticles comprising ionizable, poorly water soluble cellulosic polymers |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
WO2009073215A1 (en) * | 2007-12-06 | 2009-06-11 | Bend Research, Inc. | Pharmaceutical compositions comprising nanoparticles and a resuspending material |
CA3204372A1 (en) | 2019-07-01 | 2021-01-07 | Oakwood Laboratories, Llc | System and method for making microspheres and emulsions |
US20220361552A1 (en) * | 2019-12-10 | 2022-11-17 | Tyler White | Particles Containing a Lipid Matrix Core and Active Ingredient |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE744162A (fr) * | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
CH594444A5 (es) * | 1972-12-04 | 1978-01-13 | Gerd Birrenbach | |
GB1413186A (en) * | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
US4107288A (en) * | 1974-09-18 | 1978-08-15 | Pharmaceutical Society Of Victoria | Injectable compositions, nanoparticles useful therein, and process of manufacturing same |
US4489055A (en) * | 1978-07-19 | 1984-12-18 | N.V. Sopar S.A. | Process for preparing biodegradable submicroscopic particles containing a biologically active substance and their use |
DE2965725D1 (en) * | 1978-07-19 | 1983-07-28 | Patrick Couvreur | Biodegradable nanoparticles, pharmaceutical compositions containing them and process for their preparation |
US4272398A (en) * | 1978-08-17 | 1981-06-09 | The United States Of America As Represented By The Secretary Of Agriculture | Microencapsulation process |
DE2940676A1 (de) * | 1979-10-08 | 1981-04-16 | Krupp Polysius Ag, 4720 Beckum | Anlage zur waermebehandlung von feinkoernigem gut |
FR2515960A1 (fr) * | 1981-11-06 | 1983-05-13 | Alkhouri Fallouh Nazir | Nanocapsules ou nanoparticules biodegradables contenant une substance biologiquement active, leur preparation et leur application |
US4798786A (en) * | 1982-05-06 | 1989-01-17 | Stolle Research And Development Corporation | Living cells encapsulated in crosslinked protein |
CH653553A5 (en) * | 1982-11-01 | 1986-01-15 | Sandoz Ag | Microencapsulation process |
US4670250A (en) * | 1983-10-21 | 1987-06-02 | Bend Research, Inc. | Durable controlled release microcapsules |
IE58110B1 (en) * | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
FR2608988B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
JP2670680B2 (ja) * | 1988-02-24 | 1997-10-29 | 株式会社ビーエムジー | 生理活性物質含有ポリ乳酸系微小球およびその製造法 |
JPH02242826A (ja) * | 1988-11-25 | 1990-09-27 | Mitsui Petrochem Ind Ltd | 塩素化エチレン・α‐オレフィン共重合体ラテックスの製造方法 |
US4990431A (en) * | 1989-01-17 | 1991-02-05 | Eastman Kodak Company | Methods of forming stable dispersions of photographic materials |
FR2660193B1 (fr) * | 1990-04-03 | 1994-11-04 | Philippe Maincent | Produit opthalmique comportant des nanocapsules, son procede de preparation et utilisation des nanocapsules. |
FR2660556B1 (fr) * | 1990-04-06 | 1994-09-16 | Rhone Poulenc Sante | Microspheres, leur procede de preparation et leur utilisation. |
-
1991
- 1991-08-08 ES ES9101859A patent/ES2034891B1/es not_active Expired - Lifetime
- 1991-08-30 DE DE4128910A patent/DE4128910A1/de not_active Ceased
-
1992
- 1992-08-05 AT AT92202434T patent/ATE150642T1/de not_active IP Right Cessation
- 1992-08-05 EP EP92202434A patent/EP0529711B1/en not_active Expired - Lifetime
- 1992-08-10 JP JP4212681A patent/JP2542149B2/ja not_active Expired - Lifetime
-
1994
- 1994-09-21 US US08/309,797 patent/US5705196A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JP2542149B2 (ja) | 1996-10-09 |
ATE150642T1 (de) | 1997-04-15 |
EP0529711A1 (en) | 1993-03-03 |
JPH0657005A (ja) | 1994-03-01 |
US5705196A (en) | 1998-01-06 |
ES2034891A1 (es) | 1993-04-01 |
DE4128910A1 (de) | 1993-02-11 |
EP0529711B1 (en) | 1997-03-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ES2034891B1 (es) | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. | |
Dynarowicz-Łątka et al. | Molecular interaction in mixed monolayers at the air/water interface | |
Alivisatos et al. | Organization of'nanocrystal molecules' using DNA | |
KR0139215B1 (ko) | 습윤와이프 | |
FR2755136B1 (fr) | Procede de preparation de nanoparticules de methylidene malonate, nanoparticules contenant eventuellement une ou plusieurs molecules biologiquement actives et compositions pharmaceutiques les contenant | |
DE69426568D1 (de) | Verfahren zur umhüllung von nanopartikeln oder -tröpfchen | |
Braun et al. | Influence of viscosity and solubilization on dissolution rate | |
DE69304065T2 (de) | Herstellung und verwendung von, auf basis von cyclodextrin dispergierbaren kolloidal-systemen, in form von nanokugeln | |
FR2760641B1 (fr) | Emulsion huile-dans-eau stable, son procede de fabrication et son utilisation dans les domaines cosmetique et dermatologique | |
JPH0940545A (ja) | アスコルビン酸を含有する安定組成物 | |
DE69015849T2 (de) | Agrochemische und biozide Suspensionen. | |
Loftsson et al. | The effects of cyclodextrins on transdermal delivery of drugs | |
FR2661414B1 (fr) | Produit a base de keratines modifiees, son procede de preparation et les applications notamment en medecine humaine ou veterinaire. | |
FR2660554B1 (fr) | Composition cosmetique ou dermo-pharmaceutique aqueuse contenant en suspension des spherouides hydrates d'une substance lipidique hydrophile. | |
ATE84710T1 (de) | Verfahren zur herstellung von kolloidalen dispergierbaren proteinsystemen, wie nanopartikeln. | |
Loftsson et al. | The influence of 2-hydroxypropyl-β-cyclodextrin on diffusion rates and transdermal delivery of hydrocortisone | |
GB1389238A (en) | Process for encapsulating or coating finely divided materials by spray-drying-induced polymerisation | |
FR2425242A1 (fr) | Dispositif destine a delivrer une substance chimique a un milieu contenant un liquide aqueux, son procede de production et son application a la lutte contre des vers parasites | |
Li et al. | Organic-inorganic hybrid based on co-assembly of polyoxometalate and dopamine for synthesis of nanostructured Ag | |
Joo et al. | Colloidal stability and in vitro permeation study of poly (ɛ-caprolactone) nanocapsules containing hinokitiol | |
Kim et al. | Study of the adsorption behaviors of amphiphilic gold nanoparticles at the liquid–liquid interface dependent on surface properties | |
Egea et al. | Penetration kinetics of cis-diamminedichloroplatinum (II) loaded nanoparticles in lipid monolayers as a membrane model of the reticuloendothelial system | |
RU96100511A (ru) | Способ получения наночастиц и нанокапсул | |
TH32214A (th) | ผลิตภัณฑ์ดูแลรักษาผิว | |
RU95119860A (ru) | Иммунонаночастицы, несущие моноклональные анти-cd4-антитела, и их использование для профилактики и/или лечения патологических состояний, связанных с вич-инфекцией или в качестве биологических реагентов |