WO2009069656A1 - マイクロチップおよび血液観測装置 - Google Patents

マイクロチップおよび血液観測装置 Download PDF

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Publication number
WO2009069656A1
WO2009069656A1 PCT/JP2008/071445 JP2008071445W WO2009069656A1 WO 2009069656 A1 WO2009069656 A1 WO 2009069656A1 JP 2008071445 W JP2008071445 W JP 2008071445W WO 2009069656 A1 WO2009069656 A1 WO 2009069656A1
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WO
WIPO (PCT)
Prior art keywords
channel
liquid
microchip
monitoring device
blood monitoring
Prior art date
Application number
PCT/JP2008/071445
Other languages
English (en)
French (fr)
Inventor
Kazuya Hosokawa
Tomoko Wada
Original Assignee
Fujimori Kogyo Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujimori Kogyo Co., Ltd. filed Critical Fujimori Kogyo Co., Ltd.
Priority to CA2706646A priority Critical patent/CA2706646A1/en
Priority to CN200880117776.4A priority patent/CN101874208B/zh
Priority to BRPI0820397-0A priority patent/BRPI0820397A2/pt
Priority to EP08853986.1A priority patent/EP2228657B1/en
Priority to AU2008330621A priority patent/AU2008330621A1/en
Priority to US12/744,500 priority patent/US8425840B2/en
Priority to JP2009543828A priority patent/JP5317988B2/ja
Publication of WO2009069656A1 publication Critical patent/WO2009069656A1/ja

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/49—Blood
    • G01N33/4905—Determining clotting time of blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/42—Static mixers in which the mixing is affected by moving the components jointly in changing directions, e.g. in tubes provided with baffles or obstructions
    • B01F25/43—Mixing tubes, e.g. wherein the material is moved in a radial or partly reversed direction
    • B01F25/433—Mixing tubes wherein the shape of the tube influences the mixing, e.g. mixing tubes with varying cross-section or provided with inwardly extending profiles
    • B01F25/4337—Mixers with a diverging-converging cross-section
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples

Abstract

  全血もしくは多血小板血漿またはそれらの薬剤処理液から選択される第１の液体を流入させる第１の流路と、第１の流路に接続されて、前記第１の液体と反応しうる薬剤を含む第２の液体を流入させる第２の流路と、第１の流路と第２の流路の接続部から延設された合流流路とを内部に備えるマイクロチップであって、前記合流流路に、前記第１の液体と前記第２の液体を混合する攪拌子を有する撹拌部が設置されたことを特徴とする、マイクロチップおよびそれを用いた血液観測装置。
PCT/JP2008/071445 2007-11-26 2008-11-26 マイクロチップおよび血液観測装置 WO2009069656A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA2706646A CA2706646A1 (en) 2007-11-26 2008-11-26 Microchip and blood monitoring device
CN200880117776.4A CN101874208B (zh) 2007-11-26 2008-11-26 微型薄片及血液观测装置
BRPI0820397-0A BRPI0820397A2 (pt) 2007-11-26 2008-11-26 Microchip, métodos para medir a formação de trombo e trombólise e para medir a função plaquetária, e, dispositivo de monitoração do sangue.
EP08853986.1A EP2228657B1 (en) 2007-11-26 2008-11-26 Microchip and blood monitoring device
AU2008330621A AU2008330621A1 (en) 2007-11-26 2008-11-26 Microchip and blood monitoring device
US12/744,500 US8425840B2 (en) 2007-11-26 2008-11-26 Microchip and blood monitoring device
JP2009543828A JP5317988B2 (ja) 2007-11-26 2008-11-26 マイクロチップおよび血液観測装置

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007304981 2007-11-26
JP2007-304981 2007-11-26
JP2008-179500 2008-07-09
JP2008179500 2008-07-09

Publications (1)

Publication Number Publication Date
WO2009069656A1 true WO2009069656A1 (ja) 2009-06-04

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/071445 WO2009069656A1 (ja) 2007-11-26 2008-11-26 マイクロチップおよび血液観測装置

Country Status (10)

Country Link
US (1) US8425840B2 (ja)
EP (1) EP2228657B1 (ja)
JP (1) JP5317988B2 (ja)
KR (1) KR20100098656A (ja)
CN (1) CN101874208B (ja)
AU (1) AU2008330621A1 (ja)
BR (1) BRPI0820397A2 (ja)
CA (1) CA2706646A1 (ja)
RU (1) RU2010126151A (ja)
WO (1) WO2009069656A1 (ja)

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2352025A1 (en) * 2008-08-11 2011-08-03 Fujimori Kogyo Co., Ltd. Blood-platelet test method and blood-platelet test device
WO2011099569A1 (ja) * 2010-02-10 2011-08-18 藤森工業株式会社 血小板検査用マイクロチップ及びそれを用いた血小板検査装置
WO2012004612A1 (en) * 2010-07-09 2012-01-12 Bio Amd Holdings Limited Low volume assay apparatus
JP2013200277A (ja) * 2012-03-26 2013-10-03 Fujimori Kogyo Co Ltd マイクロチップ、及び血液観測装置
JP2014521975A (ja) * 2011-08-10 2014-08-28 高麗大学校産学協力団 マイクロチップを基盤とした血小板複合機能検査装置
JP2015510134A (ja) * 2012-03-12 2015-04-02 バイオサーフィット、 ソシエダッド アノニマ 液体試料イメージング装置及び方法
JP2015090293A (ja) * 2013-11-05 2015-05-11 藤森工業株式会社 測定方法及び測定装置
JP2015521288A (ja) * 2012-06-01 2015-07-27 コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ 血液粒子等の液体中に含まれる粒子の移動速度を特性評価するための方法及びシステム
JP2016503161A (ja) * 2012-12-31 2016-02-01 コリア ユニバーシティ リサーチ アンド ビジネス ファウンデーションＫｏｒｅａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｂｕｓｉｎｅｓｓ Ｆｏｕｎｄａｔｉｏｎ 遠心力のマイクロ流動ベースの血小板複合機能と薬物反応検査装置及び方法
JPWO2015156322A1 (ja) * 2014-04-08 2017-04-13 藤森工業株式会社 血液性状検査用マイクロチップおよび血液性状検査用装置
WO2017119508A1 (ja) 2016-01-07 2017-07-13 藤森工業株式会社 採血管、試薬及びそれらを利用した血液性状分析方法
JP6456530B1 (ja) * 2018-01-16 2019-01-23 株式会社アペレ 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置
WO2019142650A1 (ja) * 2018-01-16 2019-07-25 株式会社アペレ 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置
JP2020520634A (ja) * 2017-04-20 2020-07-16 バイオフルイディカ、インコーポレイテッド 液体サンプルからバイオマーカーを単離するための流体密封性フローシステム
WO2022114129A1 (ja) 2020-11-27 2022-06-02 藤森工業株式会社 血液凝固検査用マイクロチップの製造方法
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US11865541B2 (en) 2020-06-12 2024-01-09 Biofluidica, Inc. Dual-depth thermoplastic microfluidic device and related systems and methods

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US9140684B2 (en) 2011-10-27 2015-09-22 University Of Washington Through Its Center For Commercialization Device to expose cells to fluid shear forces and associated systems and methods
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JP2014097485A (ja) * 2012-10-18 2014-05-29 Enplas Corp 液体取扱装置
WO2014210388A1 (en) * 2013-06-26 2014-12-31 University Of Washington Through Its Center For Commercialization Fluidics device for individualized coagulation measurements
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EP2352025A1 (en) * 2008-08-11 2011-08-03 Fujimori Kogyo Co., Ltd. Blood-platelet test method and blood-platelet test device
EP2352025A4 (en) * 2008-08-11 2013-08-07 Fujimori Kogyo Co METHOD AND DEVICE FOR TESTING BLOOD PLATES
AU2009280612B2 (en) * 2008-08-11 2014-11-13 Fujimori Kogyo Co., Ltd. Blood-platelet test method and blood-platelet test device
JP5421918B2 (ja) * 2008-08-11 2014-02-19 藤森工業株式会社 血小板検査方法及び血小板検査装置
US8796031B2 (en) 2010-02-10 2014-08-05 Fujimori Kogyo Co., Ltd. Microchip for platelet examination and platelet examination device using same
WO2011099569A1 (ja) * 2010-02-10 2011-08-18 藤森工業株式会社 血小板検査用マイクロチップ及びそれを用いた血小板検査装置
JP5752055B2 (ja) * 2010-02-10 2015-07-22 藤森工業株式会社 血小板検査用マイクロチップ及びそれを用いた血小板検査装置
US9046512B2 (en) 2010-07-09 2015-06-02 Bio Amd Holdings Limited Low volume assay apparatus
CN103140291A (zh) * 2010-07-09 2013-06-05 超微生物控股有限公司 低液量化验装置
WO2012004612A1 (en) * 2010-07-09 2012-01-12 Bio Amd Holdings Limited Low volume assay apparatus
JP2014521975A (ja) * 2011-08-10 2014-08-28 高麗大学校産学協力団 マイクロチップを基盤とした血小板複合機能検査装置
US9239325B2 (en) 2011-08-10 2016-01-19 Korea University Research And Business Foundation Microchip-based apparatus for examining platelet composite functions
JP2015510134A (ja) * 2012-03-12 2015-04-02 バイオサーフィット、 ソシエダッド アノニマ 液体試料イメージング装置及び方法
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JP2015521288A (ja) * 2012-06-01 2015-07-27 コミッサリア ア レネルジー アトミーク エ オ ゼネルジ ザルタナテイヴ 血液粒子等の液体中に含まれる粒子の移動速度を特性評価するための方法及びシステム
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AU2008330621A1 (en) 2009-06-04
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