DK2262493T3 - METHODS OF TREATMENT WITH prolonged continuous infusion of Belinostat - Google Patents
METHODS OF TREATMENT WITH prolonged continuous infusion of Belinostat Download PDFInfo
- Publication number
- DK2262493T3 DK2262493T3 DK09717048T DK09717048T DK2262493T3 DK 2262493 T3 DK2262493 T3 DK 2262493T3 DK 09717048 T DK09717048 T DK 09717048T DK 09717048 T DK09717048 T DK 09717048T DK 2262493 T3 DK2262493 T3 DK 2262493T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- intravenous infusion
- use according
- phenylsulfamoyl
- acrylamide
- Prior art date
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- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 239000008354 sodium chloride injection Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
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- 239000004094 surface-active agent Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- LRBQNJMCXXYXIU-NRMVVENXSA-N tannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-NRMVVENXSA-N 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000011269 treatment regimen Methods 0.000 description 1
- 150000004684 trihydrates Chemical class 0.000 description 1
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- 229960000281 trometamol Drugs 0.000 description 1
- 231100000402 unacceptable toxicity Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000008215 water for injection Substances 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3463508P | 2008-03-07 | 2008-03-07 | |
| PCT/IB2009/005044 WO2009109861A1 (en) | 2008-03-07 | 2009-03-06 | Methods of treatment employing prolonged continuous infusion of belinostat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2262493T3 true DK2262493T3 (en) | 2015-04-27 |
Family
ID=40691318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK09717048T DK2262493T3 (en) | 2008-03-07 | 2009-03-06 | METHODS OF TREATMENT WITH prolonged continuous infusion of Belinostat |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110003777A1 (enExample) |
| EP (1) | EP2262493B1 (enExample) |
| JP (1) | JP5615189B2 (enExample) |
| CN (1) | CN102083428A (enExample) |
| AU (1) | AU2009220942B2 (enExample) |
| CA (1) | CA2717207A1 (enExample) |
| DK (1) | DK2262493T3 (enExample) |
| EA (1) | EA022880B1 (enExample) |
| ES (1) | ES2536208T3 (enExample) |
| MX (1) | MX2010009642A (enExample) |
| PL (1) | PL2262493T3 (enExample) |
| PT (1) | PT2262493E (enExample) |
| SI (1) | SI2262493T1 (enExample) |
| WO (1) | WO2009109861A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011064663A1 (en) | 2009-11-25 | 2011-06-03 | Festuccia, Claudio | Combination treatment employing belinostat and bicalutamide |
| CN109077995A (zh) * | 2012-04-27 | 2018-12-25 | 太阳医药工业有限公司 | 即可灌注的吉西他滨溶液 |
| CN103839548B (zh) * | 2012-11-26 | 2018-06-01 | 腾讯科技（北京）有限公司 | 一种语音交互方法、装置、系统和移动终端 |
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| US4642316A (en) * | 1985-05-20 | 1987-02-10 | Warner-Lambert Company | Parenteral phenytoin preparations |
| US6071923A (en) * | 1994-09-16 | 2000-06-06 | Bar-Ilan University | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| US20020025921A1 (en) * | 1999-07-26 | 2002-02-28 | Petito George D. | Composition and method for growing, protecting, and healing tissues and cells |
| JP2002527449A (ja) * | 1998-10-13 | 2002-08-27 | 藤沢薬品工業株式会社 | 環状テトラペプチド化合物およびその用途 |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| CN1308347C (zh) * | 1999-04-28 | 2007-04-04 | 德克萨斯大学董事会 | 用于通过选择性抑制vegf来治疗癌症的组合物和方法 |
| US6541661B1 (en) * | 1999-11-23 | 2003-04-01 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP2083005A1 (en) * | 2000-09-29 | 2009-07-29 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| WO2002030879A2 (en) * | 2000-09-29 | 2002-04-18 | Prolifix Limited | Carbamic acid compounds comprising a sulfonamide linkage as hdac inhibitors |
| US20050119305A1 (en) * | 2001-03-21 | 2005-06-02 | Masao Naka | Il-6 production inhibitors |
| PL368129A1 (en) * | 2001-08-09 | 2005-03-21 | Ono Pharmaceutical Co, Ltd. | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| US7041699B2 (en) * | 2002-01-11 | 2006-05-09 | Matthias Rath | Nutrient pharmaceutical formulation comprising polyphenols and use in treatment of cancer |
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| EP1482962A4 (en) * | 2002-02-15 | 2009-12-23 | Sloan Kettering Inst Cancer | METHOD OF TREATING THIOREDOXIN-MEDIATED DISEASES (TRX) |
| US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
| US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| EP2322160A1 (en) * | 2002-03-04 | 2011-05-18 | Merck HDAC Research, LLC | Methods of inducing terminal differentiation |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| WO2003087066A1 (en) * | 2002-04-11 | 2003-10-23 | Sk Chemicals, Co., Ltd. | α,β-UNSATURATED HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HISTONE DEACETYLASE INHIBITORS |
| MXPA04010199A (es) * | 2002-04-15 | 2005-07-05 | Sloan Kettering Inst Cancer | Terapia en combinacion para el tratamiento de cancer. |
| US8883148B2 (en) * | 2002-04-26 | 2014-11-11 | Asan Laboratories Company (Cayman), Limited | Prevention of joint destruction |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| WO2004064727A2 (en) * | 2003-01-16 | 2004-08-05 | Georgetown University | Method of cancer treatment using hdac inhibitors |
| CA2518318A1 (en) * | 2003-03-17 | 2004-09-30 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| PT1663194E (pt) * | 2003-08-26 | 2010-07-06 | Merck Hdac Res Llc | Utilizaão de saha para o tratamento de mesotelioma |
| US20060270016A1 (en) * | 2003-11-14 | 2006-11-30 | Holm Per S | Novel adenoviruses, nucleic acids that code for the same and the use of said viruses |
| WO2005051430A1 (de) * | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
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| EP1591109B1 (en) * | 2004-04-30 | 2008-07-02 | TopoTarget Germany AG | Formulation comprising histone deacetylase inhibitor exhibiting biphasic release |
| EP1787657A1 (en) * | 2004-08-06 | 2007-05-23 | Ono Pharmaceutical Co., Ltd. | Therapeutic agent for psychoneurotic disease |
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| WO2006060382A2 (en) * | 2004-11-30 | 2006-06-08 | Trustees Of The University Of Pennsylvania | Use of hdac and/or dnmt inhibitors for treatment of ischemic injury |
| EP1830864A2 (de) * | 2004-12-31 | 2007-09-12 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| KR101346886B1 (ko) * | 2005-01-21 | 2014-01-02 | 아스텍스 테라퓨틱스 리미티드 | 제약 화합물 |
| CA2596210C (en) * | 2005-02-03 | 2014-07-08 | Topotarget Uk Limited | Combination therapies using hdac inhibitors |
| US20060229237A1 (en) * | 2005-04-07 | 2006-10-12 | Yih-Lin Chung | Treatment of gastrointestinal distress |
| GB0509225D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
| ES2380887T3 (es) * | 2005-05-13 | 2012-05-21 | Topotarget Uk Limited | Formulaciones farmacéuticas de inhibidores de la HDAC |
| EP1743654A1 (en) * | 2005-07-15 | 2007-01-17 | TopoTarget Germany AG | Use of inhibitors of histone deacetylases in combination with NSAID for the therapy of cancer and/or inflammatory diseases |
| JP2009504751A (ja) * | 2005-08-19 | 2009-02-05 | アメリカ合衆国 | ヒストンデアセチラーゼ阻害薬の局所製剤及びその使用方法 |
| RU2008108221A (ru) * | 2005-09-07 | 2009-10-20 | Плекссикон, Инк. (Us) | Соединения, активные в отношении ppar (рецепторов активаторов пролиферации пероксисом) |
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| KR20080103977A (ko) * | 2006-02-22 | 2008-11-28 | 4에스체 악티엔게젤샤프트 | Ｅｇ５ 키네신 조절자로서 인돌로피리딘 |
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| EP1839656A1 (en) * | 2006-03-31 | 2007-10-03 | TopoTarget Germany AG | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
| WO2007129062A1 (en) * | 2006-05-08 | 2007-11-15 | Astex Therapeutics Limited | Pharmaceutical combinations of diazole derivatives for cancer treatment |
| EP2040731A4 (en) * | 2006-06-09 | 2010-05-19 | Merrion Res Iii Ltd | SOLID DOSAGE FORM FOR ORAL ADMINISTRATION CONTAINING AN ACTIVATOR |
| WO2008011603A2 (en) * | 2006-07-20 | 2008-01-24 | Wisconsin Alumni Research Foundation | Modulating notch1 signaling pathway for treating neuroendocrine tumors |
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| WO2008136838A1 (en) * | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| GB2454118B (en) * | 2007-06-06 | 2010-06-02 | Univ Maryland | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| WO2009146034A2 (en) * | 2008-03-31 | 2009-12-03 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
| US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
| US8637554B2 (en) * | 2008-05-07 | 2014-01-28 | The Trustees Of The University Of Pennsylvania | Methods for treating thyroid cancer |
-
2009
- 2009-03-06 US US12/920,484 patent/US20110003777A1/en not_active Abandoned
- 2009-03-06 PL PL09717048T patent/PL2262493T3/pl unknown
- 2009-03-06 EA EA201070913A patent/EA022880B1/ru not_active IP Right Cessation
- 2009-03-06 ES ES09717048.4T patent/ES2536208T3/es active Active
- 2009-03-06 DK DK09717048T patent/DK2262493T3/en active
- 2009-03-06 CA CA2717207A patent/CA2717207A1/en not_active Abandoned
- 2009-03-06 AU AU2009220942A patent/AU2009220942B2/en active Active
- 2009-03-06 EP EP09717048.4A patent/EP2262493B1/en active Active
- 2009-03-06 PT PT97170484T patent/PT2262493E/pt unknown
- 2009-03-06 MX MX2010009642A patent/MX2010009642A/es active IP Right Grant
- 2009-03-06 SI SI200931197T patent/SI2262493T1/sl unknown
- 2009-03-06 JP JP2010549210A patent/JP5615189B2/ja active Active
- 2009-03-06 CN CN2009801162852A patent/CN102083428A/zh active Pending
- 2009-03-06 WO PCT/IB2009/005044 patent/WO2009109861A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010009642A (es) | 2010-09-22 |
| PT2262493E (pt) | 2015-06-02 |
| AU2009220942A8 (en) | 2012-08-30 |
| CA2717207A1 (en) | 2009-09-11 |
| WO2009109861A1 (en) | 2009-09-11 |
| AU2009220942A1 (en) | 2009-09-11 |
| JP2011513378A (ja) | 2011-04-28 |
| EA201070913A1 (ru) | 2011-04-29 |
| US20110003777A1 (en) | 2011-01-06 |
| CN102083428A (zh) | 2011-06-01 |
| EP2262493B1 (en) | 2015-02-25 |
| PL2262493T3 (pl) | 2015-08-31 |
| SI2262493T1 (sl) | 2015-07-31 |
| EA022880B1 (ru) | 2016-03-31 |
| AU2009220942B2 (en) | 2015-05-28 |
| JP5615189B2 (ja) | 2014-10-29 |
| EP2262493A1 (en) | 2010-12-22 |
| HK1152247A1 (en) | 2012-02-24 |
| ES2536208T3 (es) | 2015-05-21 |
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