CN102083428A - 采用长时间连续输液Belinostat进行治疗的方法 - Google Patents
采用长时间连续输液Belinostat进行治疗的方法 Download PDFInfo
- Publication number
- CN102083428A CN102083428A CN2009801162852A CN200980116285A CN102083428A CN 102083428 A CN102083428 A CN 102083428A CN 2009801162852 A CN2009801162852 A CN 2009801162852A CN 200980116285 A CN200980116285 A CN 200980116285A CN 102083428 A CN102083428 A CN 102083428A
- Authority
- CN
- China
- Prior art keywords
- long
- disease
- time continuous
- phenyl
- acrylamide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/18—Sulfonamides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3463508P | 2008-03-07 | 2008-03-07 | |
| US61/034,635 | 2008-03-07 | ||
| PCT/IB2009/005044 WO2009109861A1 (en) | 2008-03-07 | 2009-03-06 | Methods of treatment employing prolonged continuous infusion of belinostat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN102083428A true CN102083428A (zh) | 2011-06-01 |
Family
ID=40691318
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009801162852A Pending CN102083428A (zh) | 2008-03-07 | 2009-03-06 | 采用长时间连续输液Belinostat进行治疗的方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20110003777A1 (enExample) |
| EP (1) | EP2262493B1 (enExample) |
| JP (1) | JP5615189B2 (enExample) |
| CN (1) | CN102083428A (enExample) |
| AU (1) | AU2009220942B2 (enExample) |
| CA (1) | CA2717207A1 (enExample) |
| DK (1) | DK2262493T3 (enExample) |
| EA (1) | EA022880B1 (enExample) |
| ES (1) | ES2536208T3 (enExample) |
| MX (1) | MX2010009642A (enExample) |
| PL (1) | PL2262493T3 (enExample) |
| PT (1) | PT2262493E (enExample) |
| SI (1) | SI2262493T1 (enExample) |
| WO (1) | WO2009109861A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011064663A1 (en) | 2009-11-25 | 2011-06-03 | Festuccia, Claudio | Combination treatment employing belinostat and bicalutamide |
| JP6159567B2 (ja) * | 2012-04-27 | 2017-07-05 | サン ファーマシューティカル インダストリーズ リミテッドSun Pharmaceutical Industries Ltd. | 既製のゲムシタビン注入溶液 |
| CN103839548B (zh) | 2012-11-26 | 2018-06-01 | 腾讯科技(北京)有限公司 | 一种语音交互方法、装置、系统和移动终端 |
Family Cites Families (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4642316A (en) * | 1985-05-20 | 1987-02-10 | Warner-Lambert Company | Parenteral phenytoin preparations |
| US6071923A (en) * | 1994-09-16 | 2000-06-06 | Bar-Ilan University | Retinoyloxy aryl-substituted alkylene butyrates useful for the treatment of cancer and other proliferative diseases |
| US20020025921A1 (en) * | 1999-07-26 | 2002-02-28 | Petito George D. | Composition and method for growing, protecting, and healing tissues and cells |
| IL142531A0 (en) * | 1998-10-13 | 2002-03-10 | Fujisawa Pharmaceutical Co | Cyclic peptide compound, processes for the preparation thereof and pharmaceutical compositions containing the same |
| US20070148228A1 (en) * | 1999-02-22 | 2007-06-28 | Merrion Research I Limited | Solid oral dosage form containing an enhancer |
| WO2000064946A2 (en) * | 1999-04-28 | 2000-11-02 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting vegf |
| DK1233958T3 (da) * | 1999-11-23 | 2011-10-17 | Methylgene Inc | Hæmmere af histondeacetylase |
| EP2292593A3 (en) * | 2000-09-29 | 2011-05-25 | TopoTarget UK Limited | Carbamic acid compounds comprising a sulfonamide linkage as HDAC inhibitors |
| GB0023983D0 (en) * | 2000-09-29 | 2000-11-15 | Prolifix Ltd | Therapeutic compounds |
| EP2083005A1 (en) * | 2000-09-29 | 2009-07-29 | TopoTarget UK Limited | Carbamic acid compounds comprising an amide linkage as HDAC inhibitors |
| WO2002074298A1 (en) * | 2001-03-21 | 2002-09-26 | Ono Pharmaceutical Co., Ltd. | Il-6 production inhibitors |
| EP1431267A4 (en) * | 2001-08-09 | 2004-12-22 | Ono Pharmaceutical Co | COMPOUNDS DERIVED FROM CARBOXYLIC ACID AND MEDICAMENTS COMPRISING SUCH COMPOUNDS AS ACTIVE INGREDIENT |
| US6897220B2 (en) * | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| DE60318387T2 (de) * | 2002-01-11 | 2008-12-18 | Rath, Matthias, Dr. | Polyphenole enthaltende pharmazeutische nahrungsmittelergänzungsformel und ihre anwendung in der krebsbehandlung |
| US20050288227A1 (en) * | 2002-02-15 | 2005-12-29 | Marks Paul A | Use of thioredoxin measurements for diagnostics and treatments |
| WO2003070188A2 (en) * | 2002-02-15 | 2003-08-28 | Sloan-Kettering Institute For Cancer Research | Method of treating trx mediated diseases |
| US7148257B2 (en) * | 2002-03-04 | 2006-12-12 | Merck Hdac Research, Llc | Methods of treating mesothelioma with suberoylanilide hydroxamic acid |
| US20040132825A1 (en) * | 2002-03-04 | 2004-07-08 | Bacopoulos Nicholas G. | Methods of treating cancer with HDAC inhibitors |
| MXPA04008577A (es) * | 2002-03-04 | 2005-07-13 | Aton Pharma Inc | Metodos para inducir diferenciacion terminal. |
| US20070060614A1 (en) * | 2002-03-04 | 2007-03-15 | Bacopoulos Nicholas G | Methods of treating cancer with hdac inhibitors |
| US7495022B2 (en) * | 2002-04-11 | 2009-02-24 | Sk Chemicals Co., Ltd. | α,β-unsaturated hydroxamic acid derivatives and their use as histone deacetylase inhibitors |
| AU2003226408B2 (en) * | 2002-04-15 | 2007-06-14 | Sloan-Kettering Institute For Cancer Research | Combination therapy for the treatment of cancer |
| US8883148B2 (en) * | 2002-04-26 | 2014-11-11 | Asan Laboratories Company (Cayman), Limited | Prevention of joint destruction |
| US20080004311A1 (en) * | 2002-11-12 | 2008-01-03 | Alcon, Inc. | Histone deacetylase inhibitors for treating degenerative diseases of the eye |
| US20050222013A1 (en) * | 2003-01-16 | 2005-10-06 | Georgetown University | Methods for the use of inhibitors of histone deacetylase as synergistic agents in cancer therapy |
| US7381825B2 (en) * | 2003-03-17 | 2008-06-03 | Takeda San Diego, Inc. | Histone deacetylase inhibitors |
| US20040220242A1 (en) * | 2003-05-02 | 2004-11-04 | Leland Shapiro | Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions |
| EP1491188A1 (en) * | 2003-06-25 | 2004-12-29 | G2M Cancer Drugs AG | Topical use of valproic acid for the prevention or treatment of skin disorders |
| PL379887A1 (pl) * | 2003-08-26 | 2006-11-27 | Merck Hdac Research, Llc | Sposób leczenia raka inhibitorami HDAC |
| WO2005051430A1 (de) * | 2003-11-14 | 2005-06-09 | Per Sonne Holm | Neue verwendung von adenoviren und dafür codierenden nukleinsäuren |
| JP2007511212A (ja) * | 2003-11-14 | 2007-05-10 | ホルム,ペル・ゾンネ | 新規アデノウイルス、それをコードする核酸及びその使用 |
| GB0401876D0 (en) * | 2004-01-28 | 2004-03-03 | Vereniging Het Nl Kanker I | New use for cancer antigen |
| ATE437370T1 (de) * | 2004-02-27 | 2009-08-15 | Us Gov Health & Human Serv | Pharmakodynamische tests mit durchflusszytometrie |
| DE602004014723D1 (de) * | 2004-04-30 | 2008-08-14 | Desitin Arzneimittel Gmbh | Histondeacetylase-Inhibitor enthaltende Formulierung zur zweiphasigen Freisetzung |
| JPWO2006014024A1 (ja) * | 2004-08-06 | 2008-05-01 | 小野薬品工業株式会社 | 精神神経系疾患治療剤 |
| KR20070057822A (ko) * | 2004-08-09 | 2007-06-07 | 아스텔라스세이야쿠 가부시키가이샤 | 히스톤 디아세틸라제 (hdac) 억제제 활성을 갖는히드록시아미드 화합물 |
| WO2006060382A2 (en) * | 2004-11-30 | 2006-06-08 | Trustees Of The University Of Pennsylvania | Use of hdac and/or dnmt inhibitors for treatment of ischemic injury |
| WO2006070024A2 (de) * | 2004-12-31 | 2006-07-06 | Per Sonne Holm | E1 -minus adenoviren und deren verwendung |
| CA2594477C (en) * | 2005-01-21 | 2016-07-12 | Astex Therapeutics Limited | Pharmaceutical compounds |
| NZ589276A (en) * | 2005-02-03 | 2012-06-29 | Topotarget Uk Ltd | Combination therapies using hdac inhibitors and erlotinib (tarceva) |
| US20060229237A1 (en) * | 2005-04-07 | 2006-10-12 | Yih-Lin Chung | Treatment of gastrointestinal distress |
| GB0509225D0 (en) * | 2005-05-05 | 2005-06-15 | Chroma Therapeutics Ltd | Inhibitors of enzymatic activity |
| ES2380887T3 (es) * | 2005-05-13 | 2012-05-21 | Topotarget Uk Limited | Formulaciones farmacéuticas de inhibidores de la HDAC |
| EP1743654A1 (en) * | 2005-07-15 | 2007-01-17 | TopoTarget Germany AG | Use of inhibitors of histone deacetylases in combination with NSAID for the therapy of cancer and/or inflammatory diseases |
| WO2007024574A2 (en) * | 2005-08-19 | 2007-03-01 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Topical formulations of histone deacetylase inhibitors and methods of using the same |
| TW200800872A (en) * | 2005-09-07 | 2008-01-01 | Plexxikon Inc | PPAR active compounds |
| EP2361619A1 (en) * | 2005-11-10 | 2011-08-31 | TopoTarget UK Limited | Histone deacetylase (hdac) inhibitors (pxd-101) alone for the treatment of hematological cancer |
| US8445198B2 (en) * | 2005-12-01 | 2013-05-21 | Medical Prognosis Institute | Methods, kits and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| BRPI0710073A2 (pt) * | 2006-02-22 | 2011-08-02 | 4Sc Ag | indolopiridinas |
| US8530493B2 (en) * | 2006-02-22 | 2013-09-10 | 4Sc Ag | Indolopyridines as Eg5 kinesin modulators |
| EP1839656A1 (en) * | 2006-03-31 | 2007-10-03 | TopoTarget Germany AG | Use of valproic acid for the topical treatment of mild to moderate acne vulgaris |
| WO2007129062A1 (en) * | 2006-05-08 | 2007-11-15 | Astex Therapeutics Limited | Pharmaceutical combinations of diazole derivatives for cancer treatment |
| WO2007146234A2 (en) * | 2006-06-09 | 2007-12-21 | Merrion Research Ii Limited | Solid oral dosage form containing an enhancer |
| US8338482B2 (en) * | 2006-07-20 | 2012-12-25 | Wisconsin Alumni Research Foundation | Modulating notch1 signaling pathway for treating neuroendocrine tumors |
| CA2669675A1 (en) * | 2006-11-10 | 2008-05-15 | Syndax Pharmaceuticals, Inc. | Combination of er.alpha.+ ligands and histone deacetylase inhibitors for the treatment of cancer |
| US8796330B2 (en) * | 2006-12-19 | 2014-08-05 | Methylgene Inc. | Inhibitors of histone deacetylase and prodrugs thereof |
| US7915245B2 (en) * | 2007-02-01 | 2011-03-29 | The Board Of Regents Of The University Of Texas System | Methods and compositions of trail-death receptor agonists/activators |
| US8012695B2 (en) * | 2007-02-14 | 2011-09-06 | Dana-Farber Cancer Institute, Inc. | Methods and compositions relating to promoter regulation by MUC1 and KLF proteins |
| WO2008136838A1 (en) * | 2007-05-04 | 2008-11-13 | Trustees Of Dartmouth College | Novel amide derivatives of cddo and methods of use thereof |
| WO2008154402A2 (en) * | 2007-06-06 | 2008-12-18 | University Of Maryland, Baltimore | Hdac inhibitors and hormone targeted drugs for the treatment of cancer |
| US20090246198A1 (en) * | 2008-03-31 | 2009-10-01 | Takeda Pharmaceutical Company Limited | Mapk/erk kinase inhibitors and methods of use thereof |
| US20090270497A1 (en) * | 2008-04-24 | 2009-10-29 | Pharmacyclics, Inc. | Treatment of Non-Localized Inflammation with pan-HDAC Inhibitors |
| US8637554B2 (en) * | 2008-05-07 | 2014-01-28 | The Trustees Of The University Of Pennsylvania | Methods for treating thyroid cancer |
-
2009
- 2009-03-06 CA CA2717207A patent/CA2717207A1/en not_active Abandoned
- 2009-03-06 EP EP09717048.4A patent/EP2262493B1/en active Active
- 2009-03-06 AU AU2009220942A patent/AU2009220942B2/en active Active
- 2009-03-06 EA EA201070913A patent/EA022880B1/ru not_active IP Right Cessation
- 2009-03-06 ES ES09717048.4T patent/ES2536208T3/es active Active
- 2009-03-06 DK DK09717048T patent/DK2262493T3/en active
- 2009-03-06 JP JP2010549210A patent/JP5615189B2/ja active Active
- 2009-03-06 US US12/920,484 patent/US20110003777A1/en not_active Abandoned
- 2009-03-06 PL PL09717048T patent/PL2262493T3/pl unknown
- 2009-03-06 SI SI200931197T patent/SI2262493T1/sl unknown
- 2009-03-06 WO PCT/IB2009/005044 patent/WO2009109861A1/en not_active Ceased
- 2009-03-06 PT PT97170484T patent/PT2262493E/pt unknown
- 2009-03-06 CN CN2009801162852A patent/CN102083428A/zh active Pending
- 2009-03-06 MX MX2010009642A patent/MX2010009642A/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| PL2262493T3 (pl) | 2015-08-31 |
| MX2010009642A (es) | 2010-09-22 |
| WO2009109861A1 (en) | 2009-09-11 |
| DK2262493T3 (en) | 2015-04-27 |
| EA022880B1 (ru) | 2016-03-31 |
| PT2262493E (pt) | 2015-06-02 |
| US20110003777A1 (en) | 2011-01-06 |
| EP2262493B1 (en) | 2015-02-25 |
| ES2536208T3 (es) | 2015-05-21 |
| AU2009220942A1 (en) | 2009-09-11 |
| JP2011513378A (ja) | 2011-04-28 |
| HK1152247A1 (en) | 2012-02-24 |
| EA201070913A1 (ru) | 2011-04-29 |
| CA2717207A1 (en) | 2009-09-11 |
| EP2262493A1 (en) | 2010-12-22 |
| AU2009220942A8 (en) | 2012-08-30 |
| AU2009220942B2 (en) | 2015-05-28 |
| SI2262493T1 (sl) | 2015-07-31 |
| JP5615189B2 (ja) | 2014-10-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2262478B1 (en) | Activated nitric oxide donors and methods of making and using thereof | |
| JP6360438B2 (ja) | 癌の治療 | |
| CA2286557A1 (en) | Phorbol esters as anti-neoplastic agents | |
| JP2015057409A (ja) | 多形膠芽腫の治療のためのマシテンタンを含有する組み合わせ剤 | |
| CN102083428A (zh) | 采用长时间连续输液Belinostat进行治疗的方法 | |
| KR102643626B1 (ko) | 향상된 안정성 및 생체이용률을 갖는 (e)-2,4,6-트리메톡시스티릴-3-[(카복시메틸)아미노]-4-메톡시벤질설폰의 제형 | |
| WO2011064663A1 (en) | Combination treatment employing belinostat and bicalutamide | |
| WO2009150278A1 (es) | Una composición farmacéutica de melfalano | |
| US20050148519A1 (en) | Salts of pharmacologically active compounds | |
| HK1152247B (en) | Methods of treatment employing prolonged continuous infusion of belinostat | |
| KR101327904B1 (ko) | 목시플록사신 염산염의 주사제형 | |
| US20230210793A1 (en) | Method for rapid infusion of carmustine | |
| JP6646309B2 (ja) | ヘプシジン−25産生抑制剤 | |
| TOKUNAGA et al. | Hepatic arterial infusion therapy with cisplatin using protein binding inhibition: pharmacokinetics and antineoplastic effects of cisplatin combined with L-cysteine in rats | |
| WO2020139300A2 (en) | A combination comprising granulocyte colony stimulating factor | |
| WO2009157009A1 (en) | An intravenous drug delivery system |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C12 | Rejection of a patent application after its publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20110601 |