DK224587A - Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod - Google Patents

Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

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Publication number
DK224587A
DK224587A DK224587A DK224587A DK224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A DK 224587 A DK224587 A DK 224587A
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Prior art keywords
sod
extracellular
preparing
procedure
dna fragment
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DK224587A
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English (en)
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DK224587D0 (da
Inventor
Stefan Marklund
Thomas Edlund
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Syn Tek Ab
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Application filed by Syn Tek Ab filed Critical Syn Tek Ab
Priority to DK224587A priority Critical patent/DK224587D0/da
Publication of DK224587A publication Critical patent/DK224587A/da
Publication of DK224587D0 publication Critical patent/DK224587D0/da

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0065—Oxidoreductases (1.) acting on hydrogen peroxide as acceptor (1.11)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/44—Oxidoreductases (1)
    • A61K38/446—Superoxide dismutase (1.15)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Physics & Mathematics (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
DK224587A 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod DK224587D0 (da)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym
PCT/DK1986/000098 WO1987001387A1 (en) 1985-09-03 1986-09-02 A superoxide dismutase
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Publications (2)

Publication Number Publication Date
DK224587A true DK224587A (da) 1987-05-01
DK224587D0 DK224587D0 (da) 1987-05-01

Family

ID=8129425

Family Applications (2)

Application Number Title Priority Date Filing Date
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym
DK224587A DK224587D0 (da) 1985-09-03 1987-05-01 Ekstracellulaer superoxiddismutase (ec-sod), dna-fragment, der indkoder ec-sod, fremgangsmaade til fremstilling af ec-sod samt anvendelse af ec-sod

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK402785A DK402785D0 (da) 1985-09-03 1985-09-03 Fremgangsmaade til fremstilling af et enzym

Country Status (18)

Country Link
US (1) US5130245A (da)
EP (1) EP0236385B1 (da)
JP (2) JP2643934B2 (da)
KR (1) KR920008738B1 (da)
CN (1) CN1030718C (da)
AT (1) ATE69466T1 (da)
AU (1) AU598756B2 (da)
CA (1) CA1340329C (da)
DE (1) DE3682505D1 (da)
DK (2) DK402785D0 (da)
FI (1) FI100252B (da)
HU (1) HU215937B (da)
IE (1) IE59078B1 (da)
IL (1) IL79926A (da)
NO (1) NO301132B1 (da)
SU (1) SU1779263A3 (da)
WO (1) WO1987001387A1 (da)
ZA (1) ZA871267B (da)

Families Citing this family (41)

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EP0213628A3 (en) * 1985-09-03 1988-09-21 Yeda Research And Development Company, Ltd. Expression of superoxide dismutase in eukaryotic cells
US6610520B1 (en) * 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
JPS63132820A (ja) * 1986-11-22 1988-06-04 Minoru Nakano 口腔用組成物
EP0676472A1 (de) * 1987-03-14 1995-10-11 BOEHRINGER INGELHEIM INTERNATIONAL GmbH Humane Mangan-Superoxiddismutase (hMn-SOD)
US5260204A (en) * 1987-03-14 1993-11-09 Boehringer Ingelheim International Gmbh Human manganese superoxide dismutase (hMn-SOD)
EP0284105B1 (en) * 1987-03-27 1995-11-15 Bio-Technology General Corporation Human manganese superoxide dismutase and methods of treatment
DK310788A (da) * 1987-06-09 1988-12-10 Int Cardiovascular Med Inc Praeparat indeholdende superoxid-dismutase, dets fremstilling og anvendelse til behandling af global iskaemi
JPH01238537A (ja) * 1988-03-18 1989-09-22 Toyo Jozo Co Ltd 肝障害治療剤
JPH01246225A (ja) * 1988-03-28 1989-10-02 Toyo Jozo Co Ltd 膵炎治療剤
JPH0262829A (ja) * 1988-05-18 1990-03-02 Nippon Kayaku Co Ltd 虚血に基づく傷害の予防及び治療剤
DK455789D0 (da) * 1989-09-15 1989-09-15 Symbicom Ab Polypeptid
DE4038563A1 (de) * 1990-12-04 1992-06-11 Gruenenthal Gmbh Verwendung von superoxiddismutasen zur prophylaxe und/oder behandlung von organversagen bei risikopatienten mit polytrauma
DE4239877C1 (de) * 1992-11-27 1994-03-17 Boehringer Ingelheim Int Stabilisierte Superoxid-Dismutase (SOD)-Zusammensetzung
EP0627486A1 (en) * 1993-06-04 1994-12-07 N.V. Innogenetics S.A. New extracellular superoxide dismutase, a process for preparing the same and compositions containing the same
DK75393D0 (da) * 1993-06-24 1993-06-24 Symbicom Ab Production of protein
US6127356A (en) * 1993-10-15 2000-10-03 Duke University Oxidant scavengers
US5994339A (en) * 1993-10-15 1999-11-30 University Of Alabama At Birmingham Research Foundation Oxidant scavengers
US5747026A (en) * 1993-10-15 1998-05-05 University Of Alabama At Birmingham Research Foundation Antioxidants
DE4336641C2 (de) * 1993-10-22 1995-09-07 Deutsches Rheuma Forschungszen Verwendung von Superoxid-Dismutase (SOD) zur Behandlung retroviraler Erkrankungen
WO1996009053A1 (en) * 1994-09-20 1996-03-28 Duke University Oxidoreductase activity of manganic porphyrins
US5942245A (en) * 1994-11-04 1999-08-24 Polymun Scientific Immunbiologische Forschung Gmbh Application of SOD in liposomes
MY128323A (en) * 1996-09-30 2007-01-31 Otsuka Pharma Co Ltd Thiazole derivatives for inhibition of cytokine production and of cell adhesion
US6171856B1 (en) 1997-07-30 2001-01-09 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
WO1999006059A2 (en) * 1997-07-30 1999-02-11 Board Of Regents, The University Of Texas System Methods and compositions relating to no-mediated cytotoxicity
AU737650B2 (en) 1997-11-03 2001-08-23 Duke University Substituted porphyrins
DE69928655T2 (de) 1998-04-24 2006-08-24 Duke University Substituierte porphyrine
ATE552260T1 (de) * 1999-01-25 2012-04-15 Nat Jewish Health Substituierte porphyrine und deren therapeutische verwendung
AU2002248366B2 (en) * 2001-01-19 2006-10-26 Aeolus Sciences, Inc. Cancer therapy
FI20010898A0 (fi) * 2001-04-30 2001-04-30 Ylae Herttuala Seppo Ekstrasellulaarinen superoksididismutaasi (EC-SOD) geeniterapia restenoosoin ehkäisemiseksi
AU2002312194B8 (en) * 2001-06-01 2008-05-15 Aeolus Sciences, Inc. Oxidant scavengers for treatment of diabetes or use in transplantation or induction of immune tolerance
WO2003092727A1 (en) * 2002-04-30 2003-11-13 Fit Biotech Oyj Plc Medical device
CA2488500A1 (en) * 2002-06-07 2003-12-18 Duke University Substituted porphyrins
EP1692187B1 (en) * 2003-10-31 2012-06-27 Tae-Yoon Kim EC SOD and cell transducing EC SOD and use thereof
CN100345973C (zh) * 2004-11-18 2007-10-31 中国农业大学 超氧化物歧化酶基因的表达方法及其专用载体
RU2506083C2 (ru) 2008-05-23 2014-02-10 Нэшнл Джуиш Хелт Способ лечения поражений, ассоциированных с воздействием алкилирующих веществ
US20100098768A1 (en) * 2008-10-16 2010-04-22 Clarkson University Method of neuroprotection from oxidant injury using metal oxide nanoparticles
CN102660580A (zh) * 2012-05-18 2012-09-12 深圳市北科生物科技有限公司 Sod基因修饰间充质干细胞的构建方法及其应用
RU2667966C2 (ru) * 2013-03-15 2018-09-25 Бакстер Интернэшнл Инк. Иммобилизация активного агента на субстрате
KR102271653B1 (ko) 2013-06-07 2021-07-05 백스터 인터내셔널 인코포레이티드 트리하이드록시페닐기를 포함하는 화합물을 사용한 기판 상에의 활성제의 고정화
CN104342409B (zh) * 2014-06-17 2018-05-25 吉林金梓源生物科技股份有限公司 重组人参超氧化物歧化酶的制备方法
CN104342408B (zh) * 2014-06-18 2018-05-25 吉林金梓源生物科技股份有限公司 重组蛹虫草超氧化物歧化酶的制备方法

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DK145950C (da) * 1979-05-17 1983-09-26 Forenede Bryggerier As Fremgangsmaade til isolering af cu,zn-superoxid-dismutase fra vandige oploesninger indeholdende dette enzym sammen med ledsagende proteiner
US4530901A (en) * 1980-01-08 1985-07-23 Biogen N.V. Recombinant DNA molecules and their use in producing human interferon-like polypeptides
JPS56102787A (en) * 1980-01-18 1981-08-17 Mamoru Sugiura Preparation of human placenta superoxide dismutase
JPS5729285A (en) * 1980-07-30 1982-02-17 Takeda Chem Ind Ltd Superoxide dismutase and its preparation
JPS57155991A (en) * 1981-03-23 1982-09-27 Green Cross Corp:The Preparation of superoxide dismutase derived from human placenta
DE3377363D1 (en) * 1982-03-31 1988-08-18 Ajinomoto Kk Gene coding for interleukin-2 polypeptide, recombinant dna carrying said gene, cell lines possessing the recombinant dna,and method for producing interleukin-2 using said cells
IT1150598B (it) * 1982-12-14 1986-12-17 Ines Bianchi Procedimento per la purificazione della superossidodismutasi mediante cromatografia di affinita'
EP0656418B1 (en) * 1983-10-03 2002-12-04 Chiron Corporation Superoxide dismutase and expression in microorganisms
JPS61111690A (ja) * 1984-11-06 1986-05-29 Ube Ind Ltd 組換えｄｎａおよびその用途
JPS61139390A (ja) * 1984-12-13 1986-06-26 Nippon Kayaku Co Ltd ひとｓｏｄをコ−ドする新規ｄｎａおよびそれを有する微生物

Also Published As

Publication number Publication date
DK402785D0 (da) 1985-09-03
IE862342L (en) 1987-03-03
IE59078B1 (en) 1994-01-12
AU598756B2 (en) 1990-07-05
NO301132B1 (no) 1997-09-15
EP0236385A1 (en) 1987-09-16
JPH08317793A (ja) 1996-12-03
IL79926A (en) 1994-10-07
FI871853A0 (fi) 1987-04-28
NO871816D0 (no) 1987-04-30
DK224587D0 (da) 1987-05-01
CN1030718C (zh) 1996-01-17
SU1779263A3 (ru) 1992-11-30
JP2688190B2 (ja) 1997-12-08
ATE69466T1 (de) 1991-11-15
DE3682505D1 (de) 1991-12-19
KR920008738B1 (ko) 1992-10-08
KR880700066A (ko) 1988-02-15
FI100252B (fi) 1997-10-31
CA1340329C (en) 1999-01-26
FI871853A (fi) 1987-04-28
CN86106774A (zh) 1987-07-15
JPS63501473A (ja) 1988-06-09
HU215937B (hu) 1999-03-29
EP0236385B1 (en) 1991-11-13
ZA871267B (en) 1987-10-28
US5130245A (en) 1992-07-14
HUT46059A (en) 1988-09-28
NO871816L (no) 1987-07-02
JP2643934B2 (ja) 1997-08-25
IL79926A0 (en) 1986-12-31
WO1987001387A1 (en) 1987-03-12
AU6370886A (en) 1987-03-24

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