DK2204186T3 - Immunogene komplekser og dertil relaterede fremgangsmåder - Google Patents

Immunogene komplekser og dertil relaterede fremgangsmåder Download PDF

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Publication number
DK2204186T3
DK2204186T3 DK10003539.3T DK10003539T DK2204186T3 DK 2204186 T3 DK2204186 T3 DK 2204186T3 DK 10003539 T DK10003539 T DK 10003539T DK 2204186 T3 DK2204186 T3 DK 2204186T3
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iscomatrix
antigen
complex
protein
organic complex
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DK10003539.3T
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English (en)
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John Cooper Cox
Andreas Suhrbier
Debbie Pauline Drane
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Csl Ltd
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Priority claimed from AUPP8735A external-priority patent/AUPP873599A0/en
Priority claimed from AUPQ1861A external-priority patent/AUPQ186199A0/en
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Publication of DK2204186T3 publication Critical patent/DK2204186T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Pulmonology (AREA)
  • Biotechnology (AREA)
  • AIDS & HIV (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (13)

1. Fremgangsmåde til fremstilling af et elektrostatisk associeret, immunogent kompleks, som omfatter et negativt ladet organisk kompleks og et positivt ladet antigen, hvilken fremgangsmåde i det væsentlige består i at blande: (A) et foruddannet, negativt ladet organisk kompleks, som omfatter et saponin, og (B) et isoleret, positivt ladet antigen, idet der derved dannes et immunogent kompleks, hvor det organiske kompleks og antigenet er associeret ved hjælp af elektrostatisk interaktion.
2. Fremgangsmåde ifølge krav 1, hvor antigenet er et protein, eller omfatter en peptidregion.
3. Fremgangsmåde ifølge krav 1 eller krav 2, hvor det foruddannede organiske kompleks yderligere omfatter et phospholipid.
4. Fremgangsmåde ifølge krav 3, hvor phospholipidet er et phosphoglycerid, som eventuelt er valgt fra gruppen bestående af phosphatidyl-inositol, phosphatidyl-glycerol, phosphatidsyre og cardiolipin.
5. Fremgangsmåde ifølge krav 3, hvor phospholipidet er lipid A, som eventuelt er valgt fra gruppen bestående af di-phosphoryl-lipid A og mono-phosphoryl-lipid A.
6. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 5, hvor: (a) det immunogene kompleks fremkalder et cytotoksisk T-lymfocytrespons, når det administreres til et pattedyr; (b) antigenet modificeres for at øge graden af dets positive ladning; og/eller (c) det foruddannede organiske kompleks modificeres for at øge graden af dets negative ladning.
7. Fremgangsmåde ifølge krav 6, hvor antigenet modificeres ved addition af polylysin og/eller arginin.
8. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 7, hvor det foruddannede organiske kompleks er et negativt ladet kompleks, som modificeres for at øge graden af dets negative ladning.
9. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 8, hvor antigenet ikke omfatter en hydrofob region.
10. Fremgangsmåde ifølge et hvilket som helst af kravene 1 til 9, hvor det foruddannede organiske kompleks yderligere omfatter cholesterol.
11. Vaccinesammensætning, der som den aktive bestanddel omfatter en negativt ladet organisk bærer omfattende saponin og et positivt ladet antigen, hvor bæreren og antigenet er elektrostatisk associeret, sammen med en/et eller flere farmaceutisk acceptable bærere og/eller fortyndingsmidler.
12. Fremgangsmåde til dannelse af et immunogent kompleks, som omfatter et negativt ladet organisk kompleks og et positivt ladet antigen, hvilken fremgangsmåde omfatter at udvælge et organisk kompleks, at modificere det organiske kompleks for at øge dets negative ladning og at omsætte antigenet med et organisk kompleks, som omfatter et saponin.
13. Fremgangsmåde ifølge krav 12, som yderligere omfatter trinet til at øge antigenets positive ladning inden omsætning af antigenet med det organiske kompleks.
DK10003539.3T 1999-02-17 2000-02-17 Immunogene komplekser og dertil relaterede fremgangsmåder DK2204186T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPP8735A AUPP873599A0 (en) 1999-02-17 1999-02-17 Immunogenic compositions and methods relating thereto
AUPQ1861A AUPQ186199A0 (en) 1999-07-27 1999-07-27 Immunogenic complexes and methods relating thereto-ii
EP00904734A EP1150710B1 (en) 1999-02-17 2000-02-17 Immunogenic complexes and methods relating thereto

Publications (1)

Publication Number Publication Date
DK2204186T3 true DK2204186T3 (da) 2016-07-18

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US (2) US7776343B1 (da)
EP (2) EP1150710B1 (da)
JP (1) JP5084984B2 (da)
AT (1) ATE464907T1 (da)
AU (1) AU783344B2 (da)
CA (1) CA2362204C (da)
DE (1) DE60044236D1 (da)
DK (1) DK2204186T3 (da)
ES (1) ES2572834T3 (da)
HK (1) HK1039895B (da)
NZ (1) NZ513935A (da)
WO (1) WO2000048630A1 (da)

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