DK2190863T3 - New albumin binding compositions, methods and uses - Google Patents
New albumin binding compositions, methods and uses Download PDFInfo
- Publication number
- DK2190863T3 DK2190863T3 DK08786222.3T DK08786222T DK2190863T3 DK 2190863 T3 DK2190863 T3 DK 2190863T3 DK 08786222 T DK08786222 T DK 08786222T DK 2190863 T3 DK2190863 T3 DK 2190863T3
- Authority
- DK
- Denmark
- Prior art keywords
- seq
- albumin
- polypeptide
- binding
- protein
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- Hematology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| EP07113533 | 2007-07-31 | ||
| PCT/EP2008/059389 WO2009016043A2 (en) | 2007-07-31 | 2008-07-17 | New albumin binding compositions, methods and uses |
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| DK2190863T3 true DK2190863T3 (en) | 2015-11-30 |
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| DK08786222.3T DK2190863T3 (en) | 2007-07-31 | 2008-07-17 | New albumin binding compositions, methods and uses |
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| WO (1) | WO2009016043A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2694139C (en) * | 2007-07-31 | 2018-06-05 | Affibody Ab | Albumin binding polypeptide compositions |
| US20120134984A1 (en) * | 2009-06-01 | 2012-05-31 | Olga Lubman | Molecules with extended half-lives and uses thereof |
| DK2977088T3 (en) * | 2010-03-08 | 2017-10-09 | Ge Healthcare Bioprocess R&D Ab | IMMUNOGLOBULIN G FC REGION BINDING POLYPEPTIDE |
| JP5827218B2 (ja) * | 2010-04-30 | 2015-12-02 | 株式会社三和化学研究所 | 生理活性物質等の生体内安定性向上のためのペプチド及び生体内安定性が向上した生理活性物質 |
| CN110437320B (zh) | 2010-07-09 | 2023-10-20 | 阿菲博迪公司 | 多肽 |
| EP2601216B1 (en) * | 2010-08-02 | 2018-01-03 | MacroGenics, Inc. | Covalent diabodies and uses thereof |
| BR112013007442A2 (pt) | 2010-09-28 | 2019-09-24 | Amylin Pharmaceuticals Llc | polipeptídeos construídos tendo duração de ação realçada |
| BR112013007385B1 (pt) * | 2010-09-28 | 2022-07-26 | Amylin Pharmaceuticals, Llc | Polipeptídeo quimérico, seu uso e composição que o compreende |
| DK2643349T3 (da) | 2010-11-26 | 2019-11-25 | Molecular Partners Ag | Designede repeat-proteiner, der binder til serumalbumin |
| ES2605784T3 (es) * | 2011-05-21 | 2017-03-16 | Macrogenics, Inc. | Dominios de enlazamiento a suero desinmunizados y su uso para extender la vida media en suero |
| WO2013009545A1 (en) * | 2011-07-08 | 2013-01-17 | Amylin Pharmaceuticals, Inc. | Engineered polypeptides having enhanced duration of action with reduced immunogenicity |
| ES2732475T3 (es) | 2011-07-08 | 2019-11-22 | Aegerion Pharmaceuticals Inc | Polipéptidos modificados por ingeniería genética que tienen una duración potenciada de la acción y una inmunogenicidad reducida |
| EP4616914A3 (en) | 2012-02-20 | 2025-11-19 | IPC Research, LLC | Polypeptides binding to human complement c5 |
| EP2844269A4 (en) * | 2012-03-28 | 2016-01-06 | Amylin Pharmaceuticals Llc | TRANSMUCOSAL ADMINISTRATION OF MANIPULATED POLYPEPTIDES |
| JP2020033372A (ja) * | 2012-03-28 | 2020-03-05 | アフィボディ・アーベー | 経口投与 |
| KR20140142298A (ko) * | 2012-03-28 | 2014-12-11 | 애피바디 에이비 | 경구투여 |
| JP2015519345A (ja) | 2012-05-25 | 2015-07-09 | ヤンセン バイオテツク，インコーポレーテツド | 非天然コンセンサスアルブミン結合ドメイン |
| WO2014048977A1 (en) * | 2012-09-25 | 2014-04-03 | Affibody Ab | Albumin binding polzpeptide |
| CN104768976B (zh) | 2012-10-05 | 2020-09-22 | 阿菲博迪公司 | Her3结合多肽 |
| KR102151289B1 (ko) * | 2012-10-25 | 2020-09-02 | 애피바디 에이비 | Abd 결합 폴리펩티드 |
| ES2674983T3 (es) * | 2012-10-25 | 2018-07-05 | Affibody Ab | Método para la separación de proteínas que contienen un dominio que se une a albúmina |
| WO2014076179A1 (en) | 2012-11-14 | 2014-05-22 | Affibody Ab | New polypeptide |
| US9255262B2 (en) * | 2013-03-06 | 2016-02-09 | Vision Global Holdings Ltd. | Albumin-binding arginine deminase and the use thereof |
| USRE48805E1 (en) | 2013-03-06 | 2021-11-02 | Vision Global Holdings Ltd. | Method for cancer targeting treatment and detection of arginine using albumin-binding arginine deiminase fusion protein |
| RU2015142437A (ru) | 2013-03-14 | 2017-04-27 | Дайити Санкио Ко., Лтд | Новые связывающие белки для pcsk9 |
| HK1218534A1 (zh) | 2013-03-14 | 2017-02-24 | 多伦多大学管理委员会 | 支架化肽文库以及其制备和筛选方法 |
| ES2660912T3 (es) | 2013-03-15 | 2018-03-26 | Affibody Ab | Nuevos polipéptidos |
| AU2014254019B2 (en) | 2013-04-18 | 2018-09-27 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| AU2014281828B2 (en) | 2013-06-17 | 2019-05-09 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
| KR20160068744A (ko) | 2013-08-28 | 2016-06-15 | 애피바디 에이비 | 돌연변이된 스캐폴드를 갖는 결합 폴리펩티드 |
| KR102446636B1 (ko) | 2013-08-28 | 2022-09-23 | 스위디쉬 오르펀 바이오비트럼 에이비 (피유비엘) | 인간 보체 c5에 결합하는 안정한 폴리펩티드 |
| HK1226308A1 (zh) | 2013-08-30 | 2017-09-29 | Armo Biosciences, Inc. | 使用白细胞介素-10治疗疾病和病症的方法 |
| BR112016010166A2 (pt) | 2013-11-11 | 2017-12-05 | Armo Biosciences Inc | métodos para usar interleucina-10 para tratar doenças e distúrbios |
| EP3083675B1 (en) | 2013-12-20 | 2018-03-07 | Affibody AB | Engineered albumin binding polypeptide |
| US10293043B2 (en) | 2014-06-02 | 2019-05-21 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
| MY192917A (en) | 2014-07-30 | 2022-09-15 | Ngm Biopharmaceuticals Inc | Compositions and methods of use for treating metabolic disorders |
| SI3193930T1 (sl) | 2014-09-17 | 2019-10-30 | Affibody Ab | Novi polipeptidi |
| CA2963989A1 (en) | 2014-10-14 | 2016-04-21 | Armo Biosciences, Inc. | Interleukin-15 compositions and uses thereof |
| AU2015336101A1 (en) | 2014-10-22 | 2017-04-20 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US9920118B2 (en) | 2014-10-31 | 2018-03-20 | Ngm Biopharmaceuticals, Inc. | Compositions and methods of use for treating metabolic disorders |
| KR20240110106A (ko) | 2015-01-12 | 2024-07-12 | 애피바디 에이비 | Il-17a-결합 폴리펩티드 |
| WO2016126615A1 (en) | 2015-02-03 | 2016-08-11 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
| US11052133B2 (en) | 2015-05-06 | 2021-07-06 | Protomer Technologies, Inc. | Glucose responsive insulins |
| CN107847583A (zh) | 2015-05-28 | 2018-03-27 | 阿尔莫生物科技股份有限公司 | 用于治疗癌症的聚乙二醇化白细胞介素‑10 |
| EP3331557B1 (en) | 2015-08-04 | 2021-04-07 | Duke University | Genetically encoded intrinsically disordered stealth polymers for delivery and methods of using same |
| CN108025040A (zh) | 2015-08-25 | 2018-05-11 | 阿尔莫生物科技股份有限公司 | 使用白介素-10治疗疾病和病症的方法 |
| US11752213B2 (en) | 2015-12-21 | 2023-09-12 | Duke University | Surfaces having reduced non-specific binding and antigenicity |
| CN107022031A (zh) * | 2016-01-29 | 2017-08-08 | 中国人民解放军军事医学科学院微生物流行病研究所 | 融合蛋白HSA1-Vβ1及其应用 |
| US11467156B2 (en) | 2016-06-01 | 2022-10-11 | Duke University | Nonfouling biosensors |
| WO2018057847A1 (en) | 2016-09-23 | 2018-03-29 | Duke University | Unstructured non-repetitive polypeptides having lcst behavior |
| CN107952080A (zh) * | 2016-10-14 | 2018-04-24 | 中国科学院过程工程研究所 | 一种肿瘤靶向多肽-药物偶联衍生物、其制备方法及应用 |
| US11648200B2 (en) | 2017-01-12 | 2023-05-16 | Duke University | Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature triggered hierarchical self-assembly |
| US11554097B2 (en) | 2017-05-15 | 2023-01-17 | Duke University | Recombinant production of hybrid lipid-biopolymer materials that self-assemble and encapsulate agents |
| WO2019006374A1 (en) | 2017-06-30 | 2019-01-03 | Duke University | ORDER AND DISORDER AS A DESIGN PRINCIPLE FOR STIMULI-SENSITIVE BIOPOLYMER NETWORKS |
| JP2020530453A (ja) | 2017-08-09 | 2020-10-22 | マサチューセッツ インスティテュート オブ テクノロジー | アルブミン結合ペプチド結合体及びその方法 |
| US20200239575A1 (en) * | 2017-10-06 | 2020-07-30 | University Of Utah Research Foundation | A fusion protein for targeted therapy of autoimmune disease |
| EP3691693A4 (en) | 2017-10-06 | 2021-08-25 | University Of Utah Research Foundation | FUSION PROTEIN FOR TARGETED THERAPY OF AUTOIMMUNE DISEASE |
| WO2019147954A1 (en) * | 2018-01-26 | 2019-08-01 | Duke University | Albumin binding peptide-drug (aibiped) conjugates and methods of making and using same |
| US11505576B2 (en) | 2018-03-13 | 2022-11-22 | Affibody Ab | Polypeptides based on a scaffold |
| EP3788343B1 (en) | 2018-04-30 | 2024-03-27 | Duke University | Stimuli-responsive peg-like polymer-based drug delivery platform |
| EP3829622A4 (en) | 2018-08-02 | 2022-05-11 | Duke University | DOUBLE AGONIST FUSION PROTEINS |
| WO2020051541A1 (en) * | 2018-09-07 | 2020-03-12 | Duke University | Nanoparticulate drug delivery systems |
| CN113710229A (zh) | 2019-02-25 | 2021-11-26 | 芝加哥大学 | 用与抗炎剂连接的ecm亲和肽治疗炎症性和自身免疫性病症的方法和组合物 |
| CN114206908B (zh) | 2019-06-04 | 2025-12-23 | 分子伴侣公司 | 具有改善的稳定性的经设计的锚蛋白重复结构域 |
| US11512314B2 (en) | 2019-07-12 | 2022-11-29 | Duke University | Amphiphilic polynucleotides |
| AU2020342349A1 (en) | 2019-09-02 | 2022-03-03 | Biotest Ag | Factor VIII protein with increased half-life |
| EP3785726A1 (en) | 2019-09-02 | 2021-03-03 | Biotest AG | Factor viii protein with increased half-life |
| US20220389066A1 (en) | 2019-11-05 | 2022-12-08 | Affibody Ab | Polypeptides |
| EP4106798A1 (en) | 2020-02-17 | 2022-12-28 | Biotest AG | Subcutaneous administration of factor viii |
| EP3878515A1 (en) * | 2020-03-09 | 2021-09-15 | Hober Biotech AB | Therapeutic agent targeting her2 |
| WO2022098743A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, imaging, and therapeutic methods targeting folate receptor 1 (folr1) |
| WO2022098745A1 (en) | 2020-11-03 | 2022-05-12 | Indi Molecular, Inc. | Compositions, delivery systems, and methods useful in tumor therapy |
| KR20230123989A (ko) | 2020-12-21 | 2023-08-24 | 애피바디 에이비 | 신규 폴리펩티드 |
| US20240124533A1 (en) | 2021-02-15 | 2024-04-18 | Affibody Ab | New her2-binding polypeptide |
| MX2024009732A (es) | 2022-02-08 | 2024-08-19 | Affibody Ab | Variantes de la proteina z que enlazan la linfopoyetina estromal timica y su uso medico. |
| WO2023225534A1 (en) | 2022-05-18 | 2023-11-23 | Protomer Technologies Inc. | Aromatic boron-containing compounds and related insulin analogs |
| EP4570834A1 (en) | 2022-08-10 | 2025-06-18 | Kowa Company, Ltd. | Affibody micelle drug conjugate |
| WO2024170756A1 (en) | 2023-02-17 | 2024-08-22 | Ablynx N.V. | Polypeptides binding to the neonatal fc receptor |
| AU2024265436A1 (en) | 2023-05-04 | 2025-11-06 | Affibody Ab | New polypeptide |
| WO2025073871A1 (en) | 2023-10-03 | 2025-04-10 | Bicycletx Limited | Bicyclic peptide ligand complexes specific for tfr1 |
| WO2025158010A1 (en) | 2024-01-25 | 2025-07-31 | Affibody Ab | Her2-binding polypeptide |
| CN121041473A (zh) * | 2024-05-29 | 2025-12-02 | 烟台蓝纳成生物技术股份有限公司 | 一种双功能性融合蛋白、放射性核素标记物及其应用 |
| CN118666961B (zh) * | 2024-08-23 | 2024-11-26 | 通化安睿特生物制药股份有限公司 | 人白蛋白特异结合多肽及其应用 |
Family Cites Families (16)
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| SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
| FR2718452B1 (fr) * | 1994-04-06 | 1996-06-28 | Pf Medicament | Elément d'immunogène, agent immunogène, composition pharmaceutique et procédé de préparation. |
| FR2726471B1 (fr) * | 1994-11-07 | 1997-01-31 | Pf Medicament | Procede pour ameliorer l'immunogenicite d'un compose immunogene ou d'un haptene et application a la preparation de vaccins |
| DE19742706B4 (de) * | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9823071D0 (en) * | 1998-10-21 | 1998-12-16 | Affibody Technology Ab | A method |
| GB9911287D0 (en) * | 1999-05-14 | 1999-07-14 | Affibody Technology Sweden Ab | Self-assembling protein structures |
| CA2921260A1 (en) | 1999-12-24 | 2001-06-28 | Genentech, Inc. | Methods and compositions for prolonging elimination half-times of bioactive compounds |
| US20040001827A1 (en) | 2002-06-28 | 2004-01-01 | Dennis Mark S. | Serum albumin binding peptides for tumor targeting |
| CN1169827C (zh) | 2001-08-07 | 2004-10-06 | 沈阳三生制药股份有限公司 | 一种增强多肽在体内稳定性药物的生产方法及其应用 |
| AU2001298053A1 (en) * | 2001-09-27 | 2003-04-14 | Pieris Proteolab Ag | Muteins of apolipoprotein D |
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| SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
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| CA2694139C (en) * | 2007-07-31 | 2018-06-05 | Affibody Ab | Albumin binding polypeptide compositions |
| US10208128B2 (en) * | 2009-11-04 | 2019-02-19 | Affibody Ab | HER3 binding polypeptides |
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Also Published As
| Publication number | Publication date |
|---|---|
| EP2190863B1 (en) | 2015-09-02 |
| EP2190863A2 (en) | 2010-06-02 |
| AU2008281913B2 (en) | 2013-11-07 |
| US10118949B2 (en) | 2018-11-06 |
| CN104710518A (zh) | 2015-06-17 |
| US8937153B2 (en) | 2015-01-20 |
| CN101765608B (zh) | 2015-03-11 |
| CA2694139C (en) | 2018-06-05 |
| EP2546261A3 (en) | 2013-08-14 |
| CN101765608A (zh) | 2010-06-30 |
| AU2008281913A1 (en) | 2009-02-05 |
| ES2346178T3 (es) | 2015-11-02 |
| ES2346178T1 (es) | 2010-10-13 |
| HK1211040A1 (en) | 2016-05-13 |
| EP2546261A2 (en) | 2013-01-16 |
| JP2010534486A (ja) | 2010-11-11 |
| CA2694139A1 (en) | 2009-02-05 |
| US20100273979A1 (en) | 2010-10-28 |
| JP5718638B2 (ja) | 2015-05-13 |
| DE08786222T1 (de) | 2010-11-25 |
| WO2009016043A2 (en) | 2009-02-05 |
| US20150158916A1 (en) | 2015-06-11 |
| WO2009016043A3 (en) | 2009-06-04 |
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