DK2170956T3 - Behandling af tumorer under anvendelse af specifikt anti-l1-antistof - Google Patents
Behandling af tumorer under anvendelse af specifikt anti-l1-antistof Download PDFInfo
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- DK2170956T3 DK2170956T3 DK08759230.9T DK08759230T DK2170956T3 DK 2170956 T3 DK2170956 T3 DK 2170956T3 DK 08759230 T DK08759230 T DK 08759230T DK 2170956 T3 DK2170956 T3 DK 2170956T3
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Claims (10)
1. Anti-Ll monoklonalt antistof i) der er i stand til at binde til den samme Ll-epitop genkendt af det monoklonale antistof 9.3, fremstillet af hybridomcellen deponeret under DSMZ ACC2841 og som binder LI med en affinitet (KD) på mindst 10 10, eller ii) kendetegnet ved at dets komplementaritets-bestemmende regioner (CDRs) har følgende sekvenser: LCDR1: RASQDISNYLN, LCDR2: YTSRLHS, LCDR3: QQGNTLPWT, HCDR1: RYWML, HCDR2: EINPRNDRTNYNEKFKT, og HCDR3: GGGYAMDY, og som binder LI med en affinitet (KD) på mindst 1010, eller iii) et monoklonalt antistof, fremstillet af hybridomcellen deponeret under DSMZ ACC2841.
2. Anti-Ll monoklonalt antistof ifølge krav 1 i), hvor epitopen er inden for det første immunglobulin-lignende domæne af LI.
3. Humaniseret antistof omfattende de ikke-humane CDR'er af et monoklonalt antistof ifølge krav 1 eller 2, og en framework-region (FR) fra et humant immunglobulin-molekyle, især, omfattende sekvensen af Ll_9.3hu eller Ll_9.3hu3 som vist i figur 8 a) og b).
4. Antistoffet ifølge et hvilket som helst af kravene 1 til 3, bundet til et aktivstof, fortrinsvis en toxin, en cytokin, en nanopartikel eller et radionuklid.
5. Hybridomcelle (i) der producerer det monoklonale antistof ifølge et hvilket som helst af kravene 1 eller 2, eller (ii) deponeret under DSMZ ACC2841.
6. Antistoffet ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til behandling af en tumorigen sygdom, a) fortrinsvis hos en patient der tidligere er blevet behandlet med et kemoterapeutisk lægemiddel eller med strålebehandling, mere fortrinsvis hvor patienten er mindst delvist resistent over for behandlingen med det kemoterapeutiske lægemiddel eller med strålebehandling, eller b) fortrinsvis hos en patient der er mindst delvist resistent for behandling med et givet kemoterapeutisk lægemiddel eller for strålebehandling, eller c) fortrinsvis hvor antistoffet administreres i kombination med et kemoterapeutisk lægemiddel eller med strålebehandling, mere fortrinsvis hvor det kemoterapeutiske lægemiddel eller strålebehandlingen administreres før anti-Ll-antistoffet.
7. Antistoffet ifølge et hvilket som helst af kravene 1 til 4 til anvendelse i en fremgangsmåde til sensibilisering af tumorceller i en patient til behandling med et kemoterapeutisk lægemiddel eller med strålebehandling, især hvor cellerne er mindst delvist resistente over for behandlingen med det kemoterapeutiske lægemiddel eller for strålebehandling, endnu mere især hvor efter sensibiliseringen med anti-Ll-antistoffet behandles patienten yderligere med det kemoterapeutiske lægemiddel eller med strålebehandling.
8. Antistoffet ifølge et hvilket som helst af kravene 1 til 4 til anvendelsen ifølge et hvilket som helst af kravene 6 til 7, hvor tumorcellerne eller den tumorigene sygdom er af typen valgt fra gruppen bestående af astrocytom, oligodendrogliom, meningiom, neurofibrom, glioblastom, ependymom, Schwannom, neurofibrosarcom, medulloblastom, melanom, pankreascancer, prostatacarcinom, hoved- og halscancer, brystcancer, lungecancer, ovariecancer, endometriecancer, nyrecancer, neuroblastom, skvamøs carcinom, medulloblastom, hepatom, tyktarmscancer og mesotheliom og epidermoid carcinom, eller, hvor tumorcellerne er fra en epiteltumor eller den tumorigene sygdom er en epiteltumor, især hvor epiteltumoren er pankreascancer, tyktarmscancer, ovariecancer eller endometriecancer.
9. Antistoffet ifølge et hvilket som helst af kravene 1 til 4 til anvendelse ifølge et hvilket som helst af kravene 7 til 8, hvor det kemoterapeutiske lægemiddel er et DNA-skadende middel, fortrinsvis valgt fra gruppen bestående af actinomycin-D, mitomycin C, cisplatin, doxorubicin, etoposid, verapamil, podophyllotoxin, 5-FU, taxaner, fortrinsvis paclitaxel og carboplatin, eller, hvor strålebehandlingen er valgt fra gruppen bestående af røntgenstråler, UV-stråler, γ-stråler, a- eller β-stråler, og mikrobølger.
10. Farmaceutisk præparat, omfattende antistoffet ifølge et hvilket som helst af kravene 1 til 4.
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PCT/EP2008/004773 WO2008151819A2 (en) | 2007-06-15 | 2008-06-13 | Treatment of tumors using specific anti-l1 antibody |
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US20040202666A1 (en) | 2003-01-24 | 2004-10-14 | Immunomedics, Inc. | Anti-cancer anthracycline drug-antibody conjugates |
GB0306618D0 (en) | 2003-03-22 | 2003-04-30 | Univ Newcastle | Antibody |
EP1623995A1 (en) | 2004-08-06 | 2006-02-08 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Inhibitors of L1 and ADAM10 for the treatment of carcinomas |
JP2009506790A (ja) | 2005-09-07 | 2009-02-19 | メディミューン,エルエルシー | 毒素とコンジュゲートしたeph受容体抗体 |
WO2007114550A1 (en) * | 2006-04-03 | 2007-10-11 | Korea Research Institute Of Bioscience And Biotechnology | A novel monoclonal antibody specific to the l1cam, a hybridoma producing the same and a method producing the same |
CA2661669C (en) * | 2006-08-23 | 2017-02-14 | Korea Research Institute Of Bioscience And Biotechnology | A pharmaceutical composition for treating cholangiocarcinoma, a method for inhibiting growth or invasion of cholangiocarcinoma and a method for treating cholangniocarcinoma |
WO2008046529A1 (en) | 2006-10-16 | 2008-04-24 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Treatment of chemotherapy- or radiotherapy-resistant tumors using an l1 interfering molecule |
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2008
- 2008-06-13 NO NO13000027A patent/NO2631248T3/no unknown
- 2008-06-13 WO PCT/EP2008/004773 patent/WO2008151819A2/en active Application Filing
- 2008-06-13 CA CA2691075A patent/CA2691075C/en not_active Expired - Fee Related
- 2008-06-13 EP EP13000027.6A patent/EP2631248B9/en active Active
- 2008-06-13 PT PT130000276T patent/PT2631248T/pt unknown
- 2008-06-13 CA CA2958672A patent/CA2958672A1/en not_active Abandoned
- 2008-06-13 DK DK08759230.9T patent/DK2170956T3/da active
- 2008-06-13 PL PL08759230T patent/PL2170956T3/pl unknown
- 2008-06-13 HU HUE13000027A patent/HUE036490T2/hu unknown
- 2008-06-13 ES ES13000027.6T patent/ES2658342T3/es active Active
- 2008-06-13 SI SI200831916T patent/SI2631248T1/en unknown
- 2008-06-13 DK DK13000027.6T patent/DK2631248T3/da active
- 2008-06-13 PL PL13000027T patent/PL2631248T3/pl unknown
- 2008-06-13 LT LTEP13000027.6T patent/LT2631248T/lt unknown
- 2008-06-13 SI SI200831362T patent/SI2170956T1/sl unknown
- 2008-06-13 ES ES08759230.9T patent/ES2528167T3/es active Active
- 2008-06-13 TW TW097122231A patent/TWI478939B/zh not_active IP Right Cessation
- 2008-06-13 PT PT87592309T patent/PT2170956E/pt unknown
- 2008-06-13 US US12/139,006 patent/US8138313B2/en not_active Expired - Fee Related
- 2008-06-13 EP EP08759230.9A patent/EP2170956B1/en not_active Not-in-force
- 2008-06-13 JP JP2010511542A patent/JP5921066B2/ja not_active Expired - Fee Related
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2012
- 2012-02-06 US US13/367,178 patent/US8580258B2/en not_active Expired - Fee Related
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2013
- 2013-10-03 US US14/045,019 patent/US9260521B2/en not_active Expired - Fee Related
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2014
- 2014-10-01 JP JP2014202878A patent/JP6042395B2/ja not_active Expired - Fee Related
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2015
- 2015-01-07 HR HRP20150007TT patent/HRP20150007T8/hr unknown
- 2015-01-22 CY CY20151100066T patent/CY1115960T1/el unknown
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2018
- 2018-02-01 HR HRP20180192TT patent/HRP20180192T1/hr unknown
- 2018-02-05 CY CY20181100143T patent/CY1119890T1/el unknown
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