DK2153870T3 - Sammensætninger, der omfatter ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encefalopati - Google Patents
Sammensætninger, der omfatter ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encefalopati Download PDFInfo
- Publication number
- DK2153870T3 DK2153870T3 DK09013613.6T DK09013613T DK2153870T3 DK 2153870 T3 DK2153870 T3 DK 2153870T3 DK 09013613 T DK09013613 T DK 09013613T DK 2153870 T3 DK2153870 T3 DK 2153870T3
- Authority
- DK
- Denmark
- Prior art keywords
- ornithine
- phenylbutyrate
- ammonia
- phenylacetate
- isoleucine
- Prior art date
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
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- Chemical & Material Sciences (AREA)
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- Oncology (AREA)
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- Biomedical Technology (AREA)
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Claims (14)
1. Farmaceutisk sammensætning til indgivelse til et menneske, omfattende ornithin og mindst en af phenylacetat og phenylbutyrat i et vægtforhold fra 2:01 til 01:2.
2. Farmaceutisk sammensætning ifølge krav 1, som yderligere omfatter isoleucin.
3. Farmaceutisk sammensætning ifølge krav 2, hvor isoleucin foreligger som en fri monomer aminosyre eller fysiologisk acceptabelt salt.
4. Farmaceutisk sammensætning ifølge krav 1, som i det væsentlige ikke omfatter nogen anden aminosyre.
5. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 3, som i det væsentlige ikke omfatter noget aspartat eller intet aspartat.
6. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor ornithin foreligger som en fri monomer aminosyre eller fysiologisk acceptabelt salt.
7. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor ornithin er L-ornithin.
8. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den mindst ene af phenylacetat og phenylbutyrat foreligger som natriumphenylacetat eller natriumphenylbutyrat.
9. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, der er formuleret til intravenøs eller oral indgivelse.
10. Farmaceutisk sammensætning ifølge et hvilket som helst af kravene 1 til 9, som er formuleret til intraperitoneal, intragastrisk eller intravaskulær indgivelse.
11. Farmaceutisk sammensætning ifølge et hvilket som helst af de foregående krav, hvor den mindst ene af phenylacetat og phenylbutyrat er phenylacetat.
12. Farmaceutisk sammensætning til indgivelse til et menneske, der består af ornithin og i det mindste en af phenylacetat og phenylbutyrat i et vægtforhold fra 2:1 til 1:2.
13. Farmaceutisk sammensætning ifølge krav 1, omfattende fra 1 g til 50 g ornithin og fra 1 g til 50 g phenylacetat eller phenylbutyrat.
14. Farmaceutisk sammensætning ifølge krav 1, omfattende fra 5 g til 30 g ornithin og fra 5 g til 30 g phenylacetat eller phenylbutyrat.
Applications Claiming Priority (3)
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GB0426142A GB0426142D0 (en) | 2004-11-26 | 2004-11-26 | Formulation |
GB0426141A GB0426141D0 (en) | 2004-11-26 | 2004-11-26 | Treatment |
EP05808837A EP1824563B1 (en) | 2004-11-26 | 2005-11-28 | Compositions comprising ornithine and phenylacetate or phenylbutyrate for treating hepatic encephalopathy |
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DK09013613.6T DK2153870T3 (da) | 2004-11-26 | 2005-11-28 | Sammensætninger, der omfatter ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encefalopati |
DK10014283.5T DK2319581T3 (da) | 2004-11-26 | 2005-11-28 | Sammensætninger omfattende ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encephalopati |
DK05808837.8T DK1824563T3 (da) | 2004-11-26 | 2005-11-28 | Sammensætninger, der omfatter ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encephalopati |
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DK10014283.5T DK2319581T3 (da) | 2004-11-26 | 2005-11-28 | Sammensætninger omfattende ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encephalopati |
DK05808837.8T DK1824563T3 (da) | 2004-11-26 | 2005-11-28 | Sammensætninger, der omfatter ornithin og phenylacetat eller phenylbutyrat til behandling af hepatisk encephalopati |
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US (3) | US8389576B2 (da) |
EP (3) | EP1824563B1 (da) |
JP (2) | JP5116479B2 (da) |
KR (1) | KR101380446B1 (da) |
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SG (1) | SG158073A1 (da) |
SI (3) | SI2319581T1 (da) |
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