DK2143792T3 - Enkelt-strenget, cyklisk RNA, og en fremgangsmåde til fremstilling deraf - Google Patents

Enkelt-strenget, cyklisk RNA, og en fremgangsmåde til fremstilling deraf

Info

Publication number
DK2143792T3
DK2143792T3 DK08764303.7T DK08764303T DK2143792T3 DK 2143792 T3 DK2143792 T3 DK 2143792T3 DK 08764303 T DK08764303 T DK 08764303T DK 2143792 T3 DK2143792 T3 DK 2143792T3
Authority
DK
Denmark
Prior art keywords
preparation
stranded cyclic
cyclic rna
rna
stranded
Prior art date
Application number
DK08764303.7T
Other languages
English (en)
Inventor
Hiroshi Abe
Yoshihiro Ito
Naoko Abe
Hidekazu Toyobuku
Original Assignee
Riken
Otsuka Pharma Co Ltd
Hayashi Kasei Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Riken, Otsuka Pharma Co Ltd, Hayashi Kasei Co Ltd filed Critical Riken
Application granted granted Critical
Publication of DK2143792T3 publication Critical patent/DK2143792T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0016—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the nucleic acid is delivered as a 'naked' nucleic acid, i.e. not combined with an entity such as a cationic lipid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/53—Physical structure partially self-complementary or closed
    • C12N2310/532—Closed or circular
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
DK08764303.7T 2007-05-09 2008-05-09 Enkelt-strenget, cyklisk RNA, og en fremgangsmåde til fremstilling deraf DK2143792T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007125045A JP5296328B2 (ja) 2007-05-09 2007-05-09 １本鎖環状ｒｎａおよびその製造方法
PCT/JP2008/058990 WO2008140126A1 (ja) 2007-05-09 2008-05-09 １本鎖環状ｒｎａおよびその製造方法

Publications (1)

Publication Number Publication Date
DK2143792T3 true DK2143792T3 (da) 2014-04-07

Family

ID=40002313

Family Applications (1)

Application Number Title Priority Date Filing Date
DK08764303.7T DK2143792T3 (da) 2007-05-09 2008-05-09 Enkelt-strenget, cyklisk RNA, og en fremgangsmåde til fremstilling deraf

Country Status (26)

Country Link
US (3) US20100137407A1 (da)
EP (1) EP2143792B1 (da)
JP (1) JP5296328B2 (da)
KR (1) KR101525633B1 (da)
CN (1) CN101679962A (da)
AR (1) AR072034A1 (da)
AU (1) AU2008250075B2 (da)
BR (1) BRPI0811440A2 (da)
CA (1) CA2685994A1 (da)
CO (1) CO6241167A2 (da)
CY (1) CY1115283T1 (da)
DK (1) DK2143792T3 (da)
ES (1) ES2446040T3 (da)
HK (1) HK1135140A1 (da)
HR (1) HRP20140170T1 (da)
IL (1) IL201975A (da)
MX (1) MX2009011101A (da)
MY (1) MY154495A (da)
NZ (1) NZ581251A (da)
PL (1) PL2143792T3 (da)
PT (1) PT2143792E (da)
RU (1) RU2523596C2 (da)
SI (1) SI2143792T1 (da)
TW (1) TWI468515B (da)
UA (1) UA101806C2 (da)
WO (1) WO2008140126A1 (da)

Families Citing this family (66)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110055965A1 (en) * 2008-02-15 2011-03-03 Hiroshi Abe Cycle single-stranded nucleic acid complex and method for producing the same
WO2011143659A2 (en) * 2010-05-14 2011-11-17 Fluidigm Corporation Nucleic acid isolation methods
US8785121B2 (en) 2010-07-08 2014-07-22 Bonac Corporation Single-stranded nucleic acid molecule for controlling gene expression
SG196779A1 (en) * 2010-07-08 2014-02-13 Bonac Corp Single-strand nucleic acid molecule for controlling gene expression
US8691782B2 (en) 2010-08-03 2014-04-08 Bonac Corporation Single-stranded nucleic acid molecule having nitrogen-containing alicyclic skeleton
EP3578205A1 (en) 2010-08-06 2019-12-11 ModernaTX, Inc. A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof
US20120237975A1 (en) 2010-10-01 2012-09-20 Jason Schrum Engineered nucleic acids and methods of use thereof
AR083445A1 (es) 2010-10-14 2013-02-27 Univ Mie siARN CONTRA LA FIBROSIS
US9115167B2 (en) 2011-03-10 2015-08-25 Biomics Biotechnologies Co., Ltd. Multi-targets interfering RNA molecules and their applications
EP2691101A2 (en) 2011-03-31 2014-02-05 Moderna Therapeutics, Inc. Delivery and formulation of engineered nucleic acids
US9464124B2 (en) 2011-09-12 2016-10-11 Moderna Therapeutics, Inc. Engineered nucleic acids and methods of use thereof
CA2850624A1 (en) 2011-10-03 2013-04-11 Moderna Therapeutics, Inc. Modified nucleosides, nucleotides, and nucleic acids, and uses thereof
WO2013077446A1 (ja) * 2011-11-26 2013-05-30 株式会社ボナック 遺伝子発現制御のための一本鎖核酸分子
KR20140102759A (ko) 2011-12-16 2014-08-22 모더나 세라퓨틱스, 인코포레이티드 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물
US9283287B2 (en) 2012-04-02 2016-03-15 Moderna Therapeutics, Inc. Modified polynucleotides for the production of nuclear proteins
CA2868398A1 (en) 2012-04-02 2013-10-10 Moderna Therapeutics, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9572897B2 (en) 2012-04-02 2017-02-21 Modernatx, Inc. Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
US9878056B2 (en) 2012-04-02 2018-01-30 Modernatx, Inc. Modified polynucleotides for the production of cosmetic proteins and peptides
US9663784B2 (en) 2012-05-26 2017-05-30 Bonac Corporation Single-stranded nucleic acid molecule for regulating expression of gene having delivering function
JP6144355B2 (ja) 2012-11-26 2017-06-07 モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． 化学修飾ｍＲＮＡ
JP6296434B2 (ja) * 2013-01-25 2018-03-20 国立研究開発法人理化学研究所 機能性核酸分子の構築法
US8980864B2 (en) 2013-03-15 2015-03-17 Moderna Therapeutics, Inc. Compositions and methods of altering cholesterol levels
JP6625521B2 (ja) * 2013-05-15 2020-01-08 リボカイン，エルエルシー 環状ｒｎａの細胞内翻訳
US20160194368A1 (en) 2013-09-03 2016-07-07 Moderna Therapeutics, Inc. Circular polynucleotides
CN104419704B (zh) * 2013-09-05 2016-09-14 中国科学院上海生命科学研究院 一种内含子来源环形rna分子及其成环关键核酸序列的应用
EP3052106A4 (en) 2013-09-30 2017-07-19 ModernaTX, Inc. Polynucleotides encoding immune modulating polypeptides
JP2016538829A (ja) 2013-10-03 2016-12-15 モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 低密度リポタンパク質受容体をコードするポリヌクレオチド
WO2015099122A1 (ja) 2013-12-26 2015-07-02 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
KR20170098914A (ko) 2014-12-27 2017-08-30 가부시키가이샤 보낙 유전자 발현 제어를 위한 천연형 miRNA 및 그의 용도
WO2016158809A1 (ja) 2015-03-27 2016-10-06 株式会社ボナック デリバリー機能と遺伝子発現制御能を有する一本鎖核酸分子
CN105063210A (zh) * 2015-08-12 2015-11-18 中国农业科学院北京畜牧兽医研究所 一种环状rna的鉴定方法
CN107557363B (zh) * 2016-06-30 2021-03-12 中国科学院分子细胞科学卓越创新中心 可诱导型siRNA表达载体及其制备和应用
WO2018182008A1 (ja) 2017-03-31 2018-10-04 株式会社ボナック 遺伝子発現制御機能を有する環状型核酸分子
CN110603330B (zh) 2017-04-28 2023-09-05 协和麒麟株式会社 寡核苷酸衍生物或其盐
EP3642342A4 (en) 2017-06-23 2021-03-17 Cornell University RNA MOLECULES, CIRCULAR RNA PRODUCTION METHODS, AND PROCESSING METHODS
MX2020002872A (es) * 2017-09-15 2020-10-05 Commw Scient Ind Res Org Moléculas de arn.
WO2019074071A1 (ja) * 2017-10-11 2019-04-18 日東電工株式会社 核酸分子発現の調節
MA51155A (fr) 2017-12-15 2020-10-21 Flagship Pioneering Innovations Vi Llc Compositions comprenant des polyribonucléotides circulaires et leurs utilisations
CN108251424A (zh) * 2017-12-19 2018-07-06 天利康（天津）科技有限公司 一种单链环状rna和dna及其制备方法和应用
EP3778886A4 (en) 2018-03-30 2022-11-02 Toray Industries, Inc. METHOD FOR PRODUCING A HAIRPIN SINGLE-STRANDED RNA MOLECULE
CN112399860A (zh) 2018-06-06 2021-02-23 麻省理工学院 用于在真核细胞中翻译的环状rna
AU2020231349A1 (en) 2019-03-01 2021-09-23 Flagship Pioneering Innovations Vi, Llc Compositions, methods, and kits for delivery of polyribonucleotides
IL285951B1 (en) 2019-03-01 2024-04-01 Flagship Pioneering Innovations Vi Llc Polyribonucleotides and their cosmetic uses
CN113544269A (zh) 2019-03-04 2021-10-22 旗舰创业创新第六有限责任公司 环状多核糖核苷酸及其药物组合物
KR20210142678A (ko) 2019-03-25 2021-11-25 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 변형된 원형 폴리리보뉴클레오티드를 포함하는 조성물 및 그의 용도
CA3139032A1 (en) 2019-05-22 2020-11-26 Robert Alexander WESSELHOEFT Circular rna compositions and methods
AU2020292427A1 (en) 2019-06-14 2022-01-06 Flagship Pioneering Innovations Vi, Llc Circular RNAs for cellular therapy
WO2020257730A1 (en) 2019-06-19 2020-12-24 Flagship Pioneering Innovations Vi, Llc Compositions comprising circular polyribonucleotides for protein modulation and uses thereof
CN114096674A (zh) 2019-06-19 2022-02-25 旗舰创业创新第六有限责任公司 环状多核糖核苷酸的给药方法
EP3920976B1 (en) 2019-12-04 2023-07-19 Orna Therapeutics, Inc. Circular rna compositions and methods
WO2021155171A1 (en) 2020-01-29 2021-08-05 Flagship Pioneering Innovations Vi, Llc Delivery of compositions comprising circular polyribonucleotides
TW202142689A (zh) 2020-01-29 2021-11-16 美商旗艦先鋒創新有限責任公司 用於轉譯之組合物及其使用方法
EP4153224A1 (en) 2020-05-20 2023-03-29 Flagship Pioneering Innovations VI, LLC Coronavirus antigen compositions and their uses
JP2023526423A (ja) 2020-05-20 2023-06-21 フラッグシップ パイオニアリング イノベーションズ シックス，エルエルシー 免疫原性組成物及びその使用
WO2021236952A1 (en) 2020-05-20 2021-11-25 Flagship Pioneering, Inc. Compositions and methods for producing human polyclonal antibodies
IL300947A (en) 2020-09-03 2023-04-01 Flagship Pioneering Innovations Vi Llc Immunogenic compositions and uses thereof
WO2022191642A1 (ko) 2021-03-10 2022-09-15 알지노믹스 주식회사 자가 환형화 rna 구조체
WO2023024500A1 (en) * 2021-08-27 2023-03-02 Peking University Constructs and methods for preparing circular rna
WO2023097003A2 (en) 2021-11-24 2023-06-01 Flagship Pioneering Innovations Vi, Llc Immunogenic compositions and their uses
WO2023096990A1 (en) 2021-11-24 2023-06-01 Flagship Pioneering Innovation Vi, Llc Coronavirus immunogen compositions and their uses
WO2023096963A1 (en) 2021-11-24 2023-06-01 Flagship Pioneering Innovations Vi, Llc Varicella-zoster virus immunogen compositions and their uses
AR128002A1 (es) 2021-12-17 2024-03-20 Flagship Pioneering Innovations Vi Llc Métodos de enriquecimiento de rna circular en condiciones desnaturalizantes
TW202340461A (zh) 2021-12-22 2023-10-16 美商旗艦先鋒創新有限責任公司 用於純化多核糖核苷酸之組成物和方法
TW202342064A (zh) 2021-12-23 2023-11-01 美商旗艦先鋒創新有限責任公司 編碼抗融合多肽之環狀多核糖核苷酸
CN115786374B (zh) * 2022-07-06 2023-10-13 广州吉赛生物科技股份有限公司 一种利用鱼腥藻内含子自剪切核酶精准制备环状rna的方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11137260A (ja) 1997-11-06 1999-05-25 Soyaku Gijutsu Kenkyusho:Kk 抗インフルエンザウイルス環状ダンベル型ｒｎａ−ｄｎａキメラ化合物及び抗インフルエンザウイルス剤
US6210931B1 (en) * 1998-11-30 2001-04-03 The United States Of America As Represented By The Secretary Of Agriculture Ribozyme-mediated synthesis of circular RNA
DE19956568A1 (de) 1999-01-30 2000-08-17 Roland Kreutzer Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
EP2363478B1 (en) * 1999-04-21 2019-07-24 Alnylam Pharmaceuticals, Inc. Methods and compositions for inhibiting the function of polynucleotide sequences
WO2003070918A2 (en) * 2002-02-20 2003-08-28 Ribozyme Pharmaceuticals, Incorporated Rna interference by modified short interfering nucleic acid
TR200401292T3 (tr) * 2000-12-01 2004-07-21 Max@Planck@Gesellschaft�Zur�F�Rderung�Der�Wissenschaften RNAÁgirişimineÁyolÁaçanÁküçükÁRNAÁmolekülleri
US20040019001A1 (en) * 2002-02-20 2004-01-29 Mcswiggen James A. RNA interference mediated inhibition of protein typrosine phosphatase-1B (PTP-1B) gene expression using short interfering RNA
WO2003070750A2 (en) * 2002-02-20 2003-08-28 Sirna Therapeutics, Inc Rna interference mediated inhibition of hepatitis c virus
US20090247606A1 (en) * 2001-08-28 2009-10-01 Sirna Therapeutics, Inc. RNA Interference Mediated Inhibition of Adenosine A1 Receptor (ADORA1) Gene Expression Using Short Interfering Nucleic Acid (siNA)
EP1432724A4 (en) 2002-02-20 2006-02-01 Sirna Therapeutics Inc RNA inhibition mediated inhibition of MAP KINASE GENES
JP2005517423A (ja) * 2002-02-20 2005-06-16 サーナ・セラピューティクス・インコーポレイテッド 短干渉核酸（ｓｉＮＡ）を用いるＴＧＦ−ベータおよびＴＧＦ−ベータレセプター遺伝子の発現のＲＮＡ干渉媒介性阻害
US7501503B2 (en) * 2002-12-31 2009-03-10 Mcgill University Compositions and methods for inhibiting RNase H activity of retroid reverse transcriptase
EP1644531A4 (en) * 2003-06-25 2009-03-11 Somagenics Inc TARGET-INDEPENDENT CIRCULARIZATION AND TOPOLOGICAL ASSOCIATION CAPABLE POLYNUCLEOTIDES
WO2005014810A1 (ja) * 2003-08-08 2005-02-17 National Institute Of Advanced Industrial Science And Technology ダンベル型ｄｎａの効率的な製造方法
WO2006007569A2 (en) * 2004-07-01 2006-01-19 Somagenics, Inc. Methods of preparation of gene-specific oligonucleotide libraries and uses thereof

Also Published As

Publication number Publication date
AU2008250075B2 (en) 2014-06-19
UA101806C2 (ru) 2013-05-13
BRPI0811440A2 (pt) 2014-10-21
CN101679962A (zh) 2010-03-24
HRP20140170T1 (hr) 2014-04-25
IL201975A0 (en) 2011-08-01
JP2008278784A (ja) 2008-11-20
TWI468515B (zh) 2015-01-11
PT2143792E (pt) 2014-04-03
MY154495A (en) 2015-06-30
JP5296328B2 (ja) 2013-09-25
KR20100024407A (ko) 2010-03-05
US20180073020A1 (en) 2018-03-15
EP2143792B1 (en) 2014-01-08
US20100137407A1 (en) 2010-06-03
US20190292538A1 (en) 2019-09-26
EP2143792A1 (en) 2010-01-13
IL201975A (en) 2013-12-31
HK1135140A1 (en) 2010-05-28
KR101525633B1 (ko) 2015-06-03
CY1115283T1 (el) 2017-01-04
CO6241167A2 (es) 2011-01-20
AU2008250075A1 (en) 2008-11-20
CA2685994A1 (en) 2008-11-20
MX2009011101A (es) 2009-12-11
EP2143792A4 (en) 2011-08-24
WO2008140126A1 (ja) 2008-11-20
ES2446040T3 (es) 2014-03-06
TW200909577A (en) 2009-03-01
RU2523596C2 (ru) 2014-07-20
RU2009145502A (ru) 2011-06-20
SI2143792T1 (sl) 2014-05-30
AR072034A1 (es) 2010-08-04
NZ581251A (en) 2011-11-25
PL2143792T3 (pl) 2014-07-31

Similar Documents

Publication Publication Date Title
DK2143792T3 (da) Enkelt-strenget, cyklisk RNA, og en fremgangsmåde til fremstilling deraf
DK2376015T3 (da) Pneumopedisk-ortodontisk instrument, system og fremgangsmåde.
BRPI0923828A2 (pt) método de produção de isopreno e um co-produto.
NO2021006I1 (no) Quofenix, delafloksacin
DK2200646T3 (da) RNA-Vacciner
BRPI0814466A2 (pt) Método.
DK3428148T3 (da) Aryloazol-2-yl-cyanoethylaminoforbindelser, fremgangsmåde til fremstilling og fremgangsmåde til anvendelse deraf
NL2003118A1 (nl) Alignment system, lithographic system and method.
EP2134275A4 (en) SPACER OF LATERAL SPINAL APOPHYSIS
DK2155382T3 (da) Fremgangsmåde til fremstilling af en skalkatalysator, skalkatalysator og anvendelse deraf
BRPI0912799A2 (pt) fluxímetro, e, método
DK3196309T3 (da) Thraustochytrider, fedtsyresammensætninger og fremgangsmåder til fremstilling og anvendelse deraf
ATE513831T1 (de) Pyridinä3,4-büpyrazinone
FR2929502B1 (fr) Implant nucleique.
BRPI0919699A2 (pt) conjunto de almofada, e, método de fabricação de um conjunto de almofada.
DK2402425T3 (da) Forbedret brygningsproces
BRPI0913112A2 (pt) fluxímetro, e, método.
DK2095717T3 (da) Fremgangsmåde til fremstilling af fermenteret mælk, og fermenteret mælk
DK2281164T3 (da) Fremgangsmåde til at fremstille en cementklinker, og cementklinkerproduktionsanlæg
DK2134663T3 (da) Beskyttelseslag på højtemperaturudholdende chromoxiddannende substrater, og fremgangsmåde til fremstilling deraf
BRPI1007925A2 (pt) método, e aparelho.
EP2165505A4 (en) METHOD FOR DISCOVERING NETWORK SERVICES PROVIDED BY AN OPERATOR USING AN IMS NETWORK
DK3342292T3 (da) Fast mælk og fremgangsmåde til fremstilling deraf
DK2240482T3 (da) Cykliske azaindol-3-carboxamider, deres fremstilling og deres anvendelse som lægemidler
EP2193208A4 (en) DNA AMPLIFICATION METHOD