DK210888A - Fremgangsmaade til fremstilling af en hoejresmeltende polymorf form af terfenadin - Google Patents

Fremgangsmaade til fremstilling af en hoejresmeltende polymorf form af terfenadin

Info

Publication number
DK210888A
DK210888A DK210888A DK210888A DK210888A DK 210888 A DK210888 A DK 210888A DK 210888 A DK210888 A DK 210888A DK 210888 A DK210888 A DK 210888A DK 210888 A DK210888 A DK 210888A
Authority
DK
Denmark
Prior art keywords
terfenadine
preparing
procedure
polymorph form
approx
Prior art date
Application number
DK210888A
Other languages
English (en)
Other versions
DK210888D0 (da
DK173555B1 (da
Inventor
Timothy G Fawcett
Christian T Goralski
David W Ziettlow
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8198929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK210888(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of DK210888D0 publication Critical patent/DK210888D0/da
Publication of DK210888A publication Critical patent/DK210888A/da
Application granted granted Critical
Publication of DK173555B1 publication Critical patent/DK173555B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198802108A 1986-05-07 1988-04-18 Fremgangsmåde til fremstilling af en ren polymorf form af terfenadin DK173555B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US86061986A 1986-05-07 1986-05-07
US86061986 1986-05-07
EP88106898 1988-04-29
EP88106898A EP0339118B1 (en) 1988-04-29 1988-04-29 Preparation of polymorphically pure terfenadine

Publications (3)

Publication Number Publication Date
DK210888D0 DK210888D0 (da) 1988-04-18
DK210888A true DK210888A (da) 1989-10-19
DK173555B1 DK173555B1 (da) 2001-03-12

Family

ID=8198929

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198802108A DK173555B1 (da) 1986-05-07 1988-04-18 Fremgangsmåde til fremstilling af en ren polymorf form af terfenadin

Country Status (8)

Country Link
US (1) US4742175A (da)
EP (1) EP0339118B1 (da)
AR (1) AR243612A1 (da)
AT (1) ATE107283T1 (da)
CA (1) CA1312610C (da)
DE (1) DE3850244T2 (da)
DK (1) DK173555B1 (da)
ES (1) ES2056851T3 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
IT1217837B (it) * 1988-06-17 1990-03-30 Lepetit Spa Procedimento per la preparazione del "alfa /4(1,1 dimetiletil)fenil/piperidinbutanolo"
IL93499A0 (en) * 1989-02-28 1990-11-29 Merrell Dow Pharma Preparation of the low melting polymorphic form of terfenadine
ZA903145B (en) * 1989-05-01 1991-02-27 Merrell Dow Pharma Process for the preparation of the high melting polymorphic form of terfenadine
US5247092A (en) * 1989-12-29 1993-09-21 Erregierre Industria Chimica S.P.A. Preparation of the high-melting polymorph of terfenadine
FR2681861B1 (fr) * 1991-10-01 1995-06-09 Isochem Sa Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.
US5347006A (en) * 1992-12-31 1994-09-13 Augusto Lavacchielli Method of preparing a polymorph of terfenadine
ATE254594T1 (de) * 1993-06-24 2003-12-15 Albany Molecular Res Inc Verbindungen verwendbar als zwischenprodukte zur herstellung von piperidinderivate
US20020007068A1 (en) * 1999-07-16 2002-01-17 D'ambra Thomas E. Piperidine derivatives and process for their production
US6147216A (en) * 1993-06-25 2000-11-14 Merrell Pharmaceuticals Inc. Intermediates useful for the preparation of antihistaminic piperidine derivatives
KR100333790B1 (ko) 1993-06-25 2002-11-04 메렐 파마슈티칼스 인크. 항히스타민성4-디페닐메틸/디페닐메톡시피페리딘유도체제조용신규중간체
IT1270829B (it) * 1993-09-17 1997-05-13 Recordati Chem Pharm Procedimento per la preparazione di polimorfo i della terfenadina con distribuzione granulometrica ottimale
US20030045722A1 (en) * 1994-05-18 2003-03-06 Henton Daniel R. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudomorphs thereof
WO1995031437A1 (en) * 1994-05-18 1995-11-23 Hoechst Marrion Roussel, Inc. Processes for preparing anhydrous and hydrate forms of antihistaminic piperidine derivatives, polymorphs and pseudormophs thereof
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6194431B1 (en) 1998-04-14 2001-02-27 Paul D. Rubin Methods and compositions using terfenadine metabolites in combination with leukotriene inhibitors
US6613907B2 (en) 2000-11-08 2003-09-02 Amr Technology, Inc. Process for the production of piperidine derivatives with microorganisms
TW200517114A (en) 2003-10-15 2005-06-01 Combinatorx Inc Methods and reagents for the treatment of immunoinflammatory disorders
ZA200804550B (en) 2005-11-09 2009-08-26 Combinatorx Inc Methods, compositions, and kits for the treatment of medical conditions
WO2010021681A2 (en) * 2008-08-18 2010-02-25 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US20110130711A1 (en) * 2009-11-19 2011-06-02 Follica, Inc. Hair growth treatment

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA728544B (en) * 1972-01-28 1974-02-27 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US3878217A (en) * 1972-01-28 1975-04-15 Richardson Merrell Inc Alpha-aryl-4-substituted piperidinoalkanol derivatives
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine

Also Published As

Publication number Publication date
ATE107283T1 (de) 1994-07-15
EP0339118B1 (en) 1994-06-15
EP0339118A1 (en) 1989-11-02
CA1312610C (en) 1993-01-12
AR243612A1 (es) 1993-08-31
DK210888D0 (da) 1988-04-18
DE3850244T2 (de) 1994-10-06
DK173555B1 (da) 2001-03-12
ES2056851T3 (es) 1994-10-16
DE3850244D1 (de) 1994-07-21
US4742175A (en) 1988-05-03

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
PUP Patent expired