FR2681861B1 - Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu. - Google Patents

Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.

Info

Publication number
FR2681861B1
FR2681861B1 FR9112064A FR9112064A FR2681861B1 FR 2681861 B1 FR2681861 B1 FR 2681861B1 FR 9112064 A FR9112064 A FR 9112064A FR 9112064 A FR9112064 A FR 9112064A FR 2681861 B1 FR2681861 B1 FR 2681861B1
Authority
FR
France
Prior art keywords
terfenadine
preparation
melting point
product obtained
high melting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9112064A
Other languages
English (en)
Other versions
FR2681861A1 (fr
Inventor
Wirth Didier
Deglave Marcel
Mouton Marc-Henri
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Isochem SAS
Original Assignee
Isochem SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Isochem SAS filed Critical Isochem SAS
Priority to FR9112064A priority Critical patent/FR2681861B1/fr
Priority to JP5506684A priority patent/JPH06511248A/ja
Priority to PCT/FR1992/000949 priority patent/WO1993007121A1/fr
Priority to EP92922825A priority patent/EP0628029A1/fr
Priority to US08/117,208 priority patent/US5380856A/en
Publication of FR2681861A1 publication Critical patent/FR2681861A1/fr
Application granted granted Critical
Publication of FR2681861B1 publication Critical patent/FR2681861B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR9112064A 1991-10-01 1991-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu. Expired - Fee Related FR2681861B1 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
FR9112064A FR2681861B1 (fr) 1991-10-01 1991-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.
JP5506684A JPH06511248A (ja) 1991-10-01 1992-10-01 高い融点および高純度を有する多形形態のテルフェナジンの製造方法、およびこうして得られた生成物
PCT/FR1992/000949 WO1993007121A1 (fr) 1991-10-01 1992-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu
EP92922825A EP0628029A1 (fr) 1991-10-01 1992-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu
US08/117,208 US5380856A (en) 1991-10-01 1992-10-01 Process for preparation of a polymorphic form of terphenadine having a high melting point and enhanced purity, and the product thus obtained

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9112064A FR2681861B1 (fr) 1991-10-01 1991-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.

Publications (2)

Publication Number Publication Date
FR2681861A1 FR2681861A1 (fr) 1993-04-02
FR2681861B1 true FR2681861B1 (fr) 1995-06-09

Family

ID=9417471

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9112064A Expired - Fee Related FR2681861B1 (fr) 1991-10-01 1991-10-01 Procede de preparation d'une forme polymorphique de la terfenadine, a point de fusion eleve, d'une plus grande purete et produit obtenu.

Country Status (5)

Country Link
US (1) US5380856A (fr)
EP (1) EP0628029A1 (fr)
JP (1) JPH06511248A (fr)
FR (1) FR2681861B1 (fr)
WO (1) WO1993007121A1 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1270829B (it) * 1993-09-17 1997-05-13 Recordati Chem Pharm Procedimento per la preparazione di polimorfo i della terfenadina con distribuzione granulometrica ottimale
IL112249A (en) 1994-01-25 2001-11-25 Warner Lambert Co Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1200123B (it) * 1985-09-27 1989-01-05 Ind Chimica Srl Procedimento per la preparazione di alfa-(p-terbutilfenil)-4-(idrossidifenilmetil)-1-piperidinobutanolo
US4742175A (en) * 1986-05-07 1988-05-03 Merrell Dow Pharmaceuticals Inc. Preparation of polymorphically pure terfenadine
IT1217837B (it) * 1988-06-17 1990-03-30 Lepetit Spa Procedimento per la preparazione del "alfa /4(1,1 dimetiletil)fenil/piperidinbutanolo"
ZA901360B (en) * 1989-02-28 1990-11-28 Merrell Dow Pharma Preparation of the low-melting polymorphic form of terfenadine
ZA903145B (en) * 1989-05-01 1991-02-27 Merrell Dow Pharma Process for the preparation of the high melting polymorphic form of terfenadine

Also Published As

Publication number Publication date
US5380856A (en) 1995-01-10
FR2681861A1 (fr) 1993-04-02
WO1993007121A1 (fr) 1993-04-15
EP0628029A1 (fr) 1994-12-14
JPH06511248A (ja) 1994-12-15

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Effective date: 20060630