DK2102331T3 - Anti-tumorvaccine afledt af normale kemisk modificerede CD4 -celler - Google Patents
Anti-tumorvaccine afledt af normale kemisk modificerede CD4 -cellerInfo
- Publication number
- DK2102331T3 DK2102331T3 DK08701232.4T DK08701232T DK2102331T3 DK 2102331 T3 DK2102331 T3 DK 2102331T3 DK 08701232 T DK08701232 T DK 08701232T DK 2102331 T3 DK2102331 T3 DK 2102331T3
- Authority
- DK
- Denmark
- Prior art keywords
- normal
- cells
- composition
- lymphoid cells
- lymphocytes
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 210000004970 cd4 cell Anatomy 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 abstract 8
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 210000004698 lymphocyte Anatomy 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 2
- 210000004443 dendritic cell Anatomy 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 210000001550 testis Anatomy 0.000 abstract 2
- 230000035131 DNA demethylation Effects 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700058.1A GB0700058D0 (en) | 2007-01-03 | 2007-01-03 | Anti-tumor vaccine based on normal cells |
| PCT/EP2008/050050 WO2008081035A1 (en) | 2007-01-03 | 2008-01-03 | Anti-tumor vaccine derived from normal chemically modified cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2102331T3 true DK2102331T3 (da) | 2011-10-17 |
Family
ID=37759205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08701232.4T DK2102331T3 (da) | 2007-01-03 | 2008-01-03 | Anti-tumorvaccine afledt af normale kemisk modificerede CD4 -celler |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10023839B2 (enExample) |
| EP (1) | EP2102331B1 (enExample) |
| JP (1) | JP5452231B2 (enExample) |
| AT (1) | ATE522600T1 (enExample) |
| AU (1) | AU2008203730B2 (enExample) |
| CY (1) | CY1112668T1 (enExample) |
| DK (1) | DK2102331T3 (enExample) |
| ES (1) | ES2372713T3 (enExample) |
| GB (1) | GB0700058D0 (enExample) |
| HR (1) | HRP20110899T1 (enExample) |
| PL (1) | PL2102331T3 (enExample) |
| PT (1) | PT2102331E (enExample) |
| SI (1) | SI2102331T1 (enExample) |
| WO (1) | WO2008081035A1 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011421B1 (ru) * | 2008-08-26 | 2009-02-27 | Петр Генриевич ЛОХОВ | Способ получения противоопухолевой вакцины |
| US8586359B2 (en) | 2009-07-28 | 2013-11-19 | Promising Furture, LLC | Compositions and methods of preparing alloreactive cytotoxic T cells |
| US8666674B2 (en) | 2009-07-28 | 2014-03-04 | Promising Future, Llc | Pairing processes for preparing reactive cytotoxic T cells |
| CN102597222B (zh) * | 2009-10-27 | 2015-07-15 | 因缪尼卡姆股份公司 | 用于增殖抗原特异性t细胞的方法 |
| GB201013443D0 (en) | 2010-08-11 | 2010-09-22 | Cytovac As | Compositions and methods for producing dendritic cells |
| US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| KR20230148387A (ko) | 2015-05-28 | 2023-10-24 | 카이트 파마 인코포레이티드 | T 세포 요법을 위한 진단 방법 |
| BR112017025166A2 (en) | 2015-05-28 | 2018-07-31 | Kite Pharma, Inc. | Methods of Conditioning Patients for T-Cell Therapy |
| IL292504B2 (en) | 2015-10-20 | 2024-01-01 | Kite Pharma Inc | Methods of preparing T cells for T cell therapy |
| US10689450B2 (en) | 2016-04-01 | 2020-06-23 | Kite Pharma, Inc | BCMA binding molecules and methods of use thereof |
| PL3436079T3 (pl) | 2016-04-01 | 2021-12-20 | Kite Pharma, Inc. | Antygen chimeryczny i receptory komórek t oraz sposoby ich stosowania |
| PE20190356A1 (es) | 2016-04-01 | 2019-03-07 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| TWI785009B (zh) | 2017-02-14 | 2022-12-01 | 美商凱特製藥公司 | Ｃｄ７０結合分子及使用彼之方法 |
| WO2018169922A2 (en) | 2017-03-13 | 2018-09-20 | Kite Pharma, Inc. | Chimeric antigen receptors for melanoma and uses thereof |
| ES2954311T3 (es) | 2017-04-01 | 2023-11-21 | Avm Biotechnology Llc | Reemplazo de un preacondicionamiento citotóxico antes de una inmunoterapia celular |
| CN110494158A (zh) | 2017-04-03 | 2019-11-22 | 凯德药业股份有限公司 | 使用包含优化的多功能t细胞的嵌合受体t细胞进行治疗 |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| KR20210118479A (ko) | 2017-05-26 | 2021-09-30 | 카이트 파마 인코포레이티드 | 배아 중간엽 전구 세포를 제조하고 사용하는 방법 |
| WO2019055896A1 (en) | 2017-09-15 | 2019-03-21 | Kite Pharma, Inc. | METHODS AND SYSTEMS FOR PERFORMING A PATIENT-CLEAN IMMUNOTHERAPY PROCEDURE WITH FOLLOW-UP OF BIOLOGICAL SAMPLE CHAIN OF CONTROL AND IDENTITY CHAIN |
| KR20230007557A (ko) | 2017-09-22 | 2023-01-12 | 카이트 파마 인코포레이티드 | 키메라 폴리펩티드 및 그의 용도 |
| CA3084470A1 (en) | 2017-10-18 | 2019-04-25 | Kite Pharma, Inc. | Methods of administering chimeric antigen receptor immunotherapy |
| US11390655B2 (en) | 2017-11-16 | 2022-07-19 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| EP3740285A1 (en) | 2018-01-15 | 2020-11-25 | Pfizer Inc. | Methods of administering chimeric antigen receptor immunotherapy in combination with 4-1bb agonist |
| WO2019152957A1 (en) | 2018-02-02 | 2019-08-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Dna-chimeric antigen receptor t cells for immunotherapy |
| WO2019161271A1 (en) | 2018-02-16 | 2019-08-22 | Kite Pharma, Inc. | Modified pluripotent stem cells and methods of making and use |
| WO2019200325A1 (en) | 2018-04-12 | 2019-10-17 | Kite Pharma, Inc. | Chimeric receptor t cell treatment using characteristics of the tumor microenvironment |
| EP3801572B1 (en) | 2018-06-01 | 2024-07-03 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| EP3810780A1 (en) | 2018-06-22 | 2021-04-28 | Kite Pharma Eu B.V. | Compositions and methods for making engineered t cells |
| KR20210038922A (ko) | 2018-08-02 | 2021-04-08 | 카이트 파마 인코포레이티드 | 키메라 항원 수용체 요법 t 세포 확장 동역학 및 그의 용도 |
| EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
| EP3632446B3 (en) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Immunoablative therapies |
| IL283734B2 (en) | 2018-12-12 | 2025-03-01 | Kite Pharma Inc | Chimeric antigen receptors and CAR-T cells and methods of use |
| US20220175900A1 (en) * | 2019-04-12 | 2022-06-09 | Cytovac A/S | Method for preparation of cancer/testis antigen-specific t-cells |
| TW202108150A (zh) | 2019-05-03 | 2021-03-01 | 美商凱特製藥公司 | 投與嵌合抗原受體免疫療法之方法 |
| BR112021025735A2 (pt) | 2019-06-21 | 2022-03-08 | Kite Pharma Inc | Receptores de tgf-ss e métodos de uso |
| CA3147441A1 (en) | 2019-09-03 | 2021-03-11 | Allogene Therapeutics, Inc. | Methods of preparing t cells for t cell therapy |
| US20230293530A1 (en) | 2020-06-24 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
| KR20230084470A (ko) | 2020-08-14 | 2023-06-13 | 카이트 파마 인코포레이티드 | 면역 세포 기능의 향상 |
| US12152251B2 (en) | 2020-08-25 | 2024-11-26 | Kite Pharma, Inc. | T cells with improved functionality |
| WO2022093925A1 (en) | 2020-10-28 | 2022-05-05 | Kite Pharma, Inc. | Flow cytometric method for characterization of t-cell impurities |
| IL303984A (en) | 2020-12-24 | 2023-08-01 | Kite Pharma Inc | Chimeric antigen receptors for prostate cancer |
| CA3207182A1 (en) | 2021-01-10 | 2022-07-14 | Kite Pharma, Inc. | T cell therapy |
| WO2022157288A1 (en) | 2021-01-21 | 2022-07-28 | Cytovac A/S | Method for t-cell expansion and related medical applications |
| JP2024507199A (ja) | 2021-02-20 | 2024-02-16 | カイト ファーマ インコーポレイテッド | 免疫療法を選択するための遺伝子マーカー |
| US12454563B2 (en) | 2021-03-11 | 2025-10-28 | Kite Pharma, Inc. | Immune cell function |
| WO2022221126A1 (en) | 2021-04-16 | 2022-10-20 | Kite Pharma, Inc. | Methods and systems for scheduling a patient-specific immunotherapy procedure |
| JP7688723B2 (ja) | 2021-04-16 | 2025-06-04 | カイト ファーマ インコーポレイテッド | Ｔａｃｉ／ｂｃｍａ二重結合分子 |
| US12357646B2 (en) | 2021-05-14 | 2025-07-15 | Kite Pharma, Inc. | Chimeric antigen receptor T cell therapy |
| JP2024521756A (ja) | 2021-05-24 | 2024-06-04 | カイト ファーマ インコーポレイテッド | キメラ抗原受容体 |
| CN117730100A (zh) | 2021-06-08 | 2024-03-19 | 凯德药业股份有限公司 | Gpc3结合分子 |
| WO2022269019A1 (en) | 2021-06-25 | 2022-12-29 | Cytovac A/S | Method for preparation of cytotoxic t lymphocytes with broad tumour-specific reactivity and characteristics of early differentiation cells |
| US20230027004A1 (en) | 2021-07-01 | 2023-01-26 | Kite Pharma, Inc. | Closed-system and method for autologous and allogeneic cell therapy manufacturing |
| JP2024525485A (ja) | 2021-07-02 | 2024-07-12 | カイト ファーマ インコーポレイテッド | 細胞療法適用において使用される遺伝子構築物由来の遺伝子産物におけるバリアントを特定するための方法 |
| EP4376876A1 (en) | 2021-07-26 | 2024-06-05 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
| AU2022317827B2 (en) | 2021-07-30 | 2025-12-11 | Kite Pharma, Inc. | Monitoring and management of cell therapy-induced toxicities |
| AR127745A1 (es) | 2021-10-18 | 2024-02-28 | Kite Pharma Inc | Dominios de señalización para receptores quiméricos de antígenos |
| AU2023221839A1 (en) | 2022-02-15 | 2024-08-22 | Kite Pharma, Inc. | Predicting adverse events from immunotherapy. |
| WO2023247324A1 (en) | 2022-06-24 | 2023-12-28 | Cytovac A/S | Novel combination treatment with adoptive cellular therapy |
| EP4577234A1 (en) | 2022-08-26 | 2025-07-02 | Kite Pharma, Inc. | Improving immune cell function |
| CN119997962A (zh) | 2022-10-28 | 2025-05-13 | 凯德药业股份有限公司 | 改善免疫疗法的功效和持久应答 |
| TW202530421A (zh) | 2022-10-28 | 2025-08-01 | 美商凱特製藥公司 | 用於將免疫療法最佳化之因素 |
| US20240309428A1 (en) | 2023-03-17 | 2024-09-19 | Kite Pharma, Inc. | Impact of tumor microenvironment on efficacy of immunotherapy |
| WO2025096517A1 (en) | 2023-11-01 | 2025-05-08 | Kite Pharma, Inc. | Factors for optimizing immunotherapy efficacy |
| WO2025174963A1 (en) | 2024-02-16 | 2025-08-21 | Kite Pharma, Inc. | Systems, methods, and kits for generating and administering engineered t cells and cd38 targeting compounds as a combination therapy |
| US20250290154A1 (en) | 2024-03-04 | 2025-09-18 | Kite Pharma, Inc. | Predictive markers for immunotherapy |
| WO2025231376A1 (en) | 2024-05-03 | 2025-11-06 | Kite Pharma, Inc. | Chimeric receptors binding to cll-1 and methods of use thereof |
| WO2025250819A1 (en) | 2024-05-31 | 2025-12-04 | Kite Pharma, Inc. | Tricistronic constructs for anti-gpc3 car |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
-
2007
- 2007-01-03 GB GBGB0700058.1A patent/GB0700058D0/en not_active Ceased
-
2008
- 2008-01-03 SI SI200830447T patent/SI2102331T1/sl unknown
- 2008-01-03 JP JP2009544412A patent/JP5452231B2/ja not_active Expired - Fee Related
- 2008-01-03 PL PL08701232T patent/PL2102331T3/pl unknown
- 2008-01-03 AT AT08701232T patent/ATE522600T1/de active
- 2008-01-03 AU AU2008203730A patent/AU2008203730B2/en not_active Ceased
- 2008-01-03 WO PCT/EP2008/050050 patent/WO2008081035A1/en not_active Ceased
- 2008-01-03 DK DK08701232.4T patent/DK2102331T3/da active
- 2008-01-03 HR HR20110899T patent/HRP20110899T1/hr unknown
- 2008-01-03 ES ES08701232T patent/ES2372713T3/es active Active
- 2008-01-03 PT PT08701232T patent/PT2102331E/pt unknown
- 2008-01-03 EP EP08701232A patent/EP2102331B1/en active Active
- 2008-01-03 US US12/522,048 patent/US10023839B2/en active Active
-
2011
- 2011-11-17 CY CY20111101112T patent/CY1112668T1/el unknown
-
2017
- 2017-09-18 US US15/707,474 patent/US20180036397A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10023839B2 (en) | 2018-07-17 |
| JP2010514455A (ja) | 2010-05-06 |
| PT2102331E (pt) | 2011-12-19 |
| PL2102331T3 (pl) | 2012-01-31 |
| AU2008203730A1 (en) | 2008-07-10 |
| ATE522600T1 (de) | 2011-09-15 |
| GB0700058D0 (en) | 2007-02-07 |
| SI2102331T1 (sl) | 2012-01-31 |
| JP5452231B2 (ja) | 2014-03-26 |
| US20180036397A1 (en) | 2018-02-08 |
| US20100092498A1 (en) | 2010-04-15 |
| EP2102331B1 (en) | 2011-08-31 |
| CY1112668T1 (el) | 2016-02-10 |
| ES2372713T3 (es) | 2012-01-25 |
| HRP20110899T1 (hr) | 2011-12-31 |
| WO2008081035A1 (en) | 2008-07-10 |
| AU2008203730B2 (en) | 2013-11-07 |
| EP2102331A1 (en) | 2009-09-23 |
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