ATE522600T1 - Anti-tumor impfstoff aus normalen chemisch modifizierten cd4+ zellen - Google Patents
Anti-tumor impfstoff aus normalen chemisch modifizierten cd4+ zellenInfo
- Publication number
- ATE522600T1 ATE522600T1 AT08701232T AT08701232T ATE522600T1 AT E522600 T1 ATE522600 T1 AT E522600T1 AT 08701232 T AT08701232 T AT 08701232T AT 08701232 T AT08701232 T AT 08701232T AT E522600 T1 ATE522600 T1 AT E522600T1
- Authority
- AT
- Austria
- Prior art keywords
- normal
- cells
- composition
- lymphoid cells
- lymphocytes
- Prior art date
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 8
- 239000000427 antigen Substances 0.000 abstract 5
- 102000036639 antigens Human genes 0.000 abstract 5
- 108091007433 antigens Proteins 0.000 abstract 5
- 210000004698 lymphocyte Anatomy 0.000 abstract 5
- 239000000203 mixture Substances 0.000 abstract 4
- 201000011510 cancer Diseases 0.000 abstract 3
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 abstract 2
- 210000004443 dendritic cell Anatomy 0.000 abstract 2
- 230000028993 immune response Effects 0.000 abstract 2
- 230000035755 proliferation Effects 0.000 abstract 2
- 210000001550 testis Anatomy 0.000 abstract 2
- 230000035131 DNA demethylation Effects 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 238000009169 immunotherapy Methods 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 230000000069 prophylactic effect Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
- A61K40/24—Antigen-presenting cells [APC]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4267—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0637—Immunosuppressive T lymphocytes, e.g. regulatory T cells or Treg
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/06—Anti-neoplasic drugs, anti-retroviral drugs, e.g. azacytidine, cyclophosphamide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
- C12N2502/1121—Dendritic cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Oncology (AREA)
- Mycology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700058.1A GB0700058D0 (en) | 2007-01-03 | 2007-01-03 | Anti-tumor vaccine based on normal cells |
| PCT/EP2008/050050 WO2008081035A1 (en) | 2007-01-03 | 2008-01-03 | Anti-tumor vaccine derived from normal chemically modified cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE522600T1 true ATE522600T1 (de) | 2011-09-15 |
Family
ID=37759205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT08701232T ATE522600T1 (de) | 2007-01-03 | 2008-01-03 | Anti-tumor impfstoff aus normalen chemisch modifizierten cd4+ zellen |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10023839B2 (enExample) |
| EP (1) | EP2102331B1 (enExample) |
| JP (1) | JP5452231B2 (enExample) |
| AT (1) | ATE522600T1 (enExample) |
| AU (1) | AU2008203730B2 (enExample) |
| CY (1) | CY1112668T1 (enExample) |
| DK (1) | DK2102331T3 (enExample) |
| ES (1) | ES2372713T3 (enExample) |
| GB (1) | GB0700058D0 (enExample) |
| HR (1) | HRP20110899T1 (enExample) |
| PL (1) | PL2102331T3 (enExample) |
| PT (1) | PT2102331E (enExample) |
| SI (1) | SI2102331T1 (enExample) |
| WO (1) | WO2008081035A1 (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA011421B1 (ru) * | 2008-08-26 | 2009-02-27 | Петр Генриевич ЛОХОВ | Способ получения противоопухолевой вакцины |
| US8666674B2 (en) | 2009-07-28 | 2014-03-04 | Promising Future, Llc | Pairing processes for preparing reactive cytotoxic T cells |
| US8586359B2 (en) * | 2009-07-28 | 2013-11-19 | Promising Furture, LLC | Compositions and methods of preparing alloreactive cytotoxic T cells |
| EP2494038B1 (en) * | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
| GB201013443D0 (en) | 2010-08-11 | 2010-09-22 | Cytovac As | Compositions and methods for producing dendritic cells |
| US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
| EA201792649A1 (ru) | 2015-05-28 | 2018-06-29 | Кайт Фарма, Инк. | Способы кондиционирования пациентов для t-клеточной терапии |
| EA201792642A1 (ru) | 2015-05-28 | 2018-10-31 | Кайт Фарма, Инк. | Способы диагностики для т-клеточной терапии |
| KR20180063320A (ko) | 2015-10-20 | 2018-06-11 | 카이트 파마 인코포레이티드 | T 세포 요법을 위한 t 세포를 제조하는 방법 |
| PE20200400A1 (es) | 2016-04-01 | 2020-02-26 | Kite Pharma Inc | Receptores quimericos y metodos de uso de los mismos |
| TWI691596B (zh) | 2016-04-01 | 2020-04-21 | 美商凱特製藥公司 | 嵌合抗原和ｔ細胞受體及使用方法 |
| TWI761831B (zh) | 2016-04-01 | 2022-04-21 | 美商凱特製藥公司 | 嵌合抗原受體（ｃａｒ）和ｔ細胞受體（ｔｃｒ）及彼等之用途 |
| ES2900233T3 (es) | 2017-02-14 | 2022-03-16 | Kite Pharma Inc | Moléculas que se unen a CD70 y métodos de uso de las mismas |
| TW201837175A (zh) | 2017-03-13 | 2018-10-16 | 美商凱特製藥公司 | 用於黑色素瘤之嵌合抗原受體及其用途 |
| CA3054443A1 (en) | 2017-04-01 | 2018-10-14 | Avm Biotechnology, Llc | Replacement of cytotoxic preconditioning before cellular immunotherapy |
| TW201902493A (zh) | 2017-04-03 | 2019-01-16 | 美商凱特製藥公司 | 使用併入最佳化多功能t細胞之嵌合受體t細胞之治療 |
| JOP20180042A1 (ar) | 2017-04-24 | 2019-01-30 | Kite Pharma Inc | نطاقات ربط مولد ضد متوافقة مع البشر وطرق الاستخدام |
| TWI862477B (zh) | 2017-05-26 | 2024-11-21 | 美商凱特製藥公司 | 製備和使用胚胎間充質先驅細胞的方法 |
| EP3681531A1 (en) | 2017-09-15 | 2020-07-22 | Kite Pharma, Inc. | Methods and systems for performing a patient-specific immunotherapy procedure with chain-of-custody and chain-of-identity biological sample tracking |
| WO2019060695A1 (en) | 2017-09-22 | 2019-03-28 | Kite Pharma, Inc. | CHIMERIC POLYPEPTIDES AND USES THEREOF |
| CN111479613A (zh) | 2017-10-18 | 2020-07-31 | 凯德药业股份有限公司 | 施用嵌合抗原受体免疫疗法的方法 |
| US11390655B2 (en) | 2017-11-16 | 2022-07-19 | Kite Pharma, Inc. | Modified chimeric antigen receptors and methods of use |
| CA3087481A1 (en) | 2018-01-15 | 2019-07-18 | Pfizer Inc. | Methods of administering chimeric antigen receptor immunotherapy in combination with 4-1bb agonist |
| WO2019152957A1 (en) | 2018-02-02 | 2019-08-08 | Arizona Board Of Regents On Behalf Of Arizona State University | Dna-chimeric antigen receptor t cells for immunotherapy |
| US20210040449A1 (en) | 2018-02-16 | 2021-02-11 | Kite Pharma, Inc. | Modified pluripotent stem cells and methods of making and use |
| IL310416B1 (en) | 2018-04-12 | 2025-12-01 | Kite Pharma Inc | Chimeric T-cell receptor therapy using tumor microenvironmental characteristics |
| WO2019232510A1 (en) | 2018-06-01 | 2019-12-05 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| WO2019243888A1 (en) | 2018-06-22 | 2019-12-26 | Kite Pharma Eu B.V. | Compositions and methods for making engineered t cells |
| CA3107938C (en) | 2018-08-02 | 2024-04-30 | Kite Pharma, Inc. | Chimeric antigen receptor therapy t cell expansion kinetics and uses thereof |
| EP3488851A1 (en) | 2018-10-03 | 2019-05-29 | AVM Biotechnology, LLC | Immunoablative therapies |
| EP3632446B3 (en) | 2018-10-03 | 2024-01-24 | AVM Biotechnology, LLC | Immunoablative therapies |
| CN120025452A (zh) | 2018-12-12 | 2025-05-23 | 凯德药业股份有限公司 | 嵌合抗原和t细胞受体及使用的方法 |
| EP3953454A1 (en) * | 2019-04-12 | 2022-02-16 | CytoVac A/S | Method for preparation of cancer/testis antigen-specific t-cells |
| JP2022532865A (ja) | 2019-05-03 | 2022-07-20 | カイト ファーマ インコーポレイテッド | キメラ抗原受容体免疫療法の投与方法 |
| WO2020257823A2 (en) | 2019-06-21 | 2020-12-24 | Kite Pharma, Inc. | TGF-β RECEPTORS AND METHODS OF USE |
| US20210062150A1 (en) | 2019-09-03 | 2021-03-04 | Allogene Therapeutics, Inc. | Methods of preparing t cells for t cell therapy |
| US20230293530A1 (en) | 2020-06-24 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Agents for sensitizing solid tumors to treatment |
| US20220047677A1 (en) | 2020-08-14 | 2022-02-17 | Kite Pharma, Inc. | Immune cell function |
| EP4204545A2 (en) | 2020-08-25 | 2023-07-05 | Kite Pharma, Inc. | T cells with improved functionality |
| EP4237854A1 (en) | 2020-10-28 | 2023-09-06 | Kite Pharma, Inc. | Flow cytometric method for characterization of t-cell impurities |
| WO2022140159A1 (en) | 2020-12-24 | 2022-06-30 | Kite Pharma, Inc. | Prostate cancer chimeric antigen receptors |
| CN116917737A (zh) | 2021-01-10 | 2023-10-20 | 凯德药业股份有限公司 | T细胞疗法 |
| WO2022157288A1 (en) | 2021-01-21 | 2022-07-28 | Cytovac A/S | Method for t-cell expansion and related medical applications |
| TW202241469A (zh) | 2021-02-20 | 2022-11-01 | 美商凱特製藥公司 | 免疫療法 |
| JP7690597B2 (ja) | 2021-03-11 | 2025-06-10 | カイト ファーマ インコーポレイテッド | 免疫細胞機能の改善 |
| JP7688723B2 (ja) | 2021-04-16 | 2025-06-04 | カイト ファーマ インコーポレイテッド | Ｔａｃｉ／ｂｃｍａ二重結合分子 |
| WO2022221126A1 (en) | 2021-04-16 | 2022-10-20 | Kite Pharma, Inc. | Methods and systems for scheduling a patient-specific immunotherapy procedure |
| EP4337227A2 (en) | 2021-05-14 | 2024-03-20 | Kite Pharma, Inc. | Chimeric antigen receptor t cell therapy |
| US12331315B2 (en) | 2021-05-24 | 2025-06-17 | Kite Pharma, Inc. | Chimeric antigen receptor |
| EP4352102A1 (en) | 2021-06-08 | 2024-04-17 | Kite Pharma, Inc. | Gpc3 binding molecules |
| WO2022269019A1 (en) | 2021-06-25 | 2022-12-29 | Cytovac A/S | Method for preparation of cytotoxic t lymphocytes with broad tumour-specific reactivity and characteristics of early differentiation cells |
| EP4363558A1 (en) | 2021-07-01 | 2024-05-08 | Kite Pharma, Inc. | Closed-system and method for autologous and allogeneic cell therapy manufacturing |
| US20230103457A1 (en) | 2021-07-02 | 2023-04-06 | Kite Pharma, Inc. | Method for identifying variants in gene products from gene constructs used in cell therapy applications |
| EP4376876A1 (en) | 2021-07-26 | 2024-06-05 | Kite Pharma, Inc. | Split chimeric antigen receptors and methods of use |
| EP4377694A1 (en) | 2021-07-30 | 2024-06-05 | Kite Pharma, Inc. | Monitoring and management of cell therapy-induced toxicities |
| IL311981A (en) | 2021-10-18 | 2024-06-01 | Kite Pharma Inc | Signaling domains for chimeric antigen receptors |
| KR20240144434A (ko) | 2022-02-15 | 2024-10-02 | 카이트 파마 인코포레이티드 | 면역요법으로 인한 유해사례 예측 |
| WO2023247324A1 (en) | 2022-06-24 | 2023-12-28 | Cytovac A/S | Novel combination treatment with adoptive cellular therapy |
| EP4577234A1 (en) | 2022-08-26 | 2025-07-02 | Kite Pharma, Inc. | Improving immune cell function |
| CN119997962A (zh) | 2022-10-28 | 2025-05-13 | 凯德药业股份有限公司 | 改善免疫疗法的功效和持久应答 |
| WO2024092227A1 (en) | 2022-10-28 | 2024-05-02 | Kite Pharma, Inc. | Factors for optimizing immunotherapy |
| KR20250162836A (ko) | 2023-03-17 | 2025-11-19 | 카이트 파마 인코포레이티드 | 종양 미세환경이 면역요법의 효능에 미치는 영향 |
| US20250161361A1 (en) | 2023-11-01 | 2025-05-22 | Kite Pharma, Inc. | Factors for optimizing immunotherapy efficacy |
| WO2025174963A1 (en) | 2024-02-16 | 2025-08-21 | Kite Pharma, Inc. | Systems, methods, and kits for generating and administering engineered t cells and cd38 targeting compounds as a combination therapy |
| WO2025188561A1 (en) | 2024-03-04 | 2025-09-12 | Kite Pharma, Inc. | Predictive markers for immunotherapy |
| US20250388680A1 (en) | 2024-05-03 | 2025-12-25 | Kite Pharma, Inc. | Chimeric receptors and methods of use thereof |
| WO2025250819A1 (en) | 2024-05-31 | 2025-12-04 | Kite Pharma, Inc. | Tricistronic constructs for anti-gpc3 car |
| WO2026015457A1 (en) | 2024-07-08 | 2026-01-15 | Kite Pharma, Inc. | Systems and methods for applying mechanical force to living cells to generate a phenotypic response |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003012085A1 (en) * | 2001-07-30 | 2003-02-13 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Antigen presenting cells, method for their preparation and their use for cancer vaccines |
-
2007
- 2007-01-03 GB GBGB0700058.1A patent/GB0700058D0/en not_active Ceased
-
2008
- 2008-01-03 PL PL08701232T patent/PL2102331T3/pl unknown
- 2008-01-03 JP JP2009544412A patent/JP5452231B2/ja not_active Expired - Fee Related
- 2008-01-03 EP EP08701232A patent/EP2102331B1/en active Active
- 2008-01-03 AU AU2008203730A patent/AU2008203730B2/en not_active Ceased
- 2008-01-03 PT PT08701232T patent/PT2102331E/pt unknown
- 2008-01-03 WO PCT/EP2008/050050 patent/WO2008081035A1/en not_active Ceased
- 2008-01-03 SI SI200830447T patent/SI2102331T1/sl unknown
- 2008-01-03 HR HR20110899T patent/HRP20110899T1/hr unknown
- 2008-01-03 ES ES08701232T patent/ES2372713T3/es active Active
- 2008-01-03 DK DK08701232.4T patent/DK2102331T3/da active
- 2008-01-03 AT AT08701232T patent/ATE522600T1/de active
- 2008-01-03 US US12/522,048 patent/US10023839B2/en active Active
-
2011
- 2011-11-17 CY CY20111101112T patent/CY1112668T1/el unknown
-
2017
- 2017-09-18 US US15/707,474 patent/US20180036397A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| ES2372713T3 (es) | 2012-01-25 |
| US20180036397A1 (en) | 2018-02-08 |
| GB0700058D0 (en) | 2007-02-07 |
| US10023839B2 (en) | 2018-07-17 |
| DK2102331T3 (da) | 2011-10-17 |
| PT2102331E (pt) | 2011-12-19 |
| AU2008203730A1 (en) | 2008-07-10 |
| PL2102331T3 (pl) | 2012-01-31 |
| EP2102331A1 (en) | 2009-09-23 |
| SI2102331T1 (sl) | 2012-01-31 |
| US20100092498A1 (en) | 2010-04-15 |
| CY1112668T1 (el) | 2016-02-10 |
| JP5452231B2 (ja) | 2014-03-26 |
| JP2010514455A (ja) | 2010-05-06 |
| HRP20110899T1 (hr) | 2011-12-31 |
| AU2008203730B2 (en) | 2013-11-07 |
| WO2008081035A1 (en) | 2008-07-10 |
| EP2102331B1 (en) | 2011-08-31 |
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