HRP20110899T1 - Protutumorsko cjepivo dobiveno iz normalnih, kemijski modificiranih stanica cd4+ - Google Patents
Protutumorsko cjepivo dobiveno iz normalnih, kemijski modificiranih stanica cd4+ Download PDFInfo
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- HRP20110899T1 HRP20110899T1 HR20110899T HRP20110899T HRP20110899T1 HR P20110899 T1 HRP20110899 T1 HR P20110899T1 HR 20110899 T HR20110899 T HR 20110899T HR P20110899 T HRP20110899 T HR P20110899T HR P20110899 T1 HRP20110899 T1 HR P20110899T1
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- 229960005486 vaccine Drugs 0.000 title claims 3
- 230000000259 anti-tumor effect Effects 0.000 title 1
- 239000000427 antigen Substances 0.000 claims abstract 10
- 102000036639 antigens Human genes 0.000 claims abstract 10
- 108091007433 antigens Proteins 0.000 claims abstract 10
- 210000004698 lymphocyte Anatomy 0.000 claims abstract 10
- 238000000034 method Methods 0.000 claims abstract 9
- 210000004027 cell Anatomy 0.000 claims abstract 6
- 210000004443 dendritic cell Anatomy 0.000 claims abstract 4
- 230000035755 proliferation Effects 0.000 claims abstract 4
- 230000035131 DNA demethylation Effects 0.000 claims abstract 3
- 230000006195 histone acetylation Effects 0.000 claims abstract 3
- 230000002062 proliferating effect Effects 0.000 claims abstract 3
- 230000004936 stimulating effect Effects 0.000 claims abstract 3
- 230000008105 immune reaction Effects 0.000 claims abstract 2
- 239000000126 substance Substances 0.000 claims abstract 2
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 210000001744 T-lymphocyte Anatomy 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 4
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims 4
- 230000028993 immune response Effects 0.000 claims 3
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 231100000433 cytotoxic Toxicity 0.000 claims 2
- 230000001472 cytotoxic effect Effects 0.000 claims 2
- 210000005259 peripheral blood Anatomy 0.000 claims 2
- 239000011886 peripheral blood Substances 0.000 claims 2
- 210000001550 testis Anatomy 0.000 claims 2
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 claims 1
- 230000007067 DNA methylation Effects 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 230000003213 activating effect Effects 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 230000006197 histone deacetylation Effects 0.000 claims 1
- 238000009169 immunotherapy Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 231100000405 induce cancer Toxicity 0.000 abstract 1
- 230000002381 testicular Effects 0.000 abstract 1
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- A61K39/0011—Cancer antigens
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- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- A61K39/4622—Antigen presenting cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/464484—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
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- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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Abstract
Postupak priprave antigenski prezentirajućeg pripravka obogaćenog stanicama CD4+, naznačen time što se sastoji u stimuliranju proliferacije normalnih neaktiviranih limfoidnih stanica uz pomoć normalnih zrelih dendritičkih stanica koje ne sadrže antigene na koje treba usmjeriti imunosnu reakciju koju će se inducirati, te u kemijskoj obradi proliferirajućih stanica sredstvima koja induciraju demetiliranje DNA ili acetiliranje histona kako bi se induciralo ekspresiju antigena raka odnosno testisa. Patent sadrži još 14 patentnih zahtjeva.
Claims (15)
1. Postupak priprave antigenski prezentirajućeg pripravka obogaćenog stanicama CD4+, naznačen time što se sastoji u stimuliranju proliferacije normalnih neaktiviranih limfoidnih stanica uz pomoć normalnih zrelih dendritičkih stanica koje ne sadrže antigene na koje treba usmjeriti imunosnu reakciju koju će se inducirati, te u kemijskoj obradi proliferirajućih stanica sredstvima koja induciraju demetiliranje DNA ili acetiliranje histona kako bi se induciralo ekspresiju antigena raka odnosno testisa.
2. Postupak u skladu s patentnim zahtjevom 1, naznačen time što su limfoidne stanice limfociti iz periferne krvi, izolrani iz heterologne ili autologne krvi.
3. Postupak u skladu s patentnim zahtjevom 1 ili 2, naznačen time što se antigene inducira tijekom logaritamske faze proliferacije.
4. Postupak priprave citotoksičnog pripravka, naznačen time što se sastoji u pripravi antigenski prezentirajućeg pripravka postupkom u skladu s bilo kojim od patentnih zahtjeva 1 to 3, te u upotrebi antigenski prezentirajućeg pripravka u aktivaciji T-limfocita, čime se dobiva citotoksični pripravak koji sadrži tumorski specifične citotoksične T-limfocite CD8+.
5. Postupak u skladu s patentnim zahtjevom 4, naznačen time što se broj T-limfocita povećava nakon aktivacije uz pomoć zrelih dendritičkih stanica.
6. Pripravak za induciranje imunosnog odgovora kod sisavca, naznačen time što sadrži limfoidne stanice, kod kojih je ekspresija antigena raka odnosno testisa kemijski inducirana metiliranjem DNA ili acetiliranjem histona nakon aktivacije uz pomoć normalnih zrelih dendritičkih stanica koje ne sadrže antigene na koje treba usmjeriti imunosni odgovor kojeg će se inducirati.
7. Pripravak u skladu s patentnim zahtjevom 10, naznačen time što su limfoidne stanice limfociti, po mogućnosti limfociti iz periferne krvi.
8. Pripravak u skladu s patentnim zahtjevom 6 ili 7, naznačen time što se antigene inducira tijekom logaritamske faze proliferacije.
9. Pripravak u skladu s bilo kojim od patentnih zahtjeva 7 do 8, naznačen time što limfociti koji eksprimiraju antigene uključuju stanice CD4+.
10. Pripravak u skladu s bilo kojim od patentnih zahtjeva 6 do 9, naznačen time što se demetiliranje DNA sastoji u obradi 5-aza-2-deoksicitidinom, ili inhibitorom deacetiliranja histona.
11. Cjepivo za profilaktičko ili terapijsko liječenje, naznačeno time što sadrži pripravak u skladu s bilo kojim od patentnih zahtjeva 6 do 10 i prihvatljivu podlogu.
12. Upotreba pripravka u skladu s bilo kojim od patentnih zahtjeva 6 do 10, naznačena time što je navedeni pripravak namijenjen pripravi cjepiva za stimuliranje imunosnog odgovora na tumorski antigeni.
13. Upotreba pripravka u skladu s bilo kojim od patentnih zahtjeva 6 do 10, naznačena time što je navedeni pripravak sadrži antigenski prezentirajuće stanice za aktiviranje citotoksičnih T-limfocita.
14. Postupak dobivanja tumorski specifičnih citotoksičnih T-limfocita CD8+, naznačen time što se sastoji u aktiviranju T-limfocita pripravkom u skladu s bilo kojim od patentnih zahtjeva 6 do 10, kao antigenski prezentirajućih stanica.
15. Upotreba tumorski specifičnih citotoksičnih T-limfocita CD8+, dobivenih postupkom u skladu s patentnim zahtjevom 14, naznačena time što su navedeni limfociti namijenjeni pripravi farmaceutskog pripravka za adoptivnu imunoterapiju T-stanicama.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0700058.1A GB0700058D0 (en) | 2007-01-03 | 2007-01-03 | Anti-tumor vaccine based on normal cells |
| PCT/EP2008/050050 WO2008081035A1 (en) | 2007-01-03 | 2008-01-03 | Anti-tumor vaccine derived from normal chemically modified cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20110899T1 true HRP20110899T1 (hr) | 2011-12-31 |
Family
ID=37759205
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20110899T HRP20110899T1 (hr) | 2007-01-03 | 2011-11-30 | Protutumorsko cjepivo dobiveno iz normalnih, kemijski modificiranih stanica cd4+ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US10023839B2 (hr) |
| EP (1) | EP2102331B1 (hr) |
| JP (1) | JP5452231B2 (hr) |
| AT (1) | ATE522600T1 (hr) |
| AU (1) | AU2008203730B2 (hr) |
| CY (1) | CY1112668T1 (hr) |
| DK (1) | DK2102331T3 (hr) |
| ES (1) | ES2372713T3 (hr) |
| GB (1) | GB0700058D0 (hr) |
| HR (1) | HRP20110899T1 (hr) |
| PL (1) | PL2102331T3 (hr) |
| PT (1) | PT2102331E (hr) |
| SI (1) | SI2102331T1 (hr) |
| WO (1) | WO2008081035A1 (hr) |
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| US8586359B2 (en) * | 2009-07-28 | 2013-11-19 | Promising Furture, LLC | Compositions and methods of preparing alloreactive cytotoxic T cells |
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| EP2494038B1 (en) | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
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| US10426740B1 (en) | 2010-08-18 | 2019-10-01 | Avm Biotechnology, Llc | Compositions and methods to inhibit stem cell and progenitor cell binding to lymphoid tissue and for regenerating germinal centers in lymphatic tissues |
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| US20240158869A1 (en) | 2022-10-28 | 2024-05-16 | Kite Pharma, Inc. | Factors for optimizing immunotherapy |
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| EP2102331B1 (en) | 2011-08-31 |
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| CY1112668T1 (el) | 2016-02-10 |
| PT2102331E (pt) | 2011-12-19 |
| EP2102331A1 (en) | 2009-09-23 |
| ATE522600T1 (de) | 2011-09-15 |
| JP2010514455A (ja) | 2010-05-06 |
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