DK204684A - Humant vaeksthormon frit for andre proteiner forbundet med dets native miljoe, udtrykkelsesmedium, som kan frembringe produktion af prae-hgh i en prokaryotisk vaertscelle, prokaryotisk vaert transformeret dermed og fremgangsmaade til fremstilling af modent hgh - Google Patents

Humant vaeksthormon frit for andre proteiner forbundet med dets native miljoe, udtrykkelsesmedium, som kan frembringe produktion af prae-hgh i en prokaryotisk vaertscelle, prokaryotisk vaert transformeret dermed og fremgangsmaade til fremstilling af modent hgh Download PDF

Info

Publication number
DK204684A
DK204684A DK204684A DK204684A DK204684A DK 204684 A DK204684 A DK 204684A DK 204684 A DK204684 A DK 204684A DK 204684 A DK204684 A DK 204684A DK 204684 A DK204684 A DK 204684A
Authority
DK
Denmark
Prior art keywords
thermalged
prokaryotically
prae
procaryotic
hgh
Prior art date
Application number
DK204684A
Other languages
Danish (da)
English (en)
Other versions
DK204684D0 (da
Inventor
Gregory Lawrence Gray
Herbert Louis Heyneker
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of DK204684D0 publication Critical patent/DK204684D0/da
Publication of DK204684A publication Critical patent/DK204684A/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70Vectors or expression systems specially adapted for E. coli
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/61Growth hormone [GH], i.e. somatotropin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/78Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Pseudomonas
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/12Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/30Signal or leader sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DK204684A 1983-04-25 1984-04-24 Humant vaeksthormon frit for andre proteiner forbundet med dets native miljoe, udtrykkelsesmedium, som kan frembringe produktion af prae-hgh i en prokaryotisk vaertscelle, prokaryotisk vaert transformeret dermed og fremgangsmaade til fremstilling af modent hgh DK204684A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/488,232 US4755465A (en) 1983-04-25 1983-04-25 Secretion of correctly processed human growth hormone in E. coli and Pseudomonas

Publications (2)

Publication Number Publication Date
DK204684D0 DK204684D0 (da) 1984-04-24
DK204684A true DK204684A (da) 1984-10-26

Family

ID=23938879

Family Applications (1)

Application Number Title Priority Date Filing Date
DK204684A DK204684A (da) 1983-04-25 1984-04-24 Humant vaeksthormon frit for andre proteiner forbundet med dets native miljoe, udtrykkelsesmedium, som kan frembringe produktion af prae-hgh i en prokaryotisk vaertscelle, prokaryotisk vaert transformeret dermed og fremgangsmaade til fremstilling af modent hgh

Country Status (9)

Country Link
US (1) US4755465A (xx)
EP (1) EP0127305A1 (xx)
JP (2) JPS6045595A (xx)
CA (1) CA1267099A (xx)
DK (1) DK204684A (xx)
ES (1) ES531896A0 (xx)
IL (1) IL71622A (xx)
NZ (1) NZ207924A (xx)
ZA (1) ZA843062B (xx)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK55685A (da) * 1985-02-07 1986-08-08 Nordisk Gentofte Enzym eller enzymkompleks med proteolytisk aktivitet
US5618697A (en) * 1982-12-10 1997-04-08 Novo Nordisk A/S Process for preparing a desired protein
US4859600A (en) * 1983-04-25 1989-08-22 Genentech, Inc. Recombinant procaryotic cell containing correctly processed human growth hormone
IL71991A (en) 1983-06-06 1994-05-30 Genentech Inc Preparation of human FGI and FGE in their processed form through recombinant AND tranology in prokaryotes
BG49718A3 (en) * 1983-07-15 1992-01-15 Bio- Technology General Corp Method for preparing of polypeptid with superoxiddismutasne activitty
ATE251217T1 (de) * 1984-08-16 2003-10-15 Savient Pharmaceuticals Inc Methode zur herstellung von menschlichen wachstumshormonen
IL76360A0 (en) * 1984-09-26 1986-01-31 Takeda Chemical Industries Ltd Mutual separation of proteins
US5853978A (en) * 1985-12-04 1998-12-29 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and methods of use
US6534285B1 (en) 1984-12-24 2003-03-18 Genentech, Inc. Molecularly cloned acquired immunodeficiency syndrome polypeptides and their methods of use
US4861868A (en) * 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
DK151585D0 (da) * 1985-04-03 1985-04-03 Nordisk Gentofte Dna-sekvens
US4786501A (en) * 1985-07-15 1988-11-22 International Minerals & Chemical Corp. Cylindrical implants for the controlled release of growth hormones
US4865974A (en) * 1985-09-20 1989-09-12 Cetus Corporation Bacterial methionine N-terminal peptidase
US4870017A (en) * 1985-09-20 1989-09-26 Cetus Corporation Bacterial methionine N-terminal peptidase
US5013662A (en) * 1985-09-20 1991-05-07 Cetus Corporation Bacterial methionine n-terminal peptidase
FR2597114B1 (fr) * 1986-04-10 1994-02-25 Sanofi Procede microbiologique pour l'obtention d'une proteine par culture d'une souche bacterienne mutante
FR2599753B1 (fr) * 1986-06-05 1989-12-08 Sanofi Sa Sequence d'adn composite et son application pour la production de l'hormone de croissance
IT1228925B (it) * 1987-08-07 1991-07-10 Eniricerche Spa Procedimento per la preparazione dell'ormone della crescita umano
US5744139A (en) * 1991-06-28 1998-04-28 University Of Tennessee Research Corporation Insulin-like growth factor I (IGF-1) induced improvement of depressed T4/T8 ratios
US5202119A (en) * 1991-06-28 1993-04-13 Genentech, Inc. Method of stimulating immune response
US5317012A (en) * 1991-10-04 1994-05-31 The University Of Tennessee Research Corporation Human growth hormone induced improvement in depressed T4/T8 ratio
WO1993008292A1 (en) * 1991-10-16 1993-04-29 Agracetus, Inc. Particle-mediated transformation of animal somatic cells
JPH07118577B2 (ja) * 1992-12-02 1995-12-18 株式会社リコー 電子装置用基板の検査方法
GB9526733D0 (en) 1995-12-30 1996-02-28 Delta Biotechnology Ltd Fusion proteins
MX9605082A (es) 1996-10-24 1998-04-30 Univ Autonoma De Nuevo Leon Levaduras metilotroficas modificadas geneticamente para la produccion y secrecion de hormona de crecimiento humano.
MXPA04000134A (es) * 2001-06-26 2005-06-06 Abgenix Inc Anticuerpos para ligandos de osteoprotegerina.
ES2295370T3 (es) * 2001-07-06 2008-04-16 Lg Life Sciences Ltd. Nueva aminopeptidasa derivada de bacillus licheniformis, gen que codifica la aminopeptidasa, vector de expresion que contiene el gen, transformante y metodo para su preparacion.
AU2002306484A1 (en) 2002-02-13 2003-09-04 Dow Global Technologies Inc. Over-expression of extremozyme genes in pseudomonads and closely related bacteria
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US9453251B2 (en) * 2002-10-08 2016-09-27 Pfenex Inc. Expression of mammalian proteins in Pseudomonas fluorescens
CA2524623A1 (en) * 2003-05-09 2004-11-18 Pharmexa A/S Immunogenic human tnf alpha analogues with reduced cytotoxicity and methods of their preparation
JP2007501011A (ja) * 2003-08-01 2007-01-25 ジェネンテック・インコーポレーテッド 制限多様性配列を有する結合型ポリペプチド
CN1906294B (zh) 2003-11-19 2013-09-11 陶氏环球技术公司 改良的蛋白表达系统
JP5028551B2 (ja) 2003-11-21 2012-09-19 フェネックス インコーポレイテッド Sec系分泌によって改良された発現系
KR20060114340A (ko) * 2003-12-01 2006-11-06 다우 글로벌 테크놀로지스 인크. 슈도모나드에서의 재조합 20면체 바이러스-유사 입자 생성
ES2707786T3 (es) 2004-01-16 2019-04-05 Pfenex Inc Expresión de proteínas de mamífero en Pseudomonas fluorescens
CA2553040A1 (en) 2004-02-02 2005-08-18 Ambrx, Inc. Modified human four helical bundle polypeptides and their uses
CN102603895B (zh) * 2004-06-18 2016-09-28 Ambrx公司 新颖抗原结合多肽和其用途
WO2006001027A1 (en) * 2004-06-23 2006-01-05 Usv Limited Chimeric human growth hormone derived from the placenta and pituitary isoform and processes for obtaining said chimera
BRPI0512396A (pt) * 2004-07-21 2008-03-11 Ambrx Inc polipeptìdeos biossintéticos utilizando aminoácidos codificados não naturalmente
CN101031655A (zh) 2004-07-26 2007-09-05 陶氏环球技术公司 通过株工程改进蛋白表达的方法
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
KR20070090023A (ko) 2004-12-22 2007-09-04 암브룩스, 인코포레이티드 변형 인간 성장 호르몬
KR101252835B1 (ko) 2004-12-22 2013-04-10 암브룩스, 인코포레이티드 아미노아실-tRNA 합성효소의 조성물 및 그것의 용도
NZ555386A (en) 2004-12-22 2011-01-28 Ambrx Inc Formulations of human growth hormone comprising a non-naturally encoded amino acid
WO2006073846A2 (en) 2004-12-22 2006-07-13 Ambrx, Inc. Methods for expression and purification of recombinant human growth hormone
CN101247821B (zh) * 2005-06-03 2013-01-23 Ambrx公司 经改良人类干扰素分子和其用途
KR101285904B1 (ko) 2005-08-18 2013-07-15 암브룩스, 인코포레이티드 tRNA 조성물 및 이의 용도
EP1957531B1 (en) 2005-11-07 2016-04-13 Genentech, Inc. Binding polypeptides with diversified and consensus vh/vl hypervariable sequences
PL1954710T3 (pl) * 2005-11-08 2011-09-30 Ambrx Inc Przyspieszacze do modyfikacji aminokwasów niewystępujących w przyrodzie i polipeptydów zbudowanych z aminokwasów nie występujących w przyrodzie
KR20080079643A (ko) * 2005-11-16 2008-09-01 암브룩스, 인코포레이티드 비-천연 아미노산을 포함하는 방법 및 조성물
WO2007064919A2 (en) * 2005-12-02 2007-06-07 Genentech, Inc. Binding polypeptides with restricted diversity sequences
JP5808070B2 (ja) * 2005-12-02 2015-11-10 ジェネンテック, インコーポレイテッド 結合ポリペプチド及びその使用
US20080317670A1 (en) * 2005-12-14 2008-12-25 Ambrx, Inc. Compositions Containing, Methods Involving, and Uses of Non-Natural Amino Acids and Polypeptides
PT2064333E (pt) * 2006-09-08 2014-06-09 Ambrx Inc Supressor híbrido arnt para células de vertebrados
KR20090051227A (ko) * 2006-09-08 2009-05-21 암브룩스, 인코포레이티드 척추동물 세포를 위한 하이브리드 서프레서 tRNA
EP2069396B1 (en) * 2006-09-08 2015-10-21 Ambrx, Inc. Modified human plasma polypeptide or fc scaffolds and their uses
AU2008210538B2 (en) 2007-01-31 2013-06-06 Pelican Technology Holdings, Inc. Bacterial leader sequences for increased expression
CN104163864B (zh) * 2007-03-30 2017-08-01 Ambrx公司 经修饰fgf‑21多肽和其用途
KR101530395B1 (ko) 2007-04-27 2015-06-19 피페넥스 인크. 향상된 수율 및(또는) 품질로 이종 단백질을 발현하는 특정 균주를 동정하기 위해 미생물 숙주를 신속히 스크리닝하는 방법
US20090093019A1 (en) * 2007-04-27 2009-04-09 Phelps Jamie P Production and in vivo assembly of soluble recombinant icosahedral virus-like particles
US9580719B2 (en) 2007-04-27 2017-02-28 Pfenex, Inc. Method for rapidly screening microbial hosts to identify certain strains with improved yield and/or quality in the expression of heterologous proteins
AU2008247815B2 (en) * 2007-05-02 2012-09-06 Ambrx, Inc. Modified interferon beta polypeptides and their uses
MX338336B (es) * 2007-11-20 2016-04-07 Ambrx Inc Polipeptidos de insulina modificados y sus usos.
CN101939443B (zh) 2008-02-08 2014-01-29 Ambrx公司 经修饰瘦素多肽和其用途
US20110020830A1 (en) * 2008-03-31 2011-01-27 Schneider Jane C Design for rapidly cloning one or more polypeptide chains into an expression system
PT2318029T (pt) * 2008-07-23 2018-01-10 Ambrx Inc Polipéptidos de g-csf bovino modificados e suas utilizações
ES2660000T3 (es) 2008-09-26 2018-03-20 Ambrx, Inc. Vacunas y microorganismos dependientes de la replicación de aminoácidos no naturales
EP2342223B1 (en) 2008-09-26 2017-04-26 Ambrx, Inc. Modified animal erythropoietin polypeptides and their uses
ES2640947T3 (es) 2009-05-11 2017-11-07 Pfenex, Inc. Producción de proteínas recombinantes utilizando métodos de selección no antibióticos y la incorporación de aminoácidos no naturales en las mismas
JP5840148B2 (ja) 2010-03-04 2016-01-06 フェニックス インク. 変性させることなく可溶性組換えインターフェロンタンパク質を産生する方法
MX343356B (es) 2010-03-30 2016-11-03 Pfenex Inc * Toxinas proteicas recombinantes de alto nivel de expresion.
CA2794740C (en) 2010-04-01 2019-12-31 Pfenex Inc. Methods for g-csf production in a pseudomonas host cell
US9567386B2 (en) 2010-08-17 2017-02-14 Ambrx, Inc. Therapeutic uses of modified relaxin polypeptides
PL2605789T3 (pl) 2010-08-17 2019-11-29 Ambrx Inc Zmodyfikowane polipeptydy relaksyny i ich zastosowania
AR083006A1 (es) 2010-09-23 2013-01-23 Lilly Co Eli Formulaciones para el factor estimulante de colonias de granulocitos (g-csf) bovino y variantes de las mismas
US9169304B2 (en) 2012-05-01 2015-10-27 Pfenex Inc. Process for purifying recombinant Plasmodium falciparum circumsporozoite protein
KR20240024362A (ko) 2014-10-24 2024-02-23 브리스톨-마이어스 스큅 컴퍼니 변형된 fgf-21 폴리펩티드 및 그의 용도
US10280409B2 (en) 2014-11-20 2019-05-07 Biological E Limited Codon optimized polynucleotide for high level expression of CRM197
US10118956B2 (en) 2014-12-01 2018-11-06 Pfenex Inc. Fusion partners for peptide production
SG10201912034UA (en) 2017-02-08 2020-02-27 Bristol Myers Squibb Co Modified relaxin polypeptides comprising a pharmacokinetic enhancer and uses thereof
US20190127744A1 (en) 2017-10-27 2019-05-02 Pfenex Inc. BACTERIAL LEADER SEQUENCES FOR PERlPLASMIC PROTEIN EXPRESSION
JP2021500896A (ja) 2017-10-27 2021-01-14 フェネックス インク. 組み換えerwiniaアスパラギナーゼの製造のための方法
TW202241922A (zh) 2020-12-23 2022-11-01 愛爾蘭商爵士製藥愛爾蘭有限公司 純化電荷遮蔽的融合蛋白質之方法
WO2022211829A1 (en) 2021-03-30 2022-10-06 Jazz Pharmaceuticals Ireland Ltd. Dosing of recombinant l-asparaginase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE52036B1 (en) * 1979-05-24 1987-05-27 Univ California Non-passageable viruses
ZA802992B (en) * 1979-06-01 1981-10-28 Univ California Human pre-growth hormone
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4338397A (en) * 1980-04-11 1982-07-06 President And Fellows Of Harvard College Mature protein synthesis
IE52755B1 (en) * 1980-08-26 1988-02-17 Univ California Bovine pre-growth and growth hormone
FI64813C (fi) * 1980-12-31 1984-01-10 Ilkka Antero Palva Foerfarande foer producering av ett utvalt aeggviteaemne och vid foerfarandet anvaenda rekombinantplasmidvektorer
DK582381A (da) * 1981-01-02 1982-07-03 Univ New York Remkombinat plasmid til anvendelse ved bakteriel kloning
US4775622A (en) * 1982-03-08 1988-10-04 Genentech, Inc. Expression, processing and secretion of heterologous protein by yeast
DE3380262D1 (en) * 1982-05-25 1989-08-31 Lilly Co Eli Cloning vectors for expression of exogenous protein
JPS59135892A (ja) * 1983-01-25 1984-08-04 Kunio Yamane シグナルアミノ酸配列をコードするdna

Also Published As

Publication number Publication date
CA1267099A (en) 1990-03-27
ES8602136A1 (es) 1985-12-01
AU2721984A (en) 1984-11-01
IL71622A (en) 1990-03-19
AU586609B2 (en) 1989-07-20
EP0127305A1 (en) 1984-12-05
ES531896A0 (es) 1985-12-01
IL71622A0 (en) 1984-07-31
US4755465A (en) 1988-07-05
NZ207924A (en) 1988-03-30
JPH05252936A (ja) 1993-10-05
JPS6045595A (ja) 1985-03-12
ZA843062B (en) 1984-11-28
DK204684D0 (da) 1984-04-24

Similar Documents

Publication Publication Date Title
DK204684D0 (da) Humant vaeksthormon frit for andre proteiner forbundet med dets native miljoe,udtrykkelsesmedium,som kan frembringe produktion af prae-hgh i en prokaryotisk vaertscelle,prokaryotisk vaert transformeret dermed og fremgangsmaade til fremstilling af modent hgh
DK0574402T3 (da) Ekspression af PACE i værtsceller og fremgangsmåder til anvendelse deraf
PT87394A (pt) Process for plant tissue transformation
AR241314A1 (es) Aislado de adn, vector en base en dicho aislado cultivo de celulas tratadas con dicho vector y preparacion de factor viii humano funcional.
ES8800987A1 (es) Metodo de produccion del factor viii:c humano
IT8422580A0 (it) Composizioni che le contengono e proteine di membrana cellulare, procedimento per prepararle.
ES8307500A1 (es) "metodo para inactivar los virus infecciosos contenidos en una composicion enzimatica hemocoagulante".
IT8220140A0 (it) Procedimento per la produzione di sostanze prodotte da cellule, particolarmente di anticorpi esimili.
DE69130981D1 (de) Expression von makrophagen-induzierbaren proteinen (mips) in hefezellen
EP0182448A3 (en) Production of factor viii and related products
PT66299B (en) Process for preparing stabilized glucose isomerase enzyme concentrate
DK133780A (da) Fremgangsmaade til fremstilling af interferon
DK0547064T3 (da) Proteaseresistent PDGF og anvendelsesfremgangsmåde
ZA844595B (en) Process for preparing single cell protein from sulfur energy sources
IT8448540A0 (it) Proteine umane, antisieri per esse, procedimento per prepararli e corredi di prova che li contengono
MY103362A (en) Production of proteins in active forms
BG40145A3 (en) Method for preparing 3- (3- pyridyl)- 1h, 3h- pyrolo (1, 2- c) thiazol- 7- carbonitrile
DK262784D0 (da) Mikrobiologisk fremstillet d-2-hydroxy-4-methylpentansyredehydrogenase, fremgangsmaade til dets udvinding og dets anvendelse
DK428184D0 (da) 2-oxocarbonsyrereduktase, fremgangsmaade til fremstilling heraf samt anvendelse heraf til reduktion af 2-oxocarbonsyrer og disses estere
WO1988000836A3 (fr) Immunosuppresseur et son procede de fabrication
DK163195C (da) Fremgangsmaade til radioaktiv maerkning af blodceller, oploesning til brug ved fremgangsmaaden, fremgangsmaade til fremstilling af oploesningen, og saet til radioaktiv maerkning af blodceller
IT8119533A0 (it) Metodo per la produzione di isomerasi del glucosio immobilizzata.
DK285587D0 (da) Ekspressionsvektor med evne til inducibar ekspression af et fremmed strukturgen, der baeres af ekspressionsvektoren, i vaertsceller og fremgangsmaade tilfremstilling af oenskede genprodukter
DK282387D0 (da) Sammensat dna-sekvens og dennes anvendelse til fremstilling af vaeksthormon
DK197091A (da) Fremgangsmaade til fremstilling af proteiner med fviii aktivitet og/eller fviii derivater

Legal Events

Date Code Title Description
AHS Application shelved for other reasons than non-payment