DK2023952T3 - Induktion af immunresponser mod influenzavirus ved anvendelse af polypeptid- og nukleinsyre-sammensætninger - Google Patents
Induktion af immunresponser mod influenzavirus ved anvendelse af polypeptid- og nukleinsyre-sammensætninger Download PDFInfo
- Publication number
- DK2023952T3 DK2023952T3 DK07867125.2T DK07867125T DK2023952T3 DK 2023952 T3 DK2023952 T3 DK 2023952T3 DK 07867125 T DK07867125 T DK 07867125T DK 2023952 T3 DK2023952 T3 DK 2023952T3
- Authority
- DK
- Denmark
- Prior art keywords
- epitope
- influenza
- sequence
- polypeptide
- epitopes
- Prior art date
Links
- BYYVZWFYOARRDX-UHFFFAOYSA-N C1C=CC2=C3C2C13 Chemical compound C1C=CC2=C3C2C13 BYYVZWFYOARRDX-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/605—MHC molecules or ligands thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80106506P | 2006-05-18 | 2006-05-18 | |
US83885906P | 2006-08-21 | 2006-08-21 | |
PCT/US2007/011900 WO2008054540A2 (en) | 2006-05-18 | 2007-05-18 | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2023952T3 true DK2023952T3 (da) | 2015-10-19 |
Family
ID=39344815
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK07867125.2T DK2023952T3 (da) | 2006-05-18 | 2007-05-18 | Induktion af immunresponser mod influenzavirus ved anvendelse af polypeptid- og nukleinsyre-sammensætninger |
Country Status (6)
Country | Link |
---|---|
US (1) | US9511134B2 (da) |
EP (1) | EP2023952B1 (da) |
AU (1) | AU2007314550A1 (da) |
CA (1) | CA2657849A1 (da) |
DK (1) | DK2023952T3 (da) |
WO (1) | WO2008054540A2 (da) |
Families Citing this family (60)
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US9511134B2 (en) | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
US9598462B2 (en) | 2012-01-26 | 2017-03-21 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
US8652782B2 (en) | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
US8080645B2 (en) * | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
CA2615372A1 (en) | 2007-07-13 | 2009-01-13 | Marc-Andre D'aoust | Influenza virus-like particles (vlps) comprising hemagglutinin |
US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
US8821885B2 (en) | 2007-08-27 | 2014-09-02 | Longhorn Vaccines & Diagnostics, Llc | Immunogenic compositions and methods |
WO2009085355A2 (en) | 2007-10-01 | 2009-07-09 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection and transport system and methods of use |
US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
EP2610345B1 (en) | 2007-11-27 | 2015-08-19 | Medicago Inc. | Recombinant influenza virus-like particles (VLPS) produced in transgenic plants expressing hemagglutinin |
EP2294202B1 (en) * | 2008-07-08 | 2015-05-20 | Medicago Inc. | Soluble recombinant influenza antigens |
US8658180B2 (en) | 2008-08-15 | 2014-02-25 | Mark A. Miller | Vaccines against influenza virus |
EP2168987A1 (en) * | 2008-09-22 | 2010-03-31 | Mucosis B.V. | Multifunctional linker protein containing an antibody against hemagglutinin, a conserved influenza antigen and an immunostimulating carrier binding domain |
WO2011057160A2 (en) * | 2009-11-06 | 2011-05-12 | The Regents Of The Uiversity Of California | Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120 |
US8282938B2 (en) * | 2008-11-28 | 2012-10-09 | National Institute Of Infectious Diseases | Immunogenic compositions comprising liposomes and an influenza PB2 CTL epitope obtained from the highly pathogenic H5N1 strain |
US9249187B2 (en) | 2009-01-28 | 2016-02-02 | Epimmune Inc. | Pan-DR binding polypeptides and uses thereof |
CA2787099A1 (en) | 2009-03-30 | 2010-10-14 | Anice C. Lowen | Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof |
AU2016201691B2 (en) * | 2009-04-01 | 2017-06-22 | University Of Miami | Vaccine compositions and methods of use thereof |
EP2413964B1 (en) | 2009-04-01 | 2019-11-13 | University of Miami | Vaccine compositions and methods of use thereof |
CA2762586C (en) * | 2009-05-19 | 2018-06-19 | University Of Miami | Compositions, kits and methods for in vitro antigen presentation, assessing vaccine efficacy, and assessing immunotoxicity of biologics and drugs |
JP5941841B2 (ja) * | 2009-05-26 | 2016-06-29 | アイカーン スクール オブ メディシン アット マウント サイナイ | 周期的投与によって作製されたインフルエンザウイルスに対するモノクローナル抗体及びその使用 |
US8926982B2 (en) | 2009-06-01 | 2015-01-06 | Xuguang Li | Reagents and methods for detecting influenza virus proteins |
US10272148B2 (en) | 2009-06-24 | 2019-04-30 | Medicago Inc. | Chimeric influenza virus-like particles comprising hemagglutinin |
ES2566361T3 (es) * | 2009-07-02 | 2016-04-12 | Massachusetts Institute Of Technology | Composiciones y métodos para diagnosticar y/o tratar una infección gripal |
WO2011014794A1 (en) | 2009-07-31 | 2011-02-03 | Paxvax, Inc. | Adenoviral-based vectors |
PT3354657T (pt) | 2009-09-22 | 2022-05-06 | Medicago Inc | Método de preparação de proteínas derivadas de plantas |
AU2010300623A1 (en) * | 2009-09-30 | 2012-04-19 | Saint Louis University | Peptides for inducing heterosubtypic influenza T cell responses |
KR101262300B1 (ko) * | 2009-10-06 | 2013-05-20 | 헬릭스 주식회사 | 형질전환 식물 유래의 고병원성 조류독감 바이러스 단백질 백신 및 그 제조방법 |
WO2011046996A2 (en) * | 2009-10-13 | 2011-04-21 | The Johns Hopkins University | Consensus sequence for influenza a virus |
CN102656455B (zh) * | 2009-10-21 | 2015-03-11 | 由卫生福利和体育大臣代表的荷兰王国 | 用于诊断针对病毒的免疫应答的方法 |
AU2010321731B2 (en) * | 2009-11-20 | 2017-01-05 | Takeda Vaccines, Inc. | Compositions, methods and uses for poxvirus elements in vaccine constructs |
MX342716B (es) * | 2010-02-18 | 2016-10-11 | Sinai School Medicine | Vacunas para su uso en la profilaxis y tratamiento de la enfermedad del virus de influenza. |
CA2792537A1 (en) | 2010-03-30 | 2011-10-06 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
WO2011130858A1 (en) * | 2010-04-22 | 2011-10-27 | Centre Hospitalier De L'université De Montréal | Method for the identification of t cell epitopes |
CN101879312B (zh) * | 2010-06-11 | 2012-07-25 | 北京精益泰翔技术发展有限公司 | 广谱型流感疫苗及其制备方法 |
CN102397559B (zh) * | 2010-06-11 | 2013-06-05 | 北京精益泰翔技术发展有限公司 | 广谱型流感疫苗及其制备方法 |
US20130095557A1 (en) * | 2010-07-02 | 2013-04-18 | Transgene S.A. | Immortalized avian cell lines |
CN101928787B (zh) * | 2010-08-20 | 2012-09-19 | 浙江省疾病预防控制中心 | 检测甲型h1n1流感病毒抗药性突变的引物和探针及方法 |
EP2652496B1 (en) | 2010-12-13 | 2018-01-17 | The University of Utah Research Foundation | Vaccine antigens that direct immunity to conserved epitopes |
WO2012089231A1 (en) * | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
TWI620816B (zh) | 2011-03-23 | 2018-04-11 | 苜蓿股份有限公司 | 植物衍生蛋白回收方法 |
EP2758075B1 (en) | 2011-09-20 | 2023-05-03 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
PL220281B1 (pl) | 2011-09-23 | 2015-09-30 | Inst Biochemii I Biofizyki Polskiej Akademii Nauk | Szczepionka DNA, sposób indukowania odpowiedzi immunologicznej, przeciwciała specyficznie rozpoznające białko hemaglutyniny H5 wirusa grypy i zastosowanie szczepionki DNA |
NZ627796A (en) | 2012-12-18 | 2017-07-28 | Icahn School Med Mount Sinai | Influenza virus vaccines and uses thereof |
US20160000900A1 (en) * | 2013-02-15 | 2016-01-07 | Futurewei Technologies, Inc. | Oligomeric influenza immunogenic compositions |
WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
WO2015048129A1 (en) * | 2013-09-24 | 2015-04-02 | CHOI, Duk, Kyung | Avian influenza virus polypeptides and methods of their use |
CN103613664B (zh) * | 2013-10-18 | 2015-08-12 | 广东省疾病预防控制中心 | 一种禽流感病毒h5n1的抗体分子及其检测试剂盒和用途 |
JP2018504412A (ja) | 2015-01-23 | 2018-02-15 | アイカーン スクール オブ メディシン アット マウント サイナイ | インフルエンザウイルスワクチン接種レジメン |
WO2016183292A1 (en) | 2015-05-14 | 2016-11-17 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
CN105749269A (zh) * | 2016-02-25 | 2016-07-13 | 肇庆大华农生物药品有限公司 | 一种使鸭快速产生抗禽流感抗体并维持抗体滴度的方法 |
GB201603625D0 (en) * | 2016-03-02 | 2016-04-13 | Glaxosmithkline Biolog Sa | Novel influenza antigens |
US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
WO2018187706A2 (en) | 2017-04-07 | 2018-10-11 | Icahn School Of Medicine At Mount Sinai | Anti-influenza b virus neuraminidase antibodies and uses thereof |
CN109136199B (zh) * | 2018-09-14 | 2020-02-07 | 青岛农业大学 | 一种表达h5亚型ha的复制缺陷型重组h9n2禽流感病毒 |
CN113881617B (zh) * | 2021-10-15 | 2023-09-26 | 吉林农业大学 | 靶向树突状细胞表达h7n9禽流感ha1抗原的重组乳酸菌及其应用 |
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WO2001000225A1 (en) | 1999-06-29 | 2001-01-04 | Epimmune Inc. | Hla binding peptides and their uses |
IL109664A0 (en) | 1993-05-18 | 1994-08-26 | Rijksuniversiteit | Peptides of human influenza virus for use in human t cell response inducing compositions |
JP3926839B2 (ja) * | 1993-09-14 | 2007-06-06 | エピミューン,インコーポレイティド | 万能dr−結合性ペプチドを用いる免疫応答の改変 |
US20040157780A1 (en) * | 1993-11-29 | 2004-08-12 | Epimmune Inc. | CTL inducing peptides from c-erb2 (HER-2/neu) |
JPH10298198A (ja) | 1997-04-22 | 1998-11-10 | Takara Shuzo Co Ltd | Ctl誘導用抗原ペプチド |
AU4078599A (en) * | 1998-05-13 | 1999-11-29 | Epimmune, Inc. | Expression vectors for stimulating an immune response and methods of using the same |
ATE366582T1 (de) * | 1999-12-28 | 2007-08-15 | Pharmexa Inc | Optimierte minigene und dadurch kodierte peptide |
US7462354B2 (en) * | 1999-12-28 | 2008-12-09 | Pharmexa Inc. | Method and system for optimizing minigenes and peptides encoded thereby |
US20070269456A1 (en) * | 2001-11-05 | 2007-11-22 | Lasher Alfred W | DNA-based plasmid formulations and vaccines and prophylactics containing the same |
KR20050083719A (ko) * | 2002-10-03 | 2005-08-26 | 에피뮨 인코포레이티드 | 최적화된 멀티-에피토프 구성체 및 이의 용도 |
US8080255B2 (en) * | 2003-07-11 | 2011-12-20 | Novavax Inc. | Functional influenza virus like particles (VLPs) |
WO2006071990A2 (en) | 2004-12-29 | 2006-07-06 | Mannkind Corporation | Methods to bypass cd+4 cells in the induction of an immune response |
BRPI0613625A2 (pt) * | 2005-07-19 | 2011-01-18 | Dow Global Technologies Inc | vacinas da gripe recombinantes |
JP5198290B2 (ja) * | 2006-02-02 | 2013-05-15 | グローブイミューン,インコーポレイテッド | 免疫反応を誘発する酵母ベースワクチン |
US9511134B2 (en) | 2006-05-18 | 2016-12-06 | Epimmune Inc. | Inducing immune responses to influenza virus using polypeptide and nucleic acid compositions |
-
2007
- 2007-05-18 US US11/802,106 patent/US9511134B2/en active Active
- 2007-05-18 DK DK07867125.2T patent/DK2023952T3/da active
- 2007-05-18 EP EP07867125.2A patent/EP2023952B1/en active Active
- 2007-05-18 WO PCT/US2007/011900 patent/WO2008054540A2/en active Application Filing
- 2007-05-18 AU AU2007314550A patent/AU2007314550A1/en not_active Abandoned
- 2007-05-18 CA CA002657849A patent/CA2657849A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2007314550A1 (en) | 2008-05-08 |
US9511134B2 (en) | 2016-12-06 |
WO2008054540A9 (en) | 2008-07-03 |
EP2023952B1 (en) | 2015-07-15 |
EP2023952A2 (en) | 2009-02-18 |
CA2657849A1 (en) | 2008-05-08 |
WO2008054540A2 (en) | 2008-05-08 |
WO2008054540A3 (en) | 2008-09-12 |
US20080032921A1 (en) | 2008-02-07 |
EP2023952A4 (en) | 2010-10-13 |
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