DK200578A - Thia-azaforbindelser med beta-lactamring fremgangsmaade til fremstilling deraf samt anvendelsen deraf - Google Patents

Thia-azaforbindelser med beta-lactamring fremgangsmaade til fremstilling deraf samt anvendelsen deraf

Info

Publication number
DK200578A
DK200578A DK200578A DK200578A DK200578A DK 200578 A DK200578 A DK 200578A DK 200578 A DK200578 A DK 200578A DK 200578 A DK200578 A DK 200578A DK 200578 A DK200578 A DK 200578A
Authority
DK
Denmark
Prior art keywords
lactamring
thia
beta
procedures
manufacture
Prior art date
Application number
DK200578A
Other languages
Danish (da)
English (en)
Inventor
J Gosteli
I Ernest
R B Woodward
Original Assignee
Ciba Geigy Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ciba Geigy Ag filed Critical Ciba Geigy Ag
Publication of DK200578A publication Critical patent/DK200578A/da
Priority to DK388482A priority Critical patent/DK388482A/da
Priority to DK388582A priority patent/DK388582A/da
Priority to DK398082A priority patent/DK398082A/da
Priority to DK399582A priority patent/DK399582A/da
Priority to DK401282A priority patent/DK401282A/da
Priority to DK404482A priority patent/DK404482A/da
Priority to DK405982A priority patent/DK405982A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/88—Compounds with a double bond between positions 2 and 3 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams
    • C07D205/09—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams with a sulfur atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DK200578A 1977-05-09 1978-05-08 Thia-azaforbindelser med beta-lactamring fremgangsmaade til fremstilling deraf samt anvendelsen deraf DK200578A (da)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK388482A DK388482A (da) 1977-05-09 1982-08-31 4-thio-2-oxoazetidinon-forbindelser
DK388582A DK388582A (da) 1977-05-09 1982-08-31 2-(-oxo-1-azetidinyl)-eddikesyre-forbindelser
DK398082A DK398082A (da) 1977-05-09 1982-09-06 Ylid-forbindelser
DK399582A DK399582A (da) 1978-05-08 1982-09-07 Penicillansyre-1-oxider
DK401282A DK401282A (da) 1978-05-08 1982-09-08 2-azetidinyl-butensyreester-derivater
DK404482A DK404482A (da) 1978-05-08 1982-09-09 2-(2-oxo-1-azetidinyl)-butensyreester-derivater
DK405982A DK405982A (da) 1978-05-08 1982-09-10 2-azetidinyl-2-oxoeddikesyreester-derivater

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
LU77306A LU77306A1 (ko) 1977-05-09 1977-05-09

Publications (1)

Publication Number Publication Date
DK200578A true DK200578A (da) 1978-11-10

Family

ID=19728568

Family Applications (1)

Application Number Title Priority Date Filing Date
DK200578A DK200578A (da) 1977-05-09 1978-05-08 Thia-azaforbindelser med beta-lactamring fremgangsmaade til fremstilling deraf samt anvendelsen deraf

Country Status (13)

Country Link
US (5) US4331676A (ko)
JP (1) JPS53137951A (ko)
AU (1) AU527917B2 (ko)
BE (1) BE866845A (ko)
CH (1) CH646173A5 (ko)
DE (1) DE2819655A1 (ko)
DK (1) DK200578A (ko)
ES (1) ES469568A1 (ko)
FR (8) FR2405949A1 (ko)
GB (4) GB1604753A (ko)
LU (1) LU77306A1 (ko)
NL (1) NL7804974A (ko)
SE (2) SE443980B (ko)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055573A (en) * 1976-11-19 1991-10-08 Merck & Co., Inc. Process for preparing 1-carba-2-penem-3-carboxylic acid
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IN149747B (ko) * 1977-06-07 1982-04-03 Pfizer
US4168314A (en) * 1977-11-17 1979-09-18 Merck & Co., Inc. 6-(1'-Hydroxyethyl)-2-aminoethylthio-pen-2-em-3-carboxylic acid
JPS54117459A (en) * 1978-01-20 1979-09-12 Glaxo Group Ltd Novel lactam compound
EP0042026B1 (de) * 1978-02-02 1986-01-08 Ciba-Geigy Ag 3,4-Disubstituierte Azetidin-2-onverbindungen und Verfahren zu ihrer Herstellung
IT1162268B (it) * 1978-02-16 1987-03-25 Glaxo Group Ltd Composti beta-lattamici procedimento per produrli composizioni che li contengono e intermedi per prepararli
JPS5559193A (en) * 1978-09-20 1980-05-02 Glaxo Group Ltd Bblactam compound
US4290948A (en) 1978-11-22 1981-09-22 Beecham Group Limited Process for their preparation of β-lactam antibacterial agents
AT365594B (de) * 1978-11-24 1982-01-25 Erba Farmitalia Verfahren zur herstellung von neuen 7-oxo-4-thia1-aza-bicyclo-(3,2,0)heptanderivaten
US4272437A (en) 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds
JPS5625110A (en) * 1978-12-18 1981-03-10 Bristol Myers Co Antibacterial
EP0013067A1 (en) * 1978-12-22 1980-07-09 Beecham Group Plc Bicyclic beta-lactam antibacterial agents, their use in pharmaceutical compositions, processes for their preparation and intermediates for use in such processes
IL59081A0 (en) * 1979-01-10 1980-05-30 Schering Corp 2-penem compounds and a method for preparing them
ATE18558T1 (de) * 1979-01-10 1986-03-15 Schering Corp 2-penem-verbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zusammensetzungen.
GB2043639B (en) * 1979-02-24 1983-07-20 Erba Farmitalia 3-optionally substituted methyl-2-penem derivatives
US4420426A (en) 1979-03-05 1983-12-13 Pfizer Inc. 6-Alpha-halopenicillanic acid 1,1-dioxides
US4714761A (en) * 1979-03-05 1987-12-22 Pfizer Inc. 6,6-dihalopenicillanic acid 1,1-dioxides and process
US4269771A (en) * 1979-04-06 1981-05-26 Farmitalia Carlo Erba Total synthesis of 7-oxo-4-thia-1-azabicyclo-[3,2,0]-heptane-2-carboxyl derivatives useful as β-lactamase inhibitors and antibacterial agents
US4683226A (en) * 1979-08-01 1987-07-28 Schering Corporation 6-hydroxyalkyl-2-(substituted-thio)penem-3-carboxylic acids
US4374065A (en) 1979-09-21 1983-02-15 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4378314A (en) 1979-09-21 1983-03-29 Bristol Myers Company Antibacterial agents and metal containing azetidinone intermediates therefore
US4406834A (en) 1979-09-21 1983-09-27 Bristol-Myers Company 2,6 Disubstituted penems and intermediates therefor
DE3069524D1 (en) * 1979-12-20 1984-11-29 Hoechst Uk Ltd Penem derivatives
US4482565A (en) * 1980-02-22 1984-11-13 Farmitalia Carlo Erba S.P.A. β-Lactam-containing antibacterial agents and β-lactamase inhibitors
JPS56142282A (en) * 1980-03-10 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
JPS56142283A (en) * 1980-03-17 1981-11-06 Sankyo Co Ltd Penem-3-carboxylic acid derivative and its preparation
ATE21105T1 (de) * 1980-11-06 1986-08-15 Hoechst Uk Ltd 7-oxo-4-thia-1-aza(3.2.0)heptan- und 7-oxo-4-thia-1-aza-(3.2.0)hept-2-en-derivate.
ES513672A0 (es) * 1981-07-08 1983-04-01 Hoechst Uk Ltd "procedimiento para la preparacion de derivados de penem".
EP0185651A1 (en) * 1981-07-08 1986-06-25 Hoechst Uk Limited Intermediates for the production of antibacterial penem derivates
JPS58116487A (ja) * 1981-12-28 1983-07-11 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
JPS5835190A (ja) * 1981-08-25 1983-03-01 Sankyo Co Ltd ペネム−３−カルボン酸誘導体
JPS5946289A (ja) * 1982-09-08 1984-03-15 Sumitomo Chem Co Ltd 新規なβ−ラクタム化合物及びその製造法
US4725678A (en) * 1983-06-10 1988-02-16 Pfizer Inc. Azetidinone intermediates for the preparation of penem derivatives
US4595539A (en) * 1983-06-10 1986-06-17 Pfizer Inc. Preparation of penem derivatives and azetidinone intermediates
US4680391A (en) * 1983-12-01 1987-07-14 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5229510A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. β-lactams useful in determining the amount of elastase in a clinical sample
JPS60243064A (ja) * 1984-05-17 1985-12-03 Taiho Yakuhin Kogyo Kk アゼチジノンジスルフイド誘導体
EP0379281A3 (en) * 1989-01-19 1991-03-20 Cosmopolitan Textile Company Limited Web inspecting method and apparatus
US5100880A (en) * 1991-03-20 1992-03-31 Merck & Co., Inc. Novel betalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5104862A (en) * 1991-03-20 1992-04-14 Merck & Co., Inc. Bethalactam elastase inhibitors containing phosphorous acid derivatives at the 4-position of the 2-azetidinone
US5348953A (en) * 1991-06-25 1994-09-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
CA2147129A1 (en) * 1992-10-27 1994-05-11 James B. Doherty New substituted azetidinones as anti-inflammatory and antidegenerative agents
US5591737A (en) * 1992-12-17 1997-01-07 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
WO2004039776A2 (en) * 2002-11-01 2004-05-13 Orchid Chemicals & Pharmaceuticals Ltd A process for the preparation of benzyl 2-oxo-4- (heteroaryl) dithio-alpha-isoprenyl-1- azetidineazetate derivatives
EP2209474A4 (en) 2007-10-09 2013-07-24 Sopharmia Inc BROAD SPECTRUM BETA-LACTAMASE INHIBITORS
JP2015518854A (ja) * 2012-05-23 2015-07-06 セリックスビオ プライヴェート リミテッド 多発性硬化症の治療のための組成物および方法
CN112424114B (zh) * 2018-05-07 2024-07-30 柏林自由大学 用于从含氯气体中分离、存储和运输氯气的存储介质和方法
CN114720591B (zh) * 2022-03-22 2022-12-30 北京安胜瑞力科技有限公司 一种工业废水中dmac的定量分析方法

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE648188A (ko) 1963-05-29 1964-09-16
BE755940A (fr) * 1969-09-09 1971-03-09 Hoechst Ag Azetidinones-2 portant des substituants en position 4 et leur preparation
GB1368074A (en) * 1971-02-04 1974-09-25 Beecham Group Ltd Substituted beta-lactams and their preparation
FR2143211B1 (ko) * 1971-06-24 1975-10-31 Fujisawa Pharmaceutical Co
JPS4854056A (ko) * 1971-11-12 1973-07-30
US4070477A (en) * 1975-12-08 1978-01-24 Ciba-Geigy Corporation 2-Penem compounds
IN149747B (ko) * 1977-06-07 1982-04-03 Pfizer
GB2005246A (en) * 1977-07-13 1979-04-19 Glaxo Group Ltd beta -Lactam compounds and processes for their preparation
AU3796278A (en) * 1977-07-13 1980-01-17 Glaxo Group Ltd Penams and azetidinones
US4155912A (en) * 1977-12-14 1979-05-22 Bristol-Myers Company 2-Methylpenem-3-carboxylic acid antibiotics
US4169833A (en) * 1977-12-14 1979-10-02 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4192801A (en) * 1978-04-27 1980-03-11 Bristol-Myers Company Novel phosphorane intermediates for use in preparing penem antibiotics
US4182711A (en) * 1978-04-27 1980-01-08 Bristol-Myers Company Antibacterial agents of the β-lactam type
US4272437A (en) * 1978-12-18 1981-06-09 Bristol-Myers Company Antibacterial agents, and 4-thio azetidinone intermediates
US4282150A (en) * 1978-12-18 1981-08-04 Bristol-Myers Company 2,6-Disubstituted penem compounds

Also Published As

Publication number Publication date
SE8305299L (sv) 1983-09-29
US4447360A (en) 1984-05-08
US4331676A (en) 1982-05-25
FR2422637B1 (ko) 1982-04-23
NL7804974A (nl) 1978-11-13
BE866845A (fr) 1978-11-09
FR2405934A1 (fr) 1979-05-11
FR2405949A1 (fr) 1979-05-11
US4518533A (en) 1985-05-21
US4524028A (en) 1985-06-18
FR2422637A1 (fr) 1979-11-09
FR2405946B1 (ko) 1983-09-30
GB1604751A (en) 1981-12-16
SE8305299D0 (sv) 1983-09-29
AU3588478A (en) 1979-11-15
FR2405950B1 (ko) 1981-07-31
FR2405949B1 (ko) 1980-10-24
FR2405946A1 (fr) 1979-05-11
FR2405955B1 (ko) 1981-07-31
SE7805217L (sv) 1978-11-10
FR2405945A1 (fr) 1979-05-11
GB1604754A (en) 1981-12-16
FR2411179A1 (fr) 1979-07-06
FR2405934B1 (ko) 1980-09-05
FR2405950A1 (fr) 1979-05-11
US4515717A (en) 1985-05-07
ES469568A1 (es) 1980-01-01
AU527917B2 (en) 1983-03-31
JPS53137951A (en) 1978-12-01
CH646173A5 (de) 1984-11-15
SE443980B (sv) 1986-03-17
FR2405945B1 (ko) 1982-04-09
GB1604752A (en) 1981-12-16
LU77306A1 (ko) 1979-01-18
DE2819655A1 (de) 1978-11-23
FR2405955A1 (fr) 1979-05-11
GB1604753A (en) 1981-12-16
FR2411179B1 (ko) 1982-04-23

Similar Documents

Publication Publication Date Title
DK200578A (da) Thia-azaforbindelser med beta-lactamring fremgangsmaade til fremstilling deraf samt anvendelsen deraf
DK119276A (da) Non-thrombogen medicinsk genstand samt fremgangsmade til fremstilling deraf
DK477278A (da) Fremgangsmaade til forbedring af stabiliseringen af meningokokpolysaccharid samt anvendelse af fremgangsmaaden
FI773274A (fi) Dokumentfoerdelare med hopsamlingssystem
DK397777A (da) Thiazolindinderivater samt fremgangsmaade til fremstilling deraf
DK540678A (da) Polypeptider samt fremgangsmaade til fremstilling heraf
FI780239A (fi) Med boejliga tryckplattor foersedd formcylinder foer rotationstryckmaskiner
DK21079A (da) Substituerede heterocycloske benzamider samt fremgangsmaade til fremstilling deraf
DK353577A (da) 7-acylamido-3-cephem-4-carboxylsyrederivater samt fremgangsmaade til fremstilling deraf
DK37278A (da) Meta-sulfonamido-benzamid-derivater samt fremgangsmaade til fremstilling deraf
DK147378A (da) Imidazodiazepinderivater samt fremgangsmaade til fremstilling deraf
DK545077A (da) Thiooximcephalosporin- og penicillinderivater samt fremgangsmaader til fremstilling deraf
SE7704322L (sv) Tiokarbamidderivat samt forfarande for framstellning derav
FI803248L (fi) Med differentialhjul foersedd utmatningsanordning foer paosar faestade med tejp
DK303178A (da) Benzylpyrimidiner samt fremgangsmaade til fremstilling deraf
DK391678A (da) Nitrogen-heterocycliske forbindelser fremgangsmaade til deres fremstilling samt deres anvendelse
NO150366C (no) Traadtau samt framgangsmaate for framstilling av dette
DK66978A (da) Mikrobicide 3-phenyl-oxazoldin-2,4-dion-forbindelser samt fremgangsmaade til fremstilling deraf
SE7812816L (sv) Kontinuerligt gjuten stalstang samt forfarande for tillverkning av densamma
DK402877A (da) 1-amino-2-hydroxy-3-heterocyclyloxy-propansalte deraf samt fremgangsmaade til fremstilling deraf
NO783160L (no) Taakesats, samt framgangsmaate for framstilling av slik
DK315878A (da) Amidino-benzylpyrimidiner samt fremgangsmaade til fremstilling deraf
DK13778A (da) 11beta-substituerede steroider samt fremgangsmaade til fremstilling deraf
DK285576A (da) Pentacycliske forbindelser med et eburnanlignende skelet samt fremgangsmade til fremstilling heraf
SE7813082L (sv) Tertiera segmentpolymerisat samt forfarande for framstellning av desamma

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment