DK1988090T3 - Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse deraf - Google Patents
Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse derafInfo
- Publication number
- DK1988090T3 DK1988090T3 DK06775249.3T DK06775249T DK1988090T3 DK 1988090 T3 DK1988090 T3 DK 1988090T3 DK 06775249 T DK06775249 T DK 06775249T DK 1988090 T3 DK1988090 T3 DK 1988090T3
- Authority
- DK
- Denmark
- Prior art keywords
- imidazole
- procedures
- preparing
- carboxylic acid
- acid derivatives
- Prior art date
Links
- NKWCGTOZTHZDHB-UHFFFAOYSA-N 1h-imidazol-1-ium-4-carboxylate Chemical class OC(=O)C1=CNC=N1 NKWCGTOZTHZDHB-UHFFFAOYSA-N 0.000 title 1
- 238000000034 method Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2006100239910A CN101024643A (zh) | 2006-02-20 | 2006-02-20 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| PCT/CN2006/001914 WO2007095789A1 (en) | 2006-02-20 | 2006-07-31 | Imidazol-5-carboxylic acid derivatives, preparation methods and use therrof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1988090T3 true DK1988090T3 (da) | 2013-08-05 |
Family
ID=38436915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06775249.3T DK1988090T3 (da) | 2006-02-20 | 2006-07-31 | Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse deraf |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | USRE44873E1 (https=) |
| EP (1) | EP1988090B1 (https=) |
| JP (1) | JP5250760B2 (https=) |
| KR (1) | KR101179110B1 (https=) |
| CN (2) | CN101024643A (https=) |
| AU (1) | AU2006338796B2 (https=) |
| CA (1) | CA2643005C (https=) |
| DK (1) | DK1988090T3 (https=) |
| ES (1) | ES2424154T3 (https=) |
| PL (1) | PL1988090T3 (https=) |
| PT (1) | PT1988090E (https=) |
| WO (1) | WO2007095789A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101024643A (zh) | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| JP5290190B2 (ja) * | 2006-12-06 | 2013-09-18 | サルブリス・アセット・マネイジメント・カンパニー・リミテッド | イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物 |
| CN101214242A (zh) | 2007-01-05 | 2008-07-09 | 上海艾力斯医药科技有限公司 | 新的药用组合物 |
| CN101317842A (zh) * | 2007-06-07 | 2008-12-10 | 上海艾力斯医药科技有限公司 | 一种咪唑-5-羧酸衍生物的治疗用途 |
| CN101407511B (zh) * | 2007-10-11 | 2013-01-09 | 上海艾力斯生物医药有限公司 | 一种结晶型的咪唑-5-羧酸衍生物 |
| US8207208B2 (en) * | 2008-05-15 | 2012-06-26 | Merck Sharp & Dohme Corp. | Angiotensin II receptor antagonists |
| CN101596189A (zh) * | 2008-06-05 | 2009-12-09 | 上海艾力斯生物医药有限公司 | 含有咪唑-5-羧酸类衍生物的药用组合物 |
| WO2010067913A1 (en) * | 2008-12-12 | 2010-06-17 | Pharmacostech Co., Ltd. | Method of removing the triphenylmethane protection group |
| KR101213467B1 (ko) * | 2010-04-30 | 2012-12-20 | 진양제약주식회사 | 로자탄 대사체 이엑스피-3174 이수화물의 신규한 제조 방법 |
| CN103012377A (zh) * | 2011-09-27 | 2013-04-03 | 江苏艾力斯生物医药有限公司 | 一种咪唑-5-羧酸酯的重结晶方法 |
| CN102558064B (zh) * | 2012-01-29 | 2014-04-16 | 安润医药科技（苏州）有限公司 | 抗高血压化合物及其制备方法和应用，以及其在药学上可接受的盐 |
| CN109320501B (zh) * | 2013-11-01 | 2021-06-01 | 深圳信立泰药业股份有限公司 | 阿利沙坦酯无定形及其制备方法及含所述无定形的药物组合物 |
| CN103965171A (zh) * | 2014-04-30 | 2014-08-06 | 上海艾力斯医药科技有限公司 | 一种阿利沙坦酯的制备方法 |
| CN106188012B (zh) * | 2014-06-20 | 2018-11-30 | 深圳信立泰药业股份有限公司 | 一种阿利沙坦酯结晶及其制备方法及含有该结晶的药物组合物 |
| CN105218527B (zh) * | 2015-10-10 | 2018-04-24 | 江苏宝众宝达药业有限公司 | 一种exp-3174的制备方法 |
| CN108473474B (zh) | 2016-01-20 | 2022-02-11 | 深圳信立泰药业股份有限公司 | 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物及其制备方法 |
| CN119371408B (zh) * | 2024-12-27 | 2025-04-22 | 安徽艾立德制药有限公司 | 一种无定形的阿利沙坦酯及其制备方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1334092C (en) | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
| US5138069A (en) | 1986-07-11 | 1992-08-11 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking imidazoles |
| US5196444A (en) | 1990-04-27 | 1993-03-23 | Takeda Chemical Industries, Ltd. | 1-(cyclohexyloxycarbonyloxy)ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl]benzimidazole-7-carboxylate and compositions and methods of pharmaceutical use thereof |
| US5616599A (en) * | 1991-02-21 | 1997-04-01 | Sankyo Company, Limited | Angiotensin II antagosist 1-biphenylmethylimidazole compounds and their therapeutic use |
| AT398202B (de) | 1991-10-04 | 1994-10-25 | Chem Pharm Forsch Gmbh | Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung |
| DK0573218T3 (da) * | 1992-06-02 | 2001-06-18 | Sankyo Co | 4-carboxyimidazolderivater som angiotensin-II antagonister og deres terapeutiske anvendelse |
| JPH083162A (ja) * | 1994-04-19 | 1996-01-09 | Tanabe Seiyaku Co Ltd | イミダゾピリジン誘導体及びその製法 |
| AU725689B2 (en) * | 1995-06-07 | 2000-10-19 | G.D. Searle & Co. | Epoxy-steroidal aldosterone antagonist and angiotensin II antagonist combination therapy for treatment of congestive heart failure |
| PL379420A1 (pl) * | 2003-07-31 | 2006-09-04 | Nicox S.A. | Pochodne blokerów receptora angiotensyny II |
| US20070238740A1 (en) | 2003-08-28 | 2007-10-11 | Nitromed, Inc. | Nitrosated And Nitrosylated Cardiovascular Compounds, Compositions And Methods Of Use |
| ES2334386T3 (es) | 2005-04-22 | 2010-03-09 | Daiichi Sankyo Company, Limited | Producto farmaceutico para la prevencion o el tratamiento de una enfermedad metabolica osea. |
| CN101024643A (zh) | 2006-02-20 | 2007-08-29 | 上海艾力斯医药科技有限公司 | 咪唑－5－羧酸类衍生物、制备方法及其应用 |
| JP5290190B2 (ja) | 2006-12-06 | 2013-09-18 | サルブリス・アセット・マネイジメント・カンパニー・リミテッド | イミダゾール−５−カルボン酸誘導体の塩、製造方法及びその医薬組成物 |
| CN101214242A (zh) | 2007-01-05 | 2008-07-09 | 上海艾力斯医药科技有限公司 | 新的药用组合物 |
| CN101317842A (zh) | 2007-06-07 | 2008-12-10 | 上海艾力斯医药科技有限公司 | 一种咪唑-5-羧酸衍生物的治疗用途 |
| CN101407511B (zh) | 2007-10-11 | 2013-01-09 | 上海艾力斯生物医药有限公司 | 一种结晶型的咪唑-5-羧酸衍生物 |
-
2006
- 2006-02-20 CN CNA2006100239910A patent/CN101024643A/zh active Pending
- 2006-07-31 AU AU2006338796A patent/AU2006338796B2/en not_active Ceased
- 2006-07-31 KR KR1020087022811A patent/KR101179110B1/ko not_active Expired - Fee Related
- 2006-07-31 WO PCT/CN2006/001914 patent/WO2007095789A1/zh not_active Ceased
- 2006-07-31 CN CNB2006800003978A patent/CN100506818C/zh active Active
- 2006-07-31 PT PT67752493T patent/PT1988090E/pt unknown
- 2006-07-31 ES ES06775249T patent/ES2424154T3/es active Active
- 2006-07-31 EP EP06775249.3A patent/EP1988090B1/en not_active Not-in-force
- 2006-07-31 CA CA2643005A patent/CA2643005C/en not_active Expired - Fee Related
- 2006-07-31 DK DK06775249.3T patent/DK1988090T3/da active
- 2006-07-31 PL PL06775249T patent/PL1988090T3/pl unknown
- 2006-07-31 US US13/727,587 patent/USRE44873E1/en active Active
- 2006-07-31 JP JP2008555597A patent/JP5250760B2/ja not_active Expired - Fee Related
- 2006-07-31 US US11/576,094 patent/US7858651B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ES2424154T3 (es) | 2013-09-27 |
| KR20080096707A (ko) | 2008-10-31 |
| EP1988090A1 (en) | 2008-11-05 |
| CN101024643A (zh) | 2007-08-29 |
| JP5250760B2 (ja) | 2013-07-31 |
| JP2009527509A (ja) | 2009-07-30 |
| US7858651B2 (en) | 2010-12-28 |
| USRE44873E1 (en) | 2014-04-29 |
| AU2006338796A1 (en) | 2007-08-30 |
| EP1988090A4 (en) | 2010-06-30 |
| CA2643005C (en) | 2012-05-15 |
| CN100506818C (zh) | 2009-07-01 |
| CA2643005A1 (en) | 2007-08-30 |
| PT1988090E (pt) | 2013-08-05 |
| KR101179110B1 (ko) | 2012-09-07 |
| EP1988090B1 (en) | 2013-05-01 |
| CN101031562A (zh) | 2007-09-05 |
| US20090036505A1 (en) | 2009-02-05 |
| AU2006338796B2 (en) | 2011-05-12 |
| WO2007095789A1 (en) | 2007-08-30 |
| PL1988090T3 (pl) | 2013-10-31 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK2209375T3 (da) | Parp-inhibitorforbindelser, præparater og fremgangsmåder til anvendelse deraf | |
| DK2010501T3 (da) | Imidazolbaserede forbindelser, sammensætninger omfattende disse og fremgangsmåder for deres anvendelse | |
| DK3461503T3 (da) | Fremgangsmåder til indgivelse af tetrahydrobiopterin, associerede sammensætninger og målingsfremgangsmåder | |
| IS8770A (is) | Plástrar, kerfi og aðferðir fyrir ei-ífarandi glúkósa mælingu | |
| DK2069352T3 (da) | Bestemte kemiske enheder, sammensætninger og fremgangsmåder | |
| DK3067064T3 (da) | Modificerede rsv-f-proteiner og fremgangsmåder til anvendelse deraf | |
| DK2222675T3 (da) | 5-anilinoimidazopyridiner og fremgangsmåder til deres anvendelse | |
| DK2270818T3 (da) | Polyelektrolyt og fremgangsmåde til fremstilling af polyelektrolytten | |
| DK2147315T3 (da) | Diabetesrelaterede biomarkører og fremgangsmåder til anvendelse deraf | |
| DK3851447T3 (da) | Fremgangsmåder, forbindelser, sammensætninger og vehikler til administration af 3-amino-1-propansulfonsyre | |
| DK2044002T3 (da) | Fremgangsmåde til fremstilling af 3-substituerede 2-amino-5-halobenzamider | |
| DE502007000819D1 (de) | Abgasnachbehandlungssystem | |
| DK2139987T3 (da) | Fremgangsmåder til proteinfremstilling med anti-senescens-forbindelser | |
| DK2120591T3 (da) | Ny drikkeyoghurt og fremgangsmåde til fremstilling deraf | |
| DE502007005327D1 (de) | Abgasnachbehandlungssystem | |
| DK2231614T3 (da) | Quinolinderivativer og anvendelse af disse som fungicider | |
| DE502007000724D1 (de) | Abgasnachbehandlungssystem | |
| DK2029799T3 (da) | Termostabile proteiner og fremgangsmåder til fremstilling og anvendelse heraf | |
| DK2057153T3 (da) | (3-aryl-piperazin-1-yl)-derivater af 6,7 dialkoxyquinazolin, 6,7- dialkoxyphtalazin og 6,7-dialkoxyisoquinolin | |
| DK2134663T3 (da) | Beskyttelseslag på højtemperaturudholdende chromoxiddannende substrater, og fremgangsmåde til fremstilling deraf | |
| DE502006002276D1 (de) | Integriertes medizinisches Trackingsystem | |
| DK1988090T3 (da) | Imidazol-5-carboxylsyrederivater, fremgangsmåder til fremstilling af disse og anvendelse deraf | |
| DK2201020T3 (da) | Fremgangsmåde til fremstilling af 2' -deoxy-5-azacytidin (decitabin) | |
| DK2158201T3 (da) | Derivater af 7-alkynyl-1,8-naphthyridon, fremgangsmåde til fremstilling deraf og anvendelse deraf i terapi | |
| DK2146742T3 (da) | Cellelinjer, sammensætninger omfattende disse til behandling af melanomer, fremgangsmåder til at fremstille sammensætningerne og behandlingsmetoder |